Result of FASTA (omim) for
pFN21AE3085
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3085, 250 aa
1>>>pF1KE3085 250 - 250 aa - 250 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7090+/-0.000288; mu= 13.4367+/- 0.018
mean_var=84.4607+/-16.344, 0's: 0 Z-trim(119.4): 13 B-trim: 0 in 0/53
Lambda= 0.139555
statistics sampled from 33272 (33289) to 33272 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.747), E-opt: 0.2 (0.39), width: 16
Scan time: 7.050
The best scores are: opt bits E(85289)
NP_003799 (OMIM: 604472) tumor necrosis factor lig ( 250) 1684 348.1 8.6e-96
NP_742085 (OMIM: 604472) tumor necrosis factor lig ( 247) 1661 343.5 2.1e-94
NP_001185553 (OMIM: 604472) tumor necrosis factor ( 205) 928 195.9 4.8e-50
NP_001185552 (OMIM: 604472) tumor necrosis factor ( 222) 928 195.9 5.1e-50
NP_001185551 (OMIM: 604472) tumor necrosis factor ( 223) 926 195.5 6.8e-50
NP_742084 (OMIM: 604472) tumor necrosis factor lig ( 234) 832 176.6 3.5e-44
NP_006564 (OMIM: 603969) tumor necrosis factor lig ( 285) 312 71.9 1.4e-12
NP_001139117 (OMIM: 603969) tumor necrosis factor ( 266) 285 66.5 5.6e-11
XP_006724693 (OMIM: 300451,305100,313500) PREDICTE ( 388) 163 42.0 0.0019
NP_001390 (OMIM: 300451,305100,313500) ectodysplas ( 391) 163 42.0 0.0019
NP_001005612 (OMIM: 300451,305100,313500) ectodysp ( 386) 161 41.6 0.0024
NP_001005609 (OMIM: 300451,305100,313500) ectodysp ( 389) 161 41.6 0.0025
>>NP_003799 (OMIM: 604472) tumor necrosis factor ligand (250 aa)
initn: 1684 init1: 1684 opt: 1684 Z-score: 1840.8 bits: 348.1 E(85289): 8.6e-96
Smith-Waterman score: 1684; 99.6% identity (100.0% similar) in 250 aa overlap (1-250:1-250)
10 20 30 40 50 60
pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_003 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
190 200 210 220 230 240
250
pF1KE3 HGTFLGFVKL
::::::::::
NP_003 HGTFLGFVKL
250
>>NP_742085 (OMIM: 604472) tumor necrosis factor ligand (247 aa)
initn: 1678 init1: 1661 opt: 1661 Z-score: 1815.8 bits: 343.5 E(85289): 2.1e-94
Smith-Waterman score: 1661; 99.2% identity (100.0% similar) in 247 aa overlap (1-247:1-247)
10 20 30 40 50 60
pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_742 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
190 200 210 220 230 240
250
pF1KE3 HGTFLGFVKL
::::::.
