Result of FASTA (omim) for
pFN21AE3633
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3633, 822 aa
1>>>pF1KE3633 822 - 822 aa - 822 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6166+/-0.000359; mu= 19.4394+/- 0.023
mean_var=74.1074+/-14.722, 0's: 0 Z-trim(113.8): 38 B-trim: 7 in 1/50
Lambda= 0.148985
statistics sampled from 23228 (23266) to 23228 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.273), width: 16
Scan time: 13.120
The best scores are: opt bits E(85289)
NP_037498 (OMIM: 606946) anaphase-promoting comple ( 822) 5447 1180.6 0
NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo ( 659) 230 59.2 7.1e-08
NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [H ( 659) 230 59.2 7.1e-08
XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A i ( 659) 230 59.2 7.1e-08
NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [H ( 667) 230 59.2 7.2e-08
NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [H ( 759) 230 59.2 8e-08
XP_011529703 (OMIM: 300304,300354) PREDICTED: cull ( 701) 229 59.0 8.7e-08
XP_011529702 (OMIM: 300304,300354) PREDICTED: cull ( 717) 229 59.0 8.8e-08
XP_011529701 (OMIM: 300304,300354) PREDICTED: cull ( 719) 229 59.0 8.9e-08
NP_001073341 (OMIM: 300304,300354) cullin-4B isofo ( 895) 229 59.0 1.1e-07
NP_001317553 (OMIM: 300304,300354) cullin-4B isofo ( 900) 229 59.0 1.1e-07
XP_006724847 (OMIM: 300304,300354) PREDICTED: cull ( 902) 229 59.0 1.1e-07
NP_003579 (OMIM: 300304,300354) cullin-4B isoform ( 913) 229 59.0 1.1e-07
XP_005262538 (OMIM: 300304,300354) PREDICTED: cull ( 915) 229 59.0 1.1e-07
XP_016868212 (OMIM: 603134) PREDICTED: cullin-1 is ( 455) 198 52.2 6.1e-06
XP_011514933 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06
NP_003583 (OMIM: 603134) cullin-1 [Homo sapiens] ( 776) 198 52.3 9.6e-06
XP_011514934 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06
XP_005250117 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06
XP_011514932 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06
XP_011514931 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 198 52.3 9.6e-06
NP_001311305 (OMIM: 603135) cullin-2 isoform e [Ho ( 614) 182 48.8 8.5e-05
NP_001311304 (OMIM: 603135) cullin-2 isoform d [Ho ( 682) 182 48.9 9.3e-05
NP_001185706 (OMIM: 603135) cullin-2 isoform c [Ho ( 745) 182 48.9 0.0001
XP_011518049 (OMIM: 603135) PREDICTED: cullin-2 is ( 745) 182 48.9 0.0001
NP_003582 (OMIM: 603135) cullin-2 isoform c [Homo ( 745) 182 48.9 0.0001
NP_001185708 (OMIM: 603135) cullin-2 isoform b [Ho ( 758) 182 48.9 0.0001
NP_001185707 (OMIM: 603135) cullin-2 isoform a [Ho ( 764) 182 48.9 0.0001
XP_011518046 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 182 48.9 0.00011
XP_011518045 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 182 48.9 0.00011
XP_011518047 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 182 48.9 0.00011
>>NP_037498 (OMIM: 606946) anaphase-promoting complex su (822 aa)
initn: 5447 init1: 5447 opt: 5447 Z-score: 6321.2 bits: 1180.6 E(85289): 0
Smith-Waterman score: 5447; 100.0% identity (100.0% similar) in 822 aa overlap (1-822:1-822)
10 20 30 40 50 60
pF1KE3 MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
730 740 750 760 770 780
790 800 810 820
pF1KE3 VVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS
::::::::::::::::::::::::::::::::::::::::::
NP_037 VVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS
790 800 810 820
>>NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo sap (659 aa)
initn: 199 init1: 137 opt: 230 Z-score: 262.4 bits: 59.2 E(85289): 7.1e-08
Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:331-545)
470 480 490 500 510 520
pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR
:. : : .: . .::.: :.. :: :
NP_003 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
310 320 330 340 350 360
530 540 550 560 570 580
pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ
:: : : . : . :: . : : : :.::: :. : ...... ... ..
NP_003 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS
370 380 390 400 410
590 600 610 620 630 640
pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM
:. . . ::. .:: . .... .. :.. : .. : :.:. ::: ...
