Result of FASTA (omim) for
pFN21AE3472
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3472, 1512 aa
1>>>pF1KE3472 1512 - 1512 aa - 1512 aa
Library: /omim/omim.rfq.tfa
62246620 residues in 87639 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.9951+/-0.000538; mu= 1.2804+/- 0.034
mean_var=607.5782+/-134.242, 0's: 0 Z-trim(121.7): 1649 B-trim: 3430 in 2/58
Lambda= 0.052032
statistics sampled from 36819 (39107) to 36819 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.446), width: 16
Scan time: 13.370
The best scores are: opt bits E(87639)
NP_005912 (OMIM: 600982,613762) mitogen-activated (1512) 10050 771.4 0
XP_016864973 (OMIM: 600982,613762) PREDICTED: mito (1375) 8987 691.5 1.2e-197
XP_016864974 (OMIM: 600982,613762) PREDICTED: mito (1349) 8974 690.6 2.4e-197
NP_001317360 (OMIM: 602539) mitogen-activated prot ( 622) 716 70.2 6.2e-11
XP_005257433 (OMIM: 602539) PREDICTED: mitogen-act ( 653) 716 70.2 6.3e-11
NP_002392 (OMIM: 602539) mitogen-activated protein ( 626) 714 70.0 6.9e-11
NP_976226 (OMIM: 602539) mitogen-activated protein ( 657) 714 70.1 7e-11
NP_006600 (OMIM: 609487) mitogen-activated protein ( 619) 682 67.6 3.6e-10
XP_011543813 (OMIM: 300820) PREDICTED: mitogen-act ( 748) 583 60.3 6.9e-08
XP_011543812 (OMIM: 300820) PREDICTED: mitogen-act ( 871) 583 60.4 7.6e-08
NP_001288001 (OMIM: 602425) mitogen-activated prot (1604) 587 61.1 8.7e-08
XP_011543810 (OMIM: 300820) PREDICTED: mitogen-act (1295) 583 60.7 9.5e-08
NP_001001671 (OMIM: 300820) mitogen-activated prot (1313) 583 60.7 9.6e-08
XP_011543809 (OMIM: 300820) PREDICTED: mitogen-act (1324) 583 60.7 9.6e-08
NP_001278887 (OMIM: 602425) mitogen-activated prot (1061) 580 60.3 9.9e-08
XP_016866358 (OMIM: 602425) PREDICTED: mitogen-act (1517) 580 60.5 1.2e-07
NP_005913 (OMIM: 602425) mitogen-activated protein (1608) 580 60.6 1.3e-07
XP_005267046 (OMIM: 602425) PREDICTED: mitogen-act (1554) 570 59.8 2.1e-07
NP_006715 (OMIM: 602425) mitogen-activated protein (1558) 570 59.8 2.1e-07
XP_016866366 (OMIM: 602448) PREDICTED: mitogen-act (1181) 564 59.2 2.4e-07
XP_016866365 (OMIM: 602448) PREDICTED: mitogen-act (1191) 564 59.2 2.4e-07
XP_011534141 (OMIM: 602448) PREDICTED: mitogen-act (1286) 564 59.2 2.5e-07
NP_005914 (OMIM: 602448) mitogen-activated protein (1374) 564 59.3 2.6e-07
XP_016866364 (OMIM: 602448) PREDICTED: mitogen-act (1447) 564 59.3 2.7e-07
XP_016866363 (OMIM: 602448) PREDICTED: mitogen-act (1458) 564 59.3 2.7e-07
XP_016866362 (OMIM: 602448) PREDICTED: mitogen-act (1483) 564 59.3 2.8e-07
XP_016866361 (OMIM: 602448) PREDICTED: mitogen-act (1484) 564 59.3 2.8e-07
XP_016866360 (OMIM: 602448) PREDICTED: mitogen-act (1493) 564 59.3 2.8e-07
XP_016866359 (OMIM: 602448) PREDICTED: mitogen-act (1494) 564 59.3 2.8e-07
XP_016858260 (OMIM: 604468) PREDICTED: mitogen-act ( 869) 547 57.7 4.9e-07
NP_001284538 (OMIM: 604468) mitogen-activated prot (1280) 547 57.9 6.1e-07
NP_004663 (OMIM: 604468) mitogen-activated protein (1288) 547 57.9 6.2e-07
NP_004064 (OMIM: 602913) serine/threonine-protein ( 646) 471 51.8 2.2e-05
XP_011538703 (OMIM: 616563) PREDICTED: STE20-like ( 783) 471 51.9 2.4e-05
NP_001291672 (OMIM: 616563) STE20-like serine/thre (1204) 471 52.2 3.1e-05
NP_055535 (OMIM: 616563) STE20-like serine/threoni (1235) 471 52.2 3.1e-05
NP_001257354 (OMIM: 604921) mitogen-activated prot ( 873) 453 50.6 6.6e-05
NP_003609 (OMIM: 604921) mitogen-activated protein ( 894) 453 50.7 6.6e-05
NP_002568 (OMIM: 605022) serine/threonine-protein ( 524) 433 48.8 0.00014
XP_011511172 (OMIM: 605022) PREDICTED: serine/thre ( 524) 433 48.8 0.00014
XP_016861990 (OMIM: 605022) PREDICTED: serine/thre ( 524) 433 48.8 0.00014
NP_005981 (OMIM: 603919) serine/threonine-protein ( 968) 437 49.5 0.00016
NP_001121638 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017
NP_001121639 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017
NP_001311254 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017
