Result of FASTA (omim) for
pFN21AE3035
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3035, 168 aa
1>>>pF1KE3035 168 - 168 aa - 168 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0638+/-0.000308; mu= 13.9457+/- 0.019
mean_var=68.4101+/-13.787, 0's: 0 Z-trim(117.8): 47 B-trim: 548 in 1/51
Lambda= 0.155065
statistics sampled from 30083 (30134) to 30083 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.353), width: 16
Scan time: 5.100
The best scores are: opt bits E(85289)
NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo ( 168) 1150 265.5 2.9e-71
XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 i ( 168) 1150 265.5 2.9e-71
XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 i ( 186) 1150 265.5 3.2e-71
NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precu ( 184) 622 147.4 1.1e-35
XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 i ( 221) 622 147.4 1.3e-35
XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 i ( 240) 622 147.5 1.4e-35
NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [H ( 114) 576 136.9 9.8e-33
NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 pr ( 143) 577 137.2 1e-32
NP_001191013 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10
NP_001191014 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10
NP_001265095 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10
NP_005371 (OMIM: 600613) neuroblastoma suppressor ( 181) 249 63.9 1.5e-10
NP_001265094 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10
NP_001265093 (OMIM: 600613) neuroblastoma suppress ( 181) 249 63.9 1.5e-10
NP_001191015 (OMIM: 600613) neuroblastoma suppress ( 215) 249 64.0 1.7e-10
NP_877421 (OMIM: 600613) neuroblastoma suppressor ( 216) 249 64.0 1.7e-10
NP_005445 (OMIM: 603777) cerberus precursor [Homo ( 267) 224 58.4 9.7e-09
NP_689867 (OMIM: 609068) DAN domain family member ( 189) 156 43.1 0.00028
NP_079513 (OMIM: 122860,239100,269500,605740) scle ( 213) 143 40.3 0.0023
NP_002448 (OMIM: 158370) mucin-2 precursor [Homo s (5289) 152 43.3 0.0072
>>NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo sap (168 aa)
initn: 1150 init1: 1150 opt: 1150 Z-score: 1400.3 bits: 265.5 E(85289): 2.9e-71
Smith-Waterman score: 1150; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)
10 20 30 40 50 60
pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC
70 80 90 100 110 120
130 140 150 160
pF1KE3 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
130 140 150 160
>>XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 isofo (168 aa)
initn: 1150 init1: 1150 opt: 1150 Z-score: 1400.3 bits: 265.5 E(85289): 2.9e-71
Smith-Waterman score: 1150; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)
10 20 30 40 50 60
pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQEAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSC
70 80 90 100 110 120
130 140 150 160
pF1KE3 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
130 140 150 160
>>XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 isofo (186 aa)
initn: 1150 init1: 1150 opt: 1150 Z-score: 1399.7 bits: 265.5 E(85289): 3.2e-71
Smith-Waterman score: 1150; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:19-186)
10 20 30 40
pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNS
::::::::::::::::::::::::::::::::::::::::::
XP_005 MRALRAESTSGSRQTPCRMFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNS
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 ERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 SFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNL
130 140 150 160 170 180
pF1KE3 SDSDKQ
::::::
XP_005 SDSDKQ
>>NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precursor (184 aa)
initn: 675 init1: 614 opt: 622 Z-score: 761.3 bits: 147.4 E(85289): 1.1e-35
Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (9-162:12-183)
10 20 30 40 50
pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIK-------
:.:...:. .::..:. :::: : : .. :.::. : .
NP_037 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDSEQTQSPQQPGSRNRG
10 20 30 40 50
60 70 80 90
pF1KE3 ------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY
::: :::::: :::::::: ::::::::.::. :::: ::::.:::::
NP_037 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE3 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCM
:::::::::::..::: :::::.::::.. :...: :.:: :.:: . :.. .::::::.
NP_037 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCI
120 130 140 150 160 170
160
pF1KE3 SVNLSDSDKQ
:..:
NP_037 SIDLD
180
>>XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 isofo (221 aa)
initn: 675 init1: 614 opt: 622 Z-score: 760.2 bits: 147.4 E(85289): 1.3e-35
Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (9-162:49-220)
10 20 30
pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGS
:.:...:. .::..:. :::: : : ..
XP_016 SAGWSIRRIHDVCICRSPSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQ
20 30 40 50 60 70
40 50 60 70
pF1KE3 SNNSERWQHQIK-------------------EVLASSQEALVVTERKYLKSDWCKTQPLR
:.::. : . ::: :::::: :::::::: ::::::::.
