Result of FASTA (omim) for
pFN21AE3616
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3616, 478 aa
1>>>pF1KE3616 478 - 478 aa - 478 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7847+/-0.000454; mu= 5.8488+/- 0.028
mean_var=133.4470+/-27.685, 0's: 0 Z-trim(114.0): 29 B-trim: 812 in 1/56
Lambda= 0.111025
statistics sampled from 23651 (23670) to 23651 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.278), width: 16
Scan time: 6.680
The best scores are: opt bits E(85289)
NP_006863 (OMIM: 605358) TFIIA-alpha and beta-like ( 478) 3148 516.1 8.6e-146
NP_001180416 (OMIM: 605358) TFIIA-alpha and beta-l ( 444) 2884 473.8 4.3e-133
NP_001265869 (OMIM: 600520) transcription initiati ( 326) 412 77.8 5.2e-14
NP_963889 (OMIM: 600520) transcription initiation ( 337) 412 77.8 5.3e-14
NP_056943 (OMIM: 600520) transcription initiation ( 376) 412 77.8 5.8e-14
>>NP_006863 (OMIM: 605358) TFIIA-alpha and beta-like fac (478 aa)
initn: 3148 init1: 3148 opt: 3148 Z-score: 2738.4 bits: 516.1 E(85289): 8.6e-146
Smith-Waterman score: 3148; 100.0% identity (100.0% similar) in 478 aa overlap (1-478:1-478)
10 20 30 40 50 60
pF1KE3 MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 IQSPLFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IQSPLFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 AGVTLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AGVTLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 QATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 YISLPGVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YISLPGVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 NRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 IGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGD
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 DVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW
430 440 450 460 470
>>NP_001180416 (OMIM: 605358) TFIIA-alpha and beta-like (444 aa)
initn: 2922 init1: 2884 opt: 2884 Z-score: 2510.4 bits: 473.8 E(85289): 4.3e-133
Smith-Waterman score: 2884; 100.0% identity (100.0% similar) in 437 aa overlap (42-478:8-444)
20 30 40 50 60 70
pF1KE3 RSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNSIQSPLFTLQLP
::::::::::::::::::::::::::::::
NP_001 MACLNPVLWETKVLQSKATEDFFRNSIQSPLFTLQLP
10 20 30
80 90 100 110 120 130
pF1KE3 HSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVSGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVSGH
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 LYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 TVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSP
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 QVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILKNRMYGCDSVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILKNRMYGCDSVKQ
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 PRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 FLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLF
340 350 360 370 380 390
440 450 460 470
pF1KE3 DTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW
400 410 420 430 440
>>NP_001265869 (OMIM: 600520) transcription initiation f (326 aa)
initn: 450 init1: 403 opt: 412 Z-score: 372.6 bits: 77.8 E(85289): 5.2e-14
Smith-Waterman score: 451; 34.6% identity (58.4% similar) in 332 aa overlap (154-478:47-326)
130 140 150 160 170 180
pF1KE3 TLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQ-LNPWS-LQ
: : ::. :. :...:: . : : :
NP_001 LLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLI
20 30 40 50 60 70
190 200 210 220 230
pF1KE3 ATTEKSQRIETVLQQPAILPSG--PVDRKHLENATSDILVSPGNEHKIVPEALLCHQESS
. :. .. ::.: ::.. ::.. :. ..: : ...
NP_001 QHMNASNMSAAATAATLALPAGVTPVQQ---------ILTNSGQLLQVVRAA-----NGA
80 90 100 110 120
240 250 260 270 280 290
pF1KE3 HYISLP--GVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLH
.:: : .::.. :: . .. :... . .. :. : : : : . ..
NP_001 QYIFQPQQSVVLQQQV------IPQMQPGGVQAP--VIQQVLAPLPGGISPQ--TGVIIQ
130 140 150 160 170
300 310 320 330 340 350
pF1KE3 ILKNRMYGCDSVKQPRNIEEPSNIPVSEK-DSNSQVDLSIRVTDDDIGEIIQVDGSGDTS
. . : . : .. :. :.. . ...: . . . .. . ..::::.::::
NP_001 PQQILFTGNKTQVIPTTVAAPT--PAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTS
180 190 200 210 220 230
360 370 380 390 400 410
pF1KE3 SNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPL
:.: : ::.: : : .:: : ...:.: :: :: ::.::
NP_001 SEE------DEDEEE-----DYDD----DEEED--KEKDGA------EDGQV---EEEPL
240 250 260
420 430 440 450 460 470
pF1KE3 NSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDA
:: ::::... .::::.::.::::::::::::::::.::::.: ..::::.:.::::::
NP_001 NSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDA
270 280 290 300 310 320
pF1KE3 EW
::
NP_001 EW
>>NP_963889 (OMIM: 600520) transcription initiation fact (337 aa)
initn: 511 init1: 403 opt: 412 Z-score: 372.4 bits: 77.8 E(85289): 5.3e-14
Smith-Waterman score: 451; 34.6% identity (58.4% similar) in 332 aa overlap (154-478:58-337)
130 140 150 160 170 180
pF1KE3 TLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQ-LNPWS-LQ
: : ::. :. :...:: . : : :
NP_963 LLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLI
30 40 50 60 70 80
190 200 210 220 230
pF1KE3 ATTEKSQRIETVLQQPAILPSG--PVDRKHLENATSDILVSPGNEHKIVPEALLCHQESS
. :. .. ::.: ::.. ::.. :. ..: : ...
