Result of FASTA (omim) for
pFN21AE3629
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3629, 822 aa
1>>>pF1KE3629 822 - 822 aa - 822 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1128+/-0.000425; mu= 12.5100+/- 0.026
mean_var=135.9105+/-30.491, 0's: 0 Z-trim(114.9): 218 B-trim: 1336 in 1/52
Lambda= 0.110014
statistics sampled from 24716 (24954) to 24716 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.293), width: 16
Scan time: 12.220
The best scores are: opt bits E(85289)
NP_149106 (OMIM: 616899,616900) TBC domain-contain ( 830) 5557 894.4 0
NP_001156908 (OMIM: 616899,616900) TBC domain-cont ( 893) 5020 809.2 0
NP_001156907 (OMIM: 616899,616900) TBC domain-cont ( 893) 5020 809.2 0
XP_016864337 (OMIM: 616899,616900) PREDICTED: TBC ( 787) 5016 808.5 0
XP_016864335 (OMIM: 616899,616900) PREDICTED: TBC ( 893) 5016 808.6 0
XP_011530719 (OMIM: 616899,616900) PREDICTED: TBC ( 893) 5016 808.6 0
NP_001277697 (OMIM: 616899,616900) TBC domain-cont ( 721) 4875 786.1 0
XP_016864338 (OMIM: 616899,616900) PREDICTED: TBC ( 721) 4871 785.5 0
XP_016864336 (OMIM: 616899,616900) PREDICTED: TBC ( 857) 4773 770.0 0
NP_001156909 (OMIM: 616899,616900) TBC domain-cont ( 854) 4684 755.8 1.8e-217
XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 301 60.2 4.7e-08
XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 301 60.2 4.7e-08
XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08
XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08
XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08
NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 301 60.3 5.4e-08
XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08
XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 301 60.3 5.4e-08
NP_114143 (OMIM: 610020) TBC1 domain family member ( 508) 268 54.8 1.1e-06
XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 270 55.2 1.3e-06
NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 270 55.3 1.3e-06
XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 270 55.3 1.5e-06
XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 270 55.3 1.6e-06
NP_001191169 (OMIM: 610020) TBC1 domain family mem ( 515) 265 54.3 1.6e-06
XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 270 55.3 1.6e-06
XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 270 55.3 1.6e-06
NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 251 52.2 8.6e-06
NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 251 52.2 9e-06
NP_940919 (OMIM: 610831) carabin isoform 1 [Homo s ( 446) 247 51.4 1e-05
XP_006718601 (OMIM: 610831) PREDICTED: carabin iso ( 446) 247 51.4 1e-05
XP_006718603 (OMIM: 610831) PREDICTED: carabin iso ( 446) 247 51.4 1e-05
XP_006718602 (OMIM: 610831) PREDICTED: carabin iso ( 446) 247 51.4 1e-05
NP_056342 (OMIM: 613620) TBC1 domain family member ( 808) 250 52.1 1.2e-05
NP_001273734 (OMIM: 614855) TBC1 domain family mem ( 353) 241 50.4 1.7e-05
NP_001106834 (OMIM: 614855) TBC1 domain family mem ( 413) 241 50.4 1.9e-05
NP_001317567 (OMIM: 614855) TBC1 domain family mem ( 465) 241 50.5 2.1e-05
XP_011543304 (OMIM: 610831) PREDICTED: carabin iso ( 313) 237 49.7 2.4e-05
XP_006713958 (OMIM: 614855) PREDICTED: TBC1 domain ( 693) 241 50.6 2.8e-05
NP_065824 (OMIM: 614855) TBC1 domain family member ( 693) 241 50.6 2.8e-05
NP_001106832 (OMIM: 614855) TBC1 domain family mem ( 693) 241 50.6 2.8e-05
XP_016863968 (OMIM: 614855) PREDICTED: TBC1 domain ( 389) 234 49.3 3.9e-05
XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 237 50.0 4.6e-05
XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 237 50.0 4.8e-05
XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 237 50.0 4.9e-05
NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 237 50.0 5e-05
XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 237 50.0 5e-05
NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 237 50.0 5e-05
XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 237 50.0 5e-05
XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 237 50.0 5.2e-05
XP_016857765 (OMIM: 602942) PREDICTED: ecotropic v ( 859) 237 50.0 5.2e-05
>>NP_149106 (OMIM: 616899,616900) TBC domain-containing (830 aa)
initn: 5557 init1: 5557 opt: 5557 Z-score: 4774.5 bits: 894.4 E(85289): 0
Smith-Waterman score: 5557; 100.0% identity (100.0% similar) in 822 aa overlap (1-822:9-830)
10 20 30 40 50
pF1KE3 MGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 KSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 KSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 ETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 DISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 DISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 ESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 ATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVE
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 GAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLV
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 YWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 YWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAF
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 HDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 HDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAIL
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE3 QQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 QQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE3 SGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 SGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE3 SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 SKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGK
730 740 750 760 770 780
780 790 800 810 820
pF1KE3 VIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 VIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
790 800 810 820 830
>>NP_001156908 (OMIM: 616899,616900) TBC domain-containi (893 aa)
initn: 5020 init1: 5020 opt: 5020 Z-score: 4313.4 bits: 809.2 E(85289): 0
Smith-Waterman score: 5202; 92.5% identity (92.5% similar) in 854 aa overlap (32-822:40-893)
10 20 30 40 50 60
pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
::::::::::::::::::::::::::::::
NP_001 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
10 20 30 40 50 60
70 80
pF1KE3 VAEHCERSLEDLLRERKPVR----------------------------------------
:::::::::::::::::::
NP_001 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH
70 80 90 100 110 120
90 100 110
pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
:::::::::::::::::::::::::::::::::::::
NP_001 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
610 620 630 640 650 660
600 610 620 630 640 650
pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
670 680 690 700 710 720
660 670 680 690 700 710
pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
730 740 750 760 770 780
720 730 740 750 760 770
pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
790 800 810 820 830 840
780 790 800 810 820
pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
850 860 870 880 890
>>NP_001156907 (OMIM: 616899,616900) TBC domain-containi (893 aa)
initn: 5020 init1: 5020 opt: 5020 Z-score: 4313.4 bits: 809.2 E(85289): 0
Smith-Waterman score: 5202; 92.5% identity (92.5% similar) in 854 aa overlap (32-822:40-893)
10 20 30 40 50 60
pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
::::::::::::::::::::::::::::::
NP_001 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
10 20 30 40 50 60
70 80
pF1KE3 VAEHCERSLEDLLRERKPVR----------------------------------------
:::::::::::::::::::
NP_001 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH
70 80 90 100 110 120
90 100 110
pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
:::::::::::::::::::::::::::::::::::::
NP_001 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
610 620 630 640 650 660
600 610 620 630 640 650
pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
670 680 690 700 710 720
660 670 680 690 700 710
pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
730 740 750 760 770 780
720 730 740 750 760 770
pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
790 800 810 820 830 840
780 790 800 810 820
pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
850 860 870 880 890
>>XP_016864337 (OMIM: 616899,616900) PREDICTED: TBC doma (787 aa)
initn: 5016 init1: 5016 opt: 5016 Z-score: 4310.8 bits: 808.5 E(85289): 0
Smith-Waterman score: 5016; 99.6% identity (99.9% similar) in 744 aa overlap (79-822:44-787)
50 60 70 80 90 100
pF1KE3 VDISRGKHERLVVVAEHCERSLEDLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPL
:. :::::::::::::::::::::::::::
XP_016 HNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPL
20 30 40 50 60 70
110 120 130 140 150 160
pF1KE3 PSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDII
80 90 100 110 120 130
170 180 190 200 210 220
pF1KE3 KELPETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADL
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
XP_016 KELPETVIDLLNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADL
140 150 160 170 180 190
230 240 250 260 270 280
pF1KE3 TLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFL
200 210 220 230 240 250
290 300 310 320 330 340
pF1KE3 FEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNE
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE3 LSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAAL
320 330 340 350 360 370
410 420 430 440 450 460
pF1KE3 LGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSH
380 390 400 410 420 430
470 480 490 500 510 520
pF1KE3 PDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQ
440 450 460 470 480 490
530 540 550 560 570 580
pF1KE3 MIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIG
500 510 520 530 540 550
590 600 610 620 630 640
pF1KE3 VAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKP
560 570 580 590 600 610
650 660 670 680 690 700
pF1KE3 SSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGH
620 630 640 650 660 670
710 720 730 740 750 760
pF1KE3 FKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQN
680 690 700 710 720 730
770 780 790 800 810 820
pF1KE3 FKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
740 750 760 770 780
>>XP_016864335 (OMIM: 616899,616900) PREDICTED: TBC doma (893 aa)
initn: 5016 init1: 5016 opt: 5016 Z-score: 4310.0 bits: 808.6 E(85289): 0
Smith-Waterman score: 5198; 92.4% identity (92.5% similar) in 854 aa overlap (32-822:40-893)
