Result of FASTA (ccds) for
pFN21AE3159
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3159, 378 aa
1>>>pF1KE3159 378 - 378 aa - 378 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8317+/-0.000827; mu= 14.2399+/- 0.050
mean_var=75.7527+/-14.691, 0's: 0 Z-trim(107.7): 20 B-trim: 0 in 0/52
Lambda= 0.147358
statistics sampled from 9743 (9760) to 9743 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.3), width: 16
Scan time: 2.820
The best scores are: opt bits E(32554)
CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 ( 407) 2605 563.1 1.5e-160
CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 ( 291) 1987 431.7 4e-121
CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 ( 241) 1620 353.6 1.1e-97
CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 ( 378) 1264 278.0 9.4e-75
CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 ( 378) 1262 277.6 1.3e-74
CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 ( 284) 504 116.4 3.2e-26
CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 ( 239) 364 86.6 2.5e-17
>>CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 (407 aa)
initn: 2605 init1: 2605 opt: 2605 Z-score: 2995.8 bits: 563.1 E(32554): 1.5e-160
Smith-Waterman score: 2605; 100.0% identity (100.0% similar) in 378 aa overlap (1-378:1-378)
10 20 30 40 50 60
pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS22 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS22 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS22 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS22 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS22 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS22 PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ
310 320 330 340 350 360
370
pF1KE3 NLVDRRLQVNRKKQVKMH
::::::::::::::::::
CCDS22 NLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSNMVSTLLSQD
370 380 390 400
>>CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 (291 aa)
initn: 1987 init1: 1987 opt: 1987 Z-score: 2288.0 bits: 431.7 E(32554): 4e-121
Smith-Waterman score: 1987; 100.0% identity (100.0% similar) in 287 aa overlap (1-287:1-287)
10 20 30 40 50 60
pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI
250 260 270 280 290
310 320 330 340 350 360
pF1KE3 PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ
>>CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 (241 aa)
initn: 1620 init1: 1620 opt: 1620 Z-score: 1867.6 bits: 353.6 E(32554): 1.1e-97
Smith-Waterman score: 1620; 100.0% identity (100.0% similar) in 237 aa overlap (51-287:1-237)
30 40 50 60 70 80
pF1KE3 YQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLLEEQVK
::::::::::::::::::::::::::::::
CCDS82 MQWSKEEEAAARKKVKENSAVRVLLEEQVK
10 20 30
90 100 110 120 130 140
pF1KE3 YEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 YEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNR
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE3 FSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 FSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRI
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 LEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 LEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDD
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE3 GLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRF
:::::::::::::::::::::::::::
CCDS82 GLPYPFPDGILDVILLVFVLSSIHPDRTLFI
220 230 240
>>CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 (378 aa)
initn: 1244 init1: 721 opt: 1264 Z-score: 1455.5 bits: 278.0 E(32554): 9.4e-75
Smith-Waterman score: 1264; 54.4% identity (78.2% similar) in 349 aa overlap (31-378:20-361)
10 20 30 40 50 60
pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
.:::.:.:::.::.:: ::...::.:. ::
CCDS58 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAA
10 20 30 40
70 80 90 100 110 120
pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
:..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ...
CCDS58 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE
. : .: . :. . . . : . :..: . :: : : ...: :. ..
CCDS58 NHLK----DWFLENKSEVCECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE3 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV
: . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.:::
CCDS58 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE3 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL
...: : ..:::::::.::. :: : : ::.:.:.::::.. ::.:: ..::::.::
CCDS58 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE3 KPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEK
:::::.:.::::::: .:::::::.::: ::::::::::.::::. :. ..: :.:..
CCDS58 KPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV
290 300 310 320 330 340
360 370
pF1KE3 QNLVDRRLQVNRKKQVKMH
:::::::::::: ::. :.
