Result of FASTA (omim) for
pFN21AE3390
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3390, 1204 aa
1>>>pF1KE3390 1204 - 1204 aa - 1204 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.9403+/-0.000795; mu= -30.5475+/- 0.049
mean_var=1062.4967+/-223.974, 0's: 0 Z-trim(117.7): 1500 B-trim: 0 in 0/56
Lambda= 0.039347
statistics sampled from 28265 (30009) to 28265 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.352), width: 16
Scan time: 15.340
The best scores are: opt bits E(85289)
NP_001291672 (OMIM: 616563) STE20-like serine/thre (1204) 7707 455.2 1.1e-126
NP_055535 (OMIM: 616563) STE20-like serine/threoni (1235) 6034 360.3 4.5e-98
XP_011538703 (OMIM: 616563) PREDICTED: STE20-like ( 783) 2245 145.0 1.9e-33
NP_005981 (OMIM: 603919) serine/threonine-protein ( 968) 1690 113.5 6.5e-24
XP_016865277 (OMIM: 603919) PREDICTED: serine/thre ( 860) 1313 92.1 1.7e-17
XP_005260587 (OMIM: 604965,614868) PREDICTED: seri ( 503) 880 67.3 2.9e-10
NP_006273 (OMIM: 604965,614868) serine/threonine-p ( 487) 877 67.1 3.2e-10
XP_005260588 (OMIM: 604965,614868) PREDICTED: seri ( 478) 873 66.8 3.7e-10
XP_005260590 (OMIM: 604965,614868) PREDICTED: seri ( 462) 870 66.6 4.1e-10
NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519) 870 66.7 4.4e-10
XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524) 870 66.7 4.5e-10
XP_011527322 (OMIM: 604965,614868) PREDICTED: seri ( 404) 865 66.3 4.6e-10
XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576) 870 66.8 4.8e-10
XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456) 866 66.4 4.8e-10
XP_016869245 (OMIM: 605030) PREDICTED: serine/thre ( 580) 870 66.8 4.8e-10
NP_006272 (OMIM: 605030) serine/threonine-protein ( 491) 866 66.4 5e-10
XP_016883522 (OMIM: 604965,614868) PREDICTED: seri ( 388) 862 66.1 5e-10
XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522) 866 66.5 5.2e-10
XP_016860859 (OMIM: 604666) PREDICTED: mitogen-act (1188) 854 66.2 1.4e-09
XP_016860858 (OMIM: 604666) PREDICTED: mitogen-act (1196) 854 66.2 1.5e-09
XP_005264120 (OMIM: 604666) PREDICTED: mitogen-act (1260) 854 66.2 1.5e-09
XP_006712932 (OMIM: 604666) PREDICTED: mitogen-act (1189) 847 65.8 1.9e-09
XP_005260589 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09
XP_016883519 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09
XP_016883520 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09
XP_016883518 (OMIM: 604965,614868) PREDICTED: seri ( 474) 831 64.4 1.9e-09
XP_016860852 (OMIM: 604666) PREDICTED: mitogen-act (1253) 847 65.8 2e-09
XP_005264128 (OMIM: 604666) PREDICTED: mitogen-act (1185) 846 65.7 2e-09
XP_005264119 (OMIM: 604666) PREDICTED: mitogen-act (1261) 847 65.8 2e-09
XP_016883521 (OMIM: 604965,614868) PREDICTED: seri ( 458) 828 64.3 2.1e-09
XP_016880194 (OMIM: 609426) PREDICTED: misshapen-l (1341) 842 65.6 2.5e-09
XP_016860860 (OMIM: 604666) PREDICTED: mitogen-act (1186) 839 65.3 2.6e-09
XP_016880195 (OMIM: 609426) PREDICTED: misshapen-l (1323) 840 65.4 2.7e-09
XP_006721599 (OMIM: 609426) PREDICTED: misshapen-l (1324) 840 65.4 2.7e-09
XP_016860853 (OMIM: 604666) PREDICTED: mitogen-act (1249) 839 65.4 2.7e-09
XP_006721595 (OMIM: 609426) PREDICTED: misshapen-l (1360) 840 65.5 2.7e-09
XP_006721594 (OMIM: 609426) PREDICTED: misshapen-l (1361) 840 65.5 2.8e-09
XP_005264121 (OMIM: 604666) PREDICTED: mitogen-act (1258) 832 65.0 3.6e-09
XP_016873585 (OMIM: 603166) PREDICTED: mitogen-act ( 584) 819 63.9 3.6e-09
XP_016876284 (OMIM: 604984) PREDICTED: serine/thre ( 474) 814 63.5 3.8e-09
XP_016880193 (OMIM: 609426) PREDICTED: misshapen-l (1358) 829 64.8 4.2e-09
XP_011543505 (OMIM: 603166) PREDICTED: mitogen-act ( 797) 819 64.0 4.4e-09
NP_001294919 (OMIM: 603166) mitogen-activated prot ( 812) 819 64.0 4.5e-09
NP_004570 (OMIM: 603166) mitogen-activated protein ( 820) 819 64.0 4.5e-09
