Result of FASTA (omim) for
pFN21AE3544
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3544, 412 aa
1>>>pF1KE3544 412 - 412 aa - 412 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.9334+/-0.00037; mu= -12.5184+/- 0.023
mean_var=390.3430+/-82.584, 0's: 0 Z-trim(124.8): 13 B-trim: 1587 in 1/60
Lambda= 0.064916
statistics sampled from 47272 (47302) to 47272 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.555), width: 16
Scan time: 8.450
The best scores are: opt bits E(85289)
NP_003646 (OMIM: 603079) E3 SUMO-protein ligase CB ( 560) 432 54.1 1e-06
XP_006724240 (OMIM: 608457) PREDICTED: chromobox p ( 192) 415 52.1 1.4e-06
XP_005261470 (OMIM: 608457) PREDICTED: chromobox p ( 158) 392 49.9 5.3e-06
XP_006724239 (OMIM: 608457) PREDICTED: chromobox p ( 200) 393 50.1 5.9e-06
XP_016884168 (OMIM: 608457) PREDICTED: chromobox p ( 250) 395 50.3 6.2e-06
NP_783640 (OMIM: 608457) chromobox protein homolog ( 251) 395 50.3 6.2e-06
NP_005180 (OMIM: 602770,613080) chromobox protein ( 532) 390 50.1 1.5e-05
XP_011523684 (OMIM: 602770,613080) PREDICTED: chro ( 586) 390 50.1 1.7e-05
XP_011528327 (OMIM: 608457) PREDICTED: chromobox p ( 165) 366 47.5 3e-05
XP_006724241 (OMIM: 608457) PREDICTED: chromobox p ( 166) 366 47.5 3e-05
XP_006724238 (OMIM: 608457) PREDICTED: chromobox p ( 258) 368 47.8 3.7e-05
XP_006724237 (OMIM: 608457) PREDICTED: chromobox p ( 259) 368 47.8 3.7e-05
NP_116036 (OMIM: 602770,613080) chromobox protein ( 211) 341 45.2 0.00018
>>NP_003646 (OMIM: 603079) E3 SUMO-protein ligase CBX4 [ (560 aa)
initn: 586 init1: 398 opt: 432 Z-score: 241.4 bits: 54.1 E(85289): 1e-06
Smith-Waterman score: 437; 30.2% identity (55.1% similar) in 394 aa overlap (1-385:1-355)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
::: ::::.:::.::: :.::::::.::::::.::. ::.:::::::::: ::. ::...
NP_003 MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNR
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAV----
::...:.: .::::::: ..... . : : :.: ... :.. . :: .:
NP_003 ERQEQLMGYRKRGPKPKPLVVQVPTFA---RRSNVLTGLQDSSTDNRAKLDLGAQGKGQG
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 HRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIIL
:. . . .. :... :. ..:.: :: . . .. ..: .: .:
NP_003 HQYELNSKKHHQYQ----PHSKERAGKPP--PPGKSGKYYYQLNSKKHHPYQP-------
120 130 140 150 160
180 190 200 210 220 230
pF1KE3 NLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYK
. :. : :: . : :. .: ... .. . . .::
NP_003 DPKMYDLQYQGGHKEAPS-----PTCPD----LGAKSHPPDKWAQGAGAKGYLGAVK---
170 180 190 200 210
240 250 260 270 280 290
pF1KE3 PPPAPLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLL
: .: .:::. ..: :.. :: : .: .... : .... . ..
NP_003 --PLAGAAGAPGKGSEKGPPNGMM---PA-PKEAVTGNGIGGKMKIVKNKNKNGRIVIVM
220 230 240 250 260
300 310 320 330 340 350
pF1KE3 PETVSPS--APSWREPEVLDLSLPPESAATSKRAPPEVTAAAGPAPPTAPEPAGASSEP-
. . . : . . :: . .: . .::: : :: : . ::: .