NP_001311260 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017
NP_001311263 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017
NP_001311261 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017
XP_016885050 (OMIM: 300142,300558) PREDICTED: seri ( 544) 429 48.6 0.00017
NP_001311259 (OMIM: 300142,300558) serine/threonin ( 544) 429 48.6 0.00017
>>NP_005912 (OMIM: 600982,613762) mitogen-activated prot (1512 aa)
initn: 10050 init1: 10050 opt: 10050 Z-score: 4100.3 bits: 771.4 E(87639): 0
Smith-Waterman score: 10050; 100.0% identity (100.0% similar) in 1512 aa overlap (1-1512:1-1512)
10 20 30 40 50 60
pF1KE3 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR
1450 1460 1470 1480 1490 1500
1510
pF1KE3 ELLKHPVFRTTW
::::::::::::
NP_005 ELLKHPVFRTTW
1510
>>XP_016864973 (OMIM: 600982,613762) PREDICTED: mitogen- (1375 aa)
initn: 8987 init1: 8987 opt: 8987 Z-score: 3669.5 bits: 691.5 E(87639): 1.2e-197
Smith-Waterman score: 8987; 100.0% identity (100.0% similar) in 1351 aa overlap (162-1512:25-1375)
140 150 160 170 180 190
pF1KE3 DSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKA
::::::::::::::::::::::::::::::
XP_016 MNFCKVVVLSGGEKDHECTSCFCRREMENKETLKGLHKMDDRPEERMIREKLKA
10 20 30 40 50
200 210 220 230 240 250
pF1KE3 TCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSP
60 70 80 90 100 110
260 270 280 290 300 310
pF1KE3 SPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKV
120 130 140 150 160 170
320 330 340 350 360 370
pF1KE3 MRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPS
180 190 200 210 220 230
380 390 400 410 420 430
pF1KE3 DPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSS
240 250 260 270 280 290
440 450 460 470 480 490
pF1KE3 ENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLC
300 310 320 330 340 350
500 510 520 530 540 550
pF1KE3 RSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPP
360 370 380 390 400 410
560 570 580 590 600 610
pF1KE3 AYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSG
420 430 440 450 460 470
620 630 640 650 660 670
pF1KE3 SSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLA
480 490 500 510 520 530
680 690 700 710 720 730
pF1KE3 ERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGI
540 550 560 570 580 590
740 750 760 770 780 790
pF1KE3 GGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRY
600 610 620 630 640 650
800 810 820 830 840 850
pF1KE3 KKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTR
660 670 680 690 700 710
860 870 880 890 900 910
pF1KE3 MRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKT
720 730 740 750 760 770
920 930 940 950 960 970
pF1KE3 GKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSP
780 790 800 810 820 830
980 990 1000 1010 1020 1030
pF1KE3 LSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHR
840 850 860 870 880 890
1040 1050 1060 1070 1080 1090
pF1KE3 NCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKC
900 910 920 930 940 950
1100 1110 1120 1130 1140 1150
pF1KE3 DDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKS
960 970 980 990 1000 1010
1160 1170 1180 1190 1200 1210
pF1KE3 EVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVE
1020 1030 1040 1050 1060 1070
1220 1230 1240 1250 1260 1270
pF1KE3 NGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAV
1080 1090 1100 1110 1120 1130
1280 1290 1300 1310 1320 1330
pF1KE3 KQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSV
1140 1150 1160 1170 1180 1190
1340 1350 1360 1370 1380 1390
pF1KE3 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA
1200 1210 1220 1230 1240 1250
1400 1410 1420 1430 1440 1450
pF1KE3 AARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNA
1260 1270 1280 1290 1300 1310
1460 1470 1480 1490 1500 1510
pF1KE3 EKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTT
1320 1330 1340 1350 1360 1370
pF1KE3 W
:
XP_016 W
>>XP_016864974 (OMIM: 600982,613762) PREDICTED: mitogen- (1349 aa)
initn: 8974 init1: 8974 opt: 8974 Z-score: 3664.3 bits: 690.6 E(87639): 2.4e-197