NP_003 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL
420 430 440 450 460 470
650 660 670 680 690 700
pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---
.:. . :. :...::.:.. ....::.. :. . . ::: .. : :
NP_003 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR
480 490 500 510 520 530
710 720 730 740 750 760
pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT
:: . : :
NP_003 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID
540 550 560 570 580 590
>>NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [Homo (659 aa)
initn: 199 init1: 137 opt: 230 Z-score: 262.4 bits: 59.2 E(85289): 7.1e-08
Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:331-545)
470 480 490 500 510 520
pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR
:. : : .: . .::.: :.. :: :
NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
310 320 330 340 350 360
530 540 550 560 570 580
pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ
:: : : . : . :: . : : : :.::: :. : ...... ... ..
NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS
370 380 390 400 410
590 600 610 620 630 640
pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM
:. . . ::. .:: . .... .. :.. : .. : :.:. ::: ...
NP_001 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL
420 430 440 450 460 470
650 660 670 680 690 700
pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---
.:. . :. :...::.:.. ....::.. :. . . ::: .. : :
NP_001 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR
480 490 500 510 520 530
710 720 730 740 750 760
pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT
:: . : :
NP_001 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID
540 550 560 570 580 590
>>XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A isofo (659 aa)
initn: 199 init1: 137 opt: 230 Z-score: 262.4 bits: 59.2 E(85289): 7.1e-08
Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:331-545)
470 480 490 500 510 520
pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR
:. : : .: . .::.: :.. :: :
XP_011 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
310 320 330 340 350 360
530 540 550 560 570 580
pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ
:: : : . : . :: . : : : :.::: :. : ...... ... ..
XP_011 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS
370 380 390 400 410
590 600 610 620 630 640
pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM
:. . . ::. .:: . .... .. :.. : .. : :.:. ::: ...
XP_011 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL
420 430 440 450 460 470
650 660 670 680 690 700
pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---
.:. . :. :...::.:.. ....::.. :. . . ::: .. : :
XP_011 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR
480 490 500 510 520 530
710 720 730 740 750 760
pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT
:: . : :
XP_011 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID
540 550 560 570 580 590
>>NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [Homo (667 aa)
initn: 199 init1: 137 opt: 230 Z-score: 262.3 bits: 59.2 E(85289): 7.2e-08
Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:339-553)
470 480 490 500 510 520
pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR
:. : : .: . .::.: :.. :: :
NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
310 320 330 340 350 360
530 540 550 560 570 580
pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ
:: : : . : . :: . : : : :.::: :. : ...... ... ..
NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS
370 380 390 400 410 420
590 600 610 620 630 640
pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM
:. . . ::. .:: . .... .. :.. : .. : :.:. ::: ...
NP_001 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL
430 440 450 460 470 480
650 660 670 680 690 700
pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---
.:. . :. :...::.:.. ....::.. :. . . ::: .. : :
NP_001 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR
490 500 510 520 530 540
710 720 730 740 750 760
pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT
:: . : :
NP_001 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID
550 560 570 580 590 600
>>NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [Homo (759 aa)
initn: 237 init1: 137 opt: 230 Z-score: 261.5 bits: 59.2 E(85289): 8e-08
Smith-Waterman score: 230; 26.6% identity (56.9% similar) in 218 aa overlap (497-711:431-645)
470 480 490 500 510 520
pF1KE3 GQDSEDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADR
:. : : .: . .::.: :.. :: :
NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
410 420 430 440 450 460
530 540 550 560 570 580
pF1KE3 LLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQ
:: : : . : . :: . : : : :.::: :. : ...... ... ..
NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS--DS
470 480 490 500 510
590 600 610 620 630 640
pF1KE3 PPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTM
:. . . ::. .:: . .... .. :.. : .. : :.:. ::: ...
NP_001 GPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVL
520 530 540 550 560 570
650 660 670 680 690 700
pF1KE3 DVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---
.:. . :. :...::.:.. ....::.. :. . . ::: .. : :
NP_001 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS-LACGKAR
580 590 600 610 620 630
710 720 730 740 750 760
pF1KE3 VLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLT
:: . : :
NP_001 VLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQID
640 650 660 670 680 690
>>XP_011529703 (OMIM: 300304,300354) PREDICTED: cullin-4 (701 aa)
initn: 214 init1: 214 opt: 229 Z-score: 260.8 bits: 59.0 E(85289): 8.7e-08
Smith-Waterman score: 229; 28.7% identity (56.0% similar) in 216 aa overlap (501-711:376-587)
480 490 500 510 520 530
pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ
:. .. ::: ::.: :.. :: :::
XP_011 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG
350 360 370 380 390 400
540 550 560 570 580 590
pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG
: : . : . :: . : : : :.::: :. : :. .. : ... : .
