Result of FASTA (omim) for
pFN21AE3368
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3368, 1088 aa
1>>>pF1KE3368 1088 - 1088 aa - 1088 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.5722+/-0.000523; mu= -31.7760+/- 0.032
mean_var=790.0568+/-175.152, 0's: 0 Z-trim(121.7): 502 B-trim: 2122 in 1/56
Lambda= 0.045629
statistics sampled from 38090 (38628) to 38090 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.453), width: 16
Scan time: 13.280
The best scores are: opt bits E(85289)
XP_005266399 (OMIM: 604861) PREDICTED: serine/thre (1088) 7496 510.1 2.9e-143
NP_055387 (OMIM: 604861) serine/threonine-protein (1088) 7496 510.1 2.9e-143
XP_011533344 (OMIM: 604861) PREDICTED: serine/thre (1001) 6763 461.8 9e-129
XP_016876030 (OMIM: 604861) PREDICTED: serine/thre ( 981) 6755 461.3 1.3e-128
XP_016876031 (OMIM: 604861) PREDICTED: serine/thre ( 906) 6089 417.4 1.9e-115
XP_016866967 (OMIM: 603473) PREDICTED: serine/thre (1025) 2830 202.9 8e-51
NP_004681 (OMIM: 603473) serine/threonine-protein (1130) 2830 202.9 8.6e-51
XP_016866970 (OMIM: 603473) PREDICTED: serine/thre ( 850) 2812 201.6 1.6e-50
XP_016866968 (OMIM: 603473) PREDICTED: serine/thre ( 993) 2184 160.4 4.9e-38
XP_011534554 (OMIM: 603473) PREDICTED: serine/thre (1001) 2177 159.9 6.8e-38
XP_016866966 (OMIM: 603473) PREDICTED: serine/thre (1034) 2177 159.9 7e-38
XP_016866965 (OMIM: 603473) PREDICTED: serine/thre (1058) 2177 159.9 7.1e-38
XP_016866964 (OMIM: 603473) PREDICTED: serine/thre (1163) 2177 159.9 7.7e-38
XP_016866963 (OMIM: 603473) PREDICTED: serine/thre (1163) 2177 159.9 7.7e-38
XP_016866969 (OMIM: 603473) PREDICTED: serine/thre ( 883) 2159 158.7 1.4e-37
XP_006715666 (OMIM: 603473) PREDICTED: serine/thre ( 886) 1613 122.7 9.4e-27
XP_016865715 (OMIM: 606964) PREDICTED: serine/thre ( 439) 787 68.1 1.3e-10
NP_055815 (OMIM: 615836) serine/threonine-protein ( 464) 787 68.1 1.3e-10
XP_006719121 (OMIM: 615836) PREDICTED: serine/thre ( 464) 787 68.1 1.3e-10
XP_016874525 (OMIM: 615836) PREDICTED: serine/thre ( 464) 787 68.1 1.3e-10
NP_001292031 (OMIM: 606964) serine/threonine-prote ( 465) 787 68.1 1.3e-10
XP_006715052 (OMIM: 606964) PREDICTED: serine/thre ( 465) 787 68.1 1.3e-10
NP_009202 (OMIM: 606964) serine/threonine-protein ( 465) 787 68.1 1.3e-10
XP_006715051 (OMIM: 606964) PREDICTED: serine/thre ( 465) 787 68.1 1.3e-10
XP_006719122 (OMIM: 615836) PREDICTED: serine/thre ( 412) 747 65.4 7.6e-10
XP_005253399 (OMIM: 615836) PREDICTED: serine/thre ( 423) 646 58.8 7.8e-08
XP_011518915 (OMIM: 615836) PREDICTED: serine/thre ( 371) 638 58.2 1e-07
NP_001275695 (OMIM: 160900,605377) myotonin-protei ( 530) 551 52.6 7e-06
NP_001075029 (OMIM: 160900,605377) myotonin-protei ( 624) 551 52.7 8e-06
NP_001075031 (OMIM: 160900,605377) myotonin-protei ( 625) 551 52.7 8e-06
NP_004400 (OMIM: 160900,605377) myotonin-protein k ( 629) 551 52.7 8e-06
XP_016873487 (OMIM: 613991) PREDICTED: serine/thre (1081) 557 53.3 9.2e-06
XP_011543463 (OMIM: 613991) PREDICTED: serine/thre (1135) 557 53.3 9.5e-06
XP_016873486 (OMIM: 613991) PREDICTED: serine/thre (1139) 557 53.3 9.5e-06
XP_011543461 (OMIM: 613991) PREDICTED: serine/thre (1481) 557 53.4 1.2e-05
XP_011543460 (OMIM: 613991) PREDICTED: serine/thre (1495) 557 53.4 1.2e-05
XP_011543459 (OMIM: 613991) PREDICTED: serine/thre (1530) 557 53.4 1.2e-05
NP_059995 (OMIM: 613991) serine/threonine-protein (1551) 557 53.4 1.2e-05
XP_011543458 (OMIM: 613991) PREDICTED: serine/thre (1562) 557 53.4 1.2e-05
XP_016873485 (OMIM: 613991) PREDICTED: serine/thre (1568) 557 53.4 1.2e-05
XP_011543457 (OMIM: 613991) PREDICTED: serine/thre (1569) 557 53.4 1.2e-05
NP_001075032 (OMIM: 160900,605377) myotonin-protei ( 639) 538 51.8 1.5e-05
NP_001275693 (OMIM: 160900,605377) myotonin-protei ( 655) 538 51.9 1.5e-05
XP_016858071 (OMIM: 603412) PREDICTED: serine/thre (1589) 544 52.6 2.2e-05
NP_055641 (OMIM: 603412) serine/threonine-protein (1638) 544 52.6 2.3e-05
NP_003598 (OMIM: 603412) serine/threonine-protein (1719) 544 52.6 2.4e-05