Smith-Waterman score: 8974; 100.0% identity (100.0% similar) in 1349 aa overlap (164-1512:1-1349)
140 150 160 170 180 190
pF1KE3 GASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATC
::::::::::::::::::::::::::::::
XP_016 MENKETLKGLHKMDDRPEERMIREKLKATC
10 20 30
200 210 220 230 240 250
pF1KE3 MPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPSP
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE3 GNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMR
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE3 ARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDP
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE3 MLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSEN
220 230 240 250 260 270
440 450 460 470 480 490
pF1KE3 SIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRS
280 290 300 310 320 330
500 510 520 530 540 550
pF1KE3 KWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAY
340 350 360 370 380 390
560 570 580 590 600 610
pF1KE3 KDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSS
400 410 420 430 440 450
620 630 640 650 660 670
pF1KE3 PSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAER
460 470 480 490 500 510
680 690 700 710 720 730
pF1KE3 IKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGG
520 530 540 550 560 570
740 750 760 770 780 790
pF1KE3 VDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKK
580 590 600 610 620 630
800 810 820 830 840 850
pF1KE3 LLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTRMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTRMR
640 650 660 670 680 690
860 870 880 890 900 910
pF1KE3 RRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGK
700 710 720 730 740 750
920 930 940 950 960 970
pF1KE3 GLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLS
760 770 780 790 800 810
980 990 1000 1010 1020 1030
pF1KE3 HHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNC
820 830 840 850 860 870
1040 1050 1060 1070 1080 1090
pF1KE3 PENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDD
880 890 900 910 920 930
1100 1110 1120 1130 1140 1150
pF1KE3 SFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEV
940 950 960 970 980 990
1160 1170 1180 1190 1200 1210
pF1KE3 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG
1000 1010 1020 1030 1040 1050
1220 1230 1240 1250 1260 1270
pF1KE3 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ
1060 1070 1080 1090 1100 1110
1280 1290 1300 1310 1320 1330
pF1KE3 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAH
1120 1130 1140 1150 1160 1170
1340 1350 1360 1370 1380 1390
pF1KE3 LLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAA
1180 1190 1200 1210 1220 1230
1400 1410 1420 1430 1440 1450
pF1KE3 RLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEK
1240 1250 1260 1270 1280 1290
1460 1470 1480 1490 1500 1510
pF1KE3 HSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW
1300 1310 1320 1330 1340
>>NP_001317360 (OMIM: 602539) mitogen-activated protein (622 aa)
initn: 634 init1: 219 opt: 716 Z-score: 317.6 bits: 70.2 E(87639): 6.2e-11
Smith-Waterman score: 716; 31.0% identity (60.2% similar) in 507 aa overlap (1016-1505:129-615)
990 1000 1010 1020 1030 1040
pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV
:.::.. . ..... . . . .:
NP_001 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP
100 110 120 130 140 150
1050 1060 1070 1080 1090
pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNSSSKC--DDSFGCS----
.:: : :. . : : : :: . .: .... ..:: .. . : :
NP_001 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL
160 170 180 190 200 210
1100 1110 1120 1130 1140 1150
pF1KE3 SNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF--KSEV
:.. :.. : ... .: .: :.. . .. .. . : : :. . .:
NP_001 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHV
220 230 240 250 260 270
1160 1170 1180 1190 1200 1210
pF1KE3 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG
.: . ... :. . ..: . . . . :. . . : .:. ..
