FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE3136, 348 aa
  1>>>pF1KE3136 348 - 348 aa - 348 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.8551+/-0.000316; mu= 13.7438+/- 0.020
 mean_var=78.8453+/-15.840, 0's: 0 Z-trim(117.6): 31  B-trim: 0 in 0/55
 Lambda= 0.144440
 statistics sampled from 29657 (29687) to 29657 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.348), width:  16
 Scan time:  6.240

The best scores are:                                      opt bits E(85289)
NP_061036 (OMIM: 612023) ubiquitin thioesterase OT ( 348) 2373 503.7 2.4e-142
NP_001263249 (OMIM: 612023) ubiquitin thioesterase ( 304) 1930 411.4 1.3e-114
NP_079330 (OMIM: 611745) deubiquitinating protein  (1222)  157 42.2   0.007


>>NP_061036 (OMIM: 612023) ubiquitin thioesterase OTU1 i  (348 aa)
 initn: 2373 init1: 2373 opt: 2373  Z-score: 2676.6  bits: 503.7 E(85289): 2.4e-142
Smith-Waterman score: 2373; 100.0% identity (100.0% similar) in 348 aa overlap (1-348:1-348)

               10        20        30        40        50        60
pF1KE3 MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE3 QGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLII
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE3 EEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE3 EMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVD
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE3 TQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 TQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALEL
              250       260       270       280       290       300

              310       320       330       340        
pF1KE3 ADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 ADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV
              310       320       330       340        

>>NP_001263249 (OMIM: 612023) ubiquitin thioesterase OTU  (304 aa)
 initn: 1929 init1: 1929 opt: 1930  Z-score: 2178.6  bits: 411.4 E(85289): 1.3e-114
Smith-Waterman score: 1930; 95.4% identity (97.7% similar) in 305 aa overlap (44-348:2-304)

            20        30        40        50        60        70   
pF1KE3 PAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVLQGLSSRTRVRELQ
                                     .:.  .  .::. :  ..::::::::::::
NP_001                              METLHIIYSEAKSFT--VEGLSSRTRVRELQ
                                            10          20         

            80        90       100       110       120       130   
pF1KE3 GQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAF
      30        40        50        60        70        80         

           140       150       160       170       180       190   
pF1KE3 TKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASD
      90       100       110       120       130       140         

           200       210       220       230       240       250   
pF1KE3 PDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDA
     150       160       170       180       190       200         

           260       270       280       290       300       310   
pF1KE3 GYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDV
     210       220       230       240       250       260         

           320       330       340        
pF1KE3 NRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV
       :::::::::::::::::::::::::::::::::::
NP_001 NRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV
     270       280       290       300    

>>NP_079330 (OMIM: 611745) deubiquitinating protein VCIP  (1222 aa)
 initn: 133 init1: 133 opt: 157  Z-score: 172.7  bits: 42.2 E(85289): 0.007
Smith-Waterman score: 157; 28.7% identity (52.4% similar) in 143 aa overlap (6-148:740-876)

                                        10        20        30     
pF1KE3                          MFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAG
                                     ::.   : :.    :  :  :. :::    
NP_079 SKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTIRDGPSSAPATPTKA----
     710       720       730       740       750       760         

          40        50        60        70        80        90     
pF1KE3 AWPVGSRTDTMWRLRCKAKDGTHVLQGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPP
         : .  :.   ..:  ..:: . .  :.: :   ::: .::   .: :  : :  :.::
NP_079 --PYSPTTSKEKKIRITTNDGRQSMVTLKSSTTFFELQESIAREFNIPPYLQCIRYGFPP
           770       780       790       800       810       820   

         100       110       120       130       140       150     
pF1KE3 ECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVP
       . :   ..    : .:.: :: . ::  ... ... . . ..: .  .: . :       
NP_079 KELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHTVKQEDIAVTGKLSSK
           830       840       850       860       870       880   

         160       170       180       190       200       210     
pF1KE3 ADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKR
                                                                   
NP_079 ELQEQAEKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYSIMKKTMGMADGKHCTFP
           890       900       910       920       930       940   




348 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 16:42:50 2016 done: Mon Nov  7 16:42:51 2016
 Total Scan time:  6.240 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]