NP_005397 (OMIM: 601702) rho-associated protein ki (1354) 540 52.2 2.4e-05
XP_005273381 (OMIM: 603412) PREDICTED: serine/thre (1732) 544 52.6 2.4e-05
XP_011535689 (OMIM: 614062) PREDICTED: serine/thre (1460) 541 52.3 2.4e-05
XP_005273379 (OMIM: 603412) PREDICTED: serine/thre (1754) 544 52.6 2.4e-05
>>XP_005266399 (OMIM: 604861) PREDICTED: serine/threonin (1088 aa)
initn: 7496 init1: 7496 opt: 7496 Z-score: 2693.1 bits: 510.1 E(85289): 2.9e-143
Smith-Waterman score: 7496; 100.0% identity (100.0% similar) in 1088 aa overlap (1-1088:1-1088)
10 20 30 40 50 60
pF1KE3 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT
1030 1040 1050 1060 1070 1080
pF1KE3 EGCQPVYV
::::::::
XP_005 EGCQPVYV
>>NP_055387 (OMIM: 604861) serine/threonine-protein kina (1088 aa)
initn: 7496 init1: 7496 opt: 7496 Z-score: 2693.1 bits: 510.1 E(85289): 2.9e-143
Smith-Waterman score: 7496; 100.0% identity (100.0% similar) in 1088 aa overlap (1-1088:1-1088)
10 20 30 40 50 60
pF1KE3 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT
1030 1040 1050 1060 1070 1080
pF1KE3 EGCQPVYV
::::::::
NP_055 EGCQPVYV
>>XP_011533344 (OMIM: 604861) PREDICTED: serine/threonin (1001 aa)
initn: 6760 init1: 6760 opt: 6763 Z-score: 2432.8 bits: 461.8 E(85289): 9e-129
Smith-Waterman score: 6763; 99.8% identity (99.8% similar) in 978 aa overlap (111-1088:24-1001)
90 100 110 120 130 140
pF1KE3 RYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMG
: :::::::::::::::::::::::::::
XP_011 MQRYGCRERSLERSPRLERHCPPGALQEMAGRALKQTGSRSIEAALEYISKMG
10 20 30 40 50
150 160 170 180 190 200
pF1KE3 YLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADG
60 70 80 90 100 110
210 220 230 240 250 260
pF1KE3 PTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLV
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE3 PGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQ
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE3 AGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDS
240 250 260 270 280 290
390 400 410 420 430 440
pF1KE3 LQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHI
300 310 320 330 340 350
450 460 470 480 490 500
pF1KE3 LHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAF
360 370 380 390 400 410
510 520 530 540 550 560
pF1KE3 PLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKS
420 430 440 450 460 470
570 580 590 600 610 620
pF1KE3 AKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQK
480 490 500 510 520 530
630 640 650 660 670 680
pF1KE3 VNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFG
540 550 560 570 580 590
690 700 710 720 730 740
pF1KE3 EVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDS
600 610 620 630 640 650
750 760 770 780 790 800
pF1KE3 LYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILID
660 670 680 690 700 710
810 820 830 840 850 860
pF1KE3 LDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQR
720 730 740 750 760 770
870 880 890 900 910 920
pF1KE3 ARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTE
780 790 800 810 820 830
930 940 950 960 970 980
pF1KE3 TQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSS
840 850 860 870 880 890
990 1000 1010 1020 1030 1040
pF1KE3 DIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEF
900 910 920 930 940 950
1050 1060 1070 1080
pF1KE3 TFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
960 970 980 990 1000
>>XP_016876030 (OMIM: 604861) PREDICTED: serine/threonin (981 aa)
initn: 6755 init1: 6755 opt: 6755 Z-score: 2430.1 bits: 461.3 E(85289): 1.3e-128
Smith-Waterman score: 6755; 99.9% identity (100.0% similar) in 975 aa overlap (114-1088:7-981)
90 100 110 120 130 140
pF1KE3 LLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLD
.:::::::::::::::::::::::::::::
XP_016 MRKRALKEMAGRALKQTGSRSIEAALEYISKMGYLD
10 20 30
150 160 170 180 190 200
pF1KE3 PRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTA
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE3 LEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGE
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE3 PLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGP
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE3 AAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQK
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE3 PGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHP
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE3 VKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLD
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE3 VEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKG
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE3 DKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNR
460 470 480 490 500 510
630 640 650 660 670 680
pF1KE3 RLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVC
520 530 540 550 560 570
690 700 710 720 730 740
pF1KE3 LACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYF
580 590 600 610 620 630
750 760 770 780 790 800
pF1KE3 VMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDG
640 650 660 670 680 690
810 820 830 840 850 860
pF1KE3 HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARK
700 710 720 730 740 750
870 880 890 900 910 920
pF1KE3 QHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQL
760 770 780 790 800 810
930 940 950 960 970 980
pF1KE3 KVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIR
820 830 840 850 860 870
990 1000 1010 1020 1030 1040
pF1KE3 KQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFR
880 890 900 910 920 930
1050 1060 1070 1080
pF1KE3 RFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
940 950 960 970 980
>>XP_016876031 (OMIM: 604861) PREDICTED: serine/threonin (906 aa)
initn: 6089 init1: 6089 opt: 6089 Z-score: 2193.6 bits: 417.4 E(85289): 1.9e-115
Smith-Waterman score: 6089; 100.0% identity (100.0% similar) in 889 aa overlap (1-889:1-889)
10 20 30 40 50 60
pF1KE3 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGDQLGEHAPHSS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
XP_016 PGEAEP
>>XP_016866967 (OMIM: 603473) PREDICTED: serine/threonin (1025 aa)
initn: 3116 init1: 2484 opt: 2830 Z-score: 1033.4 bits: 202.9 E(85289): 8e-51
Smith-Waterman score: 3251; 53.1% identity (71.9% similar) in 1041 aa overlap (114-1084:11-1016)
90 100 110 120 130 140
pF1KE3 LLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLD
:.:. .::..:..::::::.:.::::.: :
XP_016 MSFEILNPLGQDMVIQALQKTNNRSIEAAIEFISKMSYQD
10 20 30 40
150 160 170 180
pF1KE3 PRNEQIVRVIKQ---TSPGKGLMPTPVTRRPSFEGTGDSFA------------SYHQLS-
:: ::.. . . .: : . :.:. :..:. .:.. .::. :
XP_016 PRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESP
50 60 70 80 90 100
190 200 210 220 230
pF1KE3 ------GTPYEGPSFGA---DGPTALEEM---PRPYVDYLFPGVGPHG--PGHQHQHPP-
: : : ...: :. ... : : : . : :.: : . ::
XP_016 NSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPP
110 120 130 140 150 160
240 250 260
pF1KE3 ---------KGYGASVEAAGAHF-PLQ-GA---HYGRPHL-LVPGEPLGYG--------V
: :....: . ... :. :: : : : : .: . : :
XP_016 PSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPV
170 180 190 200 210 220
270 280 290 300 310
pF1KE3 QRSP---------SFQSKTPP-ETG-GYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHH
:.: .: : : ..: : ... . . : :. ::: :.:
XP_016 GRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPP------PYPLT
230 240 250 260 270
320 330 340 350 360 370
pF1KE3 KQAGPAAHQLHVLGSRS-QVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQ-QWPAATLA
: . :.. :: . . ... : :::...:.::: :..::... ..: .:: .. :
XP_016 AANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSA
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 RRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVT
.: . : : : ...:. :: :.::::. : . ... : :. .::::.:
XP_016 PAQSSPSSGHEIP-----TWQPNIPV--RSNSFNN--PLGNRASHSANSQPSATTVTAIT
340 350 360 370 380
440 450 460 470 480 490
pF1KE3 AAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGG
: : .::::.:::.:: :::..:.::.:.: : . :.: : :: ..