NP_742 HGTFLGL
>>NP_001185553 (OMIM: 604472) tumor necrosis factor liga (205 aa)
initn: 928 init1: 928 opt: 928 Z-score: 1019.4 bits: 195.9 E(85289): 4.8e-50
Smith-Waterman score: 1321; 88.0% identity (88.0% similar) in 233 aa overlap (18-250:1-205)
10 20 30 40 50 60
pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
:::::::::::::::::::::::::::::::::::::::::::
NP_001 MGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
10 20 30 40
70 80 90 100 110 120
pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL
:::::::::::::::::::::::::: ::::::
NP_001 EVSRLQGTGGPSQNGEGYPWQSLPEQ----------------------------HSVLHL
50 60 70
130 140 150 160 170 180
pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
80 90 100 110 120 130
190 200 210 220 230 240
pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
140 150 160 170 180 190
250
pF1KE3 HGTFLGFVKL
::::::::::
NP_001 HGTFLGFVKL
200
>>NP_001185552 (OMIM: 604472) tumor necrosis factor liga (222 aa)
initn: 928 init1: 928 opt: 928 Z-score: 1018.9 bits: 195.9 E(85289): 5.1e-50
Smith-Waterman score: 1445; 88.8% identity (88.8% similar) in 250 aa overlap (1-250:1-222)
10 20 30 40 50 60
pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL
:::::::::::::::::::::::::: ::::::
NP_001 EVSRLQGTGGPSQNGEGYPWQSLPEQ----------------------------HSVLHL
70 80 90
130 140 150 160 170 180
pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
160 170 180 190 200 210
250
pF1KE3 HGTFLGFVKL
::::::::::
NP_001 HGTFLGFVKL
220
>>NP_001185551 (OMIM: 604472) tumor necrosis factor liga (223 aa)
initn: 926 init1: 926 opt: 926 Z-score: 1016.7 bits: 195.5 E(85289): 6.8e-50
Smith-Waterman score: 1454; 89.2% identity (89.2% similar) in 250 aa overlap (1-250:1-223)
10 20 30 40 50 60
pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL
:::::::::::::::::::::::::: :::::::
NP_001 EVSRLQGTGGPSQNGEGYPWQSLPEQ---------------------------QHSVLHL
70 80 90
130 140 150 160 170 180
pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
160 170 180 190 200 210
250
pF1KE3 HGTFLGFVKL
::::::::::
NP_001 HGTFLGFVKL
220
>>NP_742084 (OMIM: 604472) tumor necrosis factor ligand (234 aa)
initn: 828 init1: 828 opt: 832 Z-score: 914.1 bits: 176.6 E(85289): 3.5e-44
Smith-Waterman score: 1535; 92.8% identity (93.6% similar) in 250 aa overlap (1-250:1-234)
10 20 30 40 50 60
pF1KE3 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGERSRKRRAVLTQKQKKQHSVLHL
:::::::::::::::::::::::::::::::::::.::::::::::::::::
NP_742 EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQK--------
70 80 90 100 110
130 140 150 160 170 180
pF1KE3 VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
.:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 --------NDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
120 130 140 150 160
190 200 210 220 230 240
pF1KE3 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_742 VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
170 180 190 200 210 220
250
pF1KE3 HGTFLGFVKL
::::::::::
NP_742 HGTFLGFVKL
230
>>NP_006564 (OMIM: 603969) tumor necrosis factor ligand (285 aa)
initn: 302 init1: 135 opt: 312 Z-score: 347.1 bits: 71.9 E(85289): 1.4e-12
Smith-Waterman score: 324; 31.8% identity (62.2% similar) in 217 aa overlap (52-250:73-284)
30 40 50 60 70 80
pF1KE3 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ
: .: ::: :.. .. :. : : :
NP_006 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA
50 60 70 80 90 100
90 100 110 120 130
pF1KE3 SLPEQS--SDALEAWE--------SGERSRKRRAVLTQKQKKQHSVLHLVPINAT-SKDD
.: : . .:. .: :.. ::..::: .. .. :.:. . : . .
NP_006 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQK
110 120 130 140 150 160
140 150 160 170 180
pF1KE3 SDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE-----
.. : : : ...:: .:. . . ....: ...:.:::. : :..::....:.
NP_006 GSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVF
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE3 -GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGT
. ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. :
NP_006 GDELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVT
230 240 250 260 270
250
pF1KE3 FLGFVKL
:.: .::
NP_006 FFGALKLL
280
>>NP_001139117 (OMIM: 603969) tumor necrosis factor liga (266 aa)
initn: 319 init1: 135 opt: 285 Z-score: 318.1 bits: 66.5 E(85289): 5.6e-11
Smith-Waterman score: 286; 30.6% identity (58.8% similar) in 216 aa overlap (52-250:73-265)
30 40 50 60 70 80
pF1KE3 VREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQ
: .: ::: :.. .. :. : : :
NP_001 KDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPA--GAGAPKA
50 60 70 80 90 100
90 100 110 120 130
pF1KE3 SLPEQS--SDALEAWE--------SGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDS
.: : . .:. .: :.. ::..::: .. ... .::
NP_001 GLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETGSYT---FVP---------
110 120 130 140
140 150 160 170 180
pF1KE3 DVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSRE------
: ...:: .:. . . ....: ...:.:::. : :..::....:.
