Result of FASTA (omim) for
pFN21AE2748
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2748, 2465 aa
1>>>pF1KE2748 2465 - 2465 aa - 2465 aa
Library: /omim/omim.rfq.tfa
65951994 residues in 93482 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9450+/-0.000476; mu= 22.8308+/- 0.030
mean_var=88.1508+/-17.449, 0's: 0 Z-trim(108.6): 24 B-trim: 0 in 0/51
Lambda= 0.136603
statistics sampled from 17481 (17503) to 17481 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.506), E-opt: 0.2 (0.187), width: 16
Scan time: 11.790
The best scores are: opt bits E(93482)
NP_055833 (OMIM: 616823) protein dopey-1 isoform a (2465) 16031 3171.5 0
XP_016866053 (OMIM: 616823) protein dopey-1 isofor (2465) 16031 3171.5 0
XP_016866048 (OMIM: 616823) protein dopey-1 isofor (2485) 15354 3038.1 0
XP_016866049 (OMIM: 616823) protein dopey-1 isofor (2485) 15354 3038.1 0
XP_016866062 (OMIM: 616823) protein dopey-1 isofor (2333) 15051 2978.3 0
XP_016866063 (OMIM: 616823) protein dopey-1 isofor (2315) 14795 2927.9 0
XP_016866055 (OMIM: 616823) protein dopey-1 isofor (2456) 14110 2792.9 0
XP_024302141 (OMIM: 616823) protein dopey-1 isofor (2456) 14110 2792.9 0
XP_016866059 (OMIM: 616823) protein dopey-1 isofor (2452) 13702 2712.5 0
XP_016866061 (OMIM: 616823) protein dopey-1 isofor (2435) 13471 2667.0 0
XP_016866050 (OMIM: 616823) protein dopey-1 isofor (2476) 13433 2659.5 0
XP_016866051 (OMIM: 616823) protein dopey-1 isofor (2476) 13433 2659.5 0
NP_001186871 (OMIM: 616823) protein dopey-1 isofor (2476) 13433 2659.5 0
XP_024302142 (OMIM: 616823) protein dopey-1 isofor (2455) 12823 2539.3 0
XP_024302143 (OMIM: 616823) protein dopey-1 isofor (2455) 12823 2539.3 0
XP_016866060 (OMIM: 616823) protein dopey-1 isofor (2450) 12393 2454.5 0
XP_011533921 (OMIM: 616823) protein dopey-1 isofor (2475) 12146 2405.8 0
XP_016883998 (OMIM: 604803) protein dopey-2 isofor (2080) 2350 475.2 4.2e-132
NP_001307643 (OMIM: 604803) protein dopey-2 [Homo (2298) 2350 475.2 4.6e-132
NP_005119 (OMIM: 604803) protein dopey-2 [Homo sap (2298) 2350 475.2 4.6e-132
>>NP_055833 (OMIM: 616823) protein dopey-1 isoform a [Ho (2465 aa)
initn: 16031 init1: 16031 opt: 16031 Z-score: 17063.8 bits: 3171.5 E(93482): 0
Smith-Waterman score: 16031; 100.0% identity (100.0% similar) in 2465 aa overlap (1-2465:1-2465)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
2410 2420 2430 2440 2450 2460
pF1KE2 GMIKT
:::::
NP_055 GMIKT
>>XP_016866053 (OMIM: 616823) protein dopey-1 isoform X4 (2465 aa)
initn: 16031 init1: 16031 opt: 16031 Z-score: 17063.8 bits: 3171.5 E(93482): 0
Smith-Waterman score: 16031; 100.0% identity (100.0% similar) in 2465 aa overlap (1-2465:1-2465)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
2410 2420 2430 2440 2450 2460
pF1KE2 GMIKT
:::::
XP_016 GMIKT
>>XP_016866048 (OMIM: 616823) protein dopey-1 isoform X1 (2485 aa)
initn: 15351 init1: 15351 opt: 15354 Z-score: 16342.7 bits: 3038.1 E(93482): 0
Smith-Waterman score: 15981; 99.2% identity (99.2% similar) in 2485 aa overlap (1-2465:1-2485)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAK--------------------KNPEEDNSGRTLGWEP
:::::::::::::::::::::::: ::::::::::::::::
XP_016 QGIHQREFKPYVVRLAKLLRKRAKDKEEDFKTVILEGLEMAKHQKNPEEDNSGRTLGWEP
2350 2360 2370 2380 2390 2400
2390 2400 2410 2420 2430 2440
pF1KE2 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
2410 2420 2430 2440 2450 2460
2450 2460
pF1KE2 PCSSKARQKIEEMVEKDFLEGMIKT
:::::::::::::::::::::::::
XP_016 PCSSKARQKIEEMVEKDFLEGMIKT
2470 2480
>>XP_016866049 (OMIM: 616823) protein dopey-1 isoform X1 (2485 aa)
initn: 15351 init1: 15351 opt: 15354 Z-score: 16342.7 bits: 3038.1 E(93482): 0
Smith-Waterman score: 15981; 99.2% identity (99.2% similar) in 2485 aa overlap (1-2465:1-2485)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAK--------------------KNPEEDNSGRTLGWEP
:::::::::::::::::::::::: ::::::::::::::::
XP_016 QGIHQREFKPYVVRLAKLLRKRAKDKEEDFKTVILEGLEMAKHQKNPEEDNSGRTLGWEP
2350 2360 2370 2380 2390 2400
2390 2400 2410 2420 2430 2440
pF1KE2 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
2410 2420 2430 2440 2450 2460
2450 2460
pF1KE2 PCSSKARQKIEEMVEKDFLEGMIKT
:::::::::::::::::::::::::
XP_016 PCSSKARQKIEEMVEKDFLEGMIKT
2470 2480
>>XP_016866062 (OMIM: 616823) protein dopey-1 isoform X1 (2333 aa)
initn: 15051 init1: 15051 opt: 15051 Z-score: 16020.3 bits: 2978.3 E(93482): 0
Smith-Waterman score: 15051; 100.0% identity (100.0% similar) in 2321 aa overlap (1-2321:1-2321)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::.