XP_016 HNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLK
80 90 100 110 120 130
80 90 100 110 120 130
pF1KE3 QTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPG
::. :::: ::::.::::::::::::::::..::: :::::.::::.. :...: :.::
XP_016 QTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPE
140 150 160 170 180 190
140 150 160
pF1KE3 LDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
:.:: . :.. .::::::.:..:
XP_016 LQPPTKKKRVTRVKQCRCISIDLD
200 210 220
>>XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 isofo (240 aa)
initn: 698 init1: 614 opt: 622 Z-score: 759.7 bits: 147.5 E(85289): 1.4e-35
Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (9-162:68-239)
10 20 30
pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGS
:.:...:. .::..:. :::: : : ..
XP_005 RTQRHASKAQAPRTRRTDSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQ
40 50 60 70 80 90
40 50 60 70
pF1KE3 SNNSERWQHQIK-------------------EVLASSQEALVVTERKYLKSDWCKTQPLR
:.::. : . ::: :::::: :::::::: ::::::::.
XP_005 HNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLK
100 110 120 130 140 150
80 90 100 110 120 130
pF1KE3 QTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPG
::. :::: ::::.::::::::::::::::..::: :::::.::::.. :...: :.::
XP_005 QTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPE
160 170 180 190 200 210
140 150 160
pF1KE3 LDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
:.:: . :.. .::::::.:..:
XP_005 LQPPTKKKRVTRVKQCRCISIDLD
220 230 240
>>NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [Homo (114 aa)
initn: 587 init1: 576 opt: 576 Z-score: 708.7 bits: 136.9 E(85289): 9.8e-33
Smith-Waterman score: 576; 70.2% identity (89.4% similar) in 104 aa overlap (59-162:10-113)
30 40 50 60 70 80
pF1KE3 AIPSPYKDGSSNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCR
:: :::::::: ::::::::.::. ::::
NP_001 MSRTAYTVGALHVTERKYLKRDWCKTQPLKQTIHEEGCN
10 20 30
90 100 110 120 130 140
pF1KE3 SRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK
::::.::::::::::::::::..::: :::::.::::.. :...: :.:: :.:: . :.
NP_001 SRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKR
40 50 60 70 80 90
150 160
pF1KE3 IQKVKQCRCMSVNLSDSDKQ
. .::::::.:..:
NP_001 VTRVKQCRCISIDLD
100 110
>>NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 precur (143 aa)
initn: 617 init1: 576 opt: 577 Z-score: 708.5 bits: 137.2 E(85289): 1e-32
Smith-Waterman score: 592; 55.2% identity (74.0% similar) in 154 aa overlap (9-162:12-142)
10 20 30 40 50
pF1KE3 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIKEVLASSQ
:.:...:. .::..:. :::: : :
NP_001 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK----------------------
10 20 30
60 70 80 90 100 110
pF1KE3 EALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESF
:: :::::::: ::::::::.::. :::: ::::.::::::::::::::::..::: ::
NP_001 -ALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSF
40 50 60 70 80 90
120 130 140 150 160
pF1KE3 QSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCMSVNLSDSDKQ
:::.::::.. :...: :.:: :.:: . :.. .::::::.:..:
NP_001 QSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
100 110 120 130 140
>>NP_001191013 (OMIM: 600613) neuroblastoma suppressor o (181 aa)
initn: 231 init1: 217 opt: 249 Z-score: 310.5 bits: 63.9 E(85289): 1.5e-10
Smith-Waterman score: 249; 35.9% identity (62.0% similar) in 92 aa overlap (69-159:31-122)
40 50 60 70 80 90
pF1KE3 SNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY
:: ::... . : :.. ::....: :: :
NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE3 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK-IQKVKQCRC
::: :. .: . ::. : : : . .: ::::: . :. : ..:. .: :
NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC
70 80 90 100 110 120
160
pF1KE3 MSVNLSDSDKQ
..
NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE
130 140 150 160 170 180
>>NP_001191014 (OMIM: 600613) neuroblastoma suppressor o (181 aa)
initn: 231 init1: 217 opt: 249 Z-score: 310.5 bits: 63.9 E(85289): 1.5e-10
Smith-Waterman score: 249; 35.9% identity (62.0% similar) in 92 aa overlap (69-159:31-122)
40 50 60 70 80 90
pF1KE3 SNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY
:: ::... . : :.. ::....: :: :
NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE3 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK-IQKVKQCRC
::: :. .: . ::. : : : . .: ::::: . :. : ..:. .: :
NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC
70 80 90 100 110 120
160
pF1KE3 MSVNLSDSDKQ
..
NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE
130 140 150 160 170 180
168 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 12:38:48 2016 done: Sun Nov 6 12:38:49 2016
Total Scan time: 5.100 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]