Result of FASTA (omim) for
pFN21AE3606
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3606, 479 aa
1>>>pF1KE3606 479 - 479 aa - 479 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1895+/-0.000307; mu= 10.2567+/- 0.019
mean_var=129.9400+/-26.168, 0's: 0 Z-trim(120.6): 5 B-trim: 352 in 2/53
Lambda= 0.112513
statistics sampled from 36044 (36049) to 36044 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.756), E-opt: 0.2 (0.423), width: 16
Scan time: 9.750
The best scores are: opt bits E(85289)
NP_060895 (OMIM: 609763) phosphatidylinositol 4-ki ( 479) 3296 546.0 8.3e-155
NP_060793 (OMIM: 612101) phosphatidylinositol 4-ki ( 481) 1853 311.8 2.7e-84
XP_005248232 (OMIM: 612101) PREDICTED: phosphatidy ( 385) 1845 310.4 5.6e-84
XP_005248231 (OMIM: 612101) PREDICTED: phosphatidy ( 476) 1801 303.4 9.3e-82
>>NP_060895 (OMIM: 609763) phosphatidylinositol 4-kinase (479 aa)
initn: 3296 init1: 3296 opt: 3296 Z-score: 2900.2 bits: 546.0 E(85289): 8.3e-155
Smith-Waterman score: 3296; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479)
10 20 30 40 50 60
pF1KE3 MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 IERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 IERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 RDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 VPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 DYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 AYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQI
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 AVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW
430 440 450 460 470
>>NP_060793 (OMIM: 612101) phosphatidylinositol 4-kinase (481 aa)
initn: 1926 init1: 1172 opt: 1853 Z-score: 1634.3 bits: 311.8 E(85289): 2.7e-84
Smith-Waterman score: 1891; 59.8% identity (78.8% similar) in 490 aa overlap (9-479:17-481)
10 20 30 40
pF1KE3 MDETSPLVSPERAQPPDYT--FPSGSGAHFPQ--VPGGAVRVAAAAG----S
:::. . . .: . :: :. .::.:::. ::: .
NP_060 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAH-PRRGAPGSAVRLLDAAGEEGEA
10 20 30 40 50
50 60 70 80 90 100
pF1KE3 G----PSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRE
: : :::. : .: . :::.: :. . :.... :
NP_060 GDEELPLPPGDVGVSRSSSAELDRSRPAV----SVTIGTS-------------------E
60 70 80 90
110 120 130 140 150 160
pF1KE3 RNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYG
: : .:::: .. .:: ::: :::::: ::::::::::::. .::.:::::.:::::
NP_060 MNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYG
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE3 HLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASET
.:::::::...:.:::::::: ::. :::::::::: :::.::.:.:::.::::.:.:::
NP_060 QLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSET
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE3 FNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAE
:::.::::.:::::. :::::::::..:.:::::::.:::::::::::.:.::::.:::.
NP_060 FNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEAD
220 230 240 250 260 270
290 300 310 320 330
pF1KE3 PLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYD---CPMDSSSSRDTDWVVVKE
::::: .:. ::::::.::::::::::::::::..:. : . . ... :. .:
NP_060 PLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDH-KESKWIDDEE
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE3 PVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDL
.::.::::::::::.:::: ::::::.::::::::::::.::..:::: ::: :::.::
NP_060 FLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDL
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE3 EEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSH
:::::::: : :::.. :..:..:::::::::::::.:.:::..:::.: :::: ...
