Result of FASTA (omim) for
pFN21AE3074
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3074, 234 aa
1>>>pF1KE3074 234 - 234 aa - 234 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7960+/-0.000357; mu= 17.1799+/- 0.022
mean_var=59.2596+/-11.743, 0's: 0 Z-trim(112.4): 56 B-trim: 0 in 0/58
Lambda= 0.166608
statistics sampled from 21274 (21329) to 21274 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.25), width: 16
Scan time: 5.450
The best scores are: opt bits E(85289)
NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 1513 371.8 5.5e-103
XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 1355 333.8 1.4e-91
NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 1345 331.4 7.1e-91
XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like M ( 179) 942 234.5 9.2e-62
NP_060271 (OMIM: 607889) CKLF-like MARVEL transmem ( 183) 329 87.2 2.1e-17
NP_612419 (OMIM: 607890) CKLF-like MARVEL transmem ( 175) 224 61.9 8e-10
NP_849199 (OMIM: 607891) CKLF-like MARVEL transmem ( 173) 185 52.5 5.3e-07
NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens ( 182) 184 52.3 6.5e-07
XP_016861135 (OMIM: 607890) PREDICTED: CKLF-like M ( 179) 178 50.9 1.7e-06
NP_002659 (OMIM: 300112) proteolipid protein 2 [Ho ( 152) 175 50.1 2.5e-06
XP_011531621 (OMIM: 607890) PREDICTED: CKLF-like M ( 151) 172 49.4 4.1e-06
XP_006721194 (OMIM: 607886) PREDICTED: CKLF-like M ( 182) 168 48.5 9.4e-06
NP_653202 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 168 48.5 9.4e-06
NP_853531 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 168 48.5 9.4e-06
XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like M ( 196) 158 46.1 5.3e-05
XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like M ( 100) 151 44.2 9.9e-05
XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like M ( 130) 151 44.3 0.00012
XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 144 42.6 0.00045
XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 144 42.6 0.00045
NP_612469 (OMIM: 607888) CKLF-like MARVEL transmem ( 156) 144 42.6 0.00045
NP_852137 (OMIM: 607890) CKLF-like MARVEL transmem ( 142) 137 40.9 0.0013
NP_001277121 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001018656 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001277119 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001277117 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001277123 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001277120 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001018657 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001277118 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_612382 (OMIM: 609959) myeloid-associated differ ( 322) 130 39.5 0.0083
NP_001018655 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001277122 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
NP_001018654 (OMIM: 609959) myeloid-associated dif ( 322) 130 39.5 0.0083
>>NP_848933 (OMIM: 607887) CKLF-like MARVEL transmembran (234 aa)
initn: 1513 init1: 1513 opt: 1513 Z-score: 1969.9 bits: 371.8 E(85289): 5.5e-103
Smith-Waterman score: 1513; 100.0% identity (100.0% similar) in 234 aa overlap (1-234:1-234)
10 20 30 40 50 60
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
130 140 150 160 170 180
190 200 210 220 230
pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
190 200 210 220 230
>>XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like MARVE (221 aa)
initn: 1372 init1: 1355 opt: 1355 Z-score: 1765.0 bits: 333.8 E(85289): 1.4e-91
Smith-Waterman score: 1355; 97.7% identity (99.5% similar) in 214 aa overlap (1-214:1-214)
10 20 30 40 50 60
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
130 140 150 160 170 180
190 200 210 220 230
pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
::::::::::::::::::::::::::::.... :
XP_016 QQSTNDYIRARTESRDVDSRPEIQRLDTLNWKPNGHQQVKG
190 200 210 220
>>NP_852662 (OMIM: 607887) CKLF-like MARVEL transmembran (208 aa)
initn: 1345 init1: 1345 opt: 1345 Z-score: 1752.4 bits: 331.4 E(85289): 7.1e-91
Smith-Waterman score: 1345; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208)
10 20 30 40 50 60
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
130 140 150 160 170 180
190 200 210 220 230
pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
::::::::::::::::::::::::::::
NP_852 QQSTNDYIRARTESRDVDSRPEIQRLDT
190 200
>>XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like MARVE (179 aa)
initn: 937 init1: 937 opt: 942 Z-score: 1229.9 bits: 234.5 E(85289): 9.2e-62
Smith-Waterman score: 1083; 86.1% identity (86.1% similar) in 208 aa overlap (1-208:1-179)
10 20 30 40 50 60
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
:::::::::::::::::::::::::::::::::
XP_011 MRSGEELDGFEGEASSTSMISGASSPYQPTTEP---------------------------
10 20 30
70 80 90 100 110 120
pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 --ILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
100 110 120 130 140 150
190 200 210 220 230
pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
::::::::::::::::::::::::::::
XP_011 QQSTNDYIRARTESRDVDSRPEIQRLDT
160 170
>>NP_060271 (OMIM: 607889) CKLF-like MARVEL transmembran (183 aa)
initn: 330 init1: 310 opt: 329 Z-score: 433.4 bits: 87.2 E(85289): 2.1e-17
Smith-Waterman score: 329; 35.9% identity (65.7% similar) in 181 aa overlap (19-193:1-179)
10 20 30 40 50
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTE--PVSQRRGLAGLRCDPDYLRGALGR--
: .:: :.:::: : : .:: . : : :
NP_060 MENGAV--YSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV
10 20 30 40
60 70 80 90 100 110
pF1KE3 LKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQI
:: :..:.:.:::: :.. :. : :::::::::::::... ..::.. .. :.
NP_060 LKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE3 NWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVN--TFLAVQK
. . .:. : .. .:..:::.... . :..:::::..:::.:. . .. :.: ..