NP_001 ------WLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFG
150 160 170 180 190 200
190 200 210 220 230 240
pF1KE3 GQGRQETLFRCIRSMP-SHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTF
. ::::::..:: . :. :::::::. .:..:: :.. ::: :...:. ::
NP_001 DELSLVTLFRCIQNMPETLPN---NSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTF
210 220 230 240 250
250
pF1KE3 LGFVKL
.: .::
NP_001 FGALKLL
260
>>XP_006724693 (OMIM: 300451,305100,313500) PREDICTED: e (388 aa)
initn: 218 init1: 112 opt: 163 Z-score: 183.0 bits: 42.0 E(85289): 0.0019
Smith-Waterman score: 172; 25.8% identity (54.9% similar) in 182 aa overlap (69-250:215-382)
40 50 60 70 80 90
pF1KE3 LGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGE
: :. : : :. : .. . : ..:
XP_006 NGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGP-QGPPGLQGPSGAADKAGT
190 200 210 220 230 240
100 110 120 130 140 150
pF1KE3 RSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQ
: . .: : : . .: . .: : ... .: . . :. .. ...
XP_006 RENQPAVVHLQGQGSAIQVKNGGVLN-------DWSRITMNPKVFK---LHPRSGELEVL
250 260 270 280 290
160 170 180 190 200 210
pF1KE3 DAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFH
:.:..:::: ..:: . .: : .. ...: ::. . ::.::.:::
XP_006 VDGTYFIYSQVEVYYINFT--DFASYEVVVDEKPFLQCTRSIETGKTN-YNTCYTAGVCL
300 310 320 330 340 350
220 230 240 250
pF1KE3 LHQGDILSVIIPRARAKLNLSPHGTFLGFVKL
:. . ..: . .: ..:.: : ::.: ..:
XP_006 LKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS
360 370 380
>>NP_001390 (OMIM: 300451,305100,313500) ectodysplasin-A (391 aa)
initn: 218 init1: 112 opt: 163 Z-score: 183.0 bits: 42.0 E(85289): 0.0019
Smith-Waterman score: 174; 25.8% identity (56.6% similar) in 182 aa overlap (69-250:215-385)
40 50 60 70 80 90
pF1KE3 LGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWESGE
: :. : : :. : .. . : ..:
NP_001 NGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGP-QGPPGLQGPSGAADKAGT
190 200 210 220 230 240
100 110 120 130 140 150
pF1KE3 RSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQ
: . .: : : :... : . .. .: ... .: . . :. .. ...
NP_001 RENQPAVVHLQG---QGSAIQ-VKNDLSGGVLNDWSRITMNPKVFK---LHPRSGELEVL
250 260 270 280 290
160 170 180 190 200 210
pF1KE3 DAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFH
:.:..:::: ..:: . .: : .. ...: ::. . ::.::.:::
NP_001 VDGTYFIYSQVEVYYINFT--DFASYEVVVDEKPFLQCTRSIETGKTN-YNTCYTAGVCL
300 310 320 330 340 350
220 230 240 250
pF1KE3 LHQGDILSVIIPRARAKLNLSPHGTFLGFVKL
:. . ..: . .: ..:.: : ::.: ..:
NP_001 LKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS
360 370 380 390
250 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:15:39 2016 done: Sun Nov 6 05:15:40 2016
Total Scan time: 7.050 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]