XP_016 PAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFP--EGTASN---------
390 400 410 420 430
500 510 520 530 540 550
pF1KE3 AGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDK
. ..: .: .:. . :::::::::: .. : .:. ... . :.: :.
XP_016 VTVMPPVAE--APNYQGPPPPYPKHLLHQNPSVP-PYESISKPSKEDQPSLPKE----DE
440 450 460 470 480
560 570 580 590 600 610
pF1KE3 SRKSAKG-DKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIK
:.:: .. :.: :.:::: :::. ::::..:::.:::::.:::: :::::::::::::.:
XP_016 SEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLK
490 500 510 520 530 540
620 630 640 650 660 670
pF1KE3 TYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLG
..::...:. :::.:: ..:: . :.::::.: :::::: :::::::::::::::::::
XP_016 SHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLG
550 560 570 580 590 600
680 690 700 710 720 730
pF1KE3 IGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSF
:::::::::: ::::.:::: ::::::::: :::::::::::::::::::::::.:::::
XP_016 IGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSF
610 620 630 640 650 660
740 750 760 770 780 790
pF1KE3 QDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPD
::::.:::::::::::::::::::: .::: :::::::::: :.::::::::::::::::
XP_016 QDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPD
670 680 690 700 710 720
800 810 820 830 840 850
pF1KE3 NILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLK
::::: :::::::::::::::::::.:::::.:.: :::::. :. : : :.::::::::
XP_016 NILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLK
730 740 750 760 770 780
860 870 880 890 900 910
pF1KE3 TLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLA
::.:: .:::::::::::::::::::::::: :::::::::::::::::::::::::::
XP_016 PLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLA
790 800 810 820 830 840
920 930 940 950 960 970
pF1KE3 PTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSA
:: :::.:::::...:::: :.:::::: ::: ::: . . :::.::::..::::::..
XP_016 QTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKT
850 860 870 880 890 900
980 990 1000 1010 1020 1030
pF1KE3 IDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTS--PNNKHP
::::::.:.: : :.: :.:: ::::::::: .. :.: .: .. :::.. :.:::
XP_016 IDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNE-EENVNDTLNGWYKNGKHP
910 920 930 940 950 960
1040 1050 1060 1070 1080
pF1KE3 EHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
:::::::::::::::::::. ::: : ....:. ..:: ::. : .
XP_016 EHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSE-QQSDEDDQNTGSEIKNRDLVYV
970 980 990 1000 1010 1020
>>NP_004681 (OMIM: 603473) serine/threonine-protein kina (1130 aa)
initn: 3451 init1: 2484 opt: 2830 Z-score: 1032.9 bits: 202.9 E(85289): 8.6e-51
Smith-Waterman score: 3553; 53.0% identity (72.1% similar) in 1155 aa overlap (1-1084:13-1121)
10 20 30 40
pF1KE3 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLD
::::::::..:. .::: ::::::.:.. :: : ::..
NP_004 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSK------P----SDAA-K
10 20 30 40
50 60 70 80 90 100
pF1KE3 AKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTS-AAAEVNRQMLQEL
:. :: .:.. .:.: :::: ..:::.::: ::::::::...: ...::: ::::.:
NP_004 AEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDL
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE3 VNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQ---TSPGKGLMP
:: :..:. .::..:..::::::.:.::::.: ::: ::.. . . .: : .
NP_004 QAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQ
110 120 130 140 150 160
170 180 190 200
pF1KE3 TPVTRRPSFEGTGDSFA------------SYHQLS-------GTPYEGPSFGA---DGPT
:.:. :..:. .:.. .::. : : : : ...: :.
NP_004 QSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPS
170 180 190 200 210 220
210 220 230 240
pF1KE3 ALEEM---PRPYVDYLFPGVGPHG--PGHQHQHPP----------KGYGASVEAAGAHF-
... : : : . : :.: : . :: : :....: . ...
NP_004 NGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRIS
230 240 250 260 270 280
250 260 270 280
pF1KE3 PLQ-GA---HYGRPHL-LVPGEPLGYG--------VQRSP---------SFQSKTPP-ET
:. :: : : : : .: . : : :.: .: : : ..
