Result of FASTA (omim) for
pFN21AE3043
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3043, 183 aa
1>>>pF1KE3043 183 - 183 aa - 183 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.3219+/-0.000299; mu= 18.1853+/- 0.019
mean_var=55.2649+/-11.243, 0's: 0 Z-trim(116.7): 25 B-trim: 0 in 0/51
Lambda= 0.172524
statistics sampled from 28138 (28162) to 28138 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.33), width: 16
Scan time: 5.160
The best scores are: opt bits E(85289)
NP_060271 (OMIM: 607889) CKLF-like MARVEL transmem ( 183) 1185 302.3 2.9e-82
NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 329 89.3 4.4e-18
XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 329 89.3 4.6e-18
NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 329 89.3 4.8e-18
XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like M ( 179) 301 82.2 4.9e-16
NP_612419 (OMIM: 607890) CKLF-like MARVEL transmem ( 175) 146 43.7 0.0002
NP_853531 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 140 42.2 0.00057
NP_653202 (OMIM: 607886) CKLF-like MARVEL transmem ( 182) 140 42.2 0.00057
XP_006721194 (OMIM: 607886) PREDICTED: CKLF-like M ( 182) 140 42.2 0.00057
>>NP_060271 (OMIM: 607889) CKLF-like MARVEL transmembran (183 aa)
initn: 1185 init1: 1185 opt: 1185 Z-score: 1597.9 bits: 302.3 E(85289): 2.9e-82
Smith-Waterman score: 1185; 100.0% identity (100.0% similar) in 183 aa overlap (1-183:1-183)
10 20 30 40 50 60
pF1KE3 MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRVLKGLQLLLSLLAFICEEVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRVLKGLQLLLSLLAFICEEVVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRAEALTEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRAEALTEP
130 140 150 160 170 180
pF1KE3 LNA
:::
NP_060 LNA
>>NP_852662 (OMIM: 607887) CKLF-like MARVEL transmembran (208 aa)
initn: 330 init1: 310 opt: 329 Z-score: 445.7 bits: 89.3 E(85289): 4.4e-18
Smith-Waterman score: 329; 35.9% identity (65.7% similar) in 181 aa overlap (1-179:19-193)
10 20 30 40
pF1KE3 MENGAV--YSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV
: .:: :.:::: : : .:: . : : :
NP_852 MRSGEELDGFEGEASSTSMISGASSPYQPTTE--PVSQRRGLAGLRCDPDYLRGALGR--
10 20 30 40 50
50 60 70 80 90 100
pF1KE3 LKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTT
:: :..:.:.:::: :.. :. : :::::::::::::... ..::.. .. :.
NP_852 LKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE3 KVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKR
. . .:. : .. .:..:::.... . :..:::::..:::.:. . .. :.: ..
NP_852 NWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVN--TFLAVQK
120 130 140 150 160 170
170 180
pF1KE3 QESQLRKPENTTRAEALTEPLNA
. ..:. .. .: ::
NP_852 WRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT
180 190 200
>>XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like MARVE (221 aa)
initn: 330 init1: 310 opt: 329 Z-score: 445.4 bits: 89.3 E(85289): 4.6e-18
Smith-Waterman score: 329; 35.9% identity (65.7% similar) in 181 aa overlap (1-179:19-193)
10 20 30 40
pF1KE3 MENGAV--YSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV
: .:: :.:::: : : .:: . : : :
XP_016 MRSGEELDGFEGEASSTSMISGASSPYQPTTE--PVSQRRGLAGLRCDPDYLRGALGR--
10 20 30 40 50
50 60 70 80 90 100
pF1KE3 LKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTT
:: :..:.:.:::: :.. :. : :::::::::::::... ..::.. .. :.
XP_016 LKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE3 KVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKR
. . .:. : .. .:..:::.... . :..:::::..:::.:. . .. :.: ..
XP_016 NWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVN--TFLAVQK
120 130 140 150 160 170
170 180
pF1KE3 QESQLRKPENTTRAEALTEPLNA
. ..:. .. .: ::
XP_016 WRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTLNWKPNGHQQVKG
180 190 200 210 220
>>NP_848933 (OMIM: 607887) CKLF-like MARVEL transmembran (234 aa)
initn: 330 init1: 310 opt: 329 Z-score: 445.0 bits: 89.3 E(85289): 4.8e-18
Smith-Waterman score: 329; 35.9% identity (65.7% similar) in 181 aa overlap (1-179:19-193)
10 20 30 40
pF1KE3 MENGAV--YSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV
: .:: :.:::: : : .:: . : : :
NP_848 MRSGEELDGFEGEASSTSMISGASSPYQPTTE--PVSQRRGLAGLRCDPDYLRGALGR--
10 20 30 40 50
50 60 70 80 90 100
pF1KE3 LKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTT
:: :..:.:.:::: :.. :. : :::::::::::::... ..::.. .. :.
NP_848 LKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE3 KVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKR
. . .:. : .. .:..:::.... . :..:::::..:::.:. . .. :.: ..