NP_003 SKYMENGMQAVKIKSGEVAEGE--ARSPSHKKRAADE---RHPPADRTFKKAAGAEEKKV
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE3 EAGDWR--PEMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFEKVAAGVAGAAGGGGSIGAS
:: : :.: :. :. : :. : . :
NP_003 EAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPS
330 340 350 360 370 380
pF1KE3 K
NP_003 HHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGG
390 400 410 420 430 440
>>XP_006724240 (OMIM: 608457) PREDICTED: chromobox prote (192 aa)
initn: 543 init1: 411 opt: 415 Z-score: 239.2 bits: 52.1 E(85289): 1.4e-06
Smith-Waterman score: 419; 47.7% identity (68.2% similar) in 151 aa overlap (1-149:1-137)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
:::::.::.:::.::: :.:.:::..::::::::: :::::::::.::: ::. :.:.:
XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLK
:.. . : .::::::: .::. : . ::.: .: . .:.:.: . ::
XP_006 EERDRASGYRKRGPKPKRLLLQPRKAHKYLRLSRKKFPPR------GPNLESHS--HR--
70 80 90 100 110
130 140 150 160 170
pF1KE3 KDIRRCHRMSRRPLPRPDPQGGS--PGLRPPISPFSETVRIINRKVKPREPKRNRIILNL
: ... : : .: :. .::
XP_006 ----RELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDI
120 130 140 150 160
180 190 200 210 220 230
pF1KE3 KVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPP
XP_006 TANSITVTFREAQAAEGFFRDRSGKF
170 180 190
>>XP_005261470 (OMIM: 608457) PREDICTED: chromobox prote (158 aa)
initn: 497 init1: 391 opt: 392 Z-score: 228.8 bits: 49.9 E(85289): 5.3e-06
Smith-Waterman score: 392; 61.5% identity (83.5% similar) in 91 aa overlap (1-91:1-91)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
:::::.::.:::.::: :.:.:::..::::::::: :::::::::.::: ::. :.:.:
XP_005 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLK
:.. . : .::::::: .::. ..:.
XP_005 EERDRASGYRKRGPKPKRLLLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKV
XP_005 ALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
130 140 150
>>XP_006724239 (OMIM: 608457) PREDICTED: chromobox prote (200 aa)
initn: 521 init1: 318 opt: 393 Z-score: 227.8 bits: 50.1 E(85289): 5.9e-06
Smith-Waterman score: 398; 46.2% identity (64.4% similar) in 160 aa overlap (1-149:1-145)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
:::::.::.:::.::: :.:.:::..::::::::: :::::::::.::: ::. :.:.:
XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 ---------ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLH
::.: : .::::::: .::. : . ::.: .: . .:.:.
XP_006 YGVLGTAGEERDRA-SGYRKRGPKPKRLLLQPRKAHKYLRLSRKKFPPR------GPNLE
70 80 90 100 110
120 130 140 150 160
pF1KE3 SSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGS--PGLRPPISPFSETVRIINRKVKPREP
: . :: : ... : : .: :. .::
XP_006 SHS--HR------RELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALP
120 130 140 150 160
170 180 190 200 210 220
pF1KE3 KRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKF
XP_006 SSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
170 180 190 200
>>XP_016884168 (OMIM: 608457) PREDICTED: chromobox prote (250 aa)
initn: 507 init1: 391 opt: 395 Z-score: 227.5 bits: 50.3 E(85289): 6.2e-06
Smith-Waterman score: 400; 43.8% identity (65.1% similar) in 169 aa overlap (1-156:1-165)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
:::::.::.:::.::: :.:.:::..::::::::: :::::::::.::: ::. :.:.:
XP_016 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 ERERELYGPKKRGPKPKTFLLKARAQAEALRISD-------VHFSVKPSASASSPKLHSS
:.. . : .::::::: .::. : . :: : . ::. ...::. .
XP_016 EERDRASGYRKRGPKPKRLLLQ-RLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVK
70 80 90 100 110
120 130 140 150 160
pF1KE3 AAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLR------PPISPFSETVRIINRKVKPR
:.. .: . . . :.: :. . :: :: .: :.
