Result of FASTA (omim) for
pFN21AE3587
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3587, 238 aa
1>>>pF1KE3587 238 - 238 aa - 238 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4311+/-0.000271; mu= 15.2154+/- 0.017
mean_var=84.7627+/-17.092, 0's: 0 Z-trim(120.8): 19 B-trim: 80 in 2/47
Lambda= 0.139307
statistics sampled from 36485 (36508) to 36485 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.428), width: 16
Scan time: 6.660
The best scores are: opt bits E(85289)
NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo ( 238) 1669 344.2 1.1e-94
NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo ( 213) 561 121.5 1.1e-27
XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 201) 545 118.3 1e-26
NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo ( 228) 541 117.5 1.9e-26
NP_004419 (OMIM: 191164) ephrin-A1 isoform a precu ( 205) 495 108.2 1.1e-23
XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 202) 477 104.6 1.3e-22
XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 298) 477 104.8 1.8e-22
XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 210) 453 99.8 3.8e-21
NP_872626 (OMIM: 191164) ephrin-A1 isoform b precu ( 183) 437 96.6 3.2e-20
NP_005218 (OMIM: 601380) ephrin-A4 isoform a precu ( 201) 333 75.7 6.7e-14
NP_872632 (OMIM: 601380) ephrin-A4 isoform c precu ( 193) 332 75.5 7.5e-14
XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 328 74.6 1.1e-13
XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 328 74.6 1.1e-13
NP_872631 (OMIM: 601380) ephrin-A4 isoform b precu ( 207) 324 73.9 2.4e-13
NP_001397 (OMIM: 602297) ephrin-B3 precursor [Homo ( 340) 220 53.2 6.9e-07
>>NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo sap (238 aa)
initn: 1669 init1: 1669 opt: 1669 Z-score: 1820.6 bits: 344.2 E(85289): 1.1e-94
Smith-Waterman score: 1669; 100.0% identity (100.0% similar) in 238 aa overlap (1-238:1-238)
10 20 30 40 50 60
pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPT
130 140 150 160 170 180
190 200 210 220 230
pF1KE3 LPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS
190 200 210 220 230
>>NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo sap (213 aa)
initn: 478 init1: 266 opt: 561 Z-score: 617.8 bits: 121.5 E(85289): 1.1e-27
Smith-Waterman score: 561; 53.4% identity (71.3% similar) in 174 aa overlap (2-165:4-170)
10 20 30 40 50
pF1KE3 MAAAPLL-LLLLLVPVPLLPLL-AQGPGGALGNRHAVYWNSSNQHLRRE------GYT
: ::: :::::.:.: :. :. . : ..:.::::: :: ... :::
NP_001 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT
10 20 30 40 50 60
60 70 80 90 100
pF1KE3 VQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQ-GFKRWE
:.:..::::::::::: :: :. :.::::::. .:. .:. : ::::::
NP_001 VEVSINDYLDIYCPHY-------GAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWE
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 CNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYIS-TPTHNLHWKCLRMKVFVCCA
:::: :: .:.::::::: .. ::::.::. :::::::: :: . . :::.::.:
NP_001 CNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPT
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 STSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGI
NP_001 NETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
180 190 200 210
>>XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (201 aa)
initn: 521 init1: 258 opt: 545 Z-score: 600.8 bits: 118.3 E(85289): 1e-26
Smith-Waterman score: 545; 47.7% identity (74.7% similar) in 174 aa overlap (8-177:6-171)
10 20 30 40 50
pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGG-ALGNRHAVYWNSSNQHLRREGYTVQVNVNDYL
.: :. : . ...: ::. :...:.:::::::: ...: : ..: .::::
XP_006 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYL
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 DIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN-ASQGFKRWECNRPHAPHS
:..::::..: : .:.::::::. .:: .:. .:.:::::::::::.:..
XP_006 DVFCPHYEDSV--------PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 PIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPT-HNLHWKCLRMKVFVC-CASTSHSGEK
:.::::::: .. ::::.::. :.::.:::. : . .::..:::: .: : . .
XP_006 PLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVHESAE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 PVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFL
:
XP_006 PSRGENAAQTPRIPSRLLAILLFLLAMLLTL
180 190 200
>>NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo sap (228 aa)
initn: 521 init1: 258 opt: 541 Z-score: 595.7 bits: 117.5 E(85289): 1.9e-26
Smith-Waterman score: 541; 49.7% identity (77.0% similar) in 161 aa overlap (8-165:6-158)
10 20 30 40 50
pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGG-ALGNRHAVYWNSSNQHLRREGYTVQVNVNDYL
.: :. : . ...: ::. :...:.:::::::: ...: : ..: .::::
NP_001 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYL
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 DIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN-ASQGFKRWECNRPHAPHS
:..::::..: : .:.::::::. .:: .:. .:.:::::::::::.:..
NP_001 DVFCPHYEDSV--------PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 PIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPT-HNLHWKCLRMKVFVCCASTSHSGEKP
:.::::::: .. ::::.::. :.::.:::. : . .::..::::
NP_001 PLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 VPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLA
NP_001 HDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
180 190 200 210 220
>>NP_004419 (OMIM: 191164) ephrin-A1 isoform a precursor (205 aa)
initn: 503 init1: 271 opt: 495 Z-score: 546.3 bits: 108.2 E(85289): 1.1e-23
Smith-Waterman score: 504; 40.3% identity (66.1% similar) in 221 aa overlap (19-238:7-204)
10 20 30 40 50 60
pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD
:::. . : ..::.:.::::: ..: : ::..:..:::.:
NP_004 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVD
10 20 30 40
70 80 90 100 110
pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNA-SQGFKRWECNRPHAPHSP
: ::::.. .:. .: :::.::.: .. :. :. :. ::.:::: : :.:
NP_004 IICPHYEDHSVADAA-------MEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGP
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE3 IKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVP
:.::::::.. :.:: ::. :: ::::: : :. . .:::.:: : .. .::
NP_004 EKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVS-GKITHS------
110 120 130 140 150
180 190 200 210 220 230
pF1KE3 TLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS
:: .:. : . ...:.: .. .:: : : . .::: . .. . .: .
