Result of FASTA (omim) for
pFN21AE3101
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3101, 267 aa
1>>>pF1KE3101 267 - 267 aa - 267 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8194+/-0.000312; mu= 13.2140+/- 0.019
mean_var=91.1985+/-17.884, 0's: 0 Z-trim(118.8): 25 B-trim: 141 in 1/54
Lambda= 0.134301
statistics sampled from 31993 (32030) to 31993 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.376), width: 16
Scan time: 5.900
The best scores are: opt bits E(85289)
NP_005445 (OMIM: 603777) cerberus precursor [Homo ( 267) 1840 366.0 4e-101
NP_689867 (OMIM: 609068) DAN domain family member ( 189) 260 59.8 4.4e-09
NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [H ( 114) 242 56.1 3.3e-08
NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 pr ( 143) 241 56.0 4.5e-08
NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precu ( 184) 241 56.1 5.5e-08
XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 i ( 221) 241 56.1 6.3e-08
XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 i ( 240) 241 56.2 6.7e-08
XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 i ( 168) 223 52.6 5.7e-07
NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo ( 168) 223 52.6 5.7e-07
XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 i ( 186) 223 52.6 6.2e-07
NP_001191014 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05
NP_001265094 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05
NP_001265093 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05
NP_005371 (OMIM: 600613) neuroblastoma suppressor ( 181) 190 46.2 5.1e-05
NP_001191013 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05
NP_001265095 (OMIM: 600613) neuroblastoma suppress ( 181) 190 46.2 5.1e-05
NP_001191015 (OMIM: 600613) neuroblastoma suppress ( 215) 190 46.3 5.8e-05
NP_877421 (OMIM: 600613) neuroblastoma suppressor ( 216) 190 46.3 5.9e-05
NP_002448 (OMIM: 158370) mucin-2 precursor [Homo s (5289) 191 47.5 0.00062
>>NP_005445 (OMIM: 603777) cerberus precursor [Homo sapi (267 aa)
initn: 1840 init1: 1840 opt: 1840 Z-score: 1936.5 bits: 366.0 E(85289): 4e-101
Smith-Waterman score: 1840; 98.5% identity (99.6% similar) in 267 aa overlap (1-267:1-267)
10 20 30 40 50 60
pF1KE3 MHLLLFQLLVLLPLGKTTWHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLLVAV
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::.:::
NP_005 MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMK
::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 MEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_005 MEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 VQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQ
190 200 210 220 230 240
250 260
pF1KE3 CKVKTEHEDGHILHAGSQDSFIPGVSA
:::::::::::::::::::::::::::
NP_005 CKVKTEHEDGHILHAGSQDSFIPGVSA
250 260
>>NP_689867 (OMIM: 609068) DAN domain family member 5 pr (189 aa)
initn: 234 init1: 213 opt: 260 Z-score: 284.1 bits: 59.8 E(85289): 4.4e-09
Smith-Waterman score: 260; 28.1% identity (58.1% similar) in 167 aa overlap (84-244:22-188)
60 70 80 90 100 110
pF1KE3 PDLLVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLI
:: . : . . ... . ::. .
NP_689 MLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPL
10 20 30 40 50
120 130 140 150 160 170
pF1KE3 QPIDGMKMEKSPLR-EEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTIT
: ... :. : ..:... . : .: ::.. .:: :..::: :...
NP_689 VPASALGSWKAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQVFS
60 70 80 90 100 110
180 190 200 210 220
pF1KE3 HEGCEKIVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSV---
. :: : ..:.::::.:.:...::. . :. :.::. . : : ::.