NP_001 SVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADS
280 290 300 310 320 330
1220 1230 1240 1250 1260 1270
pF1KE3 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ
:. . .:. ...: .:.: .: .:. .: :::. : :: :: .: ::
NP_001 ENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ
340 350 360 370 380
1280 1290 1300 1310 1320 1330
pF1KE3 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMAGGSV
: . : : . : ::. ::.....:.: :... : .... .: :.:.: ::::
NP_001 VQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSV
390 400 410 420 430 440
1340 1350 1360 1370 1380 1390
pF1KE3 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA
:. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. ....::::
NP_001 KDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGA
450 460 470 480 490 500
1400 1410 1420 1430 1440
pF1KE3 AARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPP
. :: . .::: . .. :: .:.:::. :. :::. ::::.::...:: :::
NP_001 SKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP
510 520 530 540 550 560
1450 1460 1470 1480 1490 1500
pF1KE3 WNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF
: :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..::: :
NP_001 W-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLTHHFA
570 580 590 600 610
1510
pF1KE3 RTTW
NP_001 QLMY
620
>>XP_005257433 (OMIM: 602539) PREDICTED: mitogen-activat (653 aa)
initn: 634 init1: 219 opt: 716 Z-score: 317.3 bits: 70.2 E(87639): 6.3e-11
Smith-Waterman score: 716; 31.0% identity (60.2% similar) in 507 aa overlap (1016-1505:160-646)
990 1000 1010 1020 1030 1040
pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV
:.::.. . ..... . . . .:
XP_005 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP
130 140 150 160 170 180
1050 1060 1070 1080 1090
pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNSSSKC--DDSFGCS----
.:: : :. . : : : :: . .: .... ..:: .. . : :
XP_005 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL
190 200 210 220 230 240
1100 1110 1120 1130 1140 1150
pF1KE3 SNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF--KSEV
:.. :.. : ... .: .: :.. . .. .. . : : :. . .:
XP_005 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHV
250 260 270 280 290 300
1160 1170 1180 1190 1200 1210
pF1KE3 AVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENG
.: . ... :. . ..: . . . . :. . . : .:. ..
