Result of FASTA (omim) for
pFN21AE3037
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3037, 169 aa
1>>>pF1KE3037 169 - 169 aa - 169 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2358+/-0.000332; mu= 12.5731+/- 0.021
mean_var=61.7694+/-12.297, 0's: 0 Z-trim(115.0): 20 B-trim: 0 in 0/56
Lambda= 0.163188
statistics sampled from 25172 (25187) to 25172 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.295), width: 16
Scan time: 5.210
The best scores are: opt bits E(85289)
NP_919416 (OMIM: 192320) VIP peptides isoform 2 pr ( 169) 1089 264.5 5.8e-71
NP_003372 (OMIM: 192320) VIP peptides isoform 1 pr ( 170) 1077 261.7 4.2e-70
XP_005267192 (OMIM: 192320) PREDICTED: VIP peptide ( 168) 1072 260.5 9.3e-70
XP_006715625 (OMIM: 192320) PREDICTED: VIP peptide ( 169) 1060 257.7 6.6e-69
NP_001108 (OMIM: 102980) pituitary adenylate cycla ( 176) 221 60.1 2e-09
NP_001093203 (OMIM: 102980) pituitary adenylate cy ( 176) 221 60.1 2e-09
XP_005258138 (OMIM: 102980) PREDICTED: pituitary a ( 337) 221 60.3 3.5e-09
NP_002045 (OMIM: 138030) glucagon preproprotein [H ( 180) 161 46.0 3.6e-05
XP_011527090 (OMIM: 139190) PREDICTED: somatoliber ( 107) 148 42.9 0.00019
NP_001171660 (OMIM: 139190) somatoliberin isoform ( 107) 148 42.9 0.00019
XP_011527086 (OMIM: 139190) PREDICTED: somatoliber ( 108) 136 40.0 0.0014
NP_066567 (OMIM: 139190) somatoliberin isoform 1 p ( 108) 136 40.0 0.0014
>>NP_919416 (OMIM: 192320) VIP peptides isoform 2 prepro (169 aa)
initn: 1089 init1: 1089 opt: 1089 Z-score: 1394.9 bits: 264.5 E(85289): 5.8e-71
Smith-Waterman score: 1089; 100.0% identity (100.0% similar) in 169 aa overlap (1-169:1-169)
10 20 30 40 50 60
pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP
70 80 90 100 110 120
130 140 150 160
pF1KE3 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
130 140 150 160
>>NP_003372 (OMIM: 192320) VIP peptides isoform 1 prepro (170 aa)
initn: 835 init1: 718 opt: 1077 Z-score: 1379.6 bits: 261.7 E(85289): 4.2e-70
Smith-Waterman score: 1077; 99.4% identity (99.4% similar) in 170 aa overlap (1-169:1-170)
10 20 30 40 50 60
pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVS-NISEDPV
:::::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
NP_003 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV
70 80 90 100 110 120
120 130 140 150 160
pF1KE3 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
130 140 150 160 170
>>XP_005267192 (OMIM: 192320) PREDICTED: VIP peptides is (168 aa)
initn: 994 init1: 994 opt: 1072 Z-score: 1373.4 bits: 260.5 E(85289): 9.3e-70
Smith-Waterman score: 1072; 99.4% identity (99.4% similar) in 169 aa overlap (1-169:1-168)
10 20 30 40 50 60
pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP
70 80 90 100 110 120
130 140 150 160
pF1KE3 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
::::::::::::::::::::::::::::::::::: :::::::::::::
XP_005 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRS-EGESPDFPEELEK
130 140 150 160
>>XP_006715625 (OMIM: 192320) PREDICTED: VIP peptides is (169 aa)
initn: 778 init1: 778 opt: 1060 Z-score: 1358.0 bits: 257.7 E(85289): 6.6e-69
Smith-Waterman score: 1060; 98.8% identity (98.8% similar) in 170 aa overlap (1-169:1-169)
10 20 30 40 50 60
pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
10 20 30 40 50 60
70 80 90 100 110
pF1KE3 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVS-NISEDPV
:::::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_006 LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV
70 80 90 100 110 120
120 130 140 150 160
pF1KE3 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
:::::::::::::::::::::::::::::::::::: :::::::::::::
XP_006 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRS-EGESPDFPEELEK
130 140 150 160
>>NP_001108 (OMIM: 102980) pituitary adenylate cyclase-a (176 aa)
initn: 187 init1: 150 opt: 221 Z-score: 290.3 bits: 60.1 E(85289): 2e-09
Smith-Waterman score: 222; 36.3% identity (61.8% similar) in 157 aa overlap (10-154:9-161)
10 20 30 40 50
pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKE-DID
:.::. .. :.. . : : ..::. : : : : : . : .
NP_001 MTMCSGARLALLVYGIIMHSSVYSSP---AAAGLRFPGIRPEEEAYGEDGNPLPDFDGS
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 MLQNALAENDTPYYDVS--RNARHAD---GVFTSDFSKLLGQLSAKKYLESLMGKRVSN-
.: . ..: .. : : . : :... . :.: :::: :.:.::... :..
NP_001 EPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGS
60 70 80 90 100 110
120 130 140 150 160
pF1KE3 ----ISEDPVPV-KRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELE
..: :. :::::..:::.:.: :::::::::: ..: :::
NP_001 LGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVL-GKRYKQRVKNKGRRIAY
120 130 140 150 160 170
pF1KE3 K
NP_001 L
>>NP_001093203 (OMIM: 102980) pituitary adenylate cyclas (176 aa)
initn: 187 init1: 150 opt: 221 Z-score: 290.3 bits: 60.1 E(85289): 2e-09
Smith-Waterman score: 222; 36.3% identity (61.8% similar) in 157 aa overlap (10-154:9-161)
10 20 30 40 50
pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKE-DID
:.::. .. :.. . : : ..::. : : : : : . : .
