Result of FASTA (omim) for
pFN21AE3270
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3270, 673 aa
1>>>pF1KE3270 673 - 673 aa - 673 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4372+/-0.000312; mu= 16.2376+/- 0.020
mean_var=135.5846+/-27.469, 0's: 0 Z-trim(121.6): 329 B-trim: 500 in 1/52
Lambda= 0.110146
statistics sampled from 37930 (38387) to 37930 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.777), E-opt: 0.2 (0.45), width: 16
Scan time: 13.740
The best scores are: opt bits E(85289)
NP_733749 (OMIM: 607320) RAS guanyl-releasing prot ( 673) 4690 756.8 5.8e-218
NP_001139674 (OMIM: 607320) RAS guanyl-releasing p ( 659) 3415 554.2 5.6e-157
NP_001139677 (OMIM: 607320) RAS guanyl-releasing p ( 639) 2949 480.1 1.1e-134
NP_001139679 (OMIM: 607320) RAS guanyl-releasing p ( 576) 2530 413.5 1.1e-114
NP_001139675 (OMIM: 607320) RAS guanyl-releasing p ( 581) 2185 358.7 3.5e-98
NP_001139676 (OMIM: 607320) RAS guanyl-releasing p ( 604) 2169 356.2 2.1e-97
NP_001139678 (OMIM: 607320) RAS guanyl-releasing p ( 484) 1913 315.4 3.2e-85
XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl- ( 632) 1903 313.9 1.2e-84
NP_005730 (OMIM: 603962) RAS guanyl-releasing prot ( 797) 1903 314.0 1.4e-84
XP_016877349 (OMIM: 603962) PREDICTED: RAS guanyl- ( 749) 1884 311.0 1.1e-83
XP_005254171 (OMIM: 603962) PREDICTED: RAS guanyl- ( 746) 1782 294.7 8e-79
XP_016859248 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73
XP_016859249 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73
NP_733772 (OMIM: 609531) ras guanyl-releasing prot ( 690) 1658 275.0 6.5e-73
XP_011531050 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73
XP_011531048 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73
XP_016859250 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73
XP_011531049 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 1658 275.0 6.5e-73
NP_001132960 (OMIM: 609531) ras guanyl-releasing p ( 690) 1658 275.0 6.5e-73
XP_005264303 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 1648 273.4 1.9e-72
XP_016859251 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 1648 273.4 1.9e-72
NP_056191 (OMIM: 609531) ras guanyl-releasing prot ( 689) 1648 273.4 1.9e-72
XP_016859252 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 1648 273.4 1.9e-72
NP_001092140 (OMIM: 605577,615888) RAS guanyl-rele ( 609) 1616 268.3 6.1e-71
NP_722541 (OMIM: 605577,615888) RAS guanyl-releasi ( 609) 1616 268.3 6.1e-71
NP_001092141 (OMIM: 605577,615888) RAS guanyl-rele ( 609) 1616 268.3 6.1e-71
XP_011543023 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71
XP_016872573 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71
XP_011543025 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71
XP_011543024 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71
XP_011543022 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 1616 268.3 6.1e-71
XP_005273764 (OMIM: 605577,615888) PREDICTED: RAS ( 714) 1483 247.2 1.6e-64
XP_011543020 (OMIM: 605577,615888) PREDICTED: RAS ( 715) 1483 247.2 1.6e-64
XP_016872572 (OMIM: 605577,615888) PREDICTED: RAS ( 897) 1483 247.3 1.8e-64
XP_016872571 (OMIM: 605577,615888) PREDICTED: RAS ( 898) 1483 247.3 1.8e-64
XP_016872574 (OMIM: 605577,615888) PREDICTED: RAS ( 551) 1412 235.8 3.2e-61
NP_001305327 (OMIM: 605577,615888) RAS guanyl-rele ( 464) 1325 221.9 4.2e-57
XP_011543027 (OMIM: 605577,615888) PREDICTED: RAS ( 465) 1325 221.9 4.2e-57
XP_016872575 (OMIM: 605577,615888) PREDICTED: RAS ( 465) 1325 221.9 4.2e-57
NP_001293015 (OMIM: 603962) RAS guanyl-releasing p ( 597) 1261 211.9 5.7e-54
NP_001122074 (OMIM: 603962) RAS guanyl-releasing p ( 762) 1261 212.0 6.8e-54
XP_016865171 (OMIM: 606614) PREDICTED: ras-specifi (1142) 295 58.6 1.5e-07
NP_008840 (OMIM: 606614) ras-specific guanine nucl (1237) 295 58.7 1.6e-07
XP_011531368 (OMIM: 135300,182530,610733) PREDICTE ( 978) 280 56.2 6.9e-07
XP_011531366 (OMIM: 135300,182530,610733) PREDICTE (1276) 280 56.3 8.3e-07
XP_005264572 (OMIM: 135300,182530,610733) PREDICTE (1318) 280 56.3 8.5e-07
XP_011531364 (OMIM: 135300,182530,610733) PREDICTE (1326) 280 56.3 8.5e-07
NP_005624 (OMIM: 135300,182530,610733) son of seve (1333) 280 56.3 8.5e-07
NP_005303 (OMIM: 600303) rap guanine nucleotide ex (1077) 276 55.6 1.1e-06
NP_001291204 (OMIM: 600303) rap guanine nucleotide (1094) 276 55.6 1.2e-06
>>NP_733749 (OMIM: 607320) RAS guanyl-releasing protein (673 aa)
initn: 4690 init1: 4690 opt: 4690 Z-score: 4034.1 bits: 756.8 E(85289): 5.8e-218
Smith-Waterman score: 4690; 100.0% identity (100.0% similar) in 673 aa overlap (1-673:1-673)
10 20 30 40 50 60