XP_005 SVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADS
310 320 330 340 350 360
1220 1230 1240 1250 1260 1270
pF1KE3 EDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQ
:. . .:. ...: .:.: .: .:. .: :::. : :: :: .: ::
XP_005 ENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQ
370 380 390 400 410
1280 1290 1300 1310 1320 1330
pF1KE3 VTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMAGGSV
: . : : . : ::. ::.....:.: :... : .... .: :.:.: ::::
XP_005 VQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSV
420 430 440 450 460 470
1340 1350 1360 1370 1380 1390
pF1KE3 AHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGA
:. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. ....::::
XP_005 KDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLGDFGA
480 490 500 510 520 530
1400 1410 1420 1430 1440
pF1KE3 AARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPP
. :: . .::: . .. :: .:.:::. :. :::. ::::.::...:: :::
XP_005 SKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP
540 550 560 570 580 590
1450 1460 1470 1480 1490 1500
pF1KE3 WNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVF
: :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..::: :
XP_005 W-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLTHHFA
600 610 620 630 640
1510
pF1KE3 RTTW
XP_005 QLMY
650
>>NP_002392 (OMIM: 602539) mitogen-activated protein kin (626 aa)
initn: 634 init1: 219 opt: 714 Z-score: 316.7 bits: 70.0 E(87639): 6.9e-11
Smith-Waterman score: 714; 31.1% identity (59.9% similar) in 511 aa overlap (1016-1505:129-619)
990 1000 1010 1020 1030 1040
pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV
:.::.. . ..... . . . .:
NP_002 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP
100 110 120 130 140 150
1050 1060 1070 1080 1090
pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNS--------SSKCD-DSF
.:: : :. . : : : :: . .: .... ..:: : .: : .
NP_002 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL
160 170 180 190 200 210
1100 1110 1120 1130 1140
pF1KE3 GCSSNSSNAVIPS-DETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF--
. . :: .. : :... .: .: :.. . .. .. . : : :.
NP_002 SSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR
220 230 240 250 260 270
1150 1160 1170 1180 1190 1200
pF1KE3 KSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQ
. .:.: . ... :. . ..: . . . . :. . . : .:.
NP_002 RYHVSVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLR
280 290 300 310 320 330
1210 1220 1230 1240 1250 1260
pF1KE3 VENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLM
..:. . .:. ...: .:.: .: .:. .: :::. : :: :: .
NP_002 SADSENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGREL
340 350 360 370 380
1270 1280 1290 1300 1310 1320
pF1KE3 AVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMA
: ::: . : : . : ::. ::.....:.: :... : .... .: :.:.:
NP_002 ASKQVQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP
390 400 410 420 430 440
1330 1340 1350 1360 1370 1380
pF1KE3 GGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIA
:::: :. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. ....
NP_002 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLG
450 460 470 480 490 500
1390 1400 1410 1420 1430 1440
pF1KE3 DFGAAARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMAC
::::. :: . .::: . .. :: .:.:::. :. :::. ::::.::...::
NP_002 DFGASKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT
510 520 530 540 550 560
1450 1460 1470 1480 1490 1500
pF1KE3 AKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLK
:::: :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..:::
NP_002 EKPPW-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLT
570 580 590 600 610
1510
pF1KE3 HPVFRTTW
:
NP_002 HHFAQLMY
620
>>NP_976226 (OMIM: 602539) mitogen-activated protein kin (657 aa)
initn: 634 init1: 219 opt: 714 Z-score: 316.5 bits: 70.1 E(87639): 7e-11
Smith-Waterman score: 714; 31.1% identity (59.9% similar) in 511 aa overlap (1016-1505:160-650)
990 1000 1010 1020 1030 1040
pF1KE3 PSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPV
:.::.. . ..... . . . .:
NP_976 DLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPP
130 140 150 160 170 180
1050 1060 1070 1080 1090
pF1KE3 FTQSRPLPSSNIHRPKPSRPTPGNTS-KQGDPSKNSMTLDLNS--------SSKCD-DSF
.:: : :. . : : : :: . .: .... ..:: : .: : .
NP_976 EPRSRHLSVSS-QNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPL
190 200 210 220 230 240
1100 1110 1120 1130 1140
pF1KE3 GCSSNSSNAVIPS-DETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTV---TF--
. . :: .. : :... .: .: :.. . .. .. . : : :.
NP_976 SSAENSLSGSCQSLDRSADSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR
250 260 270 280 290 300
1150 1160 1170 1180 1190 1200
pF1KE3 KSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQ
. .:.: . ... :. . ..: . . . . :. . . : .:.
