Result of FASTA (omim) for
pFN21AE3608
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3608, 1332 aa
1>>>pF1KE3608 1332 - 1332 aa - 1332 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 18.3533+/-0.000567; mu= -33.3016+/- 0.036
mean_var=1084.5168+/-235.601, 0's: 0 Z-trim(124.2): 608 B-trim: 2521 in 1/61
Lambda= 0.038945
statistics sampled from 44447 (45353) to 44447 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.532), width: 16
Scan time: 15.300
The best scores are: opt bits E(85289)
NP_722549 (OMIM: 609426) misshapen-like kinase 1 i (1332) 9048 525.3 1.1e-147
XP_011522208 (OMIM: 609426) PREDICTED: misshapen-l (1329) 9012 523.3 4.5e-147
XP_006721599 (OMIM: 609426) PREDICTED: misshapen-l (1324) 7182 420.5 4e-116
XP_016880197 (OMIM: 609426) PREDICTED: misshapen-l (1290) 6149 362.4 1.2e-98
XP_016880196 (OMIM: 609426) PREDICTED: misshapen-l (1306) 6149 362.4 1.2e-98
XP_016880193 (OMIM: 609426) PREDICTED: misshapen-l (1358) 6149 362.5 1.2e-98
XP_006721594 (OMIM: 609426) PREDICTED: misshapen-l (1361) 6149 362.5 1.2e-98
XP_006721595 (OMIM: 609426) PREDICTED: misshapen-l (1360) 6132 361.5 2.3e-98
XP_016880194 (OMIM: 609426) PREDICTED: misshapen-l (1341) 5263 312.7 1.2e-83
NP_001020108 (OMIM: 609426) misshapen-like kinase (1312) 5224 310.5 5.2e-83
NP_001155033 (OMIM: 610005,617028) TRAF2 and NCK-i (1331) 4900 292.3 1.6e-77
XP_016860839 (OMIM: 604666) PREDICTED: mitogen-act (1330) 4753 284.0 4.8e-75
NP_733763 (OMIM: 609426) misshapen-like kinase 1 i (1303) 4749 283.8 5.6e-75
NP_056531 (OMIM: 609426) misshapen-like kinase 1 i (1295) 4745 283.5 6.5e-75
XP_005264107 (OMIM: 604666) PREDICTED: mitogen-act (1338) 4727 282.5 1.3e-74
XP_005264109 (OMIM: 604666) PREDICTED: mitogen-act (1337) 4717 282.0 2e-74
NP_001308165 (OMIM: 609426) misshapen-like kinase (1240) 4386 263.4 7.4e-69
XP_016880195 (OMIM: 609426) PREDICTED: misshapen-l (1323) 4301 258.6 2.1e-67
NP_001155034 (OMIM: 610005,617028) TRAF2 and NCK-i (1323) 3143 193.5 8.2e-48
XP_016860838 (OMIM: 604666) PREDICTED: mitogen-act (1352) 2937 182.0 2.5e-44
NP_001155032 (OMIM: 610005,617028) TRAF2 and NCK-i (1352) 2778 173.0 1.2e-41
XP_005264105 (OMIM: 604666) PREDICTED: mitogen-act (1384) 2695 168.4 3.2e-40
NP_001229488 (OMIM: 604666) mitogen-activated prot (1239) 2684 167.7 4.5e-40
XP_016860842 (OMIM: 604666) PREDICTED: mitogen-act (1306) 2684 167.8 4.7e-40
XP_016860840 (OMIM: 604666) PREDICTED: mitogen-act (1311) 2684 167.8 4.7e-40
XP_016860854 (OMIM: 604666) PREDICTED: mitogen-act (1243) 2678 167.4 5.7e-40
XP_016860841 (OMIM: 604666) PREDICTED: mitogen-act (1307) 2678 167.4 6e-40
XP_005264115 (OMIM: 604666) PREDICTED: mitogen-act (1312) 2678 167.4 6e-40
XP_005264114 (OMIM: 604666) PREDICTED: mitogen-act (1315) 2678 167.4 6e-40
NP_001229489 (OMIM: 604666) mitogen-activated prot (1235) 2651 165.9 1.6e-39
XP_016860855 (OMIM: 604666) PREDICTED: mitogen-act (1243) 2651 165.9 1.6e-39
XP_016860843 (OMIM: 604666) PREDICTED: mitogen-act (1299) 2651 165.9 1.7e-39
XP_006712928 (OMIM: 604666) PREDICTED: mitogen-act (1307) 2651 165.9 1.7e-39
XP_016860844 (OMIM: 604666) PREDICTED: mitogen-act (1296) 2647 165.7 2e-39
XP_016860856 (OMIM: 604666) PREDICTED: mitogen-act (1234) 2644 165.5 2.1e-39
XP_016860850 (OMIM: 604666) PREDICTED: mitogen-act (1266) 2635 165.0 3.1e-39
XP_016860848 (OMIM: 604666) PREDICTED: mitogen-act (1274) 2635 165.0 3.1e-39
NP_663719 (OMIM: 604666) mitogen-activated protein (1273) 2630 164.7 3.8e-39
XP_016860845 (OMIM: 604666) PREDICTED: mitogen-act (1281) 2630 164.7 3.8e-39
XP_016860851 (OMIM: 604666) PREDICTED: mitogen-act (1265) 2627 164.5 4.2e-39
XP_016860849 (OMIM: 604666) PREDICTED: mitogen-act (1273) 2627 164.5 4.3e-39
XP_016860846 (OMIM: 604666) PREDICTED: mitogen-act (1276) 2626 164.5 4.4e-39
XP_005264116 (OMIM: 604666) PREDICTED: mitogen-act (1284) 2626 164.5 4.5e-39
XP_006712932 (OMIM: 604666) PREDICTED: mitogen-act (1189) 2623 164.3 4.7e-39
XP_016860852 (OMIM: 604666) PREDICTED: mitogen-act (1253) 2622 164.3 5.1e-39
XP_005264119 (OMIM: 604666) PREDICTED: mitogen-act (1261) 2622 164.3 5.1e-39
XP_005264117 (OMIM: 604666) PREDICTED: mitogen-act (1280) 2621 164.2 5.4e-39
XP_016860860 (OMIM: 604666) PREDICTED: mitogen-act (1186) 2616 163.9 6.2e-39
XP_016860847 (OMIM: 604666) PREDICTED: mitogen-act (1275) 2617 164.0 6.3e-39
XP_005264121 (OMIM: 604666) PREDICTED: mitogen-act (1258) 2616 163.9 6.5e-39
>>NP_722549 (OMIM: 609426) misshapen-like kinase 1 isofo (1332 aa)
initn: 9048 init1: 9048 opt: 9048 Z-score: 2772.4 bits: 525.3 E(85289): 1.1e-147
