Result of FASTA (omim) for
pFN21AE3038
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3038, 173 aa
1>>>pF1KE3038 173 - 173 aa - 173 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6105+/-0.000404; mu= 16.0338+/- 0.025
mean_var=58.4325+/-12.165, 0's: 0 Z-trim(110.0): 38 B-trim: 0 in 0/51
Lambda= 0.167783
statistics sampled from 18300 (18331) to 18300 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.215), width: 16
Scan time: 5.120
The best scores are: opt bits E(85289)
NP_849199 (OMIM: 607891) CKLF-like MARVEL transmem ( 173) 1116 278.4 3.9e-75
XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like M ( 196) 827 208.5 4.9e-54
XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like M ( 130) 825 207.9 5e-54
XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like M ( 100) 659 167.6 5.1e-42
NP_001307237 (OMIM: 607891) CKLF-like MARVEL trans ( 115) 445 115.9 2.2e-26
NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens ( 182) 409 107.3 1.3e-23
NP_005425 (OMIM: 602022) MAL-like protein [Homo sa ( 153) 228 63.4 1.8e-10
NP_002362 (OMIM: 188860) myelin and lymphocyte pro ( 153) 227 63.2 2.1e-10
XP_011510111 (OMIM: 602022) PREDICTED: MAL-like pr ( 149) 218 61.0 9.5e-10
NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 194 55.3 6.9e-08
XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 194 55.3 7.2e-08
NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 194 55.3 7.5e-08
NP_443118 (OMIM: 609684) protein MAL2 [Homo sapien ( 176) 186 53.3 2.3e-07
XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like M ( 179) 159 46.8 2.2e-05
NP_071883 (OMIM: 188860) myelin and lymphocyte pro ( 111) 148 44.0 9.5e-05
XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 39.0 0.0042
NP_612469 (OMIM: 607888) CKLF-like MARVEL transmem ( 156) 127 39.0 0.0042
XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 39.0 0.0042
NP_113672 (OMIM: 616970) MARVEL domain-containing ( 173) 124 38.3 0.0075
>>NP_849199 (OMIM: 607891) CKLF-like MARVEL transmembran (173 aa)
initn: 1116 init1: 1116 opt: 1116 Z-score: 1469.9 bits: 278.4 E(85289): 3.9e-75
Smith-Waterman score: 1116; 98.8% identity (98.8% similar) in 173 aa overlap (1-173:1-173)
10 20 30 40 50 60
pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_849 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
NP_849 GTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL
70 80 90 100 110 120
130 140 150 160 170
pF1KE3 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_849 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
130 140 150 160 170
>>XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like MARVE (196 aa)
initn: 846 init1: 827 opt: 827 Z-score: 1091.1 bits: 208.5 E(85289): 4.9e-54
Smith-Waterman score: 1060; 87.2% identity (87.2% similar) in 196 aa overlap (1-173:1-196)
10 20 30 40
pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEI-----------
:::::::::::::::::::::::::::::::::::::::: ::::::::
XP_011 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEILISLPITDPLH
10 20 30 40 50 60
50 60 70 80 90
pF1KE3 ------------VLGLLVWTLIAGTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYT
::::::::::::::::::::::::::::: ::::::::::::::::::
XP_011 RSALSTTARDILVLGLLVWTLIAGTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYT
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 RIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYA
130 140 150 160 170 180
160 170
pF1KE3 GNTYFSFIAWRSRTIQ
::::::::::::::::
XP_011 GNTYFSFIAWRSRTIQ
190
>>XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like MARVE (130 aa)
initn: 825 init1: 825 opt: 825 Z-score: 1090.9 bits: 207.9 E(85289): 5e-54
Smith-Waterman score: 825; 99.2% identity (99.2% similar) in 124 aa overlap (50-173:7-130)
20 30 40 50 60 70
pF1KE3 AENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVS
:::::::::::::::::::::::::::::
XP_016 MFRRIQVLGLLVWTLIAGTEYFRVPAFGWVMFVAVF
10 20 30
80 90 100 110 120 130
pF1KE3 YWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNF
40 50 60 70 80 90
140 150 160 170
pF1KE3 NSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
::::::::::::::::::::::::::::::::::
XP_016 NSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
100 110 120 130
>>XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like MARVE (100 aa)
initn: 659 init1: 659 opt: 659 Z-score: 875.3 bits: 167.6 E(85289): 5.1e-42
Smith-Waterman score: 659; 99.0% identity (99.0% similar) in 100 aa overlap (74-173:1-100)
50 60 70 80 90 100
pF1KE3 LIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVP
::::: ::::::::::::::::::::::::
XP_016 MFVAVFYWVLTVFFLIIYITMTYTRIPQVP
10 20 30
110 120 130 140 150 160
pF1KE3 WTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFS
40 50 60 70 80 90
170
pF1KE3 FIAWRSRTIQ
::::::::::
XP_016 FIAWRSRTIQ
100
>>NP_001307237 (OMIM: 607891) CKLF-like MARVEL transmemb (115 aa)
initn: 464 init1: 445 opt: 445 Z-score: 594.5 bits: 115.9 E(85289): 2.2e-26
Smith-Waterman score: 606; 65.9% identity (65.9% similar) in 173 aa overlap (1-173:1-115)
10 20 30 40 50 60
pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA
:::::::::::::::::::::::::::::::::::::::: ::::::::
NP_001 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEI-----------
10 20 30 40
70 80 90 100 110 120
pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL
:::::::::::::
NP_001 -----------------------------------------------GLCFNGSAFVLYL
50 60
130 140 150 160 170
pF1KE3 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
70 80 90 100 110
>>NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens] (182 aa)
initn: 259 init1: 259 opt: 409 Z-score: 544.7 bits: 107.3 E(85289): 1.3e-23
Smith-Waterman score: 409; 42.1% identity (71.1% similar) in 159 aa overlap (12-168:8-166)
10 20 30 40 50 60
pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA
:.: .:: :.. .: :.. : :.:. : :.. ..:::::::.:::
NP_057 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIA
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL
: : ::.:::::::: :..:. .. .:. . . .. .::: : . :: :: :::.