NP_689 RPGCSAIRLRNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVLWCLTGSSASRR
120 130 140 150 160 170
230 240 250 260
pF1KE3 -IKV-VMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
.:. .::.: :.:. :
NP_689 RVKISTMLIEGCHCSPKA
180
>>NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [Homo (114 aa)
initn: 205 init1: 117 opt: 242 Z-score: 268.3 bits: 56.1 E(85289): 3.3e-08
Smith-Waterman score: 242; 35.8% identity (65.1% similar) in 106 aa overlap (141-241:3-108)
120 130 140 150 160 170
pF1KE3 SLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQT
.: . :.. . . .. . :.: :..::
NP_001 MSRTAYTVGALHVTERKYLKRDWCKTQPLKQT
10 20 30
180 190 200 210 220
pF1KE3 ITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCSHCLPAKFTTMHLPLNCTELS
: .:::.. .. : .:.:.:.: ..: .. : ::: : : ::::: . ::: ::.
NP_001 IHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQ
40 50 60 70 80 90
230 240 250 260
pF1KE3 --SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
. : : :..:.:
NP_001 PPTKKKRVTRVKQCRCISIDLD
100 110
>>NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 precur (143 aa)
initn: 227 init1: 117 opt: 241 Z-score: 265.9 bits: 56.0 E(85289): 4.5e-08
Smith-Waterman score: 245; 37.2% identity (62.8% similar) in 113 aa overlap (141-241:25-137)
120 130 140 150 160
pF1KE3 SLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILP-------IKSHEVHWETCR
: .:::.: : . . .. . :.
NP_001 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKALHVTERKYLKRDWCK
10 20 30 40 50
170 180 190 200 210 220
pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCSHCLPAKFTTMHLP
: :..::: .:::.. .. : .:.:.:.: ..: .. : ::: : : ::::: .
NP_001 TQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVT
60 70 80 90 100 110
230 240 250 260
pF1KE3 LNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
::: ::. . : : :..:.:
NP_001 LNCPELQPPTKKKRVTRVKQCRCISIDLD
120 130 140
>>NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precursor (184 aa)
initn: 272 init1: 131 opt: 241 Z-score: 264.4 bits: 56.1 E(85289): 5.5e-08
Smith-Waterman score: 255; 29.6% identity (54.3% similar) in 186 aa overlap (63-241:14-178)
40 50 60 70 80 90
pF1KE3 VLLPRNQRELPTGNHEEAEEKPDLLVAVPHLVGTS-PAGEGQRQREKMLSRFGRFWKKPE
:.:: ::.::... . : . :.
NP_037 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPD
10 20 30
100 110 120 130 140 150
pF1KE3 REMHPSRDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVIL
. .: . .. . : ::... . : : . : ... : .
NP_037 KAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VT
40 50 60 70 80
160 170 180 190 200
pF1KE3 PIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCS
: . : :.: :..::: .:::.. .. : .:.:.:.: ..: .. : :::
NP_037 ERKYLKRDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCS
90 100 110 120 130 140
210 220 230 240 250 260
pF1KE3 HCLPAKFTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGV
: : ::::: . ::: ::. . : : :..:.:
NP_037 FCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
150 160 170 180
pF1KE3 SA
>>XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 isofo (221 aa)
initn: 256 init1: 131 opt: 241 Z-score: 263.3 bits: 56.1 E(85289): 6.3e-08
Smith-Waterman score: 255; 29.6% identity (54.3% similar) in 186 aa overlap (63-241:51-215)
40 50 60 70 80 90
pF1KE3 VLLPRNQRELPTGNHEEAEEKPDLLVAVPHLVGTS-PAGEGQRQREKMLSRFGRFWKKPE
:.:: ::.::... . : . :.
XP_016 GWSIRRIHDVCICRSPSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPD
30 40 50 60 70
100 110 120 130 140 150
pF1KE3 REMHPSRDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVIL
. .: . .. . : ::... . : : . : ... : .