NP_060 KVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE3 WRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
. ..:. .. .: ::
NP_060 QESQLRKPENTTRAEALTEPLNA
170 180
>>NP_612419 (OMIM: 607890) CKLF-like MARVEL transmembran (175 aa)
initn: 175 init1: 85 opt: 224 Z-score: 297.3 bits: 61.9 E(85289): 8e-10
Smith-Waterman score: 224; 29.2% identity (62.0% similar) in 171 aa overlap (15-185:13-172)
10 20 30 40 50 60
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
:: : .. ... ::.. : : :: : .: : . ::::
NP_612 MSHGAGLVRTTCSSGSALGPGAGAAQPSASP------LEGL-LDLSYPRTHAALLKVA
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
:.. ::::::... . . :: . :. ... . :. . . .. . :.: :
NP_612 QMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHL-FRFYRVLTCISWPL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
..:.. ....:..::::: :. .. .. .:..::::.:: .. .:. ...:
NP_612 SELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWLS---YKISCV
120 130 140 150 160
190 200 210 220 230
pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
:::.
NP_612 TQSTDAAV
170
>>NP_849199 (OMIM: 607891) CKLF-like MARVEL transmembran (173 aa)
initn: 172 init1: 79 opt: 185 Z-score: 246.7 bits: 52.5 E(85289): 5.3e-07
Smith-Waterman score: 185; 30.9% identity (59.0% similar) in 139 aa overlap (46-176:33-168)
20 30 40 50 60 70
pF1KE3 STSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIE-T
: ..:: : : ::...:.:... : :
NP_849 EPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIAGT
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE3 IMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFF
. : : . ::. .:.: .::.. . ::::. :. . : .: :::...
NP_849 EYFRVPAFG--WVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNG-SAFVLY
70 80 90 100 110
140 150 160 170 180
pF1KE3 IASIVLAALN-------HRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDY
... :. : . : .. :. .:.::.: :: ::... ::
NP_849 LSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
120 130 140 150 160 170
190 200 210 220 230
pF1KE3 IRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
>>NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens] (182 aa)
initn: 154 init1: 76 opt: 184 Z-score: 245.1 bits: 52.3 E(85289): 6.5e-07
Smith-Waterman score: 185; 30.7% identity (59.0% similar) in 166 aa overlap (24-176:13-166)
10 20 30 40 50 60
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
::: : . :: .:: : ..:. :: : .
NP_057 MAEFPSKVSTRTSSPAQGAEASVS------ALRPDLGFVRSRLGALMLL
10 20 30 40
70 80 90 100 110
pF1KE3 QVILALIAFICI-ETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWN
:..:.:... : .: . : : . ::. ..:: ::. .. ..:::.. .. :
NP_057 QLVLGLLVWALIADTPYHLYPAYG--WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWP
50 60 70 80 90 100
120 130 140 150 160
pF1KE3 LTDLV-NTG-----LSAFLFFIASIVLAAL------NHRAGAEIAAVIFGFLATAAYAVN
:. .. : . ..::. :.. :..: :.:: :: .:. :. ::.:.
NP_057 LVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRA----AASFFACLVMIAYGVS
110 120 130 140 150
170 180 190 200 210 220
pF1KE3 TFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLS
.:.. : ::
NP_057 AFFSYQAWRGVGSNAATSQMAGGYA
160 170 180
>>XP_016861135 (OMIM: 607890) PREDICTED: CKLF-like MARVE (179 aa)
initn: 131 init1: 91 opt: 178 Z-score: 237.4 bits: 50.9 E(85289): 1.7e-06
Smith-Waterman score: 178; 27.8% identity (61.1% similar) in 144 aa overlap (15-158:13-148)
10 20 30 40 50 60
pF1KE3 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
:: : .. ... ::.. : : :: : .: : . ::::
XP_016 MSHGAGLVRTTCSSGSALGPGAGAAQPSASP------LEGL-LDLSYPRTHAALLKVA
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 QVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNL
:.. ::::::... . . :: . :. ... . :. . . .. . :.: :
XP_016 QMVTLLIAFICVRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHL-FRFYRVLTCISWPL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 TDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVR
..:.. ....:..::::: :. .. .. .:... :
XP_016 SELLHYLIGTLLLLIASIVAASKSYNQSGLVAGAVRMFWGAFRNEFLFKMLIFFLMGEEK
120 130 140 150 160 170
190 200 210 220 230
pF1KE3 QQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
XP_016 GLVSGAFPS
>>NP_002659 (OMIM: 300112) proteolipid protein 2 [Homo s (152 aa)
initn: 162 init1: 100 opt: 175 Z-score: 234.5 bits: 50.1 E(85289): 2.5e-06
Smith-Waterman score: 175; 28.2% identity (66.9% similar) in 124 aa overlap (48-170:18-131)
20 30 40 50 60 70
pF1KE3 SMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMA
.. : : : :..:: :. .::. :
NP_002 MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFS---A
10 20 30 40
80 90 100 110 120 130
pF1KE3 CSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIAS
.: : . .: ........... .:: .:: ::: .:. : ..:.:..:.:
NP_002 STP--G---YSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITS
50 60 70 80 90
140 150 160 170 180 190
pF1KE3 IVLAALNHRAG-AEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRD
::. : .:.. ..:.: ..:..:: .. ....
NP_002 IVV--LVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV
100 110 120 130 140 150
200 210 220 230
pF1KE3 VDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
234 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:18:33 2016 done: Sun Nov 6 05:18:34 2016
Total Scan time: 5.450 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]