NP_001 MTMCSGARLALLVYGIIMHSSVYSSP---AAAGLRFPGIRPEEEAYGEDGNPLPDFDGS
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 MLQNALAENDTPYYDVS--RNARHAD---GVFTSDFSKLLGQLSAKKYLESLMGKRVSN-
.: . ..: .. : : . : :... . :.: :::: :.:.::... :..
NP_001 EPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGS
60 70 80 90 100 110
120 130 140 150 160
pF1KE3 ----ISEDPVPV-KRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELE
..: :. :::::..:::.:.: :::::::::: ..: :::
NP_001 LGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVL-GKRYKQRVKNKGRRIAY
120 130 140 150 160 170
pF1KE3 K
NP_001 L
>>XP_005258138 (OMIM: 102980) PREDICTED: pituitary adeny (337 aa)
initn: 213 init1: 150 opt: 221 Z-score: 285.9 bits: 60.3 E(85289): 3.5e-09
Smith-Waterman score: 222; 36.3% identity (61.8% similar) in 157 aa overlap (10-154:170-322)
10 20 30
pF1KE3 MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGD
:.::. .. :.. . : : ..::.
XP_005 LEEALCPPSYLAALLAAGGVEGMTMCSGARLALLVYGIIMHSSVYSSP---AAAGLRFPG
140 150 160 170 180 190
40 50 60 70 80 90
pF1KE3 RIPFEGANEPDQVSLKE-DIDMLQNALAENDTPYYDVS--RNARHAD---GVFTSDFSKL
: : : : : . : . .: . ..: .. : : . : :... . :.
XP_005 IRPEEEAYGEDGNPLPDFDGSEPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKV
200 210 220 230 240 250
100 110 120 130 140
pF1KE3 LGQLSAKKYLESLMGKRVSN-----ISEDPVPV-KRHSDAVFTDNYTRLRKQMAVKKYLN
: :::: :.:.::... :.. ..: :. :::::..:::.:.: ::::::::::
XP_005 LDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLA
260 270 280 290 300 310
150 160
pF1KE3 SILNGKRSSEGESPDFPEELEK
..: :::
XP_005 AVL-GKRYKQRVKNKGRRIAYL
320 330
>>NP_002045 (OMIM: 138030) glucagon preproprotein [Homo (180 aa)
initn: 188 init1: 89 opt: 161 Z-score: 213.8 bits: 46.0 E(85289): 3.6e-05
Smith-Waterman score: 161; 29.5% identity (64.8% similar) in 122 aa overlap (51-167:20-136)
30 40 50 60 70
pF1KE3 SQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDMLQNALAENDTPYYD---VSR
: ::.. . .. : . : : ...
NP_002 MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNE
10 20 30 40
80 90 100 110 120 130
pF1KE3 NARHADGVFTSDFSKLLGQLSAKKYLESLMG-KRV-SNISEDPVPVKRHSDAVFTDNYTR
. ::..:.::::.:: : . :. ... ::. :: .::.. .::....::.. .
NP_002 DKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSS
50 60 70 80 90 100
140 150 160
pF1KE3 LRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
. .:.:... ...:. :. :::::.
NP_002 YLEGQAAKEFIAWLVKGR----GRR-DFPEEVAIVEELGRRHADGSFSDEMNTILDNLAA
110 120 130 140 150 160
NP_002 RDFINWLIQTKITDRK
170 180
>>XP_011527090 (OMIM: 139190) PREDICTED: somatoliberin i (107 aa)
initn: 141 init1: 104 opt: 148 Z-score: 200.7 bits: 42.9 E(85289): 0.00019
Smith-Waterman score: 148; 32.9% identity (72.0% similar) in 82 aa overlap (77-158:28-107)
50 60 70 80 90 100
pF1KE3 NEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESL
: :.::..::... :.::::::.: :...
XP_011 MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDI
10 20 30 40 50
110 120 130 140 150 160
pF1KE3 MGKRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEE
:... .. ... : . : :.. .::: ... : ..:. .:.:.:
XP_011 MSRQQGESNQERGARARLGRQV--DSMWAEQKQMELESILVALLQKHRNSQG
60 70 80 90 100
pF1KE3 LEK
>>NP_001171660 (OMIM: 139190) somatoliberin isoform 2 pr (107 aa)
initn: 141 init1: 104 opt: 148 Z-score: 200.7 bits: 42.9 E(85289): 0.00019
Smith-Waterman score: 148; 32.9% identity (72.0% similar) in 82 aa overlap (77-158:28-107)
50 60 70 80 90 100
pF1KE3 NEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESL
: :.::..::... :.::::::.: :...
NP_001 MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDI
10 20 30 40 50
110 120 130 140 150 160
pF1KE3 MGKRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEE
:... .. ... : . : :.. .::: ... : ..:. .:.:.:
NP_001 MSRQQGESNQERGARARLGRQV--DSMWAEQKQMELESILVALLQKHRNSQG
60 70 80 90 100
pF1KE3 LEK
169 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:56:17 2016 done: Sun Nov 6 04:56:18 2016
Total Scan time: 5.210 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]