Result of FASTA (omim) for
pFN21AE3264
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3264, 643 aa
1>>>pF1KE3264 643 - 643 aa - 643 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5593+/-0.000372; mu= 15.8961+/- 0.023
mean_var=148.7316+/-31.212, 0's: 0 Z-trim(117.9): 178 B-trim: 1618 in 2/53
Lambda= 0.105165
statistics sampled from 30103 (30393) to 30103 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.356), width: 16
Scan time: 12.230
The best scores are: opt bits E(85289)
NP_001135 (OMIM: 603243) E3 ubiquitin-protein liga ( 643) 4317 667.1 5.3e-191
XP_005255947 (OMIM: 603243) PREDICTED: E3 ubiquiti ( 548) 3670 568.9 1.7e-161
NP_001310440 (OMIM: 603243) E3 ubiquitin-protein l ( 548) 3670 568.9 1.7e-161
NP_001310441 (OMIM: 603243) E3 ubiquitin-protein l ( 675) 2935 457.5 7.3e-128
NP_115807 (OMIM: 608046) E3 ubiquitin-protein liga ( 616) 437 78.4 8.4e-14
NP_757385 (OMIM: 608046) E3 ubiquitin-protein liga ( 617) 437 78.4 8.4e-14
XP_011543605 (OMIM: 608046) PREDICTED: E3 ubiquiti ( 617) 437 78.4 8.4e-14
XP_016868491 (OMIM: 144700,603046) PREDICTED: E3 u ( 537) 216 44.8 0.00095
NP_009149 (OMIM: 144700,603046) E3 ubiquitin-prote ( 664) 216 44.9 0.0011
XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquiti ( 284) 198 41.8 0.004
NP_919442 (OMIM: 615177) E3 ubiquitin-protein liga ( 311) 198 41.8 0.0043
>>NP_001135 (OMIM: 603243) E3 ubiquitin-protein ligase A (643 aa)
initn: 4317 init1: 4317 opt: 4317 Z-score: 3550.0 bits: 667.1 E(85289): 5.3e-191
Smith-Waterman score: 4317; 100.0% identity (100.0% similar) in 643 aa overlap (1-643:1-643)
10 20 30 40 50 60
pF1KE3 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 FFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 QLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 LSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNK
550 560 570 580 590 600
610 620 630 640
pF1KE3 SSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
:::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
610 620 630 640
>>XP_005255947 (OMIM: 603243) PREDICTED: E3 ubiquitin-pr (548 aa)
initn: 3670 init1: 3670 opt: 3670 Z-score: 3020.4 bits: 568.9 E(85289): 1.7e-161
Smith-Waterman score: 3670; 100.0% identity (100.0% similar) in 548 aa overlap (96-643:1-548)
70 80 90 100 110 120
pF1KE3 GGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNF
::::::::::::::::::::::::::::::
XP_005 MLVAKLIQCIVFGPLRVSERQHLKDKFWNF
10 20 30
130 140 150 160 170 180
pF1KE3 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE3 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE3 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE3 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE3 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE3 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE3 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE3 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD
460 470 480 490 500 510
610 620 630 640
pF1KE3 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
::::::::::::::::::::::::::::::::::::::
XP_005 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
520 530 540
>>NP_001310440 (OMIM: 603243) E3 ubiquitin-protein ligas (548 aa)
initn: 3670 init1: 3670 opt: 3670 Z-score: 3020.4 bits: 568.9 E(85289): 1.7e-161
Smith-Waterman score: 3670; 100.0% identity (100.0% similar) in 548 aa overlap (96-643:1-548)
70 80 90 100 110 120
pF1KE3 GGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNF
::::::::::::::::::::::::::::::
NP_001 MLVAKLIQCIVFGPLRVSERQHLKDKFWNF
10 20 30
130 140 150 160 170 180
pF1KE3 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGR
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE3 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLN
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE3 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEV
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE3 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE3 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFD
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE3 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRS
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE3 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRL
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE3 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDD
460 470 480 490 500 510
610 620 630 640
pF1KE3 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
::::::::::::::::::::::::::::::::::::::
NP_001 AASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
520 530 540
>>NP_001310441 (OMIM: 603243) E3 ubiquitin-protein ligas (675 aa)
initn: 4303 init1: 2935 opt: 2935 Z-score: 2416.6 bits: 457.5 E(85289): 7.3e-128
Smith-Waterman score: 4243; 95.3% identity (95.3% similar) in 675 aa overlap (1-643:1-675)
10 20 30 40 50 60
pF1KE3 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH
370 380 390 400 410 420
430 440
pF1KE3 FFHFDG--------------------------------SRIASWLPSFSVEVMHTTNILG
:::::: ::::::::::::::::::::::
NP_001 FFHFDGDDSSMRVTAPEDVPVGQEVEVVDSDTDAPDLWSRIASWLPSFSVEVMHTTNILG
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE3 ITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE3 SIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIRPALNSPVERPSSDQEEGETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARG
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE3 SRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRFSKSADERQRMLVQRKDELLQQARKRFLNKSSEDDAASESFLPSEGASSDPVTLRRRM
610 620 630 640 650 660
630 640
pF1KE3 LAAAAERRLQKQQTS
:::::::::::::::
NP_001 LAAAAERRLQKQQTS
670
>>NP_115807 (OMIM: 608046) E3 ubiquitin-protein ligase s (616 aa)
initn: 444 init1: 180 opt: 437 Z-score: 368.8 bits: 78.4 E(85289): 8.4e-14
Smith-Waterman score: 438; 28.8% identity (58.8% similar) in 320 aa overlap (76-382:35-333)
50 60 70 80 90 100
pF1KE3 PDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCI
:: ..: . :: : ...:..:.. .
NP_115 AVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKV
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE3 VFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLC
:: ::..: .:: .. : . . . : :. . . : :. :.::. . :
NP_115 FFGQLRAAEMEHLLERSW-YAVTETCLAFTVFRDDFSPRFVAL---FTLLLFLKCFHWLA
70 80 90 100 110 120
170 180 190 200 210
pF1KE3 KDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHT------LAFM
.:: ... ::. : :..::. . :. .. :.. : :.:
NP_115 EDRVDFMERSPNISWLFHCRIVSLMFLL-----GILDFLFVSHAYHSILTRGASVQLVFG
130 140 150 160 170
220 230 240 250 260 270
pF1KE3 AAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTD----FVMELTLLS-LDLM
..:.:. . ....::.: ::. :. :..:..:. ::. :. : .. . .:
NP_115 FEYAILMTM-VLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIM
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE3 HHIHML-LFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEE
..: . :: : ... .: . . : : . :.. ::.. . :::::
NP_115 IKVHTFPLF-------AIRPMYLAMRQFKKAVTDAIMSR----RAIRNMNTLYPDATPEE
240 250 260 270 280
340 350 360 370 380 390
pF1KE3 LAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVRE
: . .. : :: . : .:..:::.:.::.::::::.... .::::::..
NP_115 LQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSP
290 300 310 320 330 340
400 410 420 430 440 450
pF1KE3 EHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQA
NP_115 PPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEA
350 360 370 380 390 400
>>NP_757385 (OMIM: 608046) E3 ubiquitin-protein ligase s (617 aa)
initn: 433 init1: 169 opt: 437 Z-score: 368.8 bits: 78.4 E(85289): 8.4e-14
Smith-Waterman score: 438; 28.8% identity (58.8% similar) in 320 aa overlap (76-382:35-333)
50 60 70 80 90 100
pF1KE3 PDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCI
:: ..: . :: : ...:..:.. .