NP_963 QHMNASNMSAAATAATLALPAGVTPVQQ---------ILTNSGQLLQVVRAA-----NGA
90 100 110 120 130
240 250 260 270 280 290
pF1KE3 HYISLP--GVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLH
.:: : .::.. :: . .. :... . .. :. : : : : . ..
NP_963 QYIFQPQQSVVLQQQV------IPQMQPGGVQAP--VIQQVLAPLPGGISPQ--TGVIIQ
140 150 160 170 180
300 310 320 330 340 350
pF1KE3 ILKNRMYGCDSVKQPRNIEEPSNIPVSEK-DSNSQVDLSIRVTDDDIGEIIQVDGSGDTS
. . : . : .. :. :.. . ...: . . . .. . ..::::.::::
NP_963 PQQILFTGNKTQVIPTTVAAPT--PAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTS
190 200 210 220 230 240
360 370 380 390 400 410
pF1KE3 SNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPL
:.: : ::.: : : .:: : ...:.: :: :: ::.::
NP_963 SEE------DEDEEE-----DYDD----DEEED--KEKDGA------EDGQV---EEEPL
250 260 270
420 430 440 450 460 470
pF1KE3 NSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDA
:: ::::... .::::.::.::::::::::::::::.::::.: ..::::.:.::::::
NP_963 NSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDA
280 290 300 310 320 330
pF1KE3 EW
::
NP_963 EW
>>NP_056943 (OMIM: 600520) transcription initiation fact (376 aa)
initn: 653 init1: 403 opt: 412 Z-score: 371.6 bits: 77.8 E(85289): 5.8e-14
Smith-Waterman score: 597; 33.9% identity (56.1% similar) in 481 aa overlap (2-478:5-376)
10 20 30 40 50
pF1KE3 MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFF
: : :::::::::::::. ::..: ..:..:::: .:: :::.:..::.:. : :
NP_056 MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAV-DGF
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 RNSIQSPLFTLQLPHSLHQTLQSSTA--SLVIPAGRTLPSFTTAELGTSNSSANFTFPGY
.. :. :. .: :. .: . . . : .:.:. . .. .: . : :
NP_056 HSEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQ-QTVPQQAQTQQVLIPASQQATAP--
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 PIHVPAGVTLQTVSGHLYKVNVPIMVTETSGR--AGILQHPIQQVFQQLGQPSVIQTSVP
. :: . .: :. :. .: .. ::. :.::.. . :: ..:. :
NP_056 QVIVPDSKLIQ----HMNASNMSAAATAATLALPAGVT--PVQQILTNSGQ--LLQV-VR
120 130 140 150 160
180 190 200 210 220 230
pF1KE3 QLNPWSLQATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALL
: . : . .: . :::: ..:. ..::. . : . .:
NP_056 AAN--GAQYIFQPQQSV--VLQQQ-VIPQ----------------MQPGGVQAPVIQQVL
170 180 190 200
240 250 260 270 280 290
pF1KE3 CHQESSHYISLPGVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTD
::: . :::.. . . ...:. ... . ..: : : ..
NP_056 A--------PLPGGI-SPQTGVIIQPQQILFTGNKTQVI----PTTVAAPTPAQAQITAT
210 220 230 240 250
300 310 320 330 340 350
pF1KE3 IQLHILKNRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSG
: .::. .:.. .:. : ..::::.:
NP_056 GQ--------------QQPQA--QPAQ---------TQAPL-----------VLQVDGTG
260 270
360 370 380 390 400 410
pF1KE3 DTSSNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEE
::::.: : ::.: : : .:: : ...:.: :: : :::
NP_056 DTSSEE------DEDEEE-----DYDD----DEEED--KEKDGA------EDGQ---VEE
280 290 300 310
420 430 440 450 460 470
pF1KE3 DPLNSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAI
.:::: ::::... .::::.::.::::::::::::::::.::::.: ..::::.:.:::
NP_056 EPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAI
320 330 340 350 360 370
pF1KE3 GDAEW
:::::
NP_056 GDAEW
478 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 20:25:16 2016 done: Sun Nov 6 20:25:17 2016
Total Scan time: 6.680 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]