NP_004 PVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQN
290 300 310 320 330 340
290 300 310 320 330 340
pF1KE3 G-GYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRS-QVFASD
: : ... . . : :. ::: :.: : . :.. :: . . ...
NP_004 GTGQTDFMIHQNVVPAGTVNRQPPP------PYPLTAANGQSPSALQTGGSAAPSSYTNG
350 360 370 380 390 400
350 360 370 380 390 400
pF1KE3 SPPQSLLTPSRNSLNVDLYELGSTSVQ-QWPAATLARRDSLQKPGLEAPPRAHVAFRPDC
: :::...:.::: :..::... ..: .:: .. : .: . : : : ...:.
NP_004 SIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIP-----TWQPNI
410 420 430 440 450
410 420 430 440 450 460
pF1KE3 PVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGP
:: :.::::. : . ... : :. .::::.: : : .::::.:::.:: :::..:
NP_004 PV--RSNSFNN--PLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAP
460 470 480 490 500 510
470 480 490 500 510 520
pF1KE3 SHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPK
.::.:.: : . :.: : :: .. . ..: .: .:. . :::::::
NP_004 THPSWIPQPIQTVQPSPFP--EGTASN---------VTVMPPVAE--APNYQGPPPPYPK
520 530 540 550 560
530 540 550 560 570
pF1KE3 HLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKG-DKGGKDKKQIQTSPVP
::: .. : .:. ... . :.: :.:.:: .. :.: :.:::: :::.
NP_004 HLLHQNPSVP-PYESISKPSKEDQPSLPKE----DESEKSYENVDSGDKEKKQITTSPIT
570 580 590 600 610
580 590 600 610 620 630
pF1KE3 VRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEA
::::..:::.:::::.:::: :::::::::::::.:..::...:. :::.:: ..:: .
NP_004 VRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQD
620 630 640 650 660 670
640 650 660 670 680 690
pF1KE3 EQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTL
:.::::.: :::::: ::::::::::::::::::::::::::::: ::::.:::: :::
NP_004 AQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTL
680 690 700 710 720 730
700 710 720 730 740 750
pF1KE3 RKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIR
:::::: :::::::::::::::::::::::.:::::::::.:::::::::::::::::::
NP_004 RKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIR
740 750 760 770 780 790
760 770 780 790 800 810
pF1KE3 MEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWT
: .::: :::::::::: :.::::::::::::::::::::: ::::::::::::::::::
NP_004 MGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWT
800 810 820 830 840 850
820 830 840 850 860 870
pF1KE3 HNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNY
:.:::::.:.: :::::. :. : : :.:::::::: ::.:: .::::::::::::::::
NP_004 HDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNY
860 870 880 890 900 910
880 890 900 910 920 930
pF1KE3 IAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVK
:::::::: ::::::::::::::::::::::::::: :: :::.:::::...:::: :.:
NP_004 IAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAK
920 930 940 950 960 970
940 950 960 970 980 990
pF1KE3 LSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDT
::::: ::: ::: . . :::.::::..::::::..::::::.:.: : :.: :.:: ::
NP_004 LSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDT
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KE3 SNFDPVDEESPWNDASEGSTKAWDTLTS--PNNKHPEHAFYEFTFRRFFDDNGYPFRCPK
::::::: .. :.: .: .. :::.. :.::::::::::::::::::::::. ::
NP_004 SNFDPVDPDKLWSDDNE-EENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPK
1040 1050 1060 1070 1080 1090
1060 1070 1080
pF1KE3 PSGAEASQAESSDLESSDLVDQTEGCQPVYV
: : ....:. ..:: ::. : .
NP_004 PIEYEYINSQGSE-QQSDEDDQNTGSEIKNRDLVYV
1100 1110 1120 1130
>>XP_016866970 (OMIM: 603473) PREDICTED: serine/threonin (850 aa)
initn: 3020 init1: 2484 opt: 2812 Z-score: 1028.1 bits: 201.6 E(85289): 1.6e-50
Smith-Waterman score: 3158; 57.4% identity (76.2% similar) in 881 aa overlap (212-1084:1-841)
190 200 210 220 230 240
pF1KE3 SYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGH-QHQHPPKGYGASVE
..:.. ..: :: :. .:: ..:
XP_016 MEYVISRISPVPPGAWQEGYPPPPLNTS--
10 20
250 260 270 280 290
pF1KE3 AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPP-ETG-GYASLPTKGQGGPP
. : :: . : . : .:. . . . .: : : ..: : ... . . :
XP_016 --PMNPPNQG-QRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPA
30 40 50 60 70 80
300 310 320 330 340 350
pF1KE3 GAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRS-QVFASDSPPQSLLTPSRNSLNV
:. ::: :.: : . :.. :: . . ... : :::...:.::: :.