XP_016 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQIRVIGSKWSMWIY
2290 2300 2310 2320 2330
2350 2360 2370 2380 2390 2400
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
>>XP_016866063 (OMIM: 616823) protein dopey-1 isoform X1 (2315 aa)
initn: 14792 init1: 14792 opt: 14795 Z-score: 15747.7 bits: 2927.9 E(93482): 0
Smith-Waterman score: 14795; 99.5% identity (99.6% similar) in 2297 aa overlap (1-2294:1-2297)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330
pF1KE2 GG-NG--FSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLE
:: .: :. : :
XP_016 GGTDGPLFQKPQMIQVWKSEGRVYINENLNLTWYD
2290 2300 2310
>>XP_016866055 (OMIM: 616823) protein dopey-1 isoform X5 (2456 aa)
initn: 14110 init1: 14110 opt: 14110 Z-score: 15017.8 bits: 2792.9 E(93482): 0
Smith-Waterman score: 15942; 99.6% identity (99.6% similar) in 2465 aa overlap (1-2465:1-2456)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLG------
250 260 270 280 290
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ---PRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1500 1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1560 1570 1580 1590 1600 1610
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1620 1630 1640 1650 1660 1670
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1680 1690 1700 1710 1720 1730
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1740 1750 1760 1770 1780 1790
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1800 1810 1820 1830 1840 1850
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1860 1870 1880 1890 1900 1910
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1920 1930 1940 1950 1960 1970
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1980 1990 2000 2010 2020 2030
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2040 2050 2060 2070 2080 2090
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2100 2110 2120 2130 2140 2150
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2160 2170 2180 2190 2200 2210
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2220 2230 2240 2250 2260 2270
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2280 2290 2300 2310 2320 2330
2350 2360 2370 2380 2390 2400
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
2340 2350 2360 2370 2380 2390
2410 2420 2430 2440 2450 2460
pF1KE2 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
2400 2410 2420 2430 2440 2450
pF1KE2 GMIKT
:::::
XP_016 GMIKT
>>XP_024302141 (OMIM: 616823) protein dopey-1 isoform X5 (2456 aa)
initn: 14110 init1: 14110 opt: 14110 Z-score: 15017.8 bits: 2792.9 E(93482): 0
Smith-Waterman score: 15942; 99.6% identity (99.6% similar) in 2465 aa overlap (1-2465:1-2456)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLG------
250 260 270 280 290
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 ---PRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1500 1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1560 1570 1580 1590 1600 1610
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1620 1630 1640 1650 1660 1670
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1680 1690 1700 1710 1720 1730
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1740 1750 1760 1770 1780 1790
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1800 1810 1820 1830 1840 1850
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1860 1870 1880 1890 1900 1910
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1920 1930 1940 1950 1960 1970
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1980 1990 2000 2010 2020 2030
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2040 2050 2060 2070 2080 2090
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2100 2110 2120 2130 2140 2150
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2160 2170 2180 2190 2200 2210
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2220 2230 2240 2250 2260 2270
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2280 2290 2300 2310 2320 2330
2350 2360 2370 2380 2390 2400
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QGIHQREFKPYVVRLAKLLRKRAKKNPEEDNSGRTLGWEPGHLLLTICTVRSMEQLLPFF
2340 2350 2360 2370 2380 2390
2410 2420 2430 2440 2450 2460
pF1KE2 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHKPCSSKARQKIEEMVEKDFLE
