Result of FASTA (ccds) for
pFN21AE3335
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3335, 974 aa
1>>>pF1KE3335 974 - 974 aa - 974 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.5312+/-0.00115; mu= 1.4484+/- 0.067
mean_var=385.8913+/-87.766, 0's: 0 Z-trim(111.4): 284 B-trim: 0 in 0/54
Lambda= 0.065289
statistics sampled from 12024 (12333) to 12024 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.379), width: 16
Scan time: 4.080
The best scores are: opt bits E(32554)
CCDS32407.2 ERN2 gene_id:10595|Hs108|chr16 ( 926) 6305 609.6 8.9e-174
CCDS76845.1 ERN2 gene_id:10595|Hs108|chr16 ( 874) 3251 321.9 3.4e-87
CCDS45762.1 ERN1 gene_id:2081|Hs108|chr17 ( 977) 1816 186.8 1.8e-46
>>CCDS32407.2 ERN2 gene_id:10595|Hs108|chr16 (926 aa)
initn: 6305 init1: 6305 opt: 6305 Z-score: 3233.3 bits: 609.6 E(32554): 8.9e-174
Smith-Waterman score: 6305; 100.0% identity (100.0% similar) in 926 aa overlap (49-974:1-926)
20 30 40 50 60 70
pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP
::::::::::::::::::::::::::::::
CCDS32 MASAVRGSRPWPRLGLQLQFAALLLGTLSP
10 20 30
80 90 100 110 120 130
pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE3 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE3 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE3 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE3 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
700 710 720 730 740 750
800 810 820 830 840 850
pF1KE3 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
760 770 780 790 800 810
860 870 880 890 900 910
pF1KE3 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
820 830 840 850 860 870
920 930 940 950 960 970
pF1KE3 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
880 890 900 910 920
>>CCDS76845.1 ERN2 gene_id:10595|Hs108|chr16 (874 aa)
initn: 3251 init1: 3251 opt: 3251 Z-score: 1678.9 bits: 321.9 E(32554): 3.4e-87
Smith-Waterman score: 5848; 94.4% identity (94.4% similar) in 926 aa overlap (49-974:1-874)
20 30 40 50 60 70
pF1KE3 GAEPSPGRAGTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSP
::::::::::::::::::::::::::::::
CCDS76 MASAVRGSRPWPRLGLQLQFAALLLGTLSP
10 20 30
80 90 100 110 120 130
pF1KE3 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 QVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 YILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 RDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 QVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 ENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
:::::::::::
CCDS76 ENTQAPAFFLE-------------------------------------------------
400
500 510 520 530 540 550
pF1KE3 MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 ---QQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAE
410 420 430 440 450
560 570 580 590 600 610
pF1KE3 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 QLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDR
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE3 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 HPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHS
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE3 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 LHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPE
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE3 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 LLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
640 650 660 670 680 690
800 810 820 830 840 850
pF1KE3 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRA
700 710 720 730 740 750
860 870 880 890 900 910
pF1KE3 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 LEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQA
760 770 780 790 800 810
920 930 940 950 960 970
pF1KE3 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS76 LGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
820 830 840 850 860 870
>>CCDS45762.1 ERN1 gene_id:2081|Hs108|chr17 (977 aa)
initn: 2895 init1: 1791 opt: 1816 Z-score: 947.9 bits: 186.8 E(32554): 1.8e-46
Smith-Waterman score: 2907; 50.3% identity (71.3% similar) in 974 aa overlap (58-963:2-969)
30 40 50 60 70 80
pF1KE3 GTERSLGGTQGPGQPCSCPGAMASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPEN
: :: : : . :: .. . ::.
CCDS45 MPARRLLLLLTLLLPGLGIFGSTSTVTLPET
10 20 30
90 100 110 120 130 140
pF1KE3 LLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQ
::.::::::::::.::.::..::::..:::.. : .: : ::: :: ::::: ::.....
CCDS45 LLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE3 GLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE-----GPST
:: ::::::::::.:::::::::..: :.::: :.:.: .:: :.::.. :::
CCDS45 GLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPST
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 PRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAP-PMDGSPGKYMSHLASCGMGLLLTVD
::.:::.::.::.: .. ::::.:: :.: : : : :::..: : ::..:::
CCDS45 SLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYK-MSHFVSNGDGLVVTVD
160 170 180 190 200 210
270 280 290 300 310
pF1KE3 PGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHI----RLPASG
:: ::: :. . ::.. :.:...:::.. :...: .::..:.. :.. .
CCDS45 SESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPF
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 PRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVT
:..: . ..: :::::: :..:.: ..:: :::.:::: :: .:: :: ::
CCDS45 PKETEA-----KSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVT
280 290 300 310 320
380 390 400 410 420 430
pF1KE3 LQVSGEREGSPSTAVRYPSGSVA------LPSQWLLIGHHELPPVLHTTMLRVHPTLGSG
. .:: .::: :.. : . : . :::::::: : : ::. :.
CCDS45 IGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPK
330 340 350 360 370 380
440 450 460 470 480
pF1KE3 TAETRPPENTQAPAF--FLELLSLSREKL-----WDSELHPEEKT--PDSYLGLGPQDLL
:. : ... .: ..:.. . :. : : .: . :.. . .:.
CCDS45 HRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMA
390 400 410 420 430 440
490 500 510 520
pF1KE3 AASLTAVLLGGWILFV------MRQQQP-------------QVVEKQQET-PL-APADFA
. :.. :: ::. :. :.::: :....::. :. :.: :
CCDS45 TIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTA
450 460 470 480 490 500
530 540 550 560
pF1KE3 HISQ--DAQ---SLHSGAS------RRSQKRLQSPSKQAQPLDDPEAEQ--------LTV
. .. :.. : ::.: : :.. : : :. .. ..: :: ...
CCDS45 QDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVI
510 520 530 540 550 560
570 580 590 600 610 620
pF1KE3 VGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNV
:::::: ::::::.:: ::.:.::.:..: :::::.: :::... ::::::.:::.::::
CCDS45 VGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNV
570 580 590 600 610 620
630 640 650 660 670 680
pF1KE3 LRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIV
.::::::. ::.:::.::: :.::::::. :. . :::: ..::: :::::::::.::
CCDS45 IRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIV
630 640 650 660 670 680
690 700 710 720 730 740
pF1KE3 HRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQL
:::::: ::::. :...: ....::::::::: .:: ::: .::.::::::.:::.:.
CCDS45 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE
690 700 710 720 730 740
750 760 770 780 790 800
pF1KE3 LPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVA
..:: .:::::::::::::.: :::::: :: :::::: :: : :. : :. :.:
CCDS45 DCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIA
750 760 770 780 790 800
810 820 830 840 850 860
pF1KE3 RDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAG
:.:. :.. :: :::: .:: :::::: ::::::::::: .:::: . :.:. :: :
CCDS45 RELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERG
810 820 830 840 850 860
870 880 890 900 910 920
pF1KE3 GCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQV
: :::. .:.:.:..::::::::::.::: ::::::::.:::::::::::.:::..::..
CCDS45 GRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSL
870 880 890 900 910 920
930 940 950 960 970
pF1KE3 PDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYY---PPDSEARRPCPGATGR
:: :: :::.:::.:: ::.:::. :. : :: ::: ::. .
CCDS45 PDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL
930 940 950 960 970
974 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:48:13 2016 done: Mon Nov 7 18:48:13 2016
Total Scan time: 4.080 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]