NP_757 AVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKV
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE3 VFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLC
:: ::..: .:: .. : . . . : :. . . : :. :.::. . :
NP_757 FFGQLRAAEMEHLLERSW-YAVTETCLAFTVFRDDFSPRFVAL---FTLLLFLKCFHWLA
70 80 90 100 110 120
170 180 190 200 210
pF1KE3 KDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHT------LAFM
.:: ... ::. : :..::. . :. .. :.. : :.:
NP_757 EDRVDFMERSPNISWLFHCRIVSLMFLL-----GILDFLFVSHAYHSILTRGASVQLVFG
130 140 150 160 170
220 230 240 250 260 270
pF1KE3 AAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTD----FVMELTLLS-LDLM
..:.:. . ....::.: ::. :. :..:..:. ::. :. : .. . .:
NP_757 FEYAILMTM-VLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIM
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE3 HHIHML-LFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEE
..: . :: : ... .: . . : : . :.. ::.. . :::::
NP_757 IKVHTFPLF-------AIRPMYLAMRQFKKAVTDAIMSR----RAIRNMNTLYPDATPEE
240 250 260 270 280
340 350 360 370 380 390
pF1KE3 LAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVRE
: . .. : :: . : .:..:::.:.::.::::::.... .::::::..
NP_757 LQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSP
290 300 310 320 330 340
400 410 420 430 440 450
pF1KE3 EHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQA
NP_757 PPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEA
350 360 370 380 390 400
>>XP_011543605 (OMIM: 608046) PREDICTED: E3 ubiquitin-pr (617 aa)
initn: 433 init1: 169 opt: 437 Z-score: 368.8 bits: 78.4 E(85289): 8.4e-14
Smith-Waterman score: 438; 28.8% identity (58.8% similar) in 320 aa overlap (76-382:35-333)
50 60 70 80 90 100
pF1KE3 PDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCI
:: ..: . :: : ...:..:.. .
XP_011 AVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKV
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE3 VFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLC
:: ::..: .:: .. : . . . : :. . . : :. :.::. . :
XP_011 FFGQLRAAEMEHLLERSW-YAVTETCLAFTVFRDDFSPRFVAL---FTLLLFLKCFHWLA
70 80 90 100 110 120
170 180 190 200 210
pF1KE3 KDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHT------LAFM
.:: ... ::. : :..::. . :. .. :.. : :.:
XP_011 EDRVDFMERSPNISWLFHCRIVSLMFLL-----GILDFLFVSHAYHSILTRGASVQLVFG
130 140 150 160 170
220 230 240 250 260 270
pF1KE3 AAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTD----FVMELTLLS-LDLM
..:.:. . ....::.: ::. :. :..:..:. ::. :. : .. . .:
XP_011 FEYAILMTM-VLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIM
180 190 200 210 220 230
280 290 300 310 320 330
pF1KE3 HHIHML-LFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEE
..: . :: : ... .: . . : : . :.. ::.. . :::::
XP_011 IKVHTFPLF-------AIRPMYLAMRQFKKAVTDAIMSR----RAIRNMNTLYPDATPEE
240 250 260 270 280
340 350 360 370 380 390
pF1KE3 LAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSLNIADNNRVRE
: . .. : :: . : .:..:::.:.::.::::::.... .::::::..
XP_011 LQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSP
290 300 310 320 330 340
400 410 420 430 440 450
pF1KE3 EHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQA
XP_011 PPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEA
350 360 370 380 390 400
>>XP_016868491 (OMIM: 144700,603046) PREDICTED: E3 ubiqu (537 aa)
initn: 208 init1: 143 opt: 216 Z-score: 188.3 bits: 44.8 E(85289): 0.00095
Smith-Waterman score: 221; 23.5% identity (53.0% similar) in 319 aa overlap (126-419:203-506)
100 110 120 130 140 150
pF1KE3 MLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVM----WCLW
.:. . . :. ... :... ::
XP_016 SVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLL
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE3 FAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTH
.... ::.. . . :: : .. . : :: . . ... : .. : . . :
XP_016 LTAV--LHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFI----LPVLLSYVLWHH
240 250 260 270 280
220 230 240 250 260
pF1KE3 -GMHTLAF-MAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYY---TDFVMEL
...: : ..: . . ... . :.. . : .. :: :::: : ..:.