NP_060 CEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGG
400 410 420 430 440 450
460 470
pF1KE3 QRSS----SESYTQSFQSRKPFFSWW
... :.:.::. . :::::: :
NP_060 SQGRIVHLSNSFTQTVNCRKPFFSSW
460 470 480
>>XP_005248232 (OMIM: 612101) PREDICTED: phosphatidylino (385 aa)
initn: 1831 init1: 1168 opt: 1845 Z-score: 1628.7 bits: 310.4 E(85289): 5.6e-84
Smith-Waterman score: 1845; 68.6% identity (87.5% similar) in 385 aa overlap (102-479:2-385)
80 90 100 110 120 130
pF1KE3 GQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELAIERCIFPERIY
: : .:::: .. .:: ::: ::::::
XP_005 MNAFLDDPEFADIMLRAEQAIEVGIFPERIS
10 20 30
140 150 160 170 180 190
pF1KE3 QGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYL
::::::::::::. .::.:::::.:::::.:::::::...:.:::::::: ::. :::::
XP_005 QGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLIPNQGYL
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE3 SEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRI
::::: :::.::.:.:::.::::.:.::::::.::::.:::::. :::::::::..:.::
XP_005 SEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKVGRKFHRI
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE3 GLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGN
:::::.:::::::::::.:.::::.:::.::::: .:. ::::::.::::::::::::
XP_005 GLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYIIRNTDRGN
160 170 180 190 200 210
320 330 340 350 360
pF1KE3 DNWLIKYD---CPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAW
::::..:. : . . ... :. .: .::.::::::::::.:::: ::::::.:::
XP_005 DNWLVRYEKQKCEKEIDH-KESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAYPFHWAW
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE3 LPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQIL
:::::::::.::..:::: ::: :::.:: :::::::: : :::.. :..:..:::::::
XP_005 LPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSVMRGQIL
280 290 300 310 320 330
430 440 450 460 470
pF1KE3 NLTQALKDNKSPLHLVQMPPVIVETARSHQRSS----SESYTQSFQSRKPFFSWW
::::::.:.:::..:::.: :::: ... ... :.:.::. . :::::: :
XP_005 NLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSSW
340 350 360 370 380
>>XP_005248231 (OMIM: 612101) PREDICTED: phosphatidylino (476 aa)
initn: 1573 init1: 795 opt: 1801 Z-score: 1588.8 bits: 303.4 E(85289): 9.3e-82
Smith-Waterman score: 1839; 59.0% identity (77.8% similar) in 490 aa overlap (9-479:17-476)
10 20 30 40
pF1KE3 MDETSPLVSPERAQPPDYT--FPSGSGAHFPQ--VPGGAVRVAAAAG----S
:::. . . .: . :: :. .::.:::. ::: .
XP_005 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAH-PRRGAPGSAVRLLDAAGEEGEA
10 20 30 40 50
50 60 70 80 90 100
pF1KE3 G----PSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRE
: : :::. : .: . :::.: :. . :.... :
XP_005 GDEELPLPPGDVGVSRSSSAELDRSRPAV----SVTIGTS-------------------E
60 70 80 90
110 120 130 140 150 160
pF1KE3 RNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYG
: : .:::: .. .:: ::: :::::: ::::::::::::. .::.:::::.:::::
XP_005 MNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYG
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE3 HLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASET
.:::::::...:.:::::::: ::. :::::::::: :::.::.:.:::.::::.:.:::
XP_005 QLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSET
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE3 FNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAE
:::.::::.:::::. :::::::::..:.::::::: :::::::.:.::::.:::.
XP_005 FNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPK-----LFVEGYKEAEYWLRKFEAD
220 230 240 250 260 270
290 300 310 320 330
pF1KE3 PLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYD---CPMDSSSSRDTDWVVVKE
::::: .:. ::::::.::::::::::::::::..:. : . . ... :. .:
XP_005 PLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDH-KESKWIDDEE
280 290 300 310 320 330
340 350 360 370 380 390
pF1KE3 PVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDL
.::.::::::::::.:::: ::::::.::::::::::::.::..:::: ::: :::.::
XP_005 FLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDL
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE3 EEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSH
:::::::: : :::.. :..:..:::::::::::::.:.:::..:::.: :::: ...
XP_005 CEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGG
400 410 420 430 440 450
460 470
pF1KE3 QRSS----SESYTQSFQSRKPFFSWW
... :.:.::. . :::::: :
XP_005 SQGRIVHLSNSFTQTVNCRKPFFSSW
460 470
479 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:04:26 2016 done: Tue Nov 8 05:04:28 2016
Total Scan time: 9.750 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]