Result of FASTA (omim) for
pFN21AE3424
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3424, 504 aa
1>>>pF1KE3424 504 - 504 aa - 504 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0694+/-0.000369; mu= 4.2277+/- 0.023
mean_var=333.1524+/-67.646, 0's: 0 Z-trim(123.5): 43 B-trim: 0 in 0/56
Lambda= 0.070267
statistics sampled from 43284 (43329) to 43284 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.787), E-opt: 0.2 (0.508), width: 16
Scan time: 10.640
The best scores are: opt bits E(85289)
NP_004843 (OMIM: 604894) one cut domain family mem ( 504) 3466 365.0 2.9e-100
XP_016881585 (OMIM: 604894) PREDICTED: one cut dom ( 480) 2860 303.5 8.8e-82
NP_004489 (OMIM: 604164) hepatocyte nuclear factor ( 465) 1849 201.0 6.2e-51
XP_011519789 (OMIM: 604164) PREDICTED: hepatocyte ( 402) 1348 150.1 1.1e-35
NP_001073957 (OMIM: 611294) one cut domain family ( 494) 1038 118.8 3.6e-26
>>NP_004843 (OMIM: 604894) one cut domain family member (504 aa)
initn: 3466 init1: 3466 opt: 3466 Z-score: 1921.0 bits: 365.0 E(85289): 2.9e-100
Smith-Waterman score: 3466; 100.0% identity (100.0% similar) in 504 aa overlap (1-504:1-504)
10 20 30 40 50 60
pF1KE3 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 HHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 NAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 TQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 DRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRR
430 440 450 460 470 480
490 500
pF1KE3 SLEKWQDDLSTGGSSSTSSTCTKA
::::::::::::::::::::::::
NP_004 SLEKWQDDLSTGGSSSTSSTCTKA
490 500
>>XP_016881585 (OMIM: 604894) PREDICTED: one cut domain (480 aa)
initn: 2860 init1: 2860 opt: 2860 Z-score: 1589.2 bits: 303.5 E(85289): 8.8e-82
Smith-Waterman score: 2860; 100.0% identity (100.0% similar) in 410 aa overlap (1-410:1-410)
10 20 30 40 50 60
pF1KE3 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 HHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 NAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 TQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQSHGPVLAPSRERPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNK
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAAAILMGMRSNK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 DRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRR
XP_016 LSTGRTGCQSSEGEPGFQTPAQCLATSLLKLKRNHLPYSMCKFSRQILLYPALTPGSRRC
430 440 450 460 470 480
>>NP_004489 (OMIM: 604164) hepatocyte nuclear factor 6 [ (465 aa)
initn: 1348 init1: 1017 opt: 1849 Z-score: 1035.5 bits: 201.0 E(85289): 6.2e-51
Smith-Waterman score: 1890; 63.4% identity (76.3% similar) in 514 aa overlap (20-504:1-465)
10 20 30 40 50 60
pF1KE3 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
:: .::::..: ::: . . . ::
NP_004 MNAQLTMEAIGELHGVSHEPVPAPADLLGG-----------
10 20 30
70 80 90 100 110
pF1KE3 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGG---
::: .:.... :: ::. . .: :::.::::
NP_004 -----SPH--ARSSVAH-RGSHLPPAHPRSMG-----------------MASLLDGGSGG
40 50 60
120 130 140 150 160
pF1KE3 -DYR-----PELSI--PLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHH
::. :: :. ::: .:.:.:.. ::::.: .:::::::::::::::::::::
NP_004 GDYHHHHRAPEHSLAGPLHPTMTMACET-PPGMSMPTTYTTLTPLQPLPPISTVSDKF--
70 80 90 100 110 120
170 180 190 200 210 220
pF1KE3 PHPHHHPHHHHH-HHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPY-KEMPGMSQSLSPL
:: ::: ::::: ::::::.:::::::::::::::: .:::::.:: :.. ::.::::::
NP_004 PHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPL
130 140 150 160 170 180
230 240 250 260 270 280
pF1KE3 AATPLGNGLGGLHNAQQSLPNYGPPGH----DKMLSPN-FDAHHTAMLTR-GEQHLSRGL
... :::..::.::.::.:. :: ::::.:: :.::: ::: : :::::
NP_004 SSS----GLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHL----
190 200 210 220 230
290 300 310 320 330
pF1KE3 GTPPAAMMSHLNGL--HHP-GH--TQSHGPVLAPSRERPPSSSSGSQVAT---SGQLEEI
:: .: : .::: ::: .: .:.:: .:. .:: : : .:.::.. :::.:::
NP_004 -TPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTARE-PNPSVTGAQVSNGSNSGQMEEI
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE3 NTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWK
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWK
300 310 320 330 340 350
400 410 420 430 440 450
pF1KE3 WLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSK
:::::::::::::::::::::::: .:::.:. :: ::::::.::::: :::::::::::
NP_004 WLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSK
360 370 380 390 400 410
460 470 480 490 500
pF1KE3 EMQITISQQLGLELTTVSNFFMNARRRSLEKWQDDLST--GGSSSTSSTCTKA
:.::::::::::::.::::::::::::::.::::. :. :.:::.:::::::
NP_004 ELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA
420 430 440 450 460
>>XP_011519789 (OMIM: 604164) PREDICTED: hepatocyte nucl (402 aa)
initn: 877 init1: 547 opt: 1348 Z-score: 761.7 bits: 150.1 E(85289): 1.1e-35
Smith-Waterman score: 1389; 59.2% identity (72.4% similar) in 417 aa overlap (20-409:1-368)
10 20 30 40 50 60
pF1KE3 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
:: .::::..: ::: . . . ::
XP_011 MNAQLTMEAIGELHGVSHEPVPAPADLLGG-----------
10 20 30
70 80 90 100 110
pF1KE3 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGG---
::: .:.... :: ::. . .: :::.::::
XP_011 -----SPH--ARSSVAH-RGSHLPPAHPRSMG-----------------MASLLDGGSGG
40 50 60
120 130 140 150 160
pF1KE3 -DYR-----PELSI--PLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHH
::. :: :. ::: .:.:.:.. ::::.: .:::::::::::::::::::::
XP_011 GDYHHHHRAPEHSLAGPLHPTMTMACET-PPGMSMPTTYTTLTPLQPLPPISTVSDKF--
70 80 90 100 110 120
170 180 190 200 210 220
pF1KE3 PHPHHHPHHHHH-HHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPY-KEMPGMSQSLSPL
:: ::: ::::: ::::::.:::::::::::::::: .:::::.:: :.. ::.::::::
XP_011 PHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPL
130 140 150 160 170 180
230 240 250 260 270 280
pF1KE3 AATPLGNGLGGLHNAQQSLPNYGPPGH----DKMLSPN-FDAHHTAMLTR-GEQHLSRGL
... :::..::.::.::.:. :: ::::.:: :.::: ::: : :::::
XP_011 SSS----GLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHL----
190 200 210 220 230
290 300 310 320 330
pF1KE3 GTPPAAMMSHLNGL--HHP-GH--TQSHGPVLAPSRERPPSSSSGSQVAT---SGQLEEI
:: .: : .::: ::: .: .:.:: .:. .:: : : .:.::.. :::.:::
XP_011 -TPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTARE-PNPSVTGAQVSNGSNSGQMEEI
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE3 NTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWK
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWK
300 310 320 330 340 350
400 410 420 430 440 450
pF1KE3 WLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVFTDLQRRTLFAIFKENKRPSK
::::::::::::::::
XP_011 WLQEPEFQRMSALRLADQWGKLNKQTSEARHLVTSVLAADSATEVRERSG
360 370 380 390 400
>>NP_001073957 (OMIM: 611294) one cut domain family memb (494 aa)
initn: 1167 init1: 949 opt: 1038 Z-score: 590.8 bits: 118.8 E(85289): 3.6e-26
Smith-Waterman score: 1452; 52.5% identity (69.5% similar) in 531 aa overlap (23-504:2-494)
10 20 30 40 50 60
pF1KE3 MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQE
::..:::: ::. : . .: :
NP_001 MELSLESLGGLHSVAHAQAG------------------E
10 20
70 80 90 100 110
pF1KE3 LLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAA----AAAAAASRSAMVTSMASILDG
:: :: :: :.::.. :: : : :. ....... .. . . .: :
NP_001 LL---SPGHA-RSAAAQHRGLVAPGRPGLVAGMASLLDGGGGGGGGGAGGAGGAGSAGGG
30 40 50 60 70
120 130 140 150 160 170
pF1KE3 GDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHP------
.:.: ::. ::: ::.:.:.. ::.: .::::::::: :::...:.::::.
NP_001 ADFRGELAGPLHPAMGMACEA--PGLG--GTYTTLTPLQHLPPLAAVADKFHQHAAAAAV
80 90 100 110 120 130
180 190 200 210
pF1KE3 ------HPHHHPHHHHHHHH----QRLSGNVSGSFTLMRDERG-LPAMNNLYSPY-KEMP
::: ::: :::...::::::::::::. : ....::.:: ::.:
NP_001 AGAHGGHPHAHPHPAAAPPPPPPPQRLAASVSGSFTLMRDERAALASVGHLYGPYGKELP
140 150 160 170 180 190
220 230 240 250 260
pF1KE3 GMSQSLSPLAATPLGNGLG-GLHNAQQSLP--------NYGPPGH---DKMLSPNFDAHH
.:. ::: .:: :.: .::.: : : :::::: ::.: : :
NP_001 AMG---SPL--SPLPNALPPALHGAPQPPPPPPPPPLAAYGPPGHLAGDKLLPPAAFEPH
200 210 220 230 240
270 280 290 300 310
pF1KE3 TAMLTRGEQHLSRGL------------GTPPAA-MMSHLNGLHHPGHTQSHGPVLAPSRE
.:.: :.:. :.::: :. :: ... :.:: : .::: . .
NP_001 AALLGRAEDALARGLPGGGGGTGSGGAGSGSAAGLLAPLGGLAAAG---AHGPHGGGG--
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE3 RPPSSSSGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLR
:..:.:. : .. :::::::::::::::::::::::::::::.:::::::::::::
NP_001 -GPGGSGGGPSAGAAA-EEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLR
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE3 NPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEPNKDRNNSQKKSRLVF
:::::::::::::::::::::::::::::::::::::::::::: .:.: . ::.::::
NP_001 NPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQKERALQPKKQRLVF
370 380 390 400 410 420
440 450 460 470 480 490
pF1KE3 TDLQRRTLFAIFKENKRPSKEMQITISQQLGLELTTVSNFFMNARRRSLEKWQDDLST--
::::::::.::::::::::::::.::::::::::.:::::::::::: ...: .. ::
NP_001 TDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRRCMNRWAEEPSTAP
430 440 450 460 470 480
500
pF1KE3 GGSSSTSSTCTKA
:: .....: .::
NP_001 GGPAGATATFSKA
490
504 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:32:38 2016 done: Tue Nov 8 04:32:39 2016
Total Scan time: 10.640 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]