XP_016 AGAPEL---VDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 EPKRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHM
XP_016 PPAPDVLQAAGEWEPAAQPPEEEDADLAEGPPPWTPALPSSEVTVTDITANSITVTFREA
180 190 200 210 220 230
>>NP_783640 (OMIM: 608457) chromobox protein homolog 7 [ (251 aa)
initn: 503 init1: 391 opt: 395 Z-score: 227.5 bits: 50.3 E(85289): 6.2e-06
Smith-Waterman score: 400; 43.8% identity (65.1% similar) in 169 aa overlap (1-156:1-165)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
:::::.::.:::.::: :.:.:::..::::::::: :::::::::.::: ::. :.:.:
NP_783 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 ERERELYGPKKRGPKPKTFLLKARAQAEALRISD-------VHFSVKPSASASSPKLHSS
:.. . : .::::::: .::. : . :: : . ::. ...::. .
NP_783 EERDRASGYRKRGPKPKRLLLQ-RLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVK
70 80 90 100 110
120 130 140 150 160
pF1KE3 AAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLR------PPISPFSETVRIINRKVKPR
:.. .: . . . :.: :. . :: :: .: :.
NP_783 AGAPEL---VDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 EPKRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHM
NP_783 PPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFRE
180 190 200 210 220 230
>>NP_005180 (OMIM: 602770,613080) chromobox protein homo (532 aa)
initn: 576 init1: 319 opt: 390 Z-score: 220.4 bits: 50.1 E(85289): 1.5e-05
Smith-Waterman score: 399; 32.0% identity (54.8% similar) in 372 aa overlap (2-344:3-347)
10 20 30 40 50
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQ
:::.:::.::::: :...:.:::..::::::.::. :...::::::::: ::. ::..
NP_005 MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 KERERELYGPKKRGPKPKTFLLKARAQAEALRIS-----DVHFSVKPSASASSPKLHSSA
::.:.:. . .::: .:. : :.. : : :. . : :.:.:: ::.
NP_005 KEHEKEVQN-RKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSS
70 80 90 100 110
120 130 140 150 160
pF1KE3 AVHRLKKDI--RRCHRMSR-RPLPRPDPQG--GSPGLRPPISPFSETVRIINRKVKPREP
. .. .:. .: : . .:.:. : ..: :. :: . .:: : :
NP_005 SDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPIR------KKRGRKPLPPEQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 KRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKF
: .: ..: . : : :: : : : : : . .:... ..
NP_005 KATRRPVSLAKVLKTAR---KDLGAPASKLPP-PLSAPVAGLA------ALKAHAKEACG
180 190 200 210 220
230 240 250 260 270
pF1KE3 GAFALYKPPP-APLV---APSPGKAEASAPGPGLLLA-------APAAPYDA-RSSGSSG
: :. : : :. : :::.. : . . : :: : ......
NP_005 GPSAMATPENLASLMKGMASSPGRGGISWQSSIVHYMNRMTQSQAQAASRLALKAQATNK
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE3 CP-----SPTPQSSDPDDTPPKLLPETVSPSAPSWR--EPEVLDLSLPPESAATSKRAPP
: . :... .:: . :.::: : .: . . ::.. ..: :.:
NP_005 CGLGLDLKVRTQKGELGMSPPG----SKIPKAPSGGAVEQKVGNTGGPPHTHGAS-RVP-
290 300 310 320 330
340 350 360 370 380 390
pF1KE3 EVTAAAGPAPPTAPEPAGASSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCNPED
:. :.: ::
NP_005 ----AGCPGPQPAPTQELSLQVLDLQSVKNGMPGVGLLARHATATKGVPATNPAPGKGTG
340 350 360 370 380 390
>>XP_011523684 (OMIM: 602770,613080) PREDICTED: chromobo (586 aa)
initn: 576 init1: 319 opt: 390 Z-score: 219.8 bits: 50.1 E(85289): 1.7e-05
Smith-Waterman score: 399; 32.0% identity (54.8% similar) in 372 aa overlap (2-344:3-347)
10 20 30 40 50
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQ
:::.:::.::::: :...:.:::..::::::.::. :...::::::::: ::. ::..
