Result of FASTA (omim) for
pFN21AE3508
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3508, 703 aa
1>>>pF1KE3508 703 - 703 aa - 703 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6466+/-0.000451; mu= -10.8961+/- 0.028
mean_var=330.7591+/-69.270, 0's: 0 Z-trim(119.4): 41 B-trim: 35 in 1/55
Lambda= 0.070521
statistics sampled from 33309 (33350) to 33309 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.72), E-opt: 0.2 (0.391), width: 16
Scan time: 13.930
The best scores are: opt bits E(85289)
NP_005480 (OMIM: 604722) SH2 domain-containing pro ( 703) 4663 488.9 2.9e-137
NP_001239263 (OMIM: 604722) SH2 domain-containing ( 792) 4591 481.6 5.1e-135
XP_011516417 (OMIM: 604722) PREDICTED: SH2 domain- ( 804) 4560 478.4 4.6e-134
XP_011516416 (OMIM: 604722) PREDICTED: SH2 domain- ( 804) 4560 478.4 4.6e-134
NP_733745 (OMIM: 604722) SH2 domain-containing pro ( 860) 4560 478.4 4.9e-134
NP_001136006 (OMIM: 604722) SH2 domain-containing ( 700) 4492 471.5 5e-132
NP_001136005 (OMIM: 604722) SH2 domain-containing ( 702) 4480 470.2 1.2e-131
NP_001136003 (OMIM: 604722) SH2 domain-containing ( 506) 3345 354.7 5.2e-97
NP_001136004 (OMIM: 604722) SH2 domain-containing ( 506) 3345 354.7 5.2e-97
XP_016869663 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 3345 354.7 5.2e-97
XP_011516419 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 3345 354.7 5.2e-97
XP_005251696 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 3345 354.7 5.2e-97
NP_001295180 (OMIM: 604704) breast cancer anti-est ( 501) 1156 132.0 5.6e-30
XP_011540553 (OMIM: 604704) PREDICTED: breast canc ( 605) 1156 132.0 6.6e-30
NP_005481 (OMIM: 604721) SH2 domain-containing pro ( 576) 877 103.6 2.2e-21
XP_016857969 (OMIM: 604704) PREDICTED: breast canc ( 825) 780 93.8 2.8e-18
NP_003558 (OMIM: 604704) breast cancer anti-estrog ( 825) 780 93.8 2.8e-18
NP_001248337 (OMIM: 604704) breast cancer anti-est ( 825) 780 93.8 2.8e-18
NP_001248338 (OMIM: 604704) breast cancer anti-est ( 825) 780 93.8 2.8e-18
NP_001248339 (OMIM: 604704) breast cancer anti-est ( 734) 770 92.8 5.1e-18
XP_011525911 (OMIM: 604721) PREDICTED: SH2 domain- ( 510) 491 64.3 1.3e-09
XP_011525910 (OMIM: 604721) PREDICTED: SH2 domain- ( 510) 491 64.3 1.3e-09
XP_005259524 (OMIM: 604721) PREDICTED: SH2 domain- ( 605) 491 64.4 1.5e-09
XP_005259529 (OMIM: 604721) PREDICTED: SH2 domain- ( 483) 485 63.7 1.9e-09
XP_016881612 (OMIM: 604721) PREDICTED: SH2 domain- ( 399) 368 51.7 6.4e-06
XP_016881613 (OMIM: 604721) PREDICTED: SH2 domain- ( 327) 355 50.4 1.4e-05
XP_006722665 (OMIM: 604721) PREDICTED: SH2 domain- ( 485) 338 48.7 6.2e-05
>>NP_005480 (OMIM: 604722) SH2 domain-containing protein (703 aa)
initn: 4663 init1: 4663 opt: 4663 Z-score: 2585.3 bits: 488.9 E(85289): 2.9e-137
Smith-Waterman score: 4663; 100.0% identity (100.0% similar) in 703 aa overlap (1-703:1-703)
10 20 30 40 50 60
pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE
610 620 630 640 650 660
670 680 690 700
pF1KE3 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
:::::::::::::::::::::::::::::::::::::::::::
NP_005 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
670 680 690 700
>>NP_001239263 (OMIM: 604722) SH2 domain-containing prot (792 aa)
initn: 4591 init1: 4591 opt: 4591 Z-score: 2544.9 bits: 481.6 E(85289): 5.1e-135
Smith-Waterman score: 4591; 99.4% identity (99.4% similar) in 697 aa overlap (7-703:96-792)
10 20 30
pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYIL
::: : ::::::::::::::::::::::
NP_001 APWLVSWQRRGFPPSSFCPGPLRTEKLRAGRCPLLLCGGAAGEPEAGSDYVKFSKEKYIL
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE3 DSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYV
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE3 LTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGA
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE3 IIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTR
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE3 SDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPS
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE3 ATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSG
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE3 HYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSF
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE3 NPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQT
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE3 LMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAA
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE3 ELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGK
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE3 EGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLY
670 680 690 700 710 720
640 650 660 670 680 690
pF1KE3 HTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP
730 740 750 760 770 780
700
pF1KE3 AVRSSEL
:::::::
NP_001 AVRSSEL
790
>>XP_011516417 (OMIM: 604722) PREDICTED: SH2 domain-cont (804 aa)
initn: 4560 init1: 4560 opt: 4560 Z-score: 2527.8 bits: 478.4 E(85289): 4.6e-134
Smith-Waterman score: 4560; 99.7% identity (99.9% similar) in 691 aa overlap (13-703:114-804)