NP_848 NWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVN--TFLAVQK
120 130 140 150 160 170
170 180
pF1KE3 QESQLRKPENTTRAEALTEPLNA
. ..:. .. .: ::
NP_848 WRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
180 190 200 210 220 230
>>XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like MARVE (179 aa)
initn: 302 init1: 282 opt: 301 Z-score: 408.9 bits: 82.2 E(85289): 4.9e-16
Smith-Waterman score: 301; 35.3% identity (72.2% similar) in 133 aa overlap (47-179:34-164)
20 30 40 50 60 70
pF1KE3 PARGPRSGLAAYFFMGRLPLLRRVLKGLQLLLSLLAFICEEVVSQCTLCGGLYFFEFVSC
.:.:.:::: :.. :. : ::::::::::
XP_011 GEELDGFEGEASSTSMISGASSPYQPTTEPILALIAFICIETIMACSPCEGLYFFEFVSC
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE3 SAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIA
:::... ..::.. .. :. . . .:. : .. .:..:::.... . :..::::
XP_011 SAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIA
70 80 90 100 110 120
140 150 160 170 180
pF1KE3 AIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRAEALTEPLNA
:..:::.:. . .. :.: .. . ..:. .. .: ::
XP_011 AVIFGFLATAAYAVN--TFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT
130 140 150 160 170
>>NP_612419 (OMIM: 607890) CKLF-like MARVEL transmembran (175 aa)
initn: 173 init1: 108 opt: 146 Z-score: 200.5 bits: 43.7 E(85289): 0.0002
Smith-Waterman score: 146; 30.2% identity (54.1% similar) in 159 aa overlap (1-149:1-155)
10 20 30 40 50
pF1KE3 MENGAVYSPTTEEDPGPARGPRSGLA---AYFFMGRLPLLR-----RVLKGLQLLLSLLA
: .:: :: . : : :: .: : : . : : : .:: :.. :.:
NP_612 MSHGAGLVRTTC-SSGSALGPGAGAAQPSASPLEGLLDLSYPRTHAALLKVAQMVTLLIA
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 FICEEVVSQCTLCGGLY-FFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDF-YIT
::: : :. . : .:: :. ... : . .:. ::. . . :.. .
NP_612 FIC--VRSSLWTNYSAYSYFEVVTICDLIMILAFYLVHLFRFYRVLTCISWPLSELLHYL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 LGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPEN
.:: ..:.:::. .: :. .:. .:::.:.:. .
NP_612 IGT-LLLLIASIVAASKSYNQSGLVAGAIFGFMATFLCMASIWLSYKISCVTQSTDAAV
120 130 140 150 160 170
180
pF1KE3 TTRAEALTEPLNA
>>NP_853531 (OMIM: 607886) CKLF-like MARVEL transmembran (182 aa)
initn: 138 init1: 65 opt: 140 Z-score: 192.2 bits: 42.2 E(85289): 0.00057
Smith-Waterman score: 140; 28.6% identity (52.6% similar) in 154 aa overlap (9-156:6-151)
10 20 30 40 50
pF1KE3 MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV--LKGLQLL----LSLLAFI
: . :: :: : : : :. . . :: . ::: :: ::...::
NP_853 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFI
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 CEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTG
: :.:. . : . :::.: .:.. . .. . :: . ..
NP_853 CY-VASSASA------FLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 CVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRA
... :: .. .. .: :: ::::.:...: :: ..
NP_853 LIYFAISITAIAKYS-DGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTA
120 130 140 150 160
180
pF1KE3 EALTEPLNA
NP_853 HKTEEENSDSDSD
170 180
>>NP_653202 (OMIM: 607886) CKLF-like MARVEL transmembran (182 aa)
initn: 138 init1: 65 opt: 140 Z-score: 192.2 bits: 42.2 E(85289): 0.00057
Smith-Waterman score: 140; 28.6% identity (52.6% similar) in 154 aa overlap (9-156:6-151)
10 20 30 40 50
pF1KE3 MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV--LKGLQLL----LSLLAFI
: . :: :: : : : :. . . :: . ::: :: ::...::
NP_653 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFI
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 CEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTG
: :.:. . : . :::.: .:.. . .. . :: . ..
NP_653 CY-VASSASA------FLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 CVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRA
... :: .. .. .: :: ::::.:...: :: ..
NP_653 LIYFAISITAIAKYS-DGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTA
120 130 140 150 160
180
pF1KE3 EALTEPLNA
NP_653 HKTEEENSDSDSD
170 180
>>XP_006721194 (OMIM: 607886) PREDICTED: CKLF-like MARVE (182 aa)
initn: 138 init1: 65 opt: 140 Z-score: 192.2 bits: 42.2 E(85289): 0.00057
Smith-Waterman score: 140; 28.6% identity (52.6% similar) in 154 aa overlap (9-156:6-151)
10 20 30 40 50
pF1KE3 MENGAVYSPTTEEDPGPARGPRSGLAAYFFMGRLPLLRRV--LKGLQLL----LSLLAFI
: . :: :: : : : :. . . :: . ::: :: ::...::
XP_006 MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFI
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 CEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTG
: :.:. . : . :::.: .:.. . .. . :: . ..
XP_006 CY-VASSASA------FLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 CVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFITMLYEKRQESQLRKPENTTRA
... :: .. .. .: :: ::::.:...: :: ..
XP_006 LIYFAISITAIAKYS-DGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTA
120 130 140 150 160
180
pF1KE3 EALTEPLNA
XP_006 HKTEEENSDSDSD
170 180
183 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:52:30 2016 done: Sun Nov 6 17:52:31 2016
Total Scan time: 5.160 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]