XP_011 MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 KERERELYGPKKRGPKPKTFLLKARAQAEALRIS-----DVHFSVKPSASASSPKLHSSA
::.:.:. . .::: .:. : :.. : : :. . : :.:.:: ::.
XP_011 KEHEKEVQN-RKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSS
70 80 90 100 110
120 130 140 150 160
pF1KE3 AVHRLKKDI--RRCHRMSR-RPLPRPDPQG--GSPGLRPPISPFSETVRIINRKVKPREP
. .. .:. .: : . .:.:. : ..: :. :: . .:: : :
XP_011 SDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPIR------KKRGRKPLPPEQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 KRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKF
: .: ..: . : : :: : : : : : . .:... ..
XP_011 KATRRPVSLAKVLKTAR---KDLGAPASKLPP-PLSAPVAGLA------ALKAHAKEACG
180 190 200 210 220
230 240 250 260 270
pF1KE3 GAFALYKPPP-APLV---APSPGKAEASAPGPGLLLA-------APAAPYDA-RSSGSSG
: :. : : :. : :::.. : . . : :: : ......
XP_011 GPSAMATPENLASLMKGMASSPGRGGISWQSSIVHYMNRMTQSQAQAASRLALKAQATNK
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE3 CP-----SPTPQSSDPDDTPPKLLPETVSPSAPSWR--EPEVLDLSLPPESAATSKRAPP
: . :... .:: . :.::: : .: . . ::.. ..: :.:
XP_011 CGLGLDLKVRTQKGELGMSPPG----SKIPKAPSGGAVEQKVGNTGGPPHTHGAS-RVP-
290 300 310 320 330
340 350 360 370 380 390
pF1KE3 EVTAAAGPAPPTAPEPAGASSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCNPED
:. :.: ::
XP_011 ----AGCPGPQPAPTQELSLQVLDLQSVKNGMPGVGLLARHATATKGVPATNPAPGKGTG
340 350 360 370 380 390
>>XP_011528327 (OMIM: 608457) PREDICTED: chromobox prote (165 aa)
initn: 485 init1: 318 opt: 366 Z-score: 215.3 bits: 47.5 E(85289): 3e-05
Smith-Waterman score: 371; 58.0% identity (76.0% similar) in 100 aa overlap (1-91:1-99)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
:::::.::.:::.::: :.:.:::..::::::::: :::::::::.::: ::. :.:.:
XP_011 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 ---------ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLH
::.: : .::::::: .::. ..:.
XP_011 YGVLGTAGEERDRA-SGYRKRGPKPKRLLLQEPPAPDVLQAAGEWEPAAQPPEEEDADLA
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 SSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKR
XP_011 EGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
120 130 140 150 160
>>XP_006724241 (OMIM: 608457) PREDICTED: chromobox prote (166 aa)
initn: 475 init1: 318 opt: 366 Z-score: 215.3 bits: 47.5 E(85289): 3e-05
Smith-Waterman score: 371; 58.0% identity (76.0% similar) in 100 aa overlap (1-91:1-99)
10 20 30 40 50 60
pF1KE3 MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQK
:::::.::.:::.::: :.:.:::..::::::::: :::::::::.::: ::. :.:.:
XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 ---------ERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLH
::.: : .::::::: .::. ..:.
XP_006 YGVLGTAGEERDRA-SGYRKRGPKPKRLLLQEPPAPDVLQAAGEWEPAAQPPEEEADADL
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 SSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKR
XP_006 AEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
120 130 140 150 160
412 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 10:17:08 2016 done: Tue Nov 8 10:17:10 2016
Total Scan time: 8.450 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]