Result of FASTA (omim) for
pFN21AE3385
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3385, 1171 aa
1>>>pF1KE3385 1171 - 1171 aa - 1171 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.3336+/-0.000595; mu= -3.9949+/- 0.037
mean_var=689.1980+/-150.056, 0's: 0 Z-trim(116.9): 892 B-trim: 0 in 0/62
Lambda= 0.048854
statistics sampled from 27333 (28470) to 27333 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.334), width: 16
Scan time: 17.150
The best scores are: opt bits E(85289)
NP_001106710 (OMIM: 606868) homeodomain-interactin (1171) 7789 566.4 3.6e-160
XP_011514381 (OMIM: 606868) PREDICTED: homeodomain (1350) 7748 563.6 2.9e-159
XP_011514382 (OMIM: 606868) PREDICTED: homeodomain (1349) 7729 562.3 7.3e-159
NP_073577 (OMIM: 606868) homeodomain-interacting p (1198) 4059 303.5 5e-81
XP_011514380 (OMIM: 606868) PREDICTED: homeodomain (1376) 4032 301.7 2e-80
XP_011514383 (OMIM: 606868) PREDICTED: homeodomain (1206) 4027 301.3 2.4e-80
XP_011514379 (OMIM: 606868) PREDICTED: homeodomain (1377) 4018 300.7 4e-80
XP_006715998 (OMIM: 606868) PREDICTED: homeodomain (1191) 4010 300.1 5.5e-80
XP_016867558 (OMIM: 606868) PREDICTED: homeodomain (1191) 4010 300.1 5.5e-80
XP_006710506 (OMIM: 608003) PREDICTED: homeodomain (1247) 3349 253.5 6e-66
XP_005270668 (OMIM: 608003) PREDICTED: homeodomain (1256) 3172 241.1 3.4e-62
XP_005270670 (OMIM: 608003) PREDICTED: homeodomain (1210) 3123 237.6 3.7e-61
XP_005270669 (OMIM: 608003) PREDICTED: homeodomain (1210) 3123 237.6 3.7e-61
NP_938009 (OMIM: 608003) homeodomain-interacting p (1210) 3123 237.6 3.7e-61
XP_005270666 (OMIM: 608003) PREDICTED: homeodomain (1281) 3123 237.6 3.8e-61
NP_689909 (OMIM: 608003) homeodomain-interacting p (1075) 3117 237.1 4.6e-61
XP_016856094 (OMIM: 608003) PREDICTED: homeodomain (1209) 3114 236.9 5.7e-61
XP_005270667 (OMIM: 608003) PREDICTED: homeodomain (1280) 3114 237.0 5.9e-61
NP_001265091 (OMIM: 604424) homeodomain-interactin (1194) 3066 233.5 5.9e-60
NP_001265092 (OMIM: 604424) homeodomain-interactin (1194) 3066 233.5 5.9e-60
NP_001041665 (OMIM: 604424) homeodomain-interactin (1194) 3066 233.5 5.9e-60
XP_016872566 (OMIM: 604424) PREDICTED: homeodomain (1194) 3066 233.5 5.9e-60
XP_005252786 (OMIM: 604424) PREDICTED: homeodomain (1215) 3002 229.1 1.4e-58
NP_005725 (OMIM: 604424) homeodomain-interacting p (1215) 3002 229.1 1.4e-58
XP_016872565 (OMIM: 604424) PREDICTED: homeodomain (1215) 3002 229.1 1.4e-58
XP_011539279 (OMIM: 608003) PREDICTED: homeodomain (1241) 2944 225.0 2.3e-57
XP_016856095 (OMIM: 608003) PREDICTED: homeodomain ( 605) 2769 212.2 8.1e-54
NP_938010 (OMIM: 608003) homeodomain-interacting p ( 836) 1321 110.3 5.1e-23
NP_653286 (OMIM: 611712) homeodomain-interacting p ( 616) 1139 97.3 3.1e-19
XP_006723099 (OMIM: 611712) PREDICTED: homeodomain ( 619) 1139 97.3 3.2e-19
NP_852003 (OMIM: 608003) homeodomain-interacting p ( 816) 1133 97.1 4.9e-19
NP_569122 (OMIM: 600855,614104) dual specificity t ( 529) 769 71.1 2e-11
NP_567824 (OMIM: 600855,614104) dual specificity t ( 584) 769 71.2 2.2e-11
XP_011527787 (OMIM: 600855,614104) PREDICTED: dual ( 725) 771 71.5 2.2e-11
XP_016883775 (OMIM: 600855,614104) PREDICTED: dual ( 734) 771 71.5 2.2e-11
XP_006724042 (OMIM: 600855,614104) PREDICTED: dual ( 754) 771 71.5 2.3e-11
NP_569120 (OMIM: 600855,614104) dual specificity t ( 754) 771 71.5 2.3e-11
XP_016883774 (OMIM: 600855,614104) PREDICTED: dual ( 754) 771 71.5 2.3e-11
XP_016883773 (OMIM: 600855,614104) PREDICTED: dual ( 754) 771 71.5 2.3e-11
XP_011527786 (OMIM: 600855,614104) PREDICTED: dual ( 761) 771 71.5 2.3e-11
NP_001387 (OMIM: 600855,614104) dual specificity t ( 763) 771 71.5 2.3e-11
XP_011527785 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11
XP_006724040 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11
XP_006724041 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11
XP_006724039 (OMIM: 600855,614104) PREDICTED: dual ( 763) 771 71.5 2.3e-11
XP_011527784 (OMIM: 600855,614104) PREDICTED: dual ( 770) 771 71.5 2.3e-11
XP_005259455 (OMIM: 604556,615812) PREDICTED: dual ( 629) 729 68.4 1.6e-10
NP_004705 (OMIM: 604556,615812) dual specificity t ( 629) 729 68.4 1.6e-10
NP_003836 (OMIM: 609181) dual specificity tyrosine ( 520) 695 65.9 7.5e-10
NP_006474 (OMIM: 604556,615812) dual specificity t ( 589) 695 66.0 8.1e-10
>>NP_001106710 (OMIM: 606868) homeodomain-interacting pr (1171 aa)
initn: 7789 init1: 7789 opt: 7789 Z-score: 2996.5 bits: 566.4 E(85289): 3.6e-160
Smith-Waterman score: 7789; 100.0% identity (100.0% similar) in 1171 aa overlap (1-1171:1-1171)