NP_004 --PQAHDNPQEK-----RLAADDPEV-RVLHSI-GHSAAPRLFPLAWTVLLLPLLLLQTP
160 170 180 190 200
>>XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (202 aa)
initn: 434 init1: 262 opt: 477 Z-score: 526.9 bits: 104.6 E(85289): 1.3e-22
Smith-Waterman score: 477; 59.2% identity (75.8% similar) in 120 aa overlap (48-165:47-159)
20 30 40 50 60 70
pF1KE3 LPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGP
::::.:..::::::::::: ::
XP_016 RFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHY-------GAPL
20 30 40 50 60
80 90 100 110 120 130
pF1KE3 GPGGGAEQYVLYMVSRNGYRTCNASQ-GFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGY
:. :.::::::. .:. .:. : :::::::::: :: .:.::::::: .. ::::.
XP_016 PPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGF
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE3 EFHAGHEYYYIS-TPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVL
::. :::::::: :: . . :::.::.:
XP_016 EFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLF
130 140 150 160 170 180
>>XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (298 aa)
initn: 434 init1: 262 opt: 477 Z-score: 524.6 bits: 104.8 E(85289): 1.8e-22
Smith-Waterman score: 477; 59.2% identity (75.8% similar) in 120 aa overlap (48-165:143-255)
20 30 40 50 60 70
pF1KE3 LPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGP
::::.:..::::::::::: ::
XP_016 RFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHY-------GAPL
120 130 140 150 160
80 90 100 110 120 130
pF1KE3 GPGGGAEQYVLYMVSRNGYRTCNASQ-GFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGY
:. :.::::::. .:. .:. : :::::::::: :: .:.::::::: .. ::::.
XP_016 PPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGF
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE3 EFHAGHEYYYIS-TPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVL
::. :::::::: :: . . :::.::.:
XP_016 EFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLF
230 240 250 260 270 280
>>XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (210 aa)
initn: 443 init1: 258 opt: 453 Z-score: 500.6 bits: 99.8 E(85289): 3.8e-21
Smith-Waterman score: 453; 48.2% identity (75.5% similar) in 139 aa overlap (32-165:10-140)
10 20 30 40 50
pF1KE3 AAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQ---HLRREGYTVQVNVNDY
: ... :...: ..: : ..: .:::
XP_011 MQTLEPACFRFSLHTNTNKQCTLGFQRGDYHIDVCINDY
10 20 30
60 70 80 90 100 110
pF1KE3 LDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN-ASQGFKRWECNRPHAPH
::..::::..: : .:.::::::. .:: .:. .:.:::::::::::.:.
XP_011 LDVFCPHYEDSV--------PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPN
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE3 SPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPT-HNLHWKCLRMKVFVCCASTSHSGEK
.:.::::::: .. ::::.::. :.::.:::. : . .::..::::
XP_011 GPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIG
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE3 PVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFL
XP_011 VHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
160 170 180 190 200 210
>>NP_872626 (OMIM: 191164) ephrin-A1 isoform b precursor (183 aa)
initn: 448 init1: 216 opt: 437 Z-score: 484.0 bits: 96.6 E(85289): 3.2e-20
Smith-Waterman score: 437; 49.6% identity (74.0% similar) in 131 aa overlap (19-148:7-130)
10 20 30 40 50 60
pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD
:::. . : ..::.:.::::: ..: : ::..:..:::.:
NP_872 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVD
10 20 30 40
70 80 90 100 110
pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNA-SQGFKRWECNRPHAPHSP
: ::::.. .:. .: :::.::.: .. :. :. :. ::.:::: : :.:
NP_872 IICPHYEDHSVADAA-------MEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGP
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE3 IKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVP
:.::::::.. :.:: ::. :: :::::
NP_872 EKLSEKFQRFTPFTLGKEFKEGHSYYYISHSPQAHDNPQEKRLAADDPEVRVLHSIGHSA
110 120 130 140 150 160
>>NP_005218 (OMIM: 601380) ephrin-A4 isoform a precursor (201 aa)
initn: 378 init1: 218 opt: 333 Z-score: 370.5 bits: 75.7 E(85289): 6.7e-14
Smith-Waterman score: 474; 45.1% identity (67.6% similar) in 173 aa overlap (8-178:3-164)
10 20 30 40 50 60
pF1KE3 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD
:: :: : .:.. :. . ::.::::::: .: : .:....:::::
NP_005 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLD
10 20 30 40 50
70 80 90 100 110
pF1KE3 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNAS--QGFKRWECNRPHAPHS
: ::::. :::: : : ..::::. ::..:.: ...::: :. : . :
NP_005 IVCPHYE--------GPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFG-H-
60 70 80 90 100
120 130 140 150 160 170
pF1KE3 PIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPV
..::::.::.. ::::.:: :. :::::.:: . .:::..: ::: . . .::
NP_005 -VQFSEKIQRFTPFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE3 PTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS
NP_005 GSPGESGTSGWRGGDTPSPLCLLLLLLLLILRLLRIL
170 180 190 200
238 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:00:24 2016 done: Mon Nov 7 01:00:25 2016
Total Scan time: 6.660 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]