XP_016 GTVNRQPPP------PYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNM
90 100 110 120 130
360 370 380 390 400 410
pF1KE3 DLYELGSTSVQ-QWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRP
.::... ..: .:: .. : .: . : : : ...:. :: :.::::. :
XP_016 ELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIP-----TWQPNIPV--RSNSFNN--PLG
140 150 160 170 180 190
420 430 440 450 460 470
pF1KE3 GPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPA
. ... : :. .::::.: : : .::::.:::.:: :::..:.::.:.: : . :.
XP_016 NRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPS
200 210 220 230 240 250
480 490 500 510 520 530
pF1KE3 PAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSL
: : :: .. . ..: .: .:. . :::::::::: .. : .:.
XP_016 PFP--EGTASN---------VTVMPPVAE--APNYQGPPPPYPKHLLHQNPSVP-PYESI
260 270 280 290
540 550 560 570 580 590
pF1KE3 CAGMEQSLRAGPNEPEGGDKSRKSAKG-DKGGKDKKQIQTSPVPVRKNSRDEEKRESRIK
... . :.: :.:.:: .. :.: :.:::: :::. ::::..:::.:::::.
XP_016 SKPSKEDQPSLPKE----DESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQ
300 310 320 330 340 350
600 610 620 630 640 650
pF1KE3 SYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNY
:::: :::::::::::::.:..::...:. :::.:: ..:: . :.::::.: ::::::
XP_016 SYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNY
360 370 380 390 400 410
660 670 680 690 700 710
pF1KE3 NRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKA
::::::::::::::::::::::::::::: ::::.:::: ::::::::: :::::::::
XP_016 IRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKA
420 430 440 450 460 470
720 730 740 750 760 770
pF1KE3 ERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAEL
::::::::::::::.:::::::::.:::::::::::::::::::: .::: :::::::::
XP_016 ERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAEL
480 490 500 510 520 530
780 790 800 810 820 830
pF1KE3 TLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDS
: :.::::::::::::::::::::: :::::::::::::::::::.:::::.:.: ::::
XP_016 TCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDS
540 550 560 570 580 590
840 850 860 870 880 890
pF1KE3 MEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCD
:. :. : : :.:::::::: ::.:: .:::::::::::::::::::::::: :::::::
XP_016 MDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCD
600 610 620 630 640 650
900 910 920 930 940 950
pF1KE3 WWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSA
:::::::::::::::::::: :: :::.:::::...:::: :.:::::: ::: ::: .
XP_016 WWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGP
660 670 680 690 700 710
960 970 980 990 1000 1010
pF1KE3 DHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDAS
. :::.::::..::::::..::::::.:.: : :.: :.:: ::::::::: .. :.: .
XP_016 EDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDN
720 730 740 750 760 770
1020 1030 1040 1050 1060 1070
pF1KE3 EGSTKAWDTLTS--PNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLES
: .. :::.. :.::::::::::::::::::::::. ::: : ....:. ..
XP_016 E-EENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSE-QQ
780 790 800 810 820 830
1080
pF1KE3 SDLVDQTEGCQPVYV
:: ::. : .
XP_016 SDEDDQNTGSEIKNRDLVYV
840 850
>>XP_016866968 (OMIM: 603473) PREDICTED: serine/threonin (993 aa)
initn: 2800 init1: 2021 opt: 2184 Z-score: 803.8 bits: 160.4 E(85289): 4.9e-38
Smith-Waterman score: 2911; 51.2% identity (70.1% similar) in 1020 aa overlap (1-940:13-988)
10 20 30 40
pF1KE3 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLD
::::::::..:. .::: ::::::.:.. :: : ::..
XP_016 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSK---------P-SDAA-K
10 20 30 40
50 60 70 80 90 100
pF1KE3 AKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTS-AAAEVNRQMLQEL
:. :: .:.. .:.: :::: ..:::.::: ::::::::...: ...::: ::::.:
XP_016 AEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDL
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE3 VNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQ---TSPGKGLMP
:: :..:. .::..:..::::::.:.::::.: ::: ::.. . . .: : .