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
610 620 630 640 650 660
670
pF1KE3 MDPPSTASSKLDS
:::::::::::::
NP_733 MDPPSTASSKLDS
670
>>NP_001139674 (OMIM: 607320) RAS guanyl-releasing prote (659 aa)
initn: 4570 init1: 3415 opt: 3415 Z-score: 2939.2 bits: 554.2 E(85289): 5.6e-157
Smith-Waterman score: 4546; 97.9% identity (97.9% similar) in 673 aa overlap (1-673:1-659)
10 20 30 40 50 60
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDL----------
130 140 150 160 170
190 200 210 220 230 240
pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----PGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
180 190 200 210 220
250 260 270 280 290 300
pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
590 600 610 620 630 640
670
pF1KE3 MDPPSTASSKLDS
:::::::::::::
NP_001 MDPPSTASSKLDS
650
>>NP_001139677 (OMIM: 607320) RAS guanyl-releasing prote (639 aa)
initn: 2949 init1: 2949 opt: 2949 Z-score: 2539.2 bits: 480.1 E(85289): 1.1e-134
Smith-Waterman score: 4381; 94.9% identity (94.9% similar) in 673 aa overlap (1-673:1-639)
10 20 30 40 50 60
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
:::::::::::::::::::::::::::::::::::::::::
NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT-------------------
190 200 210 220
250 260 270 280 290 300
pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
230 240 250 260
310 320 330 340 350 360
pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
570 580 590 600 610 620
670
pF1KE3 MDPPSTASSKLDS
:::::::::::::
NP_001 MDPPSTASSKLDS
630
>>NP_001139679 (OMIM: 607320) RAS guanyl-releasing prote (576 aa)
initn: 4029 init1: 2530 opt: 2530 Z-score: 2179.9 bits: 413.5 E(85289): 1.1e-114
Smith-Waterman score: 3839; 85.6% identity (85.6% similar) in 673 aa overlap (1-673:1-576)
10 20 30 40 50 60
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
:::::::::::::::::::::::::::::::::::::::::
NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT-------------------
190 200 210 220
250 260 270 280 290 300
pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
NP_001 ------------------------------------------------------------
310 320 330 340 350 360
pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------------ALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
230 240 250 260
370 380 390 400 410 420
pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
270 280 290 300 310 320
430 440 450 460 470 480
pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
330 340 350 360 370 380
490 500 510 520 530 540
pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
390 400 410 420 430 440
550 560 570 580 590 600
pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
450 460 470 480 490 500
610 620 630 640 650 660
pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
510 520 530 540 550 560
670
pF1KE3 MDPPSTASSKLDS
:::::::::::::
NP_001 MDPPSTASSKLDS
570
>>NP_001139675 (OMIM: 607320) RAS guanyl-releasing prote (581 aa)
initn: 2227 init1: 2167 opt: 2185 Z-score: 1883.6 bits: 358.7 E(85289): 3.5e-98
Smith-Waterman score: 3872; 86.3% identity (86.3% similar) in 673 aa overlap (1-673:1-581)
10 20 30 40 50 60
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
::::::::::::::::::
NP_001 AISRLKDSHAHLSPDSTK------------------------------------------
310
370 380 390 400 410 420
pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
::::::::::
NP_001 --------------------------------------------------LSLDLFYTED
320
430 440 450 460 470 480
pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
330 340 350 360 370 380
490 500 510 520 530 540
pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
390 400 410 420 430 440
550 560 570 580 590 600
pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
450 460 470 480 490 500
610 620 630 640 650 660
pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
510 520 530 540 550 560
670
pF1KE3 MDPPSTASSKLDS
:::::::::::::
NP_001 MDPPSTASSKLDS
570 580
>>NP_001139676 (OMIM: 607320) RAS guanyl-releasing prote (604 aa)
initn: 2229 init1: 2169 opt: 2169 Z-score: 1869.6 bits: 356.2 E(85289): 2.1e-97
Smith-Waterman score: 4075; 89.7% identity (89.7% similar) in 673 aa overlap (1-673:1-604)
10 20 30 40 50 60
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
::::::::::::::::::
NP_001 AISRLKDSHAHLSPDSTK------------------------------------------
310
370 380 390 400 410 420
pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
:::::::::::::::::::::::::::::::::
NP_001 ---------------------------ELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
320 330 340 350
430 440 450 460 470 480
pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
