Result of FASTA (omim) for
pFN21AE3252
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3252, 588 aa
1>>>pF1KE3252 588 - 588 aa - 588 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5009+/-0.000414; mu= 19.8215+/- 0.026
mean_var=95.3417+/-18.756, 0's: 0 Z-trim(113.1): 46 B-trim: 0 in 0/54
Lambda= 0.131351
statistics sampled from 22236 (22280) to 22236 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.619), E-opt: 0.2 (0.261), width: 16
Scan time: 8.140
The best scores are: opt bits E(85289)
NP_057700 (OMIM: 607421,610852) thioredoxin domain ( 588) 3815 733.7 4e-211
XP_005272156 (OMIM: 603575) PREDICTED: nucleoside ( 148) 311 69.1 1.1e-11
XP_006714779 (OMIM: 603575) PREDICTED: nucleoside ( 149) 307 68.4 1.9e-11
NP_003542 (OMIM: 603575) nucleoside diphosphate ki ( 212) 305 68.2 3.2e-11
XP_016865434 (OMIM: 603575) PREDICTED: nucleoside ( 278) 305 68.3 3.9e-11
NP_001295355 (OMIM: 608294) nucleoside diphosphate ( 186) 275 62.4 1.5e-09
NP_001295357 (OMIM: 608294) nucleoside diphosphate ( 186) 275 62.4 1.5e-09
NP_001295356 (OMIM: 608294) nucleoside diphosphate ( 186) 275 62.4 1.5e-09
XP_016861003 (OMIM: 608294) PREDICTED: nucleoside ( 186) 275 62.4 1.5e-09
XP_016861002 (OMIM: 608294) PREDICTED: nucleoside ( 190) 275 62.4 1.5e-09
NP_005784 (OMIM: 608294) nucleoside diphosphate ki ( 194) 275 62.4 1.6e-09
NP_932076 (OMIM: 613465) nucleoside diphosphate ki ( 340) 274 62.5 2.7e-09
XP_016856588 (OMIM: 613465) PREDICTED: nucleoside ( 367) 274 62.5 2.8e-09
NP_037462 (OMIM: 613465) nucleoside diphosphate ki ( 376) 274 62.5 2.9e-09
NP_001295363 (OMIM: 608294) nucleoside diphosphate ( 141) 234 54.5 2.7e-07
NP_005000 (OMIM: 601818) nucleoside diphosphate ki ( 187) 190 46.3 0.00011
XP_016861007 (OMIM: 608294) PREDICTED: nucleoside ( 111) 184 45.0 0.00016
XP_016861006 (OMIM: 608294) PREDICTED: nucleoside ( 114) 182 44.6 0.00021
XP_016856589 (OMIM: 613465) PREDICTED: nucleoside ( 252) 185 45.5 0.00026
XP_005245163 (OMIM: 613465) PREDICTED: nucleoside ( 252) 185 45.5 0.00026
XP_016861001 (OMIM: 608294) PREDICTED: nucleoside ( 264) 182 44.9 0.00039
NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 172 42.7 0.00075
NP_001273368 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011
NP_001273365 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011
NP_001273367 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011
NP_001273369 (OMIM: 601818) nucleoside diphosphate ( 117) 170 42.3 0.0011
>>NP_057700 (OMIM: 607421,610852) thioredoxin domain-con (588 aa)
initn: 3815 init1: 3815 opt: 3815 Z-score: 3911.3 bits: 733.7 E(85289): 4e-211
Smith-Waterman score: 3815; 99.7% identity (99.7% similar) in 588 aa overlap (1-588:1-588)
10 20 30 40 50 60
pF1KE3 MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 ILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 AAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 GFIIEAEHKTVLTEEQVVNFYSRIADQRDFEEFVSFMTSGLSYILVVSQGSKHNPPSEET
::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
NP_057 GFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEET
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 EPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 DAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 FAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 TQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD
490 500 510 520 530 540
550 560 570 580
pF1KE3 PEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
550 560 570 580
>>XP_005272156 (OMIM: 603575) PREDICTED: nucleoside diph (148 aa)
initn: 525 init1: 252 opt: 311 Z-score: 330.5 bits: 69.1 E(85289): 1.1e-11
Smith-Waterman score: 311; 38.4% identity (68.8% similar) in 138 aa overlap (450-587:12-146)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD
...::..::: . ...:.: :. ..::
XP_005 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT
10 20 30 40
480 490 500 510 520 530
pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT
..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::.
XP_005 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
. :: :::.:: .: . :.: .:: :: . : : : : :::
XP_005 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEEKL
110 120 130 140
>>XP_006714779 (OMIM: 603575) PREDICTED: nucleoside diph (149 aa)
initn: 525 init1: 252 opt: 307 Z-score: 326.4 bits: 68.4 E(85289): 1.9e-11
Smith-Waterman score: 307; 37.7% identity (68.8% similar) in 138 aa overlap (450-587:12-146)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD
...::..::: . ...:.: :. ..::
XP_006 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT
10 20 30 40
480 490 500 510 520 530
pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT
..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::.
XP_006 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
. :: :::.:: .: . :.: .:: :: . : : : : ::.