10 20 30 40 50 60
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 AAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 QAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 LADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 QSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTT
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 DSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 PVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 TTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 PAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQF
1090 1100 1110 1120 1130 1140
1150 1160 1170
pF1KE3 AHQTYISASPASTVYTGYPLSPAKVNQYPYI
:::::::::::::::::::::::::::::::
NP_001 AHQTYISASPASTVYTGYPLSPAKVNQYPYI
1150 1160 1170
>>XP_011514381 (OMIM: 606868) PREDICTED: homeodomain-int (1350 aa)
initn: 7748 init1: 7748 opt: 7748 Z-score: 2980.3 bits: 563.6 E(85289): 2.9e-159
Smith-Waterman score: 7748; 100.0% identity (100.0% similar) in 1165 aa overlap (7-1171:186-1350)
10 20 30
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
::::::::::::::::::::::::::::::
XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
400 410 420 430 440 450
280 290 300 310 320 330
pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
460 470 480 490 500 510
340 350 360 370 380 390
pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
520 530 540 550 560 570
400 410 420 430 440 450
pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
580 590 600 610 620 630
460 470 480 490 500 510
pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
640 650 660 670 680 690
520 530 540 550 560 570
pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
700 710 720 730 740 750
580 590 600 610 620 630
pF1KE3 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ
760 770 780 790 800 810
640 650 660 670 680 690
pF1KE3 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQL
820 830 840 850 860 870
700 710 720 730 740 750
pF1KE3 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL
880 890 900 910 920 930
760 770 780 790 800 810
pF1KE3 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA
940 950 960 970 980 990
820 830 840 850 860 870
pF1KE3 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA
1000 1010 1020 1030 1040 1050
880 890 900 910 920 930
pF1KE3 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN
1060 1070 1080 1090 1100 1110
940 950 960 970 980 990
pF1KE3 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY
1120 1130 1140 1150 1160 1170
1000 1010 1020 1030 1040 1050
pF1KE3 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV
1180 1190 1200 1210 1220 1230
1060 1070 1080 1090 1100 1110
pF1KE3 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ
1240 1250 1260 1270 1280 1290
1120 1130 1140 1150 1160 1170
pF1KE3 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
1300 1310 1320 1330 1340 1350
>>XP_011514382 (OMIM: 606868) PREDICTED: homeodomain-int (1349 aa)
initn: 4456 init1: 4456 opt: 7729 Z-score: 2973.1 bits: 562.3 E(85289): 7.3e-159
Smith-Waterman score: 7729; 99.9% identity (99.9% similar) in 1165 aa overlap (7-1171:186-1349)
10 20 30
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
::::::::::::::::::::::::::::::
XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
400 410 420 430 440 450
280 290 300 310 320 330
pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
460 470 480 490 500 510
340 350 360 370 380 390
pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
520 530 540 550 560 570
400 410 420 430 440 450
pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
580 590 600 610 620 630
460 470 480 490 500 510
pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
640 650 660 670 680 690
520 530 540 550 560 570
pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
700 710 720 730 740 750
580 590 600 610 620 630
pF1KE3 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQ
760 770 780 790 800 810
640 650 660 670 680 690
pF1KE3 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQL
::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::
XP_011 GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ-AWPSGTQQILLPPAWQQL
820 830 840 850 860 870
700 710 720 730 740 750
pF1KE3 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPL
880 890 900 910 920 930
760 770 780 790 800 810
pF1KE3 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCA
940 950 960 970 980 990
820 830 840 850 860 870
pF1KE3 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHA
1000 1010 1020 1030 1040 1050
880 890 900 910 920 930