360 370 380 390 400 410
490 500 510 520 530 540
pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
420 430 440 450 460 470
550 560 570 580 590 600
pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
480 490 500 510 520 530
610 620 630 640 650 660
pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
540 550 560 570 580 590
670
pF1KE3 MDPPSTASSKLDS
:::::::::::::
NP_001 MDPPSTASSKLDS
600
>>NP_001139678 (OMIM: 607320) RAS guanyl-releasing prote (484 aa)
initn: 1913 init1: 1913 opt: 1913 Z-score: 1651.0 bits: 315.4 E(85289): 3.2e-85
Smith-Waterman score: 3031; 71.9% identity (71.9% similar) in 673 aa overlap (1-673:1-484)
10 20 30 40 50 60
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL
:::::::::::::::::::::::::::::::::::::::::
NP_001 PMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT-------------------
190 200 210 220
250 260 270 280 290 300
pF1KE3 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS
NP_001 ------------------------------------------------------------
310 320 330 340 350 360
pF1KE3 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS
NP_001 ------------------------------------------------------------
370 380 390 400 410 420
pF1KE3 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED
::::::::::
NP_001 --------------------------------------------------LSLDLFYTED
230
430 440 450 460 470 480
pF1KE3 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDP
240 250 260 270 280 290
490 500 510 520 530 540
pF1KE3 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFL
300 310 320 330 340 350
550 560 570 580 590 600
pF1KE3 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDA
360 370 380 390 400 410
610 620 630 640 650 660
pF1KE3 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPV
420 430 440 450 460 470
670
pF1KE3 MDPPSTASSKLDS
:::::::::::::
NP_001 MDPPSTASSKLDS
480
>>XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl-rele (632 aa)
initn: 1877 init1: 1483 opt: 1903 Z-score: 1640.9 bits: 313.9 E(85289): 1.2e-84
Smith-Waterman score: 1903; 48.4% identity (76.2% similar) in 601 aa overlap (4-602:8-601)
10 20 30 40 50
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRR-HKTCPSPREISKVMASMNLGLLSEGG
... :: . : . .: . . . . :: .:.. ..:: :..:.
XP_011 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 CSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQE
: :.:...::::::. :.::. ...:...:.:: :. ::.: ...: :. : . ..
XP_011 -SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSP
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 LRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGG
:.::..::::. . ....: .: ... .: : .:. . :: :.... .
XP_011 GLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDW
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 PGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR
. . .::::::::::::: ::..:::::::.::. :. .: ..:.... :.
XP_011 SRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG
:..: :..: :..:.:::.:::::: : ::.:. :::.:::.::::::::::::: :
XP_011 ENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE3 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL
:::::.:::::.. .:. . .:.: :.::::.: :: :::... :. :..:.:::::
XP_011 GLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE3 KDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL
:::.::.::.:: : ::.... :: :: ...::: :: :: ::.::.:::::::::
XP_011 KDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE3 FYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVF
.:::::::::::::::: .. : .: . :.::.:: ::.:::: :...::...:.:::
XP_011 YYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVF
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE3 KNYDPEGRGTISQEDFERLSGNFPFA-CHGLHPPPRQGRGSFSREELTGYLLRASAICSK
:::: . : ::::.::.....:::. : . :.: .::.:.:.:..:::.: ::
XP_011 KNYDHDQDGYISQEEFEKIAASFPFSFC--VMDKDREG--LISRDEITAYFMRASSIYSK
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE3 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP
:::.: :.:.:.:. ::::::.:.:::::: ::::::..::. :::.:.: : :::::
XP_011 LGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR-
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE3 GAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETD
::. ..:
XP_011 -AKNPVAPTENNTSVGPVSNLCSLGAKDLLHGNKYSESR
600 610 620 630
>>NP_005730 (OMIM: 603962) RAS guanyl-releasing protein (797 aa)
initn: 1877 init1: 1483 opt: 1903 Z-score: 1639.7 bits: 314.0 E(85289): 1.4e-84
Smith-Waterman score: 1904; 47.0% identity (74.3% similar) in 634 aa overlap (4-634:8-629)
10 20 30 40 50
pF1KE3 MNRKDSKRKSHQECTGKIGGRGRPRQVRR-HKTCPSPREISKVMASMNLGLLSEGG
... :: . : . .: . . . . :: .:.. ..:: :..:.