Smith-Waterman score: 9048; 99.8% identity (99.9% similar) in 1332 aa overlap (1-1332:1-1332)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPV
::::::::::::::::::::::::::::::::::::::::::::::::::.::: :::::
NP_722 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
1270 1280 1290 1300 1310 1320
1330
pF1KE3 FMTLNRNCIMNW
::::::::::::
NP_722 FMTLNRNCIMNW
1330
>>XP_011522208 (OMIM: 609426) PREDICTED: misshapen-like (1329 aa)
initn: 6915 init1: 6915 opt: 9012 Z-score: 2761.5 bits: 523.3 E(85289): 4.5e-147
Smith-Waterman score: 9012; 99.6% identity (99.7% similar) in 1332 aa overlap (1-1332:1-1329)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLKDHIDRSRKKR---EETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE3 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE3 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE3 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE3 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPV
::::::::::::::::::::::::::::::::::::::::::::::::::.::: :::::
XP_011 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE3 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE3 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE3 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE3 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE3 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KE3 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE3 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KE3 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KE3 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
1260 1270 1280 1290 1300 1310
1330
pF1KE3 FMTLNRNCIMNW
::::::::::::
XP_011 FMTLNRNCIMNW
1320
>>XP_006721599 (OMIM: 609426) PREDICTED: misshapen-like (1324 aa)
initn: 7251 init1: 4064 opt: 7182 Z-score: 2205.8 bits: 420.5 E(85289): 4e-116
Smith-Waterman score: 8617; 95.0% identity (95.1% similar) in 1361 aa overlap (1-1332:1-1324)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
370 380 390 400 410 420
430 440 450
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY-----------------------------
:::::::::::::::::::::::::::::::
XP_006 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
:::: :::::::::::::::::::
XP_006 AVRA-------------------------------------SNPDLRRSDPGWERSDSVL
730 740
760 770 780 790 800 810
pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
:::::::::::::::::::.::: ::::::::::::::::::::::::::::::::::::
XP_006 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
750 760 770 780 790 800
820 830 840 850 860 870
pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
810 820 830 840 850 860
880 890 900 910 920 930
pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
870 880 890 900 910 920
940 950 960 970 980 990
pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
930 940 950 960 970 980
1000 1010 1020 1030 1040 1050
pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
990 1000 1010 1020 1030 1040
1060 1070 1080 1090 1100 1110
pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
1050 1060 1070 1080 1090 1100
1120 1130 1140 1150 1160 1170
pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
1110 1120 1130 1140 1150 1160
1180 1190 1200 1210 1220 1230
pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
1170 1180 1190 1200 1210 1220
1240 1250 1260 1270 1280 1290
pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
1230 1240 1250 1260 1270 1280
1300 1310 1320 1330
pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
:::::::::::::::::::::::::::::::::::::::::
XP_006 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
1290 1300 1310 1320
>>XP_016880197 (OMIM: 609426) PREDICTED: misshapen-like (1290 aa)
initn: 6035 init1: 6035 opt: 6149 Z-score: 1892.3 bits: 362.4 E(85289): 1.2e-98
Smith-Waterman score: 8522; 97.6% identity (97.7% similar) in 1290 aa overlap (72-1332:1-1290)
50 60 70 80 90 100
pF1KE3 GRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQL
::::::::::::::::::::::::::::::
XP_016 MLKKYSHHRNIATYYGAFIKKSPPGNDDQL
10 20 30
110 120 130 140 150 160
pF1KE3 WLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE3 TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGI
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE3 TAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTE
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE3 QLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSS
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE3 IMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQ
280 290 300 310 320 330
410 420 430 440 450