pF1KE3 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGN
1060 1070 1080 1090 1100 1110
940 950 960 970 980 990
pF1KE3 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITY
1120 1130 1140 1150 1160 1170
1000 1010 1020 1030 1040 1050
pF1KE3 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTV
1180 1190 1200 1210 1220 1230
1060 1070 1080 1090 1100 1110
pF1KE3 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQ
1240 1250 1260 1270 1280 1290
1120 1130 1140 1150 1160 1170
pF1KE3 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
1300 1310 1320 1330 1340
>>NP_073577 (OMIM: 606868) homeodomain-interacting prote (1198 aa)
initn: 3978 init1: 3939 opt: 4059 Z-score: 1575.6 bits: 303.5 E(85289): 5e-81
Smith-Waterman score: 7725; 97.7% identity (97.7% similar) in 1198 aa overlap (1-1171:1-1198)
10 20 30 40 50 60
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
490 500 510 520 530 540
550 560 570 580 590
pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQ------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
550 560 570 580 590 600
600 610 620 630
pF1KE3 ---------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
:::::::::::::::::::::::::::::::::::::::
NP_073 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE3 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE3 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE3 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE3 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE3 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE3 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE3 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE3 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE3 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
1150 1160 1170 1180 1190
>>XP_011514380 (OMIM: 606868) PREDICTED: homeodomain-int (1376 aa)
initn: 7185 init1: 3898 opt: 4032 Z-score: 1564.7 bits: 301.7 E(85289): 2e-80
Smith-Waterman score: 7665; 97.7% identity (97.7% similar) in 1192 aa overlap (7-1171:186-1376)
10 20 30
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
::::::::::::::::::::::::::::::
XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
400 410 420 430 440 450
280 290 300 310 320 330
pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
460 470 480 490 500 510
340 350 360 370 380 390
pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
520 530 540 550 560 570
400 410 420 430 440 450
pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
580 590 600 610 620 630
460 470 480 490 500 510
pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
640 650 660 670 680 690
520 530 540 550 560 570
pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
700 710 720 730 740 750
580 590 600
pF1KE3 STNLTMTFNNQLTTVHNQ---------------------------PSAASMAAVAQRSMP
:::::::::::::::::: :::::::::::::::
XP_011 STNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMP
760 770 780 790 800 810
610 620 630 640 650 660
pF1KE3 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ
820 830 840 850 860 870
670 680 690 700 710 720
pF1KE3 IQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQPGLLAQ-AWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA
880 890 900 910 920 930
730 740 750 760 770 780
pF1KE3 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST
940 950 960 970 980 990
790 800 810 820 830 840
pF1KE3 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV
1000 1010 1020 1030 1040 1050
850 860 870 880 890 900
pF1KE3 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY
1060 1070 1080 1090 1100 1110
910 920 930 940 950 960
pF1KE3 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS
1120 1130 1140 1150 1160 1170
970 980 990 1000 1010 1020
pF1KE3 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR
1180 1190 1200 1210 1220 1230
1030 1040 1050 1060 1070 1080
pF1KE3 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT
1240 1250 1260 1270 1280 1290
1090 1100 1110 1120 1130 1140
pF1KE3 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS
1300 1310 1320 1330 1340 1350
1150 1160 1170
pF1KE3 PASTVYTGYPLSPAKVNQYPYI
::::::::::::::::::::::
XP_011 PASTVYTGYPLSPAKVNQYPYI
1360 1370
>>XP_011514383 (OMIM: 606868) PREDICTED: homeodomain-int (1206 aa)
initn: 3946 init1: 3907 opt: 4027 Z-score: 1563.4 bits: 301.3 E(85289): 2.4e-80
Smith-Waterman score: 7693; 97.5% identity (97.6% similar) in 1196 aa overlap (3-1171:11-1206)
10 20 30 40 50
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYS
:. ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MWALKKREHKPLITGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 QSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 NLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTAT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 HPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNK
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 FSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 VSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRY
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 ISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNC
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 LDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHL
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 LDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVH
550 560 570 580 590 600
600 610 620
pF1KE3 NQ---------------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQ
:: :::::::::::::::::::::::::::::::
XP_011 NQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQ
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE3 QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQ
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE3 QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLT
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE3 GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSK
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE3 RVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISS
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE3 DTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDT
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE3 KGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGH
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE3 SSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYS
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KE3 FPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQ
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE3 HTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKV
1150 1160 1170 1180 1190 1200
1170
pF1KE3 NQYPYI
::::::
XP_011 NQYPYI
>>XP_011514379 (OMIM: 606868) PREDICTED: homeodomain-int (1377 aa)
initn: 3898 init1: 3898 opt: 4018 Z-score: 1559.4 bits: 300.7 E(85289): 4e-80
Smith-Waterman score: 7684; 97.7% identity (97.7% similar) in 1192 aa overlap (7-1171:186-1377)
10 20 30
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
::::::::::::::::::::::::::::::
XP_011 GLQEATLENKCQVLKRLNIESPPDLAVPLPGMASHVQVFSPHTLQSSAFCSVKKLKIEPS
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE3 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVT
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE3 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQN
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE3 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKC
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE3 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
400 410 420 430 440 450
280 290 300 310 320 330
pF1KE3 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS
460 470 480 490 500 510
340 350 360 370 380 390
pF1KE3 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL
520 530 540 550 560 570
400 410 420 430 440 450
pF1KE3 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEA
580 590 600 610 620 630
460 470 480 490 500 510
pF1KE3 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRI
640 650 660 670 680 690
520 530 540 550 560 570
pF1KE3 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPST
700 710 720 730 740 750
580 590 600
pF1KE3 STNLTMTFNNQLTTVHNQ---------------------------PSAASMAAVAQRSMP
:::::::::::::::::: :::::::::::::::
XP_011 STNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMP
760 770 780 790 800 810
610 620 630 640 650 660
pF1KE3 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQ
820 830 840 850 860 870
670 680 690 700 710 720
pF1KE3 IQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA
880 890 900 910 920 930
730 740 750 760 770 780
pF1KE3 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVST
940 950 960 970 980 990
790 800 810 820 830 840
pF1KE3 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIV
1000 1010 1020 1030 1040 1050
850 860 870 880 890 900
pF1KE3 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPY
1060 1070 1080 1090 1100 1110
910 920 930 940 950 960
pF1KE3 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSS
1120 1130 1140 1150 1160 1170
970 980 990 1000 1010 1020
pF1KE3 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHR
1180 1190 1200 1210 1220 1230
1030 1040 1050 1060 1070 1080
pF1KE3 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGT
1240 1250 1260 1270 1280 1290
1090 1100 1110 1120 1130 1140
pF1KE3 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISAS
1300 1310 1320 1330 1340 1350
1150 1160 1170
pF1KE3 PASTVYTGYPLSPAKVNQYPYI
::::::::::::::::::::::
XP_011 PASTVYTGYPLSPAKVNQYPYI
1360 1370
>>XP_006715998 (OMIM: 606868) PREDICTED: homeodomain-int (1191 aa)
initn: 3929 init1: 3890 opt: 4010 Z-score: 1557.0 bits: 300.1 E(85289): 5.5e-80
Smith-Waterman score: 7676; 97.7% identity (97.7% similar) in 1191 aa overlap (8-1171:1-1191)
10 20 30 40 50 60
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
480 490 500 510 520 530
550 560 570 580 590
pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQ------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
540 550 560 570 580 590
600 610 620 630
pF1KE3 ---------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
:::::::::::::::::::::::::::::::::::::::
XP_006 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE3 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE3 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
720 730 740 750 760 770
760 770 780 790 800 810
pF1KE3 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
780 790 800 810 820 830
820 830 840 850 860 870
pF1KE3 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
840 850 860 870 880 890
880 890 900 910 920 930
pF1KE3 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
900 910 920 930 940 950
940 950 960 970 980 990
pF1KE3 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
960 970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KE3 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
1020 1030 1040 1050 1060 1070
1060 1070 1080 1090 1100 1110
pF1KE3 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
1080 1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE3 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
1140 1150 1160 1170 1180 1190
>>XP_016867558 (OMIM: 606868) PREDICTED: homeodomain-int (1191 aa)
initn: 3929 init1: 3890 opt: 4010 Z-score: 1557.0 bits: 300.1 E(85289): 5.5e-80
Smith-Waterman score: 7676; 97.7% identity (97.7% similar) in 1191 aa overlap (8-1171:1-1191)
10 20 30 40 50 60
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE3 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
480 490 500 510 520 530
550 560 570 580 590
pF1KE3 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQ------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
540 550 560 570 580 590
600 610 620 630
pF1KE3 ---------------------PSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
:::::::::::::::::::::::::::::::::::::::
XP_016 ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE3 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE3 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
720 730 740 750 760 770
760 770 780 790 800 810
pF1KE3 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
780 790 800 810 820 830
820 830 840 850 860 870
pF1KE3 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
840 850 860 870 880 890
880 890 900 910 920 930
pF1KE3 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
900 910 920 930 940 950
940 950 960 970 980 990
pF1KE3 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
960 970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KE3 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
1020 1030 1040 1050 1060 1070
1060 1070 1080 1090 1100 1110
pF1KE3 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
1080 1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE3 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
1140 1150 1160 1170 1180 1190
>>XP_006710506 (OMIM: 608003) PREDICTED: homeodomain-int (1247 aa)
initn: 3894 init1: 2468 opt: 3349 Z-score: 1305.0 bits: 253.5 E(85289): 6e-66
Smith-Waterman score: 4618; 61.4% identity (79.9% similar) in 1224 aa overlap (8-1171:72-1247)
10 20 30
pF1KE3 MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSS
:::..::::: ...::::::.::::::::.
XP_006 AHLLEAHRLLLQSVLCDRPRESIQLHFRLSMASQLQVFSPPSVSSSAFCSAKKLKIEPSG
50 60 70 80 90 100
40 50 60 70 80 90
pF1KE3 NWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLP-YEQTIVFPG-STGHIVV
::..: .:..: :..::..: .: ...: : : ..: :.: ...:. .. ::::
XP_006 -WDVSGQSSNDKYYTHSKTLPATQG---QANSSHQVANFNIPAYDQGLLLPAPAVEHIVV
110 120 130 140 150
100 110 120 130 140 150
pF1KE3 TSA-SSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMI
:.: :: :.. ... . ..: .::.::::. ::::::::::::.....::::::::::..