XP_016 YALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEF
290 300 310 320 330 340
270 280 290 300 310 320
pF1KE3 TLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARF
. . . . . ..: : ... ::. . . .. . :: .. :. :
XP_016 IFGVVMFGNGAYTMMFE----SGSKIRAFMMCLHAYFNIYLQA---KNGWKTF--MNRRT
350 360 370 380 390
330 340 350 360 370
pF1KE3 AV----ATPE----ELAVNNDDCAICWDSMQ-AARKLPCGHLFHNSCLRSWLEQDTSCPT
:: . :: .: :: ::::. . .:: ::.: :: :::.:: . .::
XP_016 AVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPM
400 410 420 430 440 450
380 390 400 410 420 430
pF1KE3 CRMSL----NIADNNRVREEH---QGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIA
:.... .: ::. : ... .. :. : ::::. .::. .
XP_016 CHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRE
460 470 480 490 500 510
440 450 460 470 480 490
pF1KE3 SWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITT
XP_016 RNGVIQHTGAAAEEFNDDTD
520 530
>>NP_009149 (OMIM: 144700,603046) E3 ubiquitin-protein l (664 aa)
initn: 208 init1: 143 opt: 216 Z-score: 187.2 bits: 44.9 E(85289): 0.0011
Smith-Waterman score: 221; 23.5% identity (53.0% similar) in 319 aa overlap (126-419:330-633)
100 110 120 130 140 150
pF1KE3 MLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVM----WCLW
.:. . . :. ... :... ::
NP_009 SVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLL
300 310 320 330 340 350
160 170 180 190 200 210
pF1KE3 FAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTH
.... ::.. . . :: : .. . : :: . . ... : .. : . . :
NP_009 LTAV--LHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFI----LPVLLSYVLWHH
360 370 380 390 400 410
220 230 240 250 260
pF1KE3 -GMHTLAF-MAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYY---TDFVMEL
...: : ..: . . ... . :.. . : .. :: :::: : ..:.
NP_009 YALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEF
420 430 440 450 460 470
270 280 290 300 310 320
pF1KE3 TLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARF
. . . . . ..: : ... ::. . . .. . :: .. :. :
NP_009 IFGVVMFGNGAYTMMFE----SGSKIRAFMMCLHAYFNIYLQA---KNGWKTF--MNRRT
480 490 500 510 520
330 340 350 360 370
pF1KE3 AV----ATPE----ELAVNNDDCAICWDSMQ-AARKLPCGHLFHNSCLRSWLEQDTSCPT
:: . :: .: :: ::::. . .:: ::.: :: :::.:: . .::
NP_009 AVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPM
530 540 550 560 570 580
380 390 400 410 420 430
pF1KE3 CRMSL----NIADNNRVREEH---QGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIA
:.... .: ::. : ... .. :. : ::::. .::. .
NP_009 CHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRE
590 600 610 620 630 640
440 450 460 470 480 490
pF1KE3 SWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQLTRSVEITT
NP_009 RNGVIQHTGAAAEEFNDDTD
650 660
>>XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquitin-pr (284 aa)
initn: 193 init1: 170 opt: 198 Z-score: 177.0 bits: 41.8 E(85289): 0.004
Smith-Waterman score: 198; 41.7% identity (68.1% similar) in 72 aa overlap (322-387:183-254)
300 310 320 330 340
pF1KE3 LVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSM---
..: .: . :: . .. .: .: :..
XP_005 AWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALG
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE3 QAARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSL---NIADNNRVREEHQGENLDENLVP
. .:.:::.::::..:. :::: :::.:: :: : : :
XP_005 ERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSS
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE3 VAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQ
XP_005 SSPSNENATSNS
280
643 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:38:14 2016 done: Sun Nov 6 01:38:16 2016
Total Scan time: 12.230 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]