XP_011 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIM--IQFKQVKYMQNQNVPGN
410 420 430 440 450 460
600 610 620 630 640
pF1KE3 VYAV--ILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDV
. . ::. .:: . ....: .. : . : .. : :.:. ::: .. .
XP_011 IELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKA
470 480 490 500 510 520
650 660 670 680 690 700
pF1KE3 ELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VL
:. . . :. :...::.:.. ..:::...:. . . ::: .. : : ::
XP_011 EFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVL
530 540 550 560 570 580
710 720 730 740 750 760
pF1KE3 REEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNL
..: :
XP_011 AKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAA
590 600 610 620 630 640
>>XP_011529702 (OMIM: 300304,300354) PREDICTED: cullin-4 (717 aa)
initn: 217 init1: 155 opt: 229 Z-score: 260.7 bits: 59.0 E(85289): 8.8e-08
Smith-Waterman score: 229; 28.0% identity (56.1% similar) in 214 aa overlap (501-711:394-603)
480 490 500 510 520 530
pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ
:. .. ::: ::.: :.. :: :::
XP_011 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG
370 380 390 400 410 420
540 550 560 570 580 590
pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG
: : . : . :: . : : : :.::: :. : .... ... . . .
XP_011 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELT
430 440 450 460 470 480
600 610 620 630 640 650
pF1KE3 VYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVEL
: ::. .:: . ....: .. : . : .. : :.:. ::: .. .:.
XP_011 VN--ILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF
490 500 510 520 530 540
660 670 680 690 700
pF1KE3 ADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VLRE
. . :. :...::.:.. ..:::...:. . . ::: .. : : :: .
XP_011 KEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVLAK
550 560 570 580 590
710 720 730 740 750 760
pF1KE3 EPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLES
.: :
XP_011 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIV
600 610 620 630 640 650
>>XP_011529701 (OMIM: 300304,300354) PREDICTED: cullin-4 (719 aa)
initn: 214 init1: 214 opt: 229 Z-score: 260.6 bits: 59.0 E(85289): 8.9e-08
Smith-Waterman score: 229; 28.7% identity (56.0% similar) in 216 aa overlap (501-711:394-605)
480 490 500 510 520 530
pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ
:. .. ::: ::.: :.. :: :::
XP_011 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG
370 380 390 400 410 420
540 550 560 570 580 590
pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG
: : . : . :: . : : : :.::: :. : :. .. : ... : .
XP_011 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIM--IQFKQVKYMQNQNVPGN
430 440 450 460 470 480
600 610 620 630 640
pF1KE3 VYAV--ILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDV
. . ::. .:: . ....: .. : . : .. : :.:. ::: .. .
XP_011 IELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKA
490 500 510 520 530 540
650 660 670 680 690 700
pF1KE3 ELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VL
:. . . :. :...::.:.. ..:::...:. . . ::: .. : : ::
XP_011 EFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVL
550 560 570 580 590
710 720 730 740 750 760
pF1KE3 REEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNL
..: :
XP_011 AKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAA
600 610 620 630 640 650
>>NP_001073341 (OMIM: 300304,300354) cullin-4B isoform 2 (895 aa)
initn: 217 init1: 155 opt: 229 Z-score: 259.2 bits: 59.0 E(85289): 1.1e-07
Smith-Waterman score: 229; 28.0% identity (56.1% similar) in 214 aa overlap (501-711:572-781)
480 490 500 510 520 530
pF1KE3 EDDSGEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQ
:. .. ::: ::.: :.. :: :::
NP_001 AELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYG-KDVFEAFYKKDLAKRLLVG
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE3 FSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFG
: : . : . :: . : : : :.::: :. : .... ... . . .
NP_001 KSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELT
610 620 630 640 650 660
600 610 620 630 640 650
pF1KE3 VYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVEL
: ::. .:: . ....: .. : . : .. : :.:. ::: .. .:.
NP_001 VN--ILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEF
670 680 690 700 710
660 670 680 690 700
pF1KE3 ADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQG---VLRE
. . :. :...::.:.. ..:::...:. . . ::: .. : : :: .
NP_001 KEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS-LACGKARVLAK
720 730 740 750 760 770
710 720 730 740 750 760
pF1KE3 EPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLES
.: :
NP_001 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIV
780 790 800 810 820 830
822 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:24:28 2016 done: Sat Nov 5 22:24:30 2016
Total Scan time: 13.120 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]