CCDS58 QNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
350 360 370
>>CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 (378 aa)
initn: 1244 init1: 724 opt: 1262 Z-score: 1453.2 bits: 277.6 E(32554): 1.3e-74
Smith-Waterman score: 1262; 54.7% identity (77.9% similar) in 349 aa overlap (31-378:20-361)
10 20 30 40 50 60
pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
.:::.: :::.::.:: ::...::.:. ::
CCDS45 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAA
10 20 30 40
70 80 90 100 110 120
pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
:..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ...
CCDS45 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE
. : .: . :. . . . : . :..: . :: : : ...: :. ..
CCDS45 NHLK----DWFLENKSEVPECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTLPVEENV-TQ
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE3 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV
: . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.:::
CCDS45 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE3 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL
...: : ..:::::::.::. :: : : ::.:.:.::::.: ::.:: ..::::.::
CCDS45 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE3 KPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEK
:::::.:.::::::: .:::::::.::: ::::::::::.::::. :. ..: :.:..
CCDS45 KPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV
290 300 310 320 330 340
360 370
pF1KE3 QNLVDRRLQVNRKKQVKMH
:::::::::::: ::. :.
CCDS45 QNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
350 360 370
>>CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 (284 aa)
initn: 630 init1: 443 opt: 504 Z-score: 584.3 bits: 116.4 E(32554): 3.2e-26
Smith-Waterman score: 515; 34.1% identity (53.8% similar) in 320 aa overlap (54-373:16-253)
30 40 50 60 70 80
pF1KE3 GYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLLEEQVKYER
:.::: :.:..... ...: : :.
CCDS43 MASLQRKGLQARILTSEEEE-----KLKRDQTLVSDFKQQ-KLEQ
10 20 30
90 100 110 120 130 140
pF1KE3 EASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSR
::.: :: ::: ....:::::.: ::: :.
CCDS43 EAQKNWDLFYKRNSTNFFKDRHWTTREFEEL-----------------------------
40 50 60 70
150 160 170 180 190 200
pF1KE3 MHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEV
: :.: . .::.
CCDS43 RSCREFEDQK--------------------------------------------LTMLEA
80
210 220 230 240 250 260
pF1KE3 GCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLP
:::.:: .::.: :..:. : : :::. :.: ::.. : . .: .: :. : :
CCDS43 GCGVGNCLFPLL---EEDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLL
90 100 110 120 130 140
270 280 290 300 310 320
pF1KE3 YPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKG
: .::..:.::::..:::.:. :.. . :.:::: .:::::: ::...:::: .
CCDS43 DHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKAS
150 160 170 180 190 200
330 340 350 360 370
pF1KE3 HCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQNLVDRRLQVNRKKQVKMH
:.:::::: ::::.:::: . ..: .. .: : : ::.:.
CCDS43 SKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQ
210 220 230 240 250 260
CCDS43 SKFLKPPKNPSPVVLGLDPKS
270 280
>>CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 (239 aa)
initn: 492 init1: 334 opt: 364 Z-score: 424.6 bits: 86.6 E(32554): 2.5e-17
Smith-Waterman score: 364; 45.0% identity (69.0% similar) in 129 aa overlap (245-373:80-208)
220 230 240 250 260 270
pF1KE3 LNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVI
: . .: .: :. : : : .::.
CCDS77 KRNSTNFFKDRHWTTREFEELRSCREQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVV
50 60 70 80 90 100
280 290 300 310 320 330
pF1KE3 LLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRG
.:.::::..:::.:. :.. . :.:::: .:::::: ::...:::: . :.::::::
CCDS77 MLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQ
110 120 130 140 150 160
340 350 360 370
pF1KE3 DGTRAYFFTKGEVHSMFCKASLDEKQNLVDRRLQVNRKKQVKMH
::::.:::: . ..: .. .: : : ::.:.
CCDS77 DGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPS
170 180 190 200 210 220
CCDS77 PVVLGLDPKS
230
378 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:20:42 2016 done: Mon Nov 7 03:20:42 2016
Total Scan time: 2.820 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]