XP_011517813 (OMIM: 606808,607101) PREDICTED: myos (1009) 819 64.1 5.1e-09
NP_001155036 (OMIM: 610005,617028) TRAF2 and NCK-i (1297) 823 64.5 5.2e-09
NP_001155035 (OMIM: 610005,617028) TRAF2 and NCK-i (1305) 823 64.5 5.2e-09
NP_001155038 (OMIM: 610005,617028) TRAF2 and NCK-i (1268) 822 64.4 5.3e-09
NP_001155032 (OMIM: 610005,617028) TRAF2 and NCK-i (1352) 823 64.5 5.3e-09
NP_001155037 (OMIM: 610005,617028) TRAF2 and NCK-i (1276) 822 64.4 5.3e-09
>>NP_001291672 (OMIM: 616563) STE20-like serine/threonin (1204 aa)
initn: 7707 init1: 7707 opt: 7707 Z-score: 2395.1 bits: 455.2 E(85289): 1.1e-126
Smith-Waterman score: 7707; 100.0% identity (100.0% similar) in 1204 aa overlap (1-1204:1-1204)
10 20 30 40 50 60
pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 RDEAKRIKGEQEKELSKFQNMLKNRKKEEQEFVQKQQQELDGSLKKIIQQQKAELANIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEAKRIKGEQEKELSKFQNMLKNRKKEEQEFVQKQQQELDGSLKKIIQQQKAELANIER
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 ECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 YNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 EEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 SQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLH
1150 1160 1170 1180 1190 1200
pF1KE3 STGS
::::
NP_001 STGS
>>NP_055535 (OMIM: 616563) STE20-like serine/threonine-p (1235 aa)
initn: 5971 init1: 5929 opt: 6034 Z-score: 1881.7 bits: 360.3 E(85289): 4.5e-98
Smith-Waterman score: 7635; 97.5% identity (97.5% similar) in 1235 aa overlap (1-1204:1-1235)
10 20 30 40 50 60
pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
850 860 870 880 890 900
910 920
pF1KE3 RDEAKRIKGEQEKELSKFQNMLKNRKKE-------------------------------E
:::::::::::::::::::::::::::: :
NP_055 RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQE
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE3 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE3 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE3 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE3 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200
pF1KE3 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
:::::::::::::::::::::::::::::::::::
NP_055 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
1210 1220 1230
>>XP_011538703 (OMIM: 616563) PREDICTED: STE20-like seri (783 aa)
initn: 4234 init1: 2194 opt: 2245 Z-score: 721.6 bits: 145.0 E(85289): 1.9e-33
Smith-Waterman score: 3926; 60.9% identity (60.9% similar) in 1235 aa overlap (1-1204:1-783)
10 20 30 40 50 60
pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACIL
:::::::::::::::::::::::::::::::
XP_011 RELIAEAKAEVTEEVEDGKEEDEEEETENSL-----------------------------
310 320 330
370 380 390 400 410 420
pF1KE3 ESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIK
XP_011 ------------------------------------------------------------
430 440 450 460 470 480
pF1KE3 ENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQM
XP_011 ------------------------------------------------------------
490 500 510 520 530 540
pF1KE3 FENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKD
XP_011 ------------------------------------------------------------
550 560 570 580 590 600
pF1KE3 VISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV
XP_011 ------------------------------------------------------------
610 620 630 640 650 660
pF1KE3 PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADT
XP_011 ------------------------------------------------------------
670 680 690 700 710 720
pF1KE3 DQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG
XP_011 ------------------------------------------------------------
730 740 750 760 770 780
pF1KE3 ENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSI
XP_011 ------------------------------------------------------------
