Result of FASTA (omim) for
pFN21AE3113
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3113, 286 aa
1>>>pF1KE3113 286 - 286 aa - 286 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6882+/-0.000414; mu= 10.7139+/- 0.026
mean_var=176.8829+/-36.224, 0's: 0 Z-trim(117.7): 24 B-trim: 712 in 1/54
Lambda= 0.096434
statistics sampled from 29840 (29864) to 29840 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.35), width: 16
Scan time: 6.620
The best scores are: opt bits E(85289)
NP_001099043 (OMIM: 609112) F-box/SPRY domain-cont ( 286) 1974 286.5 3.8e-77
NP_001139788 (OMIM: 611658) SPRY domain-containing ( 263) 540 87.0 4.2e-17
NP_001306599 (OMIM: 611658) SPRY domain-containing ( 263) 540 87.0 4.2e-17
NP_116030 (OMIM: 611658) SPRY domain-containing SO ( 263) 540 87.0 4.2e-17
XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain ( 233) 516 83.6 3.9e-16
NP_543138 (OMIM: 611660) SPRY domain-containing SO ( 273) 516 83.7 4.3e-16
NP_079382 (OMIM: 611657) SPRY domain-containing SO ( 273) 490 80.1 5.3e-15
>>NP_001099043 (OMIM: 609112) F-box/SPRY domain-containi (286 aa)
initn: 1974 init1: 1974 opt: 1974 Z-score: 1505.9 bits: 286.5 E(85289): 3.8e-77
Smith-Waterman score: 1974; 100.0% identity (100.0% similar) in 286 aa overlap (1-286:1-286)
10 20 30 40 50 60
pF1KE3 MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKT
190 200 210 220 230 240
250 260 270 280
pF1KE3 LAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
250 260 270 280
>>NP_001139788 (OMIM: 611658) SPRY domain-containing SOC (263 aa)
initn: 515 init1: 209 opt: 540 Z-score: 428.1 bits: 87.0 E(85289): 4.2e-17
Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (111-282:45-219)
90 100 110 120 130 140
pF1KE3 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS
.:... .:::.:. .:..:. ..: :.:::
NP_001 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS
20 30 40 50 60 70
150 160 170 180 190
pF1KE3 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG
::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...:::
NP_001 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE3 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR
:.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: :::
NP_001 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR
140 150 160 170 180 190
260 270 280
pF1KE3 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
:: ::::::::.:. .: . :::.
NP_001 GLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPL
200 210 220 230 240 250
>>NP_001306599 (OMIM: 611658) SPRY domain-containing SOC (263 aa)
initn: 515 init1: 209 opt: 540 Z-score: 428.1 bits: 87.0 E(85289): 4.2e-17
Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (111-282:45-219)
90 100 110 120 130 140
pF1KE3 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS
.:... .:::.:. .:..:. ..: :.:::
NP_001 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS
20 30 40 50 60 70
150 160 170 180 190
pF1KE3 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG
::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...:::
NP_001 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE3 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR
:.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: :::
NP_001 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR
140 150 160 170 180 190
260 270 280
pF1KE3 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
:: ::::::::.:. .: . :::.
NP_001 GLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPL
200 210 220 230 240 250
>>NP_116030 (OMIM: 611658) SPRY domain-containing SOCS b (263 aa)
initn: 515 init1: 209 opt: 540 Z-score: 428.1 bits: 87.0 E(85289): 4.2e-17
Smith-Waterman score: 540; 46.3% identity (75.1% similar) in 177 aa overlap (111-282:45-219)
90 100 110 120 130 140
pF1KE3 SLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQS
.:... .:::.:. .:..:. ..: :.:::
NP_116 TPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQS
20 30 40 50 60 70
150 160 170 180 190
pF1KE3 TDGARTKIGFSEGRHAWEVWWEGPL---GTVAVIGIATKRAPMQCQGYVALLGSDDQSWG
::::: : :.:.: ::::. : :: :: ::.:.:: ::.: . :.:::::...:::
NP_116 TDGARGKRGYSRGLHAWEISW--PLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWG
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE3 WNLVDNNLLHNGEVNGS--FPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFR
:.. ..: :... :. .: ... . .. ::. :.::::. ::.. : .:: :::
NP_116 WDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFR
140 150 160 170 180 190
260 270 280
pF1KE3 GLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
:: ::::::::.:. .: . :::.