XP_016 QAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQ
110 120 130 140 150 160
170 180 190 200
pF1KE3 TPVTRRPSFEGTGDSFA------------SYHQLS-------GTPYEGPSFGA---DGPT
:.:. :..:. .:.. .::. : : : : ...: :.
XP_016 QSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPS
170 180 190 200 210 220
210 220 230 240
pF1KE3 ALEEM---PRPYVDYLFPGVGPHG--PGHQHQHPP----------KGYGASVEAAGAHF-
... : : : . : :.: : . :: : :....: . ...
XP_016 NGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRIS
230 240 250 260 270 280
250 260 270 280
pF1KE3 PLQ-GA---HYGRPHL-LVPGEPLGYG--------VQRSP---------SFQSKTPP-ET
:. :: : : : : .: . : : :.: .: : : ..
XP_016 PVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQN
290 300 310 320 330 340
290 300 310 320 330 340
pF1KE3 G-GYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRS-QVFASD
: : ... . . : :. ::: :.: : . :.. :: . . ...
XP_016 GTGQTDFMIHQNVVPAGTVNRQPPP------PYPLTAANGQSPSALQTGGSAAPSSYTNG
350 360 370 380 390 400
350 360 370 380 390 400
pF1KE3 SPPQSLLTPSRNSLNVDLYELGSTSVQ-QWPAATLARRDSLQKPGLEAPPRAHVAFRPDC
: :::...:.::: :..::... ..: .:: .. : .: . : : : ...:.
XP_016 SIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIP-----TWQPNI
410 420 430 440 450
410 420 430 440 450 460
pF1KE3 PVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGP
:: :.::::. : . ... : :. .::::.: : : .::::.:::.:: :::..:
XP_016 PV--RSNSFNN--PLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAP
460 470 480 490 500 510
470 480 490 500 510 520
pF1KE3 SHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPK
.::.:.: : . :.: : :: .. . ..: .: .:. . :::::::
XP_016 THPSWIPQPIQTVQPSPFP--EGTASN---------VTVMPPVAE--APNYQGPPPPYPK
520 530 540 550 560
530 540 550 560 570
pF1KE3 HLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKG-DKGGKDKKQIQTSPVP
::: .. : .:. ... . :.: :.:.:: .. :.: :.:::: :::.
XP_016 HLLHQNPSVP-PYESISKPSKEDQPSLPKE----DESEKSYENVDSGDKEKKQITTSPIT
570 580 590 600 610
580 590 600 610 620 630
pF1KE3 VRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEA
::::..:::.:::::.:::: :::::::::::::.:..::...:. :::.:: ..:: .
XP_016 VRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQD
620 630 640 650 660 670
640 650 660 670 680 690
pF1KE3 EQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTL
:.::::.: :::::: ::::::::::::::::::::::::::::: ::::.:::: :::
XP_016 AQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTL
680 690 700 710 720 730
700 710 720 730 740 750
pF1KE3 RKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIR
:::::: :::::::::::::::::::::::.:::::::::.:::::::::::::::::::
XP_016 RKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIR
740 750 760 770 780 790
760 770 780 790 800 810
pF1KE3 MEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWT
: .::: :::::::::: :.::::::::::::::::::::: ::::::::::::::::::
XP_016 MGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWT
800 810 820 830 840 850
820 830 840 850 860 870
pF1KE3 HNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNY
:.:::::.:.: :::::. :. : : :.:::::::: ::.:: .::::::::::::::::
XP_016 HDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNY
860 870 880 890 900 910
880 890 900 910 920
pF1KE3 IAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLK----------VIN-W
:::::::: ::::::::::::::::::::::::::: :: :::.: :.: :
XP_016 IAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKIWGFTMLPRLVLNFW
920 930 940 950 960 970
930 940 950 960 970 980
pF1KE3 ENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAP
...:.: :.
XP_016 AQAIHLPRPPKVLGLQV
980 990
>>XP_011534554 (OMIM: 603473) PREDICTED: serine/threonin (1001 aa)
initn: 2796 init1: 2017 opt: 2177 Z-score: 801.3 bits: 159.9 E(85289): 6.8e-38
Smith-Waterman score: 2900; 52.0% identity (70.8% similar) in 993 aa overlap (1-924:13-961)
10 20 30 40
pF1KE3 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLD
::::::::..:. .::: ::::::.:.. :: : ::..