790 800 810 820 830 840
pF1KE3 SLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ---ETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKE
340 350 360 370 380
850 860 870 880 890 900
pF1KE3 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
390 400 410 420 430 440
910 920
pF1KE3 RDEAKRIKGEQEKELSKFQNMLKNRKKE-------------------------------E
:::::::::::::::::::::::::::: :
XP_011 RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQE
450 460 470 480 490 500
930 940 950 960 970 980
pF1KE3 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKH
510 520 530 540 550 560
990 1000 1010 1020 1030 1040
pF1KE3 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAK
570 580 590 600 610 620
1050 1060 1070 1080 1090 1100
pF1KE3 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEA
630 640 650 660 670 680
1110 1120 1130 1140 1150 1160
pF1KE3 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ
690 700 710 720 730 740
1170 1180 1190 1200
pF1KE3 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
:::::::::::::::::::::::::::::::::::
XP_011 EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
750 760 770 780
>>NP_005981 (OMIM: 603919) serine/threonine-protein kina (968 aa)
initn: 3577 init1: 1489 opt: 1690 Z-score: 550.3 bits: 113.5 E(85289): 6.5e-24
Smith-Waterman score: 3102; 46.4% identity (64.9% similar) in 1233 aa overlap (1-1198:1-964)
10 20 30 40 50
pF1KE3 MSFFNFRKIFKLGS-EKKK-KQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSV
:.: :::.:..:.. ::.: ..::::.:::.:.. :::.::::::::::::::.::::..
NP_005 MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 LAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDA
:::::::.::::::::::.:::.:::.:::: ::::: :.:....:::.:::: ::::::
NP_005 LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 VMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSA
.::::.: ::: ::::::.: :.:::.::...::::::::::.:.::.:::.::::::::
NP_005 IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 KNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL
:: .:.:.:::::::::::::::::::: :: :::::::.:::::::::::.::::::::
NP_005 KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 NPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT-VDSN
::::::::::::.:::: ::.:: .:.:::: :.:: ..: ...:::.::::. . ::
NP_005 NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 KPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNA
: .:::.::::::: ::.:::..: :::.. .. ::. :.. .::.
NP_005 KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDA---------------ASTLENH-TQNS
310 320 330 340
360 370 380 390 400 410
pF1KE3 CILESVSEKTERSNSEDKLNSKILNEKPTTD-EPEKAVEDINEHITDAQLEAMTELHDRT
:: . : . :: :.:.:.: : .. ...:: .. . ::.
NP_005 ------SEVSPPSLNADK----PLEESPSTPLAPSQSQDSVNEPCSQPS-------GDRS
350 360 370 380
420 430 440 450 460 470
pF1KE3 AVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQE
.:.. :. :.::.. . .
NP_005 L----------------------QTTSPPVVAPGNENGLAVPVP----------------
390 400
480 490 500 510 520 530
pF1KE3 KQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDK
: ::. . ..: : ::
NP_005 --------LRKSRPV------SMD----------ARIQ----------------------
410 420
540 550 560 570 580 590
pF1KE3 TQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGG
:::. :.:.: : : .: :
NP_005 --------------------VAQE--------------KQVAEQGGDL------SPAA--
430 440
600 610 620 630 640 650
pF1KE3 TKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSV
:. : ..:. :. ::. :
NP_005 -------------------NRSQKASQSR--------PN---------SSALE-------
450
660 670 680 690 700 710
pF1KE3 VADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININ
.::.:
NP_005 -------TLGGE------------------------------------------------
460
720 730 740 750 760 770
pF1KE3 SDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKD
: ::: :: . : . :: .: . :.: . ..:. :: .:.