10 20 30 40
pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEK
:. :::::::::::::::::::::::::::
XP_011 NPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEK
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE3 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE3 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV
210 220 230 240 250 260
170 180 190 200 210 220
pF1KE3 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT
270 280 290 300 310 320
230 240 250 260 270 280
pF1KE3 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA
330 340 350 360 370 380
290 300 310 320 330 340
pF1KE3 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ
390 400 410 420 430 440
350 360 370 380 390 400
pF1KE3 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ
450 460 470 480 490 500
410 420 430 440 450 460
pF1KE3 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW
510 520 530 540 550 560
470 480 490 500 510 520
pF1KE3 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM
570 580 590 600 610 620
530 540 550 560 570 580
pF1KE3 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS
630 640 650 660 670 680
590 600 610 620 630 640
pF1KE3 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV
690 700 710 720 730 740
650 660 670 680 690 700
pF1KE3 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE
750 760 770 780 790 800
pF1KE3 L
:
XP_011 L
>>XP_011516416 (OMIM: 604722) PREDICTED: SH2 domain-cont (804 aa)
initn: 4560 init1: 4560 opt: 4560 Z-score: 2527.8 bits: 478.4 E(85289): 4.6e-134
Smith-Waterman score: 4560; 99.7% identity (99.9% similar) in 691 aa overlap (13-703:114-804)
10 20 30 40
pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEK
:. :::::::::::::::::::::::::::
XP_011 NPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEK
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE3 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE3 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV
210 220 230 240 250 260
170 180 190 200 210 220
pF1KE3 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT
270 280 290 300 310 320
230 240 250 260 270 280
pF1KE3 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA
330 340 350 360 370 380
290 300 310 320 330 340
pF1KE3 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ
390 400 410 420 430 440
350 360 370 380 390 400
pF1KE3 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ
450 460 470 480 490 500
410 420 430 440 450 460
pF1KE3 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW
510 520 530 540 550 560
470 480 490 500 510 520
pF1KE3 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM
570 580 590 600 610 620
530 540 550 560 570 580
pF1KE3 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS
630 640 650 660 670 680
590 600 610 620 630 640
pF1KE3 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV
690 700 710 720 730 740
650 660 670 680 690 700
pF1KE3 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE
750 760 770 780 790 800
pF1KE3 L
:
XP_011 L
>>NP_733745 (OMIM: 604722) SH2 domain-containing protein (860 aa)
initn: 4560 init1: 4560 opt: 4560 Z-score: 2527.4 bits: 478.4 E(85289): 4.9e-134
Smith-Waterman score: 4560; 99.7% identity (99.9% similar) in 691 aa overlap (13-703:170-860)
10 20 30 40
pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEK
:. :::::::::::::::::::::::::::
NP_733 NPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEK
140 150 160 170 180 190
50 60 70 80 90 100
pF1KE3 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWR
200 210 220 230 240 250
110 120 130 140 150 160
pF1KE3 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 NQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPV
260 270 280 290 300 310
170 180 190 200 210 220
pF1KE3 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 NRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPT
320 330 340 350 360 370
230 240 250 260 270 280
pF1KE3 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 STSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPA
380 390 400 410 420 430
290 300 310 320 330 340
pF1KE3 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 SPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQ
440 450 460 470 480 490
350 360 370 380 390 400
pF1KE3 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 PPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQ
500 510 520 530 540 550
410 420 430 440 450 460
pF1KE3 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 SLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW
560 570 580 590 600 610
470 480 490 500 510 520
pF1KE3 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTM
620 630 640 650 660 670
530 540 550 560 570 580
pF1KE3 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLS
680 690 700 710 720 730
590 600 610 620 630 640
pF1KE3 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV
740 750 760 770 780 790
650 660 670 680 690 700
pF1KE3 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSE
800 810 820 830 840 850
pF1KE3 L
:
NP_733 L
860
>>NP_001136006 (OMIM: 604722) SH2 domain-containing prot (700 aa)
initn: 4492 init1: 4492 opt: 4492 Z-score: 2491.3 bits: 471.5 E(85289): 5e-132