10 20 30 40 50 60
pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
::::::::::::::::::::::::::::::
XP_016 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
10 20 30 40 50 60
70 80
pF1KE3 VAEHCERSLEDLLRERKPVR----------------------------------------
:::::::::::::::::::
XP_016 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH
70 80 90 100 110 120
90 100 110
pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
:::::::::::::::::::::::::::::::::::::
XP_016 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
610 620 630 640 650 660
600 610 620 630 640 650
pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
670 680 690 700 710 720
660 670 680 690 700 710
pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
730 740 750 760 770 780
720 730 740 750 760 770
pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
790 800 810 820 830 840
780 790 800 810 820
pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
850 860 870 880 890
>>XP_011530719 (OMIM: 616899,616900) PREDICTED: TBC doma (893 aa)
initn: 5016 init1: 5016 opt: 5016 Z-score: 4310.0 bits: 808.6 E(85289): 0
Smith-Waterman score: 5198; 92.4% identity (92.5% similar) in 854 aa overlap (32-822:40-893)
10 20 30 40 50 60
pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
::::::::::::::::::::::::::::::
XP_011 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
10 20 30 40 50 60
70 80
pF1KE3 VAEHCERSLEDLLRERKPVR----------------------------------------
:::::::::::::::::::
XP_011 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH
70 80 90 100 110 120
90 100 110
pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
:::::::::::::::::::::::::::::::::::::
XP_011 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_011 LNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
610 620 630 640 650 660
600 610 620 630 640 650
pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
670 680 690 700 710 720
660 670 680 690 700 710
pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
730 740 750 760 770 780
720 730 740 750 760 770
pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
790 800 810 820 830 840
780 790 800 810 820
pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
850 860 870 880 890
>>NP_001277697 (OMIM: 616899,616900) TBC domain-containi (721 aa)
initn: 4875 init1: 4875 opt: 4875 Z-score: 4190.4 bits: 786.1 E(85289): 0
Smith-Waterman score: 4875; 100.0% identity (100.0% similar) in 721 aa overlap (102-822:1-721)
80 90 100 110 120 130
pF1KE3 DLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRK
::::::::::::::::::::::::::::::
NP_001 MPSKKPLPSGPKSDVWSLGIILFELCVGRK
10 20 30
140 150 160 170 180 190
pF1KE3 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE3 TPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE3 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE3 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE3 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE3 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE3 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE3 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE3 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE3 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE3 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL
640 650 660 670 680 690
800 810 820
pF1KE3 VKMKYPRICILDGGINKIKPTGLLTIPSPQI
:::::::::::::::::::::::::::::::
NP_001 VKMKYPRICILDGGINKIKPTGLLTIPSPQI
700 710 720
>>XP_016864338 (OMIM: 616899,616900) PREDICTED: TBC doma (721 aa)
initn: 4871 init1: 4871 opt: 4871 Z-score: 4186.9 bits: 785.5 E(85289): 0
Smith-Waterman score: 4871; 99.9% identity (100.0% similar) in 721 aa overlap (102-822:1-721)
80 90 100 110 120 130
pF1KE3 DLLRERKPVRYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWSLGIILFELCVGRK
::::::::::::::::::::::::::::::
XP_016 MPSKKPLPSGPKSDVWSLGIILFELCVGRK
10 20 30
140 150 160 170 180 190
pF1KE3 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRP
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE3 TPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSI
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE3 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVT
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE3 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRI
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE3 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTD
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE3 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNN
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE3 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE3 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLF
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE3 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPK
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE3 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNS
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE3 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHL
640 650 660 670 680 690
800 810 820
pF1KE3 VKMKYPRICILDGGINKIKPTGLLTIPSPQI
:::::::::::::::::::::::::::::::
XP_016 VKMKYPRICILDGGINKIKPTGLLTIPSPQI
700 710 720