NP_976 RYHVSVHHKDYSDGRRTFPR-IRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLR
310 320 330 340 350 360
1210 1220 1230 1240 1250 1260
pF1KE3 VENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLM
..:. . .:. ...: .:.: .: .:. .: :::. : :: :: .
NP_976 SADSENALSVQE---RNVP----TKSP-SAPINWRRGKLLGQGAFGRVYLCYDVDTGREL
370 380 390 400 410
1270 1280 1290 1300 1310 1320
pF1KE3 AVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNL--FIEWMA
: ::: . : : . : ::. ::.....:.: :... : .... .: :.:.:
NP_976 ASKQVQF-DPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP
420 430 440 450 460 470
1330 1340 1350 1360 1370 1380
pF1KE3 GGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIA
:::: :. :::. :::. .::.:.:.:.:::: :.:.:::.::::.: ::.:. ....
NP_976 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGN-VKLG
480 490 500 510 520 530
1390 1400 1410 1420 1430 1440
pF1KE3 DFGAAARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMAC
::::. :: . .::: . .. :: .:.:::. :. :::. ::::.::...::
NP_976 DFGASKRLQTICMSGTG----MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT
540 550 560 570 580 590
1450 1460 1470 1480 1490 1500
pF1KE3 AKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLK
:::: :: .. .: :::::. : :..:::.: :: :: . .. ..:: ..:::
NP_976 EKPPW-AEYEA--MAAIFKIATQPTNPQLPSHISEHGRDF-LRRIFVEARQRPSAEELLT
600 610 620 630 640
1510
pF1KE3 HPVFRTTW
:
NP_976 HHFAQLMY
650
>>NP_006600 (OMIM: 609487) mitogen-activated protein kin (619 aa)
initn: 591 init1: 240 opt: 682 Z-score: 303.8 bits: 67.6 E(87639): 3.6e-10
Smith-Waterman score: 682; 41.8% identity (69.3% similar) in 280 aa overlap (1233-1505:347-613)
1210 1220 1230 1240 1250 1260
pF1KE3 PIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQD
...: : :.: :. .: :::. : :
NP_006 FTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSP-RAPTNWRLGKLLGQGAFGRVYLCYD
320 330 340 350 360 370
1270 1280 1290 1300 1310
pF1KE3 VGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATC----EKSN
: :: .::::: . : : . :.::. ::.....: : :... : : ....
NP_006 VDTGRELAVKQVQF-DPDSPETSKEVNALECEIQLLKNLLHERIVQYYG--CLRDPQEKT
380 390 400 410 420 430
1320 1330 1340 1350 1360 1370
pF1KE3 YNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLID
..:.:.: :::. :. :::. :.:. .::.:.:.:. ::: :.:.:::.::::.: :
NP_006 LSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRD
440 450 460 470 480 490
1380 1390 1400 1410 1420 1430
pF1KE3 STGQRLRIADFGAAARLAS---KGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSV
:::. ....::::. :: . .::: . .. :: .:.:::. :. :::. :.:::
NP_006 STGN-VKLGDFGASKRLQTICLSGTG----MKSVTGTPYWMSPEVISGEGYGRKADIWSV
500 510 520 530 540
1440 1450 1460 1470 1480 1490
pF1KE3 GCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQD
.:...:: :::: :: .. .: :::::. : :..: :.: :: :. . .. .
NP_006 ACTVVEMLTEKPPW-AEFEA--MAAIFKIATQPTNPKLPPHVSDYTRDF-LKRIFVEAKL
550 560 570 580 590 600
1500 1510
pF1KE3 RPPSRELLKHPVFRTTW
:: . :::.:
NP_006 RPSADELLRHMFVHYH
610
>>XP_011543813 (OMIM: 300820) PREDICTED: mitogen-activat (748 aa)
initn: 449 init1: 239 opt: 583 Z-score: 262.8 bits: 60.3 E(87639): 6.9e-08
Smith-Waterman score: 583; 36.1% identity (66.7% similar) in 288 aa overlap (1227-1509:69-344)
1200 1210 1220 1230 1240 1250
pF1KE3 ASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQI--GLGAF
: :.: . : . .:... : :..