NP_005 ------KLANGSLE------PPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKE
470 480 490 500 510
780 790 800 810 820 830
pF1KE3 SGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRF
::.:... . :::::.::::.:::::::.:::::......: ::.::::::::::::.
NP_005 MGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRL
520 530 540 550 560 570
840 850 860 870 880 890
pF1KE3 LQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEH
:::::.: : ::..: . : ::. .:::::. .::. .: :.::::.:::: .:..::.:
NP_005 LQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDH
580 590 600 610 620 630
900 910 920
pF1KE3 TNRLRDEAKRIKGEQEKELSKFQNMLKNRKKE----------------------------
. : :.::.::. ::... ..::..:: :::
NP_005 AVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKK
640 650 660 670 680 690
930 940 950 960 970 980
pF1KE3 ---EQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHL
...:: ::...:. ..:.. ... :. . ::::: .::.:.: ::::.::.::..:
NP_005 QLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQL
700 710 720 730 740 750
990 1000 1010 1020 1030 1040
pF1KE3 QEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQR
::.:::.:::::::::.:::.::..:::: :::::::::.::.:: :: ::.::::::::
NP_005 QERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQR
760 770 780 790 800 810
1050 1060 1070 1080 1090 1100
pF1KE3 SEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQL
::.::::::.::::.::. .. ..:.:::::. :::::::.::. :.:::::::::.
NP_005 SEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLA
820 830 840 850 860 870
1110 1120 1130 1140 1150 1160
pF1KE3 QCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARK
:::.:. ::.::::::::::::::::::: ::: :.:.:::::.:::::::.:::.. .:
NP_005 QCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQK
880 890 900 910 920 930
1170 1180 1190 1200
pF1KE3 LQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
.:::.:::.. :.:: :::: :. .::.: :
NP_005 KREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS
940 950 960
>>XP_016865277 (OMIM: 603919) PREDICTED: serine/threonin (860 aa)
initn: 3101 init1: 1235 opt: 1313 Z-score: 435.2 bits: 92.1 E(85289): 1.7e-17
Smith-Waterman score: 2585; 44.1% identity (62.0% similar) in 1125 aa overlap (107-1198:1-856)
80 90 100 110 120 130
pF1KE3 MVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVC
.:::: ::::::.::::.: ::: ::::::
XP_016 MIEFCPGGAVDAIMLELDRGLTEPQIQVVC
10 20 30
140 150 160 170 180 190
pF1KE3 KQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYW
.: :.:::.::...::::::::::.:.::.:::.:::::::::: .:.:.::::::::::
XP_016 RQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYW
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE3 MAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLA
:::::::::: :: :::::::.:::::::::::.::::::::::::::::::::.::::
XP_016 MAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLL
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE3 QPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT-VDSNKPIRELIAEAKAEVTEEV
::.:: .:.:::: :.:: ..: ...:::.::::. . ::: .:::.::::::: ::.
XP_016 TPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEI
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE3 EDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDK
:::..: :::.. .. ::. :.. .::. :: . : . :
XP_016 EDGRDEGEEEDA---------------VDAASTLENH-TQNS------SEVSPPSLNAD-
220 230 240
380 390 400 410 420 430
pF1KE3 LNSKILNEKPTTD-EPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLP
: :.:.:.: : .. ...:: .. . ::.
XP_016 ---KPLEESPSTPLAPSQSQDSVNEPCSQPS-------GDRSL-----------------
250 260 270 280
440 450 460 470 480 490
pF1KE3 DTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDT
.:.. :. :.::.. . . : ::. .