NP_057 DTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYI
60 70 80 90 100 110
130 140 150 160 170
pF1KE3 SAAVVDASSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
.: .. ...: . : .. .:. ::.:::: :: : :. ...::. :::
NP_057 TAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQ
120 130 140 150 160 170
NP_057 MAGGYA
180
>>NP_005425 (OMIM: 602022) MAL-like protein [Homo sapien (153 aa)
initn: 194 init1: 136 opt: 228 Z-score: 308.9 bits: 63.4 E(85289): 1.8e-10
Smith-Waterman score: 228; 33.9% identity (67.7% similar) in 124 aa overlap (36-156:23-143)
10 20 30 40 50 60
pF1KE3 RARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGTEYF
:: .:.. :...:.::::..:.:.
NP_005 MASPDPPATSYAPSDVPSGVALFLTIPFAFFL-PELIFGFLVWTMVAATHIV
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 RVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAV-
::::.:... ......::. :. : :. . : .. ..:.. .::.::::
NP_005 YPLLQGWVMYVSLTSFLISLMFLLSYLFGFYKRFES--WRVLDSLYHGTTGILYMSAAVL
60 70 80 90 100
130 140 150 160 170
pF1KE3 -VDASSVSPER-DSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
: :. :: . : . . .:.:::::..:. :
NP_005 QVHATIVSEKLLDPRIYYINSAASFFAFIATLLYILHAFSIYYH
110 120 130 140 150
>>NP_002362 (OMIM: 188860) myelin and lymphocyte protein (153 aa)
initn: 161 init1: 125 opt: 227 Z-score: 307.6 bits: 63.2 E(85289): 2.1e-10
Smith-Waterman score: 227; 28.9% identity (65.1% similar) in 149 aa overlap (24-169:6-152)
10 20 30 40 50 60
pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA
.:..:.. . :: .:.. :...: ::: :.:
NP_002 MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVA
10 20 30 40
70 80 90 100 110 120
pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL
.. . ::::::.: .: :. ..:.:: .. .. :.:. .. .: ..::
NP_002 SSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHG--GETSWVTLDAAYHCTAALFYL
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 SAAVVDASSVSPERDSHNFNSW---AASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
::.:..: .. .:. .. . :. :....:. :. .. ::.: :.:
NP_002 SASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS
110 120 130 140 150
>>XP_011510111 (OMIM: 602022) PREDICTED: MAL-like protei (149 aa)
initn: 187 init1: 129 opt: 218 Z-score: 296.0 bits: 61.0 E(85289): 9.5e-10
Smith-Waterman score: 218; 34.2% identity (69.4% similar) in 111 aa overlap (49-156:31-139)
20 30 40 50 60 70
pF1KE3 FAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAV
...:.::::..:.:. ::::.:..
XP_011 MEKLTEDSRKKKKGAGIFGKETRIQNTTKLLIFGFLVWTMVAATHIVYPLLQGWVMYVSL
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE3 SYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAV--VDASSVSPER-D
. ......::. :. : :. . : .. ..:.. .::.:::: : :. :: . :
XP_011 TSFLISLMFLLSYLFGFYKRFES--WRVLDSLYHGTTGILYMSAAVLQVHATIVSEKLLD
70 80 90 100 110
140 150 160 170
pF1KE3 SHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
. . .:.:::::..:. :
XP_011 PRIYYINSAASFFAFIATLLYILHAFSIYYH
120 130 140
>>NP_852662 (OMIM: 607887) CKLF-like MARVEL transmembran (208 aa)
initn: 148 init1: 83 opt: 194 Z-score: 262.6 bits: 55.3 E(85289): 6.9e-08
Smith-Waterman score: 194; 31.7% identity (59.7% similar) in 139 aa overlap (33-168:46-176)
10 20 30 40 50 60
pF1KE3 EPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGT
: ..:: : : ::...:.:... : :
NP_852 STSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIE-T
20 30 40 50 60 70
70 80 90 100 110
pF1KE3 EYFRVPAFG--WVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNG-SAFVLY
. : : . ::. : .:.: .::.. . ::::. :. . : .: :::...
NP_852 IMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFF
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE3 LSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
... :. : . : .. :. .:.::.: :: ::... ::
NP_852 IASIVLAALN-------HRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDY
140 150 160 170 180
NP_852 IRARTESRDVDSRPEIQRLDT
190 200
173 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 02:20:40 2016 done: Sun Nov 6 02:20:41 2016
Total Scan time: 5.120 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]