2400 2410 2420 2430 2440 2450
pF1KE2 GMIKT
:::::
XP_024 GMIKT
>>XP_016866059 (OMIM: 616823) protein dopey-1 isoform X7 (2452 aa)
initn: 15128 init1: 13699 opt: 13702 Z-score: 14583.2 bits: 2712.5 E(93482): 0
Smith-Waterman score: 15696; 97.9% identity (97.9% similar) in 2485 aa overlap (1-2465:1-2452)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELM-------------
190 200 210 220
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::
XP_016 --------------------ATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
230 240 250 260
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
570 580 590 600 610 620
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
630 640 650 660 670 680
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
690 700 710 720 730 740
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
750 760 770 780 790 800
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1470 1480 1490 1500 1510 1520
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1530 1540 1550 1560 1570 1580
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1590 1600 1610 1620 1630 1640
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1650 1660 1670 1680 1690 1700
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1710 1720 1730 1740 1750 1760
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1770 1780 1790 1800 1810 1820
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1830 1840 1850 1860 1870 1880
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1890 1900 1910 1920 1930 1940
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1950 1960 1970 1980 1990 2000
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
2010 2020 2030 2040 2050 2060
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2070 2080 2090 2100 2110 2120
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2130 2140 2150 2160 2170 2180
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2190 2200 2210 2220 2230 2240
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2250 2260 2270 2280 2290 2300
2350 2360 2370 2380
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAK--------------------KNPEEDNSGRTLGWEP
:::::::::::::::::::::::: ::::::::::::::::
XP_016 QGIHQREFKPYVVRLAKLLRKRAKDKEEDFKTVILEGLEMAKHQKNPEEDNSGRTLGWEP
2310 2320 2330 2340 2350 2360
2390 2400 2410 2420 2430 2440
pF1KE2 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
2370 2380 2390 2400 2410 2420
2450 2460
pF1KE2 PCSSKARQKIEEMVEKDFLEGMIKT
:::::::::::::::::::::::::
XP_016 PCSSKARQKIEEMVEKDFLEGMIKT
2430 2440 2450
>>XP_016866061 (OMIM: 616823) protein dopey-1 isoform X9 (2435 aa)
initn: 14985 init1: 13471 opt: 13471 Z-score: 14337.2 bits: 2667.0 E(93482): 0
Smith-Waterman score: 15519; 97.2% identity (97.2% similar) in 2485 aa overlap (1-2465:1-2435)
10 20 30 40 50 60
pF1KE2 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNTEELELLSDSKYRNYVAAIDKALKNFEYSSEWADLISALGKLNKVLQNNAKYQVVPKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTIGKRLAQCLHPALPGGVHRKALETYEIIFKIIGPKRLAKDLFLYSSGLFPLLANAAMS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPTLLSLYEIYYLPLGKTLKPGLQGLLTGILPGLEEGSEYYERTNMLLEKVAAAVDQSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYSALWGSLLTSPAVRLPGITYVLAHLNRKLSMEDQLYIIGSDIELMVEAVSTSVQDSSV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQRSTLDLILFCFPFHMSQATRPDMIRILSAALHVVLRRDMSLNRRLYAWLLGFDNNGA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIGPRSTRHSNPEEHATYYFTTFSKELLVQAMVGILQVNGFGEENTLMQDLKPFRILISL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKPELGPVILEDVLIEVFRTLYSQCKAELDLQTEPPFSKDHAQLSSKLRENKKTAELIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANLLFNSFEPYYMWDYVARWFEECCRRTLHVRLQIGPGDSNDSSELQLTNFCLLVDFLL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVSLPTRSMRVLCQETYIEIQTEHLPQLLLRMISALTSHLQTLHLSELTDSLRLCSKIL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVQPPLLSASTGGVLQFPSGQNNSVKEWEDKKVSSVSHENPTEVFEDGENPPSSRSSES
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFTEFIQYQADRTDDIDRELSEGQGAAAIPIGSTSSETETASTVGSEETIIQTPSVVTQG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TATRSRKTAQKTAMQCCLEYVQQFLTRLINLYIIQNNSFSQSLATEHQGDLGREQGETSK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WDRNSQGDVKEKNISKQKTSKEYLSAFLAACQLFLECSSFPVYIAEGNHTSELRSEKLET