XP_011 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSK------P----SDAA-K
10 20 30 40
50 60 70 80 90 100
pF1KE3 AKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTS-AAAEVNRQMLQEL
:. :: .:.. .:.: :::: ..:::.::: ::::::::...: ...::: ::::.:
XP_011 AEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDL
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE3 VNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQ---TSPGKGLMP
:: :..:. .::..:..::::::.:.::::.: ::: ::.. . . .: : .
XP_011 QAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQ
110 120 130 140 150 160
170 180 190 200
pF1KE3 TPVTRRPSFEGTGDSFA------------SYHQLS-------GTPYEGPSFGA---DGPT
:.:. :..:. .:.. .::. : : : : ...: :.
XP_011 QSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPS
170 180 190 200 210 220
210 220 230 240
pF1KE3 ALEEM---PRPYVDYLFPGVGPHG--PGHQHQHPP----------KGYGASVEAAGAHF-
... : : : . : :.: : . :: : :....: . ...
XP_011 NGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRIS
230 240 250 260 270 280
250 260 270 280
pF1KE3 PLQ-GA---HYGRPHL-LVPGEPLGYG--------VQRSP---------SFQSKTPP-ET
:. :: : : : : .: . : : :.: .: : : ..
XP_011 PVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQN
290 300 310 320 330 340
290 300 310 320 330 340
pF1KE3 G-GYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRS-QVFASD
: : ... . . : :. ::: :.: : . :.. :: . . ...
XP_011 GTGQTDFMIHQNVVPAGTVNRQPPP------PYPLTAANGQSPSALQTGGSAAPSSYTNG
350 360 370 380 390 400
350 360 370 380 390 400
pF1KE3 SPPQSLLTPSRNSLNVDLYELGSTSVQ-QWPAATLARRDSLQKPGLEAPPRAHVAFRPDC
: :::...:.::: :..::... ..: .:: .. : .: . : : : ...:.
XP_011 SIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIP-----TWQPNI
410 420 430 440 450
410 420 430 440 450 460
pF1KE3 PVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGP
:: :.::::. : . ... : :. .::::.: : : .::::.:::.:: :::..:
XP_011 PV--RSNSFNN--PLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAP
460 470 480 490 500 510
470 480 490 500 510 520
pF1KE3 SHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPK
.::.:.: : . :.: : :: .. . ..: .: .:. . :::::::
XP_011 THPSWIPQPIQTVQPSPFP--EGTASN---------VTVMPPVAE--APNYQGPPPPYPK
520 530 540 550 560
530 540 550 560 570
pF1KE3 HLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKG-DKGGKDKKQIQTSPVP
::: .. : .:. ... . :.: :.:.:: .. :.: :.:::: :::.
XP_011 HLLHQNPSVP-PYESISKPSKEDQPSLPKE----DESEKSYENVDSGDKEKKQITTSPIT
570 580 590 600 610
580 590 600 610 620 630
pF1KE3 VRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEA
::::..:::.:::::.:::: :::::::::::::.:..::...:. :::.:: ..:: .
XP_011 VRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQD
620 630 640 650 660 670
640 650 660 670 680 690
pF1KE3 EQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTL
:.::::.: :::::: ::::::::::::::::::::::::::::: ::::.:::: :::
XP_011 AQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTL
680 690 700 710 720 730
700 710 720 730 740 750
pF1KE3 RKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIR
:::::: :::::::::::::::::::::::.:::::::::.:::::::::::::::::::
XP_011 RKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIR
740 750 760 770 780 790
760 770 780 790 800 810
pF1KE3 MEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWT
: .::: :::::::::: :.::::::::::::::::::::: ::::::::::::::::::
XP_011 MGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWT
800 810 820 830 840 850
820 830 840 850 860 870
pF1KE3 HNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNY
:.:::::.:.: :::::. :. : : :.:::::::: ::.:: .::::::::::::::::
XP_011 HDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNY
860 870 880 890 900 910
880 890 900 910 920 930
pF1KE3 IAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVK
:::::::: ::::::::::::::::::::::::::: :: :::.:
XP_011 IAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKDLEVAASCILTRFYS
920 930 940 950 960 970
940 950 960 970 980 990
pF1KE3 LSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDT
XP_011 CLLWEGDRRVYVVHLPQNWDLSGCF
980 990 1000
1088 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:20:37 2016 done: Mon Nov 7 18:20:39 2016
Total Scan time: 13.280 Total Display time: 0.330
Function used was FASTA [36.3.4 Apr, 2011]