XP_006 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEDLAS
110 120 130 140
>>NP_003542 (OMIM: 603575) nucleoside diphosphate kinase (212 aa)
initn: 525 init1: 252 opt: 305 Z-score: 322.4 bits: 68.2 E(85289): 3.2e-11
Smith-Waterman score: 305; 38.0% identity (68.6% similar) in 137 aa overlap (450-586:12-145)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD
...::..::: . ...:.: :. ..::
NP_003 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT
10 20 30 40
480 490 500 510 520 530
pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT
..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::.
NP_003 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
. :: :::.:: .: . :.: .:: :: . : : : : ::
NP_003 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEVIVEPIPIGQAAK
110 120 130 140 150
NP_003 DYLNLHIMPTLLEGLTELCKQKPADPLIWLADWLLKNNPNKPKLCHHPIVEEPY
160 170 180 190 200 210
>>XP_016865434 (OMIM: 603575) PREDICTED: nucleoside diph (278 aa)
initn: 529 init1: 252 opt: 305 Z-score: 320.8 bits: 68.3 E(85289): 3.9e-11
Smith-Waterman score: 305; 38.0% identity (68.6% similar) in 137 aa overlap (450-586:12-145)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFD
...::..::: . ...:.: :. ..::
XP_016 MEISMPPPQIYVEKTLAIIKPDIV-DKEEEIQDIILRSGFT
10 20 30 40
480 490 500 510 520 530
pF1KE3 LTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPT
..: .:. :.::: ..: . :: :. .: ..: :: ..:::.. .:.. : .:.::.
XP_016 IVQRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPN
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 DPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
. :: :::.:: .: . :.: .:: :: . : : : : ::
XP_016 NSLVAKETHPDSLRAIYGTDDLRNALHG-SNDFAAAEREIR-FMFPEVIVEPIPIGQAAK
110 120 130 140 150
XP_016 DYLNLHIMPTLLEGLTELCKQKPADPLFWYMCCRREHWTLRSILLVCMSGIRMSLPHCAD
160 170 180 190 200 210
>>NP_001295355 (OMIM: 608294) nucleoside diphosphate kin (186 aa)
initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09
Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG
:: ::.:::: :... : . . .
NP_001 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK
10 20 30 40
480 490 500 510 520 530
pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG
: ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: :::
NP_001 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
:: .:. ..:::::..::.. .: .::.... :.. . .: : :
NP_001 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ
110 120 130 140 150 160
NP_001 LRCGPVCYSPEGGVHYVAGTGGLGPA
170 180
>>NP_001295357 (OMIM: 608294) nucleoside diphosphate kin (186 aa)
initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09
Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG
:: ::.:::: :... : . . .
NP_001 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK
10 20 30 40
480 490 500 510 520 530
pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG
: ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: :::
NP_001 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
:: .:. ..:::::..::.. .: .::.... :.. . .: : :
NP_001 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ
110 120 130 140 150 160
NP_001 LRCGPVCYSPEGGVHYVAGTGGLGPA
170 180
>>NP_001295356 (OMIM: 608294) nucleoside diphosphate kin (186 aa)
initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09
Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG
:: ::.:::: :... : . . .
NP_001 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK
10 20 30 40
480 490 500 510 520 530
pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG
: ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: :::
NP_001 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
:: .:. ..:::::..::.. .: .::.... :.. . .: : :
NP_001 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ
110 120 130 140 150 160
NP_001 LRCGPVCYSPEGGVHYVAGTGGLGPA
170 180
>>XP_016861003 (OMIM: 608294) PREDICTED: nucleoside diph (186 aa)
initn: 418 init1: 211 opt: 275 Z-score: 292.4 bits: 62.4 E(85289): 1.5e-09
Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:11-150)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG
:: ::.:::: :... : . . .
XP_016 MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK
10 20 30 40
480 490 500 510 520 530
pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG
: ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: :::
XP_016 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
:: .:. ..:::::..::.. .: .::.... :.. . .: : :
XP_016 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ
110 120 130 140 150 160
XP_016 LRCGPVCYSPEGGVHYVAGTGGLGPA
170 180
>>XP_016861002 (OMIM: 608294) PREDICTED: nucleoside diph (190 aa)
initn: 418 init1: 211 opt: 275 Z-score: 292.2 bits: 62.4 E(85289): 1.5e-09
Smith-Waterman score: 275; 32.1% identity (67.9% similar) in 140 aa overlap (450-587:15-154)
420 430 440 450 460 470
pF1KE3 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQR--EQILKIVKEAG
:: ::.:::: :... : . . .
XP_016 MRSEMASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNK
10 20 30 40
480 490 500 510 520 530
pF1KE3 FDLTQVKKMFLTPEQTEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMG
: ........ :. ...: . :. ::. :.:... :: ..::.. .:. :: :::
XP_016 FLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMG
50 60 70 80 90 100
540 550 560 570 580
pF1KE3 PTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
:: .:. ..:::::..::.. .: .::.... :.. . .: : :
XP_016 PTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQ
110 120 130 140 150 160
XP_016 LRCGPVCYSPEGGVHYVAGTGGLGPA
170 180 190
588 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:48:58 2016 done: Mon Nov 7 18:48:59 2016
Total Scan time: 8.140 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]