pF1KE3 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEY----------
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQR
340 350 360 370 380 390
460 470 480 490
pF1KE3 -------------------KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQ
:::::::::::::::::::::::::::::::::::::::::
XP_016 QLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQ
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 QQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIP
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE3 QASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAA
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE3 FPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRT
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE3 SSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNAS
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE3 SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDH
::::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::
XP_016 SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDH
700 710 720 730 740 750
800 810 820 830 840 850
pF1KE3 RSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTP
760 770 780 790 800 810
860 870 880 890 900 910
pF1KE3 GGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDV
820 830 840 850 860 870
920 930 940 950 960 970
pF1KE3 VQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPIT
880 890 900 910 920 930
980 990 1000 1010 1020 1030
pF1KE3 ALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNL
940 950 960 970 980 990
1040 1050 1060 1070 1080 1090
pF1KE3 LVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRN
1000 1010 1020 1030 1040 1050
1100 1110 1120 1130 1140 1150
pF1KE3 KILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM
1060 1070 1080 1090 1100 1110
1160 1170 1180 1190 1200 1210
pF1KE3 AFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITP
1120 1130 1140 1150 1160 1170
1220 1230 1240 1250 1260 1270
pF1KE3 HAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEK
1180 1190 1200 1210 1220 1230
1280 1290 1300 1310 1320 1330
pF1KE3 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
1240 1250 1260 1270 1280 1290
>>XP_016880196 (OMIM: 609426) PREDICTED: misshapen-like (1306 aa)
initn: 6035 init1: 6035 opt: 6149 Z-score: 1892.2 bits: 362.4 E(85289): 1.2e-98
Smith-Waterman score: 8621; 97.6% identity (97.7% similar) in 1306 aa overlap (56-1332:1-1306)
30 40 50 60 70 80
pF1KE3 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATY
::::::::::::::::::::::::::::::
XP_016 MDVTEDEEEEIKQEINMLKKYSHHRNIATY
10 20 30
90 100 110 120 130 140
pF1KE3 YGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLH
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE3 AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 PDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDF
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE3 IDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSG
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE3 SEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEA
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE3 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQA
340 350 360 370 380 390
450 460 470
pF1KE3 EREQEY-----------------------------KRKQLEEQRQSERLQRQLQQEHAYL
:::::: :::::::::::::::::::::::::
XP_016 EREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEYKRKQLEEQRQSERLQRQLQQEHAYL
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE3 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP
460 470 480 490 500 510
540 550 560 570 580 590
pF1KE3 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV
520 530 540 550 560 570
600 610 620 630 640 650
pF1KE3 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPA
580 590 600 610 620 630
660 670 680 690 700 710
pF1KE3 WVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTP
640 650 660 670 680 690
720 730 740 750 760 770
pF1KE3 KPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: :
XP_016 KPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPD
700 710 720 730 740 750
780 790 800 810 820 830
pF1KE3 SSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDD
760 770 780 790 800 810
840 850 860 870 880 890
pF1KE3 EEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEER
820 830 840 850 860 870
900 910 920 930 940 950
pF1KE3 NLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVD
880 890 900 910 920 930
960 970 980 990 1000 1010
pF1KE3 LGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKK
940 950 960 970 980 990
1020 1030 1040 1050 1060 1070
pF1KE3 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITIS
1000 1010 1020 1030 1040 1050
1080 1090 1100 1110 1120 1130
pF1KE3 GKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKS
1060 1070 1080 1090 1100 1110
1140 1150 1160 1170 1180 1190
pF1KE3 SVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGN
1120 1130 1140 1150 1160 1170
1200 1210 1220 1230 1240 1250
pF1KE3 SYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPT
1180 1190 1200 1210 1220 1230
1260 1270 1280 1290 1300 1310
pF1KE3 SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGS
1240 1250 1260 1270 1280 1290
1320 1330
pF1KE3 SQVYFMTLNRNCIMNW
::::::::::::::::
XP_016 SQVYFMTLNRNCIMNW
1300
>>XP_016880193 (OMIM: 609426) PREDICTED: misshapen-like (1358 aa)
initn: 8158 init1: 6035 opt: 6149 Z-score: 1892.0 bits: 362.5 E(85289): 1.2e-98
Smith-Waterman score: 8944; 97.5% identity (97.6% similar) in 1361 aa overlap (1-1332:1-1358)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLKDHIDRSRKKR---EETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
360 370 380 390 400 410
430 440 450
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY-----------------------------
:::::::::::::::::::::::::::::::
XP_016 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
720 730 740 750 760 770
760 770 780 790 800 810
pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
:::::::::::::::::::.::: ::::::::::::::::::::::::::::::::::::
XP_016 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
780 790 800 810 820 830
820 830 840 850 860 870
pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
840 850 860 870 880 890
880 890 900 910 920 930
pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
900 910 920 930 940 950
940 950 960 970 980 990
pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
960 970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
1020 1030 1040 1050 1060 1070
1060 1070 1080 1090 1100 1110
pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
1080 1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
1140 1150 1160 1170 1180 1190
1180 1190 1200 1210 1220 1230
pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
1200 1210 1220 1230 1240 1250
1240 1250 1260 1270 1280 1290
pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
1260 1270 1280 1290 1300 1310
1300 1310 1320 1330
pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
:::::::::::::::::::::::::::::::::::::::::
XP_016 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
1320 1330 1340 1350
>>XP_006721594 (OMIM: 609426) PREDICTED: misshapen-like (1361 aa)
initn: 6035 init1: 6035 opt: 6149 Z-score: 1892.0 bits: 362.5 E(85289): 1.2e-98
Smith-Waterman score: 8980; 97.7% identity (97.8% similar) in 1361 aa overlap (1-1332:1-1361)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
370 380 390 400 410 420
430 440 450
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY-----------------------------
:::::::::::::::::::::::::::::::
XP_006 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
:::::::::::::::::::.::: ::::::::::::::::::::::::::::::::::::
XP_006 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330
pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
:::::::::::::::::::::::::::::::::::::::::
XP_006 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
1330 1340 1350 1360
>>XP_006721595 (OMIM: 609426) PREDICTED: misshapen-like (1360 aa)
initn: 6429 init1: 3242 opt: 6132 Z-score: 1886.8 bits: 361.5 E(85289): 2.3e-98
Smith-Waterman score: 8963; 97.6% identity (97.7% similar) in 1361 aa overlap (1-1332:1-1360)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
370 380 390 400 410 420
430 440 450
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY-----------------------------
:::::::::::::::::::::::::::::::
XP_006 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
:::::::::::::::::::.::: ::::::::::::::::::::::::::::::::::::
XP_006 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
:::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_006 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGR-DGDTDSVSTMVVHDV
850 860 870 880 890
880 890 900 910 920 930
pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
900 910 920 930 940 950
940 950 960 970 980 990
pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
960 970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
1020 1030 1040 1050 1060 1070
1060 1070 1080 1090 1100 1110
pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
1080 1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
1140 1150 1160 1170 1180 1190
1180 1190 1200 1210 1220 1230
pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
1200 1210 1220 1230 1240 1250
1240 1250 1260 1270 1280 1290
pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
1260 1270 1280 1290 1300 1310
1300 1310 1320 1330
pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
:::::::::::::::::::::::::::::::::::::::::
XP_006 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
1320 1330 1340 1350 1360
>>XP_016880194 (OMIM: 609426) PREDICTED: misshapen-like (1341 aa)
initn: 8178 init1: 4991 opt: 5263 Z-score: 1623.0 bits: 312.7 E(85289): 1.2e-83
Smith-Waterman score: 8795; 96.3% identity (96.3% similar) in 1361 aa overlap (1-1332:1-1341)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
370 380 390 400 410 420
430 440 450
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEY-----------------------------
:::::::::::::::::::::::::::::::
XP_016 LQEKEQQRRLEDMQALRREEERRQAEREQEYIRHRLEEEQRQLEILQQQLLQEQALLLEY
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 VEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPS
::::::::::: :::::::::::::::::::::::::::::
XP_016 VEPQEGPHKSL--------------------QDQPTRNLAAFPASHDPDPAIPAPTATPS
610 620 630 640
640 650 660 670 680 690
pF1KE3 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQ
650 660 670 680 690 700
700 710 720 730 740 750
pF1KE3 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVL
710 720 730 740 750 760
760 770 780 790 800 810
pF1KE3 PASHGHLPQAGSLERNRVGASSKLDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
:::::::::::::::::::.::: ::::::::::::::::::::::::::::::::::::
XP_016 PASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLD
770 780 790 800 810 820
820 830 840 850 860 870
pF1KE3 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDV
830 840 850 860 870 880
880 890 900 910 920 930
pF1KE3 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSK
890 900 910 920 930 940
940 950 960 970 980 990
pF1KE3 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRK
950 960 970 980 990 1000
1000 1010 1020 1030 1040 1050
pF1KE3 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKV
1010 1020 1030 1040 1050 1060
1060 1070 1080 1090 1100 1110
pF1KE3 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVG
1070 1080 1090 1100 1110 1120
1120 1130 1140 1150 1160 1170
pF1KE3 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTV
1130 1140 1150 1160 1170 1180
1180 1190 1200 1210 1220 1230
pF1KE3 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYE
1190 1200 1210 1220 1230 1240
1240 1250 1260 1270 1280 1290
pF1KE3 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHK
1250 1260 1270 1280 1290 1300
1300 1310 1320 1330
pF1KE3 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
:::::::::::::::::::::::::::::::::::::::::
XP_016 RAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
1310 1320 1330 1340
>>NP_001020108 (OMIM: 609426) misshapen-like kinase 1 is (1312 aa)
initn: 4991 init1: 4991 opt: 5224 Z-score: 1611.3 bits: 310.5 E(85289): 5.2e-83
Smith-Waterman score: 8863; 98.3% identity (98.4% similar) in 1332 aa overlap (1-1332:1-1312)
10 20 30 40 50 60
pF1KE3 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
::::::::::::::::::::::::::::::::::::::::::
NP_001 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------
550 560 570 580
610 620 630 640 650 660
pF1KE3 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE3 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE3 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGASSKLDSSPV
::::::::::::::::::::::::::::::::::::::::::::::::::.::: :::::
NP_001 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE3 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEG
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE3 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLH
830 840 850 860 870 880
910 920 930 940 950 960
pF1KE3 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIY
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KE3 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KE3 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KE3 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KE3 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KE3 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KE3 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
1250 1260 1270 1280 1290 1300
1330
pF1KE3 FMTLNRNCIMNW
::::::::::::
NP_001 FMTLNRNCIMNW
1310
1332 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:25:16 2016 done: Sat Nov 5 22:25:18 2016
Total Scan time: 15.300 Total Display time: 0.810
Function used was FASTA [36.3.4 Apr, 2011]