NP_116 GLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPL
200 210 220 230 240 250
>>XP_016862998 (OMIM: 611660) PREDICTED: SPRY domain-con (233 aa)
initn: 472 init1: 164 opt: 516 Z-score: 410.7 bits: 83.6 E(85289): 3.9e-16
Smith-Waterman score: 516; 42.5% identity (70.5% similar) in 193 aa overlap (93-280:36-227)
70 80 90 100 110 120
pF1KE3 CKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRN
: : : ..:. .. ..::.. .: : :
XP_016 SGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQ-LRHAWNPEDRSLN
10 20 30 40 50 60
130 140 150 160 170 180
pF1KE3 VYIKKNG-FTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEG-PLGTVAVIGIATKRAPM
:..: . .:.::.:.:::::: : :.: ..: :::.. : . :: ::.:.:: :::.
XP_016 VFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPL
70 80 90 100 110 120
190 200 210 220 230
pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNG--SFPQCNNAPK-YQIGERIRVILDME
. ::.::.::: .::::.: . : :.:. . ..: . . . . . . :.:::.
XP_016 HSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMD
130 140 150 160 170 180
240 250 260 270 280
pF1KE3 DKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
. ::.: ..:::::::: :::.::::.:. :::. :.
XP_016 EGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDQN
190 200 210 220 230
>>NP_543138 (OMIM: 611660) SPRY domain-containing SOCS b (273 aa)
initn: 460 init1: 164 opt: 516 Z-score: 409.9 bits: 83.7 E(85289): 4.3e-16
Smith-Waterman score: 516; 42.5% identity (70.5% similar) in 193 aa overlap (93-280:36-227)
70 80 90 100 110 120
pF1KE3 CKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRN
: : : ..:. .. ..::.. .: : :
NP_543 SGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQ-LRHAWNPEDRSLN
10 20 30 40 50 60
130 140 150 160 170 180
pF1KE3 VYIKKNG-FTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEG-PLGTVAVIGIATKRAPM
:..: . .:.::.:.:::::: : :.: ..: :::.. : . :: ::.:.:: :::.
NP_543 VFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPL
70 80 90 100 110 120
190 200 210 220 230
pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNG--SFPQCNNAPK-YQIGERIRVILDME
. ::.::.::: .::::.: . : :.:. . ..: . . . . . . :.:::.
NP_543 HSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMD
130 140 150 160 170 180
240 250 260 270 280
pF1KE3 DKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
. ::.: ..:::::::: :::.::::.:. :::. :.
NP_543 EGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRS
190 200 210 220 230 240
NP_543 IRSALGRQRLQDISSLPLPQSLKNYLQYQ
250 260 270
>>NP_079382 (OMIM: 611657) SPRY domain-containing SOCS b (273 aa)
initn: 441 init1: 162 opt: 490 Z-score: 390.3 bits: 80.1 E(85289): 5.3e-15
Smith-Waterman score: 490; 39.4% identity (69.4% similar) in 193 aa overlap (93-280:36-227)
70 80 90 100 110 120
pF1KE3 CKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRN
: :.: ..: . .. . :....:: : :
NP_079 TGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQ-LLHSWNNNDRSLN
10 20 30 40 50 60
130 140 150 160 170 180
pF1KE3 VYIKKNG-FTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEG-PLGTVAVIGIATKRAPM
:..:.. . .::.:.:::::. : :.:...: :.:.. : :: ::.:.:: ::.
NP_079 VFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPL
70 80 90 100 110 120
190 200 210 220 230
pF1KE3 QCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGS--FPQCNNAPK-YQIGERIRVILDME
. ::..:.:.. .::::.: : : :.:. . : .: . . . . . . : :::.
NP_079 HSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMD
130 140 150 160 170 180
240 250 260 270 280
pF1KE3 DKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
: ::.: ...::::::: :::.::::.:. :. . ::
NP_079 DGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRS
190 200 210 220 230 240
NP_079 VRLALGRERLGEIHTLPLPASLKAYLLYQ
250 260 270
286 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:30:07 2016 done: Sun Nov 6 10:30:08 2016
Total Scan time: 6.620 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]