>>XP_016864336 (OMIM: 616899,616900) PREDICTED: TBC doma (857 aa)
initn: 4773 init1: 4773 opt: 4773 Z-score: 4101.8 bits: 770.0 E(85289): 0
Smith-Waterman score: 4955; 92.1% identity (92.2% similar) in 818 aa overlap (32-786:40-857)
10 20 30 40 50 60
pF1KE3 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
::::::::::::::::::::::::::::::
XP_016 GAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVV
10 20 30 40 50 60
70 80
pF1KE3 VAEHCERSLEDLLRERKPVR----------------------------------------
:::::::::::::::::::
XP_016 VAEHCERSLEDLLRERKPVSCSTVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDRKGH
70 80 90 100 110 120
90 100 110
pF1KE3 -----------------------YPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
:::::::::::::::::::::::::::::::::::::
XP_016 IKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEVIAQGIFKTTDHMPSKKPLPSGPKSDVWS
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE3 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTLIVLAEEHGCLDIIKELPETVIDL
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE3 LNKCLTFHPSKRPTPDELMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKCLTFHPSKRPTPDQLMKDKVFSEVSPLYTPFTKPASLFSSSLRCADLTLPEDISQLC
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE3 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDINNDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQG
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE3 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLI
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE3 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IREKDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAK
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE3 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLD
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE3 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELS
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE3 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDR
610 620 630 640 650 660
600 610 620 630 640 650
pF1KE3 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPSSDSSGGRSS
670 680 690 700 710 720
660 670 680 690 700 710
pF1KE3 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APYFSAECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPSKKTKS
730 740 750 760 770 780
720 730 740 750 760 770
pF1KE3 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKPKLLVVDIRNSEDFIRGHISGSINIPFSAAFTAEGELTQGPYTAMLQNFKGKVIVIVG
790 800 810 820 830 840
780 790 800 810 820
pF1KE3 HVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTIPSPQI
::::::::
XP_016 HVAKHTAE
850
>>NP_001156909 (OMIM: 616899,616900) TBC domain-containi (854 aa)
initn: 5212 init1: 4684 opt: 4684 Z-score: 4025.5 bits: 755.8 E(85289): 1.8e-217
Smith-Waterman score: 5172; 92.8% identity (94.2% similar) in 847 aa overlap (1-822:9-854)
10 20 30 40 50
pF1KE3 MGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDIS
10 20 30 40 50 60
60 70 80 90 100
pF1KE3 RGKHERLVVVAEHCERSLEDLLRERKPVRYPSYL--APEVIAQGIFKTTDHMPSKKPL-P
:::::::::::::::::::::::::::: . : : ::. ::. . : .. : :
NP_001 RGKHERLVVVAEHCERSLEDLLRERKPVSCSTVLCIAFEVL-QGLQYMNKHGIVHRALSP
70 80 90 100 110
110 120 130 140
pF1KE3 ---------------------SGPKSDV-WSLGIILFELCVGRKLFQSLDISERLKFLLT
.. .:: . .: . :::::::::::::::::::
NP_001 HNILLDRKGHIKLAKFGLYHMTAHGDDVDFPIGYPSYLAPEGRKLFQSLDISERLKFLLT
120 130 140 150 160 170
150 160 170 180 190 200
pF1KE3 LDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDCVDDTLIVLAEEHGCLDIIKELPETVIDLLNKCLTFHPSKRPTPDELMKDKVFSEVSP
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE3 LYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYTPFTKPASLFSSSLRCADLTLPEDISQLCKDINNDYLAERSIEEVYYLWCLAGGDLEK
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE3 ELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGE
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE3 AFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFYPLLEDDQSNLPHSNSNNELSAAATLPLIIREKDTEYQLNRIILFDRLLKAYPYKKNQ
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE3 IWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDEL
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE3 LSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYL
480 490 500 510 520 530
510 520 530 540 550 560
pF1KE3 YNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLH
540 550 560 570 580 590
570 580 590 600 610 620
pF1KE3 KIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESI
600 610 620 630 640 650
630 640 650 660 670 680
pF1KE3 NLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFCWTPKSATYRQHAQPPKPSSDSSGGRSSAPYFSAECPDPPKTDLSRESIPLNDLKSE
660 670 680 690 700 710
690 700 710 720 730 740
pF1KE3 VSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPRISAEDLIDLCELTVTGHFKTPSKKTKSSKPKLLVVDIRNSEDFIRGHISGSINIPF
720 730 740 750 760 770
750 760 770 780 790 800
pF1KE3 SAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAFTAEGELTQGPYTAMLQNFKGKVIVIVGHVAKHTAEFAAHLVKMKYPRICILDGGIN
780 790 800 810 820 830
810 820
pF1KE3 KIKPTGLLTIPSPQI
:::::::::::::::
NP_001 KIKPTGLLTIPSPQI
840 850
822 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 02:04:04 2016 done: Mon Nov 7 02:04:06 2016
Total Scan time: 12.220 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]