XP_011 QIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTY
40 50 60 70 80 90
1260 1270 1280 1290 1300 1310
pF1KE3 SSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATC
. : ..:... . .:.:.. :.. : :.::: . ..:.: ::...::..
XP_011 GIVYAGRDLSNQVRIAIKEIPE-RDSRYSQP-----LHEEIALHKYLKHRNIVQYLGSVS
100 110 120 130 140 150
1320 1330 1340 1350 1360 1370
pF1KE3 EKSNYNLFIEWMAGGSVAHLL-SKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGA
:.. ..:.: . :::.. :: ::.: .:: .. ::.:.:.::.:::::::.:::.::
XP_011 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD
160 170 180 190 200 210
1380 1390 1400 1410 1420 1430
pF1KE3 NLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQQ-YGRSCD
:.:... . ..:.:::.. ::: :.. . ::. .::::.. .: . :: :
XP_011 NVLVNTYSGVVKISDFGTSKRLA----GVNPCTETFTGTLQYMAPEIIDQGPRGYGAPAD
220 230 240 250 260
1440 1450 1460 1470 1480 1490
pF1KE3 VWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLEL
.::.::.::::: .:::.. . .. : .::.. : :: :: : : :.:
XP_011 IWSLGCTIIEMATSKPPFH--ELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEP
270 280 290 300 310 320
1500 1510
pF1KE3 QPQDRPPSRELLKHPVFRTTW
.:. : . :::.. .:
XP_011 DPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSV
330 340 350 360 370 380
>>XP_011543812 (OMIM: 300820) PREDICTED: mitogen-activat (871 aa)
initn: 449 init1: 239 opt: 583 Z-score: 262.1 bits: 60.4 E(87639): 7.6e-08
Smith-Waterman score: 583; 36.1% identity (66.7% similar) in 288 aa overlap (1227-1509:192-467)
1200 1210 1220 1230 1240 1250
pF1KE3 ASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQI--GLGAF
: :.: . : . .:... : :..
XP_011 QIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTY
170 180 190 200 210 220
1260 1270 1280 1290 1300 1310
pF1KE3 SSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATC
. : ..:... . .:.:.. :.. : :.::: . ..:.: ::...::..
XP_011 GIVYAGRDLSNQVRIAIKEIPE-RDSRYSQP-----LHEEIALHKYLKHRNIVQYLGSVS
230 240 250 260 270
1320 1330 1340 1350 1360 1370
pF1KE3 EKSNYNLFIEWMAGGSVAHLL-SKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGA
:.. ..:.: . :::.. :: ::.: .:: .. ::.:.:.::.:::::::.:::.::
XP_011 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD
280 290 300 310 320 330
1380 1390 1400 1410 1420 1430
pF1KE3 NLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQQ-YGRSCD
:.:... . ..:.:::.. ::: :.. . ::. .::::.. .: . :: :
XP_011 NVLVNTYSGVVKISDFGTSKRLA----GVNPCTETFTGTLQYMAPEIIDQGPRGYGAPAD
340 350 360 370 380 390
1440 1450 1460 1470 1480 1490
pF1KE3 VWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLEL
.::.::.::::: .:::.. . .. : .::.. : :: :: : : :.:
XP_011 IWSLGCTIIEMATSKPPFH--ELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEP
400 410 420 430 440
1500 1510
pF1KE3 QPQDRPPSRELLKHPVFRTTW
.:. : . :::.. .:
XP_011 DPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSV
450 460 470 480 490 500
1512 residues in 1 query sequences
62246620 residues in 87639 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Jul 13 16:35:30 2017 done: Thu Jul 13 16:35:32 2017
Total Scan time: 13.370 Total Display time: 0.240
Function used was FASTA [36.3.4 Apr, 2011]