XP_016 -----QTTSPPVVAPGNENGLAVPVP------------------------LRKSRPV---
290 300
500 510 520 530 540 550
pF1KE3 ILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEA
..: : ::
XP_016 ---SMD----------ARIQ----------------------------------------
310
560 570 580 590 600 610
pF1KE3 ADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEG
:::. :.:.: : : .: :
XP_016 --VAQE--------------KQVAEQGGDL------SPAA--------------------
320 330
620 630 640 650 660 670
pF1KE3 KNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASK
:. : ..:. :. ::. : .::.:
XP_016 -NRSQKASQSR--------PN---------SSALE--------------TLGGE------
340 350
680 690 700 710 720 730
pF1KE3 VTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTET
: :::
XP_016 ------------------------------------------------KLANGSLE----
360
740 750 760 770 780 790
pF1KE3 ILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKK
:: . : . :: .: . :.: . ..:. :: .:. ::.:... . :::::.
XP_016 --PPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKR
370 380 390 400 410 420
800 810 820 830 840 850
pF1KE3 TRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQ
::::.:::::::.:::::......: ::.::::::::::::.:::::.: : ::..: .
XP_016 TRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHEL
430 440 450 460 470 480
860 870 880 890 900 910
pF1KE3 QREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKE
: ::. .:::::. .::. .: :.::::.:::: .:..::.:. : :.::.::. ::...
XP_016 QLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRD
490 500 510 520 530 540
920 930 940
pF1KE3 LSKFQNMLKNRKKE-------------------------------EQEFVQKQQQELDGS
..::..:: ::: ...:: ::...:. .
XP_016 YTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELA
550 560 570 580 590 600
950 960 970 980 990 1000
pF1KE3 LKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQ
.:.. ... :. . ::::: .::.:.: ::::.::.::..:::.:::.:::::::::.:
XP_016 MKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQ
610 620 630 640 650 660
1010 1020 1030 1040 1050 1060
pF1KE3 RHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINS
::.::..:::: :::::::::.::.:: :: ::.::::::::::.::::::.::::.::.
XP_016 RHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHING
670 680 690 700 710 720
1070 1080 1090 1100 1110 1120
pF1KE3 TATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCH
.. ..:.:::::. :::::::.::. :.:::::::::. :::.:. ::.::::::::
XP_016 GGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCH
730 740 750 760 770 780
1130 1140 1150 1160 1170 1180
pF1KE3 LLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLN
::::::::::: ::: :.:.:::::.:::::::.:::.. .: .:::.:::.. :.:: :
XP_016 LLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPN
790 800 810 820 830 840
1190 1200
pF1KE3 PSTQSRISKFYPIPSLHSTGS
::: :. .::.: :
XP_016 PSTPSKAAKFFPYSSADAS
850 860
>>XP_005260587 (OMIM: 604965,614868) PREDICTED: serine/t (503 aa)
initn: 737 init1: 428 opt: 880 Z-score: 305.2 bits: 67.3 E(85289): 2.9e-10
Smith-Waterman score: 880; 32.6% identity (66.7% similar) in 481 aa overlap (12-479:26-487)
10 20 30 40
pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFG
.: . :: . . . . .::. .... .::.:..:
XP_005 MASFITDVQCLPNGLHILLSSSEPDIGRQLKKLDEDSLTK--QPEEVFDVLEKLGEGSYG
10 20 30 40 50
50 60 70 80 90 100
pF1KE3 KVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWI
.:::: .:::. ..: : . ..:. :.. . ::.:. .:: :..:: ... ...:::
XP_005 SVYKAIHKETGQIVAIKQVPVESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE3 LIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLD
..:.:..:.:. .. .. :::..: .. ..:: .:.::: . ::::.::::::.. .
XP_005 VMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLI
: :::::::... : :. .:.. ::::.::::::. .. :. ::.:::::: :
XP_005 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAI
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE3 EMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQL
:::: .::. ...:::... : . :::. .: ::.:: ::.:.:: :. . : :..::
XP_005 EMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQL
240 250 260 270 280 290
290 300 310 320 330
pF1KE3 LQHPFV-TVDSNKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASK
:::::: .. . . .:.:: :: : . ... : : .:..::.: ... . :
XP_005 LQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVG
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE3 RASSDLSIASSEEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKA--
. . .::. : . ... . : :.::. . .... : .: :
XP_005 DEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSF
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE3 VEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKEN
.: .... . :.... . . . .:.. : .:. : : . .: . ..
