Result of FASTA (omim) for
pFN21AE3215
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3215, 491 aa
1>>>pF1KE3215 491 - 491 aa - 491 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.5176+/-0.000512; mu= -26.8773+/- 0.032
mean_var=837.2885+/-177.334, 0's: 0 Z-trim(125.6): 95 B-trim: 937 in 1/59
Lambda= 0.044324
statistics sampled from 49657 (49820) to 49657 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.584), width: 16
Scan time: 9.730
The best scores are: opt bits E(85289)
NP_079090 (OMIM: 606872) E3 ubiquitin-protein liga ( 491) 3705 252.0 2.9e-66
NP_001271220 (OMIM: 606872) E3 ubiquitin-protein l ( 490) 3687 250.8 6.4e-66
XP_016868132 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 531) 3667 249.6 1.6e-65
XP_016868133 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 440) 3363 230.1 1e-59
XP_011514882 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 370) 2848 197.0 7.5e-50
XP_016868134 (OMIM: 606872) PREDICTED: E3 ubiquiti ( 370) 2848 197.0 7.5e-50
>>NP_079090 (OMIM: 606872) E3 ubiquitin-protein ligase H (491 aa)
initn: 3705 init1: 3705 opt: 3705 Z-score: 1310.7 bits: 252.0 E(85289): 2.9e-66
Smith-Waterman score: 3705; 100.0% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KE3 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH
430 440 450 460 470 480
490
pF1KE3 PDQTRYRPYYQ
:::::::::::
NP_079 PDQTRYRPYYQ
490
>>NP_001271220 (OMIM: 606872) E3 ubiquitin-protein ligas (490 aa)
initn: 3315 init1: 3315 opt: 3687 Z-score: 1304.5 bits: 250.8 E(85289): 6.4e-66
Smith-Waterman score: 3687; 99.8% identity (99.8% similar) in 491 aa overlap (1-491:1-490)
10 20 30 40 50 60
pF1KE3 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -GFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG
70 80 90 100 110
130 140 150 160 170 180
pF1KE3 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH
420 430 440 450 460 470
490
pF1KE3 PDQTRYRPYYQ
:::::::::::
NP_001 PDQTRYRPYYQ
480 490
>>XP_016868132 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (531 aa)
initn: 3667 init1: 3667 opt: 3667 Z-score: 1297.1 bits: 249.6 E(85289): 1.6e-65
Smith-Waterman score: 3667; 100.0% identity (100.0% similar) in 486 aa overlap (6-491:46-531)
10 20 30
pF1KE3 MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQA
::::::::::::::::::::::::::::::
XP_016 VWCGTYLLRAGNNRSYSGSAELRARTSGRYNELQGTNSSGSLGGLDVRRRIPIKLISKQA
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE3 NKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQI
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE3 NILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRI
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE3 EQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTE
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE3 IPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE3 SVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIM
320 330 340 350 360 370
340 350 360 370 380 390
pF1KE3 PPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQM
380 390 400 410 420 430
400 410 420 430 440 450
pF1KE3 PPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWP
440 450 460 470 480 490
460 470 480 490
pF1KE3 APRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
::::::::::::::::::::::::::::::::::::
XP_016 APRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
500 510 520 530
>>XP_016868133 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (440 aa)
initn: 3315 init1: 3315 opt: 3363 Z-score: 1193.1 bits: 230.1 E(85289): 1e-59
Smith-Waterman score: 3363; 99.8% identity (99.8% similar) in 441 aa overlap (51-491:1-440)
30 40 50 60 70 80
pF1KE3 DVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFA
:::::::::: :::::::::::::::::::
XP_016 MPAKAPPGDE-GFDYNEEERYDCKGGELFA
10 20
90 100 110 120 130 140
pF1KE3 NQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKK
30 40 50 60 70 80
150 160 170 180 190 200
pF1KE3 GDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRA
90 100 110 120 130 140
210 220 230 240 250 260
pF1KE3 SLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDI
150 160 170 180 190 200
270 280 290 300 310 320
pF1KE3 RAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHP
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE3 EYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSA
270 280 290 300 310 320
390 400 410 420 430 440
pF1KE3 PPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLS
330 340 350 360 370 380
450 460 470 480 490
pF1KE3 PPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
390 400 410 420 430 440
>>XP_011514882 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (370 aa)
initn: 2848 init1: 2848 opt: 2848 Z-score: 1016.0 bits: 197.0 E(85289): 7.5e-50
Smith-Waterman score: 2848; 100.0% identity (100.0% similar) in 370 aa overlap (122-491:1-370)
100 110 120 130 140 150
pF1KE3 DFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDP
::::::::::::::::::::::::::::::
XP_011 MIPCKHVFCYDCAILHEKKGDKMCPGCSDP
10 20 30
160 170 180 190 200 210
pF1KE3 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE3 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE3 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE3 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE3 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP
280 290 300 310 320 330
460 470 480 490
pF1KE3 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
::::::::::::::::::::::::::::::::::::::::
XP_011 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
340 350 360 370
>>XP_016868134 (OMIM: 606872) PREDICTED: E3 ubiquitin-pr (370 aa)
initn: 2848 init1: 2848 opt: 2848 Z-score: 1016.0 bits: 197.0 E(85289): 7.5e-50
Smith-Waterman score: 2848; 100.0% identity (100.0% similar) in 370 aa overlap (122-491:1-370)
100 110 120 130 140 150
pF1KE3 DFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDP
::::::::::::::::::::::::::::::
XP_016 MIPCKHVFCYDCAILHEKKGDKMCPGCSDP
10 20 30
160 170 180 190 200 210
pF1KE3 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAP
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE3 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAP
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE3 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHP
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE3 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHI
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE3 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSP
280 290 300 310 320 330
460 470 480 490
pF1KE3 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
::::::::::::::::::::::::::::::::::::::::
XP_016 GIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
340 350 360 370
491 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 19:27:00 2016 done: Mon Nov 7 19:27:02 2016
Total Scan time: 9.730 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]