Result of FASTA (omim) for
pFN21AE3090
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3090, 260 aa
1>>>pF1KE3090 260 - 260 aa - 260 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7261+/-0.00037; mu= 18.2662+/- 0.023
mean_var=66.3702+/-13.359, 0's: 0 Z-trim(113.4): 23 B-trim: 28 in 1/49
Lambda= 0.157430
statistics sampled from 22641 (22663) to 22641 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.266), width: 16
Scan time: 6.420
The best scores are: opt bits E(85289)
NP_000779 (OMIM: 125450) deoxycytidine kinase [Hom ( 260) 1761 408.6 5.6e-114
NP_550438 (OMIM: 251880,601465,617068,617070) deox ( 277) 846 200.8 2.1e-51
NP_001305789 (OMIM: 251880,601465,617068,617070) d ( 180) 669 160.5 2e-39
NP_001305790 (OMIM: 251880,601465,617068,617070) d ( 180) 669 160.5 2e-39
XP_011530949 (OMIM: 251880,601465,617068,617070) P ( 271) 633 152.5 7.7e-37
NP_001305792 (OMIM: 251880,601465,617068,617070) d ( 174) 609 146.8 2.4e-35
NP_001305791 (OMIM: 251880,601465,617068,617070) d ( 174) 609 146.8 2.4e-35
NP_550440 (OMIM: 251880,601465,617068,617070) deox ( 189) 390 97.1 2.4e-20
NP_001305788 (OMIM: 251880,601465,617068,617070) d ( 183) 349 87.8 1.5e-17
NP_001258979 (OMIM: 188250,609560,617069) thymidin ( 168) 321 81.4 1.2e-15
NP_001258863 (OMIM: 188250,609560,617069) thymidin ( 216) 321 81.5 1.4e-15
NP_001166114 (OMIM: 188250,609560,617069) thymidin ( 234) 321 81.5 1.5e-15
NP_001166115 (OMIM: 188250,609560,617069) thymidin ( 240) 321 81.5 1.5e-15
NP_001166116 (OMIM: 188250,609560,617069) thymidin ( 247) 321 81.6 1.5e-15
NP_004605 (OMIM: 188250,609560,617069) thymidine k ( 265) 321 81.6 1.6e-15
NP_001258864 (OMIM: 188250,609560,617069) thymidin ( 146) 140 40.3 0.0025
>>NP_000779 (OMIM: 125450) deoxycytidine kinase [Homo sa (260 aa)
initn: 1761 init1: 1761 opt: 1761 Z-score: 2167.2 bits: 408.6 E(85289): 5.6e-114
Smith-Waterman score: 1761; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:1-260)
10 20 30 40 50 60
pF1KE3 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
190 200 210 220 230 240
250 260
pF1KE3 DFKDKYESLVEKVKEFLSTL
::::::::::::::::::::
NP_000 DFKDKYESLVEKVKEFLSTL
250 260
>>NP_550438 (OMIM: 251880,601465,617068,617070) deoxygua (277 aa)
initn: 835 init1: 671 opt: 846 Z-score: 1043.7 bits: 200.8 E(85289): 2.1e-51
Smith-Waterman score: 846; 47.5% identity (77.9% similar) in 263 aa overlap (1-260:18-277)
10 20 30 40
pF1KE3 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQ
:: : .. : . : ...:::::::.::::::..: .
NP_550 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 LCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLS
.:.:. :::: : :.:.. . . . .. ::.:.:::..: :::.::::.. ::
NP_550 TYPEWHVATEPVATWQNIQAAGT---QKACTAQSLGNLLDMMYREPARWSYTFQTFSFLS
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 RIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMN
:...:: . :: .:.::: .:::::::::::::.::.:. ... :: ::::::...
NP_550 RLKVQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLL
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 NQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKT
.:.. . : :.:::::.:..::.:.: :.:.::.:: : :::.:: .::.::.:.: :
NP_550 WEFASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKL
180 190 200 210 220 230
230 240 250 260
pF1KE3 NFDYLQEVPILTLDVNEDFKD---KYESLVEKVKEFLSTL
.:. :...:.:.::::.::.. : :.:...:. :...:
NP_550 HFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
240 250 260 270
>>NP_001305789 (OMIM: 251880,601465,617068,617070) deoxy (180 aa)
initn: 650 init1: 650 opt: 669 Z-score: 829.0 bits: 160.5 E(85289): 2e-39
Smith-Waterman score: 669; 52.2% identity (83.9% similar) in 180 aa overlap (84-260:1-180)
60 70 80 90 100 110
pF1KE3 PVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLN
:::..: :::.::::.. :::...:: .
NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP
10 20 30
120 130 140 150 160 170
pF1KE3 GKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELD
:: .:.::: .:::::::::::::.::.:. ... :: ::::::... .:.. . :
NP_001 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE3 GIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPI
:.:::::.:..::.:.: :.:.::.:: : :::.:: .::.::.:.: : .:. :...:.
NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV
100 110 120 130 140 150
240 250 260
pF1KE3 LTLDVNEDFKD---KYESLVEKVKEFLSTL
:.::::.::.. : :.:...:. :...:
NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL
160 170 180
>>NP_001305790 (OMIM: 251880,601465,617068,617070) deoxy (180 aa)
initn: 650 init1: 650 opt: 669 Z-score: 829.0 bits: 160.5 E(85289): 2e-39
Smith-Waterman score: 669; 52.2% identity (83.9% similar) in 180 aa overlap (84-260:1-180)
60 70 80 90 100 110
pF1KE3 PVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLN
:::..: :::.::::.. :::...:: .
NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP
10 20 30
120 130 140 150 160 170
pF1KE3 GKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELD
:: .:.::: .:::::::::::::.::.:. ... :: ::::::... .:.. . :
NP_001 EKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE3 GIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPI
:.:::::.:..::.:.: :.:.::.:: : :::.:: .::.::.:.: : .:. :...:.
NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV
100 110 120 130 140 150
240 250 260
pF1KE3 LTLDVNEDFKD---KYESLVEKVKEFLSTL
:.::::.::.. : :.:...:. :...:
NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL
160 170 180
>>XP_011530949 (OMIM: 251880,601465,617068,617070) PREDI (271 aa)
initn: 814 init1: 449 opt: 633 Z-score: 782.4 bits: 152.5 E(85289): 7.7e-37
Smith-Waterman score: 786; 45.2% identity (75.7% similar) in 263 aa overlap (1-260:18-271)
10 20 30 40
pF1KE3 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQ
:: : .. : . : ...:::::::.::::::..: .
XP_011 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 LCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLS
.:.:. :::: : :.:.. . . . .. ::.:.:::..: :::.::::.. ::
XP_011 TYPEWHVATEPVATWQNIQAAG---TQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLS
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 RIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMN
:...:: . :: .:.::: .::: ::::.::.:. ... :: ::::::...
XP_011 RLKVQLEPFPEKLLQARKPVQIFER------YIFAKNLFENGSLSDIEWHIYQDWHSFLL
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 NQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKT
.:.. . : :.:::::.:..::.:.: :.:.::.:: : :::.:: .::.::.:.: :
XP_011 WEFASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKL
180 190 200 210 220 230
230 240 250 260
pF1KE3 NFDYLQEVPILTLDVNEDFKD---KYESLVEKVKEFLSTL
.:. :...:.:.::::.::.. : :.:...:. :...:
XP_011 HFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
240 250 260 270
>>NP_001305792 (OMIM: 251880,601465,617068,617070) deoxy (174 aa)
initn: 629 init1: 449 opt: 609 Z-score: 755.5 bits: 146.8 E(85289): 2.4e-35
Smith-Waterman score: 609; 48.9% identity (80.6% similar) in 180 aa overlap (84-260:1-174)
60 70 80 90 100 110
pF1KE3 PVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLN
:::..: :::.::::.. :::...:: .
NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP
10 20 30
120 130 140 150 160 170
pF1KE3 GKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELD
:: .:.::: .::: ::::.::.:. ... :: ::::::... .:.. . :
NP_001 EKLLQARKPVQIFER------YIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH
40 50 60 70 80
180 190 200 210 220 230
pF1KE3 GIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPI
:.:::::.:..::.:.: :.:.::.:: : :::.:: .::.::.:.: : .:. :...:.
NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV
90 100 110 120 130 140
240 250 260
pF1KE3 LTLDVNEDFKD---KYESLVEKVKEFLSTL
:.::::.::.. : :.:...:. :...:
NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL
150 160 170
>>NP_001305791 (OMIM: 251880,601465,617068,617070) deoxy (174 aa)
initn: 629 init1: 449 opt: 609 Z-score: 755.5 bits: 146.8 E(85289): 2.4e-35
Smith-Waterman score: 609; 48.9% identity (80.6% similar) in 180 aa overlap (84-260:1-174)
60 70 80 90 100 110
pF1KE3 PVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLN
:::..: :::.::::.. :::...:: .
NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP
10 20 30
120 130 140 150 160 170
pF1KE3 GKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELD
:: .:.::: .::: ::::.::.:. ... :: ::::::... .:.. . :
NP_001 EKLLQARKPVQIFER------YIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLH
40 50 60 70 80
180 190 200 210 220 230
pF1KE3 GIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPI
:.:::::.:..::.:.: :.:.::.:: : :::.:: .::.::.:.: : .:. :...:.
NP_001 GFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPV
90 100 110 120 130 140
240 250 260
pF1KE3 LTLDVNEDFKD---KYESLVEKVKEFLSTL
:.::::.::.. : :.:...:. :...:
NP_001 LVLDVNDDFSEEVTKQEDLMREVNTFVKNL
150 160 170
>>NP_550440 (OMIM: 251880,601465,617068,617070) deoxygua (189 aa)
initn: 427 init1: 231 opt: 390 Z-score: 486.2 bits: 97.1 E(85289): 2.4e-20
Smith-Waterman score: 390; 46.0% identity (71.5% similar) in 137 aa overlap (1-137:18-151)
10 20 30 40
pF1KE3 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQ
:: : .. : . : ...:::::::.::::::..: .
NP_550 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 LCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLS
.:.:. :::: : :.:.. . . . .. ::.:.:::..: :::.::::.. ::
NP_550 TYPEWHVATEPVATWQNIQAAG---TQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLS
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 RIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMN
:...:: . :: .:.::: .::::::::: :
NP_550 RLKVQLEPFPEKLLQARKPVQIFERSVYSDRLHFEALMNIPVLVLDVNDDFSEEVTKQED
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 NQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKT
NP_550 LMREVNTFVKNL
180
>>NP_001305788 (OMIM: 251880,601465,617068,617070) deoxy (183 aa)
initn: 389 init1: 193 opt: 349 Z-score: 436.1 bits: 87.8 E(85289): 1.5e-17
Smith-Waterman score: 349; 43.8% identity (71.1% similar) in 128 aa overlap (1-128:18-142)
10 20 30 40
pF1KE3 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQ
:: : .. : . : ...:::::::.::::::..: .
NP_001 MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 LCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLS
.:.:. :::: : :.:.. . . . .. ::.:.:::..: :::.::::.. ::
NP_001 TYPEWHVATEPVATWQNIQAAG---TQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLS
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 RIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMN
:...:: . :: .:.::: .:::
NP_001 RLKVQLEPFPEKLLQARKPVQIFERLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVN
120 130 140 150 160 170
>>NP_001258979 (OMIM: 188250,609560,617069) thymidine ki (168 aa)
initn: 351 init1: 169 opt: 321 Z-score: 402.2 bits: 81.4 E(85289): 1.2e-15
Smith-Waterman score: 358; 35.4% identity (68.0% similar) in 175 aa overlap (85-259:1-160)
60 70 80 90 100 110
pF1KE3 VARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNG
::. ::..:.:::. ::. :.
NP_001 MYHDASRWGLTLQTYV-------QLTMLDR
10 20
120 130 140 150 160 170
pF1KE3 KLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDG
. . . : ..:::..: ::::. :::.: : :..... ..: ::. .. :..:
NP_001 HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL--
30 40 50 60 70 80
180 190 200 210 220 230
pF1KE3 IIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL
:.::...:::: .:. : :.::. ::::::: .:. :: ::.. .: . . .:.:
NP_001 IVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSL-----FPMAAPVL
90 100 110 120 130
240 250 260
pF1KE3 TLDVNEDFKDKYESLVEKVKEFLSTL
...... .. : : :. .. . :
NP_001 VIEADHHMERMLE-LFEQNRDRILTPENRKHCP
140 150 160
260 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:14:03 2016 done: Sun Nov 6 05:14:04 2016
Total Scan time: 6.420 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]