XP_005 LEYFEQKEKENQINSFGK--SVPGPLKNSSDWK------IPQDGDYEFLKSWTVEDLQKR
420 430 440 450 460
460 470 480 490 500 510
pF1KE3 NIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANI
...:. .:.... ..: : :.:
XP_005 --LLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
470 480 490 500
>>NP_006273 (OMIM: 604965,614868) serine/threonine-prote (487 aa)
initn: 737 init1: 428 opt: 877 Z-score: 304.4 bits: 67.1 E(85289): 3.2e-10
Smith-Waterman score: 877; 32.6% identity (66.9% similar) in 478 aa overlap (18-479:11-471)
10 20 30 40 50
pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDL---NPEDFWEIIGELGDGAFGKVYKAQNKETS
..: ... .: .::. .... .::.:..:.:::: .:::.
NP_006 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETG
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 VLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVD
..: : . ..:. :.. . ::.:. .:: :..:: ... ...:::..:.:..:.:.
NP_006 QIVAIKQVPVESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 AVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS
.. .. :::..: .. ..:: .:.::: . ::::.::::::.. .: :::::::.
NP_006 DIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHE
.. : :. .:.. ::::.::::::. .. :. ::.:::::: ::::: .::. .
NP_006 GQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYAD
180 190 200 210 220
240 250 260 270 280 290
pF1KE3 LNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDS
..:::... : . :::. .: ::.:: ::.:.:: :. . : :..:::::::: .. .
NP_006 IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG
230 240 250 260 270 280
300 310 320 330 340
pF1KE3 NKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASKRASSDLSIASS
. .:.:: :: : . ... : : .:..::.: ... . : . . .::.
NP_006 VSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVAST
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE3 EEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKA--VEDINEHITDA
: . ... . : :.::. . .... : .: : .: .... .
NP_006 MTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKEN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE3 QLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIE
:.... . . . .:.. : .:. : : . .: . .. ...:. .:
NP_006 QINSFGK--SVPGPLKNSSDWK------IPQDGDYEFLKSWTVEDLQKR--LLALDPMME
410 420 430 440 450
470 480 490 500 510 520
pF1KE3 HNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTK
.... ..: : :.:
NP_006 QEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
460 470 480
>>XP_005260588 (OMIM: 604965,614868) PREDICTED: serine/t (478 aa)
initn: 737 init1: 428 opt: 873 Z-score: 303.3 bits: 66.8 E(85289): 3.7e-10
Smith-Waterman score: 873; 36.5% identity (69.4% similar) in 392 aa overlap (12-392:26-408)
10 20 30 40
pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFG
.: . :: . . . . .::. .... .::.:..:
XP_005 MASFITDVQCLPNGLHILLSSSEPDIGRQLKKLDEDSLTK--QPEEVFDVLEKLGEGSYG
10 20 30 40 50
50 60 70 80 90 100
pF1KE3 KVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWI
.:::: .:::. ..: : . ..:. :.. . ::.:. .:: :..:: ... ...:::
XP_005 SVYKAIHKETGQIVAIKQVPVESD--LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE3 LIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLD
..:.:..:.:. .. .. :::..: .. ..:: .:.::: . ::::.::::::.. .
XP_005 VMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLI
: :::::::... : :. .:.. ::::.::::::. .. :. ::.:::::: :
XP_005 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAI
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE3 EMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQL
:::: .::. ...:::... : . :::. .: ::.:: ::.:.:: :. . : :..::
XP_005 EMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQL
240 250 260 270 280 290
290 300 310 320 330
pF1KE3 LQHPFV-TVDSNKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASK
:::::: .. . . .:.:: :: : . ... : : .:..::.: ... . :
XP_005 LQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVG
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE3 RASSDLSIASSEEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKAVE
. . .::. : . ... . : :.::. . .... : .: :
XP_005 DEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSF
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE3 DINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNI
XP_005 LEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFKTSQEQQSGKDICIQNCQGN
420 430 440 450 460 470
>>XP_005260590 (OMIM: 604965,614868) PREDICTED: serine/t (462 aa)
initn: 737 init1: 428 opt: 870 Z-score: 302.5 bits: 66.6 E(85289): 4.1e-10
Smith-Waterman score: 870; 36.5% identity (69.7% similar) in 389 aa overlap (18-392:11-392)
10 20 30 40 50
pF1KE3 MSFFNFRKIFKLGSEKKKKQYEHVKRDL---NPEDFWEIIGELGDGAFGKVYKAQNKETS
..: ... .: .::. .... .::.:..:.:::: .:::.