XP_006 TAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLM
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE3 QNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVV
.: . .. :.:::.:.:.:.:.:..::::::::::.::::::.:::::::::::::::.
XP_006 LQNRT-VVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVA
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE3 KCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTC
:::::.:.:::::::::::::::::::::::::.:::.:.::.:::::.:::::::::::
XP_006 KCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTC
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE3 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_006 LVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE3 PSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE3 FLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDH
:::::::::::::::::::::::::::::::::::::::::::: . :::::::::..:
XP_006 FLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEH
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE3 EAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADK
: :::::::::::::::::::::::::.:::::.:::.:::::::.::::::::::::::
XP_006 ELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADK
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE3 RITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAP
::::..:::: :::::::::::::.::::::::::::::::.::::.. . . .:
XP_006 RITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTASVLASSSTAAAAT
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE3 STSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPG
. .: ... : .... ::: . .:::... :: ::.:::.. :::::..:::::.
XP_006 LSLANSDVSLLNYQSALY-PSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPA
640 650 660 670 680 690
640 650 660 670
pF1KE3 FQ-GLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQ----------------
:: ::::. .::.:. :::.:::::: :::.::::::: :.:.:
XP_006 FQTGLQAT-TKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVA
700 710 720 730 740 750
680 690 700
pF1KE3 -----------------------------QAWPSGTQQILLPPAWQQLTGVATHTSVQHA
::::.:::::::: .:::: ::: :.::: .
XP_006 TITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPT
760 770 780 790 800 810
710 720 730 740 750 760
pF1KE3 TVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQP
..:::.:.. ::::::::.:.::..:. :::::.:::.:::: .:::::::::::.:::
XP_006 AMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQ
820 830 840 850 860 870
770 780 790 800 810 820
pF1KE3 TSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSV
.:. :.:.:: .. : . :. .: ::. : .: ::: .::
XP_006 SSSLPSKKNKQ-SAPVSSKSSLDVLPSQVYS-----------------LVGSSPLRTTS-
880 890 900 910
830 840 850 860 870 880
pF1KE3 TCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNV
. : . . :.: :.::::::: :::::: :::::::..:. :.:. : :.::
XP_006 -----SYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNV
920 930 940 950 960 970
890 900 910 920 930 940
pF1KE3 ISCVTVHDSPYSDSSSNTSPYSVQQRAG--HNNANAFDTKGSLENHCTGNPRTIIVPPLK
:: :::.::: :::: .::::.. .. :...... : . ::. :::::::::
XP_006 ISYVTVNDSPDSDSSL-SSPYSTDTLSALRGNSGSVLEGPGRVVADGTGT-RTIIVPPLK
980 990 1000 1010 1020
950 960 970 980 990 1000
pF1KE3 TQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQ
:: : .: ... ..:. :.... :.:.::.::: :: :: : .
XP_006 TQ----LGDC------TVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGT--S
1030 1040 1050 1060 1070
1010 1020 1030 1040 1050 1060
pF1KE3 QQQPLNLSQAQQH----ITTDRTGSH--RRQQAYITPTMAQAPYSFPHNSPSHGTVHPHL
::::::: :: . .:... :::::...: ..::::.: :.:: :.: ::::
XP_006 AAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAP-LSQAPYTFQHGSPLHSTGHPHL
1080 1090 1100 1110 1120 1130
1070 1080 1090 1100 1110
pF1KE3 AAAAAAAHLPTQPHLYTYTAP---AALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQV
: : : :::.: :::::.:: ::::::...::: . :::.::.. .:..:...::::
XP_006 APAPA--HLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQV
1140 1150 1160 1170 1180 1190
1120 1130 1140 1150 1160 1170
pF1KE3 PVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
:::.:: .: : .. :.:: ::: :.::..: .::.::::::::.:..:: :.
XP_006 PVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL
1200 1210 1220 1230 1240
1171 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:38:19 2016 done: Sun Nov 6 05:38:22 2016
Total Scan time: 17.150 Total Display time: 0.670
Function used was FASTA [36.3.4 Apr, 2011]