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCEHVQPPQWLQTLMNACSQASDFSVQSVAISLVMDLVGLTQSVAMVTGENINSVEPAQP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPNQGRVAVVIRPPLTQGNLRYIAEKTEFFKHVALTLWDQLGDGTPQHHQKSVELFYQL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLVPSSSICEDVISQQLTHKDKKIRMEAHAKFAVLWHLTRDLHINKSSSFVRSFDRSLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMLDSLNSLDGSTSSVGQAWLNQVLQRHDIARVLEPLLLLLLHPKTQRVSVQRVQAERYW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSPCYPGEESDKHFMQNFACSNVSQVQLITSKGNGEKPLTMDEIENFSLTVNPLSDRLS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTSSETIPMVVSDFDLPDQQIEILQSSDSGCSQSSAGDNLSYEVDPETVNAQEDSQMP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESSPDDDVQQVVFDLICKVVSGLEVESASVTSQLEIEAMPPKCSDIDPDEETIKIEDDS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQSQNALLSNESSQFLSVSAEGGHECVANGISRNSSSPCISGTTHTLHDSSVASIETKS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQRSHSSIQFSFKEKLSEKVSEKETIVKESGKQPGAKPKVKLARKKDDDKKKSSNEKLKQ
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVFFSDGLDLENWYSCGEGDISEIESDMGSPGSRKSPNFNIHPLYQHVLLYLQLYDSSR
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYAFSAIKAILKTNPIAFVNAISTTSVNNAYTPQLSLLQNLLARHRISVMGKDFYSHIP
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSNHNFRSSMYIEILISLCLYYMRSHYPTHVKVTAQDLIGNRNMQMMSIEILTLLFTEL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKVIESSAKGFPSFISDMLSKCKVQKVILHCLLSSIFSAQKWHSEKMAGKNLVAVEEGFS
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSLINFSEDEFDNGSTLQSQLLKVLQRLIVLEHRVMTIPEENETGFDFVVSDLEHISPH
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPMTSLQYLHAQPITCQGMFLCAVIRALHQHCACKMHPQWIGLITSTLPYMGKVLQRVVV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVTLQLCRNLDNLIQQYKYETGLSDSRPLWMASIIPPDMILTLLEGITAIIHYCLLDPTT
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYHQLLVSVDQKHLFEARSGILSILHMIMSSVTLLWSILHQADSSEKMTIAASASLTTIN
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGATKNLRQQILELLGPISMNHGVHFMAAIAFVWNERRQNKTTTRTKVIPAASEEQLLLV
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVRSISVMRAETVIQTVKEVLKQPPAIAKDKKHLSLEVCMLQFFYAYIQRIPVPNLVDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WASLLILLKDSIQLSLPAPGQFLILGVLNEFIMKNPSLENKKDQRDLQDVTHKIVDAIGA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAGSSLEQTTWLRRNLEVKPSPKIMVDGTNLESDVEDMLSPAMETANITPSVYSVHALTL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHSAHNAPSYRACVQLLSSLSGY
::::::::::::::::::::::::::::::::::::::::
XP_016 LSEVLAHLLDMVFYSDEKERVIPLLVNIMHYVVPYLRNHS--------------------
2050 2060 2070 2080
2110 2120 2130 2140 2150 2160
pF1KE2 QYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
::::::::::::::::::::::::::::::
XP_016 ------------------------------WRAIMDNLMTHDKTTFRDLMTRVAVAQSSS
2090 2100 2110
2170 2180 2190 2200 2210 2220
pF1KE2 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNLFANRDVELEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVPTLHSQV
2120 2130 2140 2150 2160 2170
2230 2240 2250 2260 2270 2280
pF1KE2 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLFFRVLLLRMSPQHLTSLWPTMITELVQVFLLMEQELTADEDISRTSGPSVAGLETTYT
2180 2190 2200 2210 2220 2230
2290 2300 2310 2320 2330 2340
pF1KE2 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNGFSTSYNSQRWLNLYLSACKFLDLALALPSENLPQFQMYRWAFIPEASDDSGLEVRR
2240 2250 2260 2270 2280 2290
2350 2360 2370 2380
pF1KE2 QGIHQREFKPYVVRLAKLLRKRAK--------------------KNPEEDNSGRTLGWEP
:::::::::::::::::::::::: ::::::::::::::::
XP_016 QGIHQREFKPYVVRLAKLLRKRAKDKEEDFKTVILEGLEMAKHQKNPEEDNSGRTLGWEP
2300 2310 2320 2330 2340 2350
2390 2400 2410 2420 2430 2440
pF1KE2 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GHLLLTICTVRSMEQLLPFFNVLSQVFNSKVTSRCGGHSGSPILYSNAFPNKDMKLENHK
2360 2370 2380 2390 2400 2410
2450 2460
pF1KE2 PCSSKARQKIEEMVEKDFLEGMIKT
:::::::::::::::::::::::::
XP_016 PCSSKARQKIEEMVEKDFLEGMIKT
2420 2430
2465 residues in 1 query sequences
65951994 residues in 93482 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Jun 20 10:35:01 2019 done: Thu Jun 20 10:35:03 2019
Total Scan time: 11.790 Total Display time: 1.390
Function used was FASTA [36.3.4 Apr, 2011]