XP_005 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETG
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 VLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVD
..: : . ..: .:.. . ::.:. .:: :..:: ... ...:::..:.:..:.:.
XP_005 QIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 AVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS
.. .. :::..: .. ..:: .:.::: . ::::.::::::.. .: :::::::.
XP_005 DIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHE
.. : :. .:.. ::::.::::::. .. :. ::.:::::: ::::: .::. .
XP_005 GQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYAD
180 190 200 210 220
240 250 260 270 280 290
pF1KE3 LNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV-TVDS
..:::... : . :::. .: ::.:: ::.:.:: :. . : :..:::::::: .. .
XP_005 IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG
230 240 250 260 270 280
300 310 320 330 340
pF1KE3 NKPIRELIAEA-----KAEVTEEVE---DGKEEDEEEETENSLPIPASKRASSDLSIASS
. .:.:: :: : . ... : : .:..::.: ... . : . . .::.
XP_005 VSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVAST
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE3 EEDKLSQNACILESVSEK--TERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQL
: . ... . : :.::. . .... : .: :
XP_005 MTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKEN
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE3 EAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHN
XP_005 QINSFGKSVPGPLKNSSDWKIPQDGDYEFKTSQEQQSGKDICIQNCQGNLLCRYAF
410 420 430 440 450 460
>>NP_001243241 (OMIM: 605030) serine/threonine-protein k (519 aa)
initn: 786 init1: 423 opt: 870 Z-score: 301.9 bits: 66.7 E(85289): 4.4e-10
Smith-Waterman score: 872; 38.6% identity (69.3% similar) in 394 aa overlap (2-375:19-400)
10 20 30
pF1KE3 MSFFNFRKIFKLGSEKKK-KQYEHVKRDL---NPEDFWEIIGE
: :. .. : :.:. .. .....: .::. .... .
NP_001 MLQLMDSGITICLRNGAASVFKKKEWSTQGEENKQDSKLKKLSEDSLTKQPEEVFDVLEK
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY
::.:..:.:.:: .::.. ..: : . ..:. :.. . ::.:. .:: : .:: ...
NP_001 LGEGSYGSVFKAIHKESGQVVAIKQVPVESD--LQEIIKEISIMQQCDSPYVVKYYGSYF
70 80 90 100 110
100 110 120 130 140 150
pF1KE3 YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAG
...:::..:.:..:.:. .. .. : :..: .. :.:: .:.::: . ::::.:::
NP_001 KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAG
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE3 NILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVW
:::.. .: :::::::... : :. .:.. ::::.::::::. .. :. ::.:
NP_001 NILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIW
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE3 SLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDA
::::: ::::: .::. ...:::... : . :::. .: ::..: ::.:::: :: .
NP_001 SLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQ
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE3 RWTTSQLLQHPFVTVDSNKPI---RELIAEA---KAEVTEEVEDGKEEDEEEETENSLP-
: :..:::::::. . ::. :.::.:: ::. :: . ::.::. :. :
NP_001 RATATQLLQHPFIK--NAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS
300 310 320 330 340 350
340 350 360 370 380
pF1KE3 ---IPAS------KRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNE
. .: ::.: .: . . . .:. .::: . : ::::.
NP_001 HTMVKTSVESVGTMRATSTMS--EGAQTMIEHNSTMLES-DLGTMVINSEDEEEEDGTMK
360 370 380 390 400
390 400 410 420 430 440
pF1KE3 KPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVD
NP_001 RNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFL
410 420 430 440 450 460
1204 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:07:00 2016 done: Mon Nov 7 20:07:02 2016
Total Scan time: 15.340 Total Display time: 0.260
Function used was FASTA [36.3.4 Apr, 2011]