Smith-Waterman score: 4492; 97.6% identity (98.7% similar) in 697 aa overlap (7-703:4-700)
10 20 30 40 50 60
pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS
:: .. .::. ...:.::::::::::::::::::::::::::::::::
NP_001 MTERCSLWSALSAAACCFYRGSFVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRS
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE3 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE3 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE
600 610 620 630 640 650
670 680 690 700
pF1KE3 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
:::::::::::::::::::::::::::::::::::::::::::
NP_001 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
660 670 680 690 700
>>NP_001136005 (OMIM: 604722) SH2 domain-containing prot (702 aa)
initn: 4480 init1: 4480 opt: 4480 Z-score: 2484.7 bits: 470.2 E(85289): 1.2e-131
Smith-Waterman score: 4480; 99.9% identity (100.0% similar) in 677 aa overlap (27-703:26-702)
10 20 30 40 50 60
pF1KE3 MTAVGRRCPALGSRGAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRS
:.::::::::::::::::::::::::::::::::
NP_001 MTERCSLWSALSAAACCFYRGSFVQVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRS
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGES
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSM
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQ
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRK
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQI
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE3 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE3 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTE
600 610 620 630 640 650
670 680 690 700
pF1KE3 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
:::::::::::::::::::::::::::::::::::::::::::
NP_001 FQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
660 670 680 690 700
>>NP_001136003 (OMIM: 604722) SH2 domain-containing prot (506 aa)
initn: 3345 init1: 3345 opt: 3345 Z-score: 1862.7 bits: 354.7 E(85289): 5.2e-97
Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 506 aa overlap (198-703:1-506)
170 180 190 200 210 220
pF1KE3 LRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLP
::::::::::::::::::::::::::::::
NP_001 MKRRSVTMTDGLTADKVTRSDGCPTSTSLP
10 20 30
230 240 250 260 270 280
pF1KE3 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE3 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE3 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE3 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE3 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE3 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE3 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE3 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
460 470 480 490 500
>>NP_001136004 (OMIM: 604722) SH2 domain-containing prot (506 aa)
initn: 3345 init1: 3345 opt: 3345 Z-score: 1862.7 bits: 354.7 E(85289): 5.2e-97
Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 506 aa overlap (198-703:1-506)
170 180 190 200 210 220
pF1KE3 LRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLP
::::::::::::::::::::::::::::::
NP_001 MKRRSVTMTDGLTADKVTRSDGCPTSTSLP
10 20 30
230 240 250 260 270 280
pF1KE3 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE3 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE3 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE3 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE3 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE3 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE3 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE3 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
460 470 480 490 500
>>XP_016869663 (OMIM: 604722) PREDICTED: SH2 domain-cont (506 aa)
initn: 3345 init1: 3345 opt: 3345 Z-score: 1862.7 bits: 354.7 E(85289): 5.2e-97
Smith-Waterman score: 3345; 100.0% identity (100.0% similar) in 506 aa overlap (198-703:1-506)
170 180 190 200 210 220
pF1KE3 LRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLP
::::::::::::::::::::::::::::::
XP_016 MKRRSVTMTDGLTADKVTRSDGCPTSTSLP
10 20 30
230 240 250 260 270 280
pF1KE3 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVAR
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE3 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRG
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE3 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIP
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE3 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELL
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE3 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE3 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFP
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE3 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGF
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE3 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
460 470 480 490 500
703 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:37:20 2016 done: Sat Nov 5 02:37:22 2016
Total Scan time: 13.930 Total Display time: 0.200
Function used was FASTA [36.3.4 Apr, 2011]