XP_016 KAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VT
80 90 100 110 120
160 170 180 190 200
pF1KE3 PIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCS
: . : :.: :..::: .:::.. .. : .:.:.:.: ..: .. : :::
XP_016 ERKYLKRDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCS
130 140 150 160 170
210 220 230 240 250 260
pF1KE3 HCLPAKFTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGV
: : ::::: . ::: ::. . : : :..:.:
XP_016 FCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
180 190 200 210 220
pF1KE3 SA
>>XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 isofo (240 aa)
initn: 256 init1: 131 opt: 241 Z-score: 262.8 bits: 56.2 E(85289): 6.7e-08
Smith-Waterman score: 255; 29.6% identity (54.3% similar) in 186 aa overlap (63-241:70-234)
40 50 60 70 80 90
pF1KE3 VLLPRNQRELPTGNHEEAEEKPDLLVAVPHLVGTS-PAGEGQRQREKMLSRFGRFWKKPE
:.:: ::.::... . : . :.
XP_005 QRHASKAQAPRTRRTDSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPD
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE3 REMHPSRDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVIL
. .: . .. . : ::... . : : . : ... : .
XP_005 KAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VT
100 110 120 130 140
160 170 180 190 200
pF1KE3 PIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQH---SHTSCS
: . : :.: :..::: .:::.. .. : .:.:.:.: ..: .. : :::
XP_005 ERKYLKRDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCS
150 160 170 180 190
210 220 230 240 250 260
pF1KE3 HCLPAKFTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGV
: : ::::: . ::: ::. . : : :..:.:
XP_005 FCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
200 210 220 230 240
pF1KE3 SA
>>XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 isofo (168 aa)
initn: 151 init1: 136 opt: 223 Z-score: 246.1 bits: 52.6 E(85289): 5.7e-07
Smith-Waterman score: 223; 27.4% identity (64.6% similar) in 113 aa overlap (134-241:45-157)
110 120 130 140 150 160
pF1KE3 PFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCR
:.: . . .:: ... . . .. . :.
XP_011 LVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCK
20 30 40 50 60 70
170 180 190 200 210 220
pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFP---GAAQHSHTSCSHCLPAKFTTMHLP
: :. ::...:::.. .. : .:.:.:.: ..: ..: ::. : : . :.. .
XP_011 TQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVE
80 90 100 110 120 130
230 240 250 260
pF1KE3 LNCTELSSV--IKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
:.: :. .: .. :..:.:
XP_011 LECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
140 150 160
>>NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo sap (168 aa)
initn: 151 init1: 136 opt: 223 Z-score: 246.1 bits: 52.6 E(85289): 5.7e-07
Smith-Waterman score: 223; 27.4% identity (64.6% similar) in 113 aa overlap (134-241:45-157)
110 120 130 140 150 160
pF1KE3 PFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCR
:.: . . .:: ... . . .. . :.
NP_071 LVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCK
20 30 40 50 60 70
170 180 190 200 210 220
pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFP---GAAQHSHTSCSHCLPAKFTTMHLP
: :. ::...:::.. .. : .:.:.:.: ..: ..: ::. : : . :.. .
NP_071 TQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVE
80 90 100 110 120 130
230 240 250 260
pF1KE3 LNCTELSSV--IKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
:.: :. .: .. :..:.:
NP_071 LECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
140 150 160
>>XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 isofo (186 aa)
initn: 136 init1: 136 opt: 223 Z-score: 245.5 bits: 52.6 E(85289): 6.2e-07
Smith-Waterman score: 223; 27.4% identity (64.6% similar) in 113 aa overlap (134-241:63-175)
110 120 130 140 150 160
pF1KE3 PFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCR
:.: . . .:: ... . . .. . :.
XP_005 LVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCK
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE3 TVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFP---GAAQHSHTSCSHCLPAKFTTMHLP
: :. ::...:::.. .. : .:.:.:.: ..: ..: ::. : : . :.. .
XP_005 TQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVE
100 110 120 130 140 150
230 240 250 260
pF1KE3 LNCTELSSV--IKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
:.: :. .: .. :..:.:
XP_005 LECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
160 170 180
267 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:51:48 2016 done: Sun Nov 6 04:51:49 2016
Total Scan time: 5.900 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]