NP_005 MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 CSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQE
: :.:...::::::. :.::. ...:...:.:: :. ::.: ...: :. : . ..
NP_005 -SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSP
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 LRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGG
:.::..::::. . ....: .: ... .: : .:. . :: :.... .
NP_005 GLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDW
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 PGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVR
. . .::::::::::::: ::..:::::::.::. :. .: ..:.... :.
NP_005 SRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 GCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTG
:..: :..: :..:.:::.:::::: : ::.:. :::.:::.::::::::::::: :
NP_005 ENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE3 GLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHL
:::::.:::::.. .:. . .:.: :.::::.: :: :::... :. :..:.:::::
NP_005 GLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHL
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE3 KDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL
:::.::.::.:: : ::.... :: :: ...::: :: :: ::.::.:::::::::
NP_005 KDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE3 FYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVF
.:::::::::::::::: .. : .: . :.::.:: ::.:::: :...::...:.:::
NP_005 YYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVF
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE3 KNYDPEGRGTISQEDFERLSGNFPFA-CHGLHPPPRQGRGSFSREELTGYLLRASAICSK
:::: . : ::::.::.....:::. : . :.: .::.:.:.:..:::.: ::
NP_005 KNYDHDQDGYISQEEFEKIAASFPFSFC--VMDKDREGL--ISRDEITAYFMRASSIYSK
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE3 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP
:::.: :.:.:.:. ::::::.:.:::::: ::::::..::. :::.:.: : :::::
NP_005 LGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR-
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE3 GAKGDAGPPGAPVPSTPAPH-ASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWET
::. ..: . :. . : :... : :: :
NP_005 -AKNPVAPTENNTSVGPVSNLCSLGAKD-----LLHAPEEGPFTFPNGEAVEHGEESKDR
600 610 620 630 640
660 670
pF1KE3 DTVPCPVMDPPSTASSKLDS
NP_005 TIMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPS
650 660 670 680 690 700
>>XP_016877349 (OMIM: 603962) PREDICTED: RAS guanyl-rele (749 aa)
initn: 1877 init1: 1483 opt: 1884 Z-score: 1623.7 bits: 311.0 E(85289): 1.1e-83
Smith-Waterman score: 1885; 49.2% identity (76.3% similar) in 591 aa overlap (46-634:3-581)
20 30 40 50 60 70
pF1KE3 GKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSL
..:: :..:. : :.:...::::::. :.:
XP_016 MMVSLGHLAKGA-SLDDLIDSCIQSFDADGNL
10 20 30
80 90 100 110 120 130
pF1KE3 CHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEV
:. ...:...:.:: :. ::.: ...: :. : . .. :.::..::::. . .
XP_016 CRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVM
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 MHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSL
...: .: ... .: : .:. . :: :.... . . . .:::::::
XP_016 FKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSL
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 LFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQ
:::::: ::..:::::::.::. :. .: ..:.... :. :..: :..: :..:.:::
XP_016 LFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQ
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE3 VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPD
.:::::: : ::.:. :::.:::.::::::::::::: ::::::.:::::.. .:. .
XP_016 LMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHE
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE3 STKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLH
.:.: :.::::.: :: :::... :. :..:.::::::::.::.::.:: : ::...
XP_016 INKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVN
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE3 LPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPK
. :: :: ...::: :: :: ::.::.:::::::::.:::::::::::::::: .
XP_016 VHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHR
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE3 SLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLS
. : .: . :.::.:: ::.:::: :...::...:.::::::: . : ::::.::...
XP_016 APPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIA
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE3 GNFPFA-CHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFC
..:::. : . :.: .::.:.:.:..:::.: :::::.: :.:.:.:. :::::
XP_016 ASFPFSFC--VMDKDREGL--ISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFC
460 470 480 490 500
560 570 580 590 600 610
pF1KE3 DSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPH
:.:.:::::: ::::::..::. :::.:.: : ::::: ::. ..: . :. .
XP_016 DNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR--AKNPVAPTENNTSVGPVSN
510 520 530 540 550 560
620 630 640 650 660 670
pF1KE3 -ASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
: :... : :: :
XP_016 LCSLGAKD-----LLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKISLRLKRAV
570 580 590 600 610 620
673 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:36:05 2016 done: Sun Nov 6 10:36:07 2016
Total Scan time: 13.740 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]