Result of FASTA (ccds) for
pFN21AE2746
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2746, 587 aa
1>>>pF1KE2746 587 - 587 aa - 587 aa
Library: human.CCDS.faa
18921897 residues in 33420 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6358+/-0.000865; mu= 16.8044+/- 0.052
mean_var=66.7608+/-13.503, 0's: 0 Z-trim(106.7): 20 B-trim: 105 in 1/50
Lambda= 0.156969
statistics sampled from 9222 (9235) to 9222 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.276), width: 16
Scan time: 1.490
The best scores are: opt bits E(33420)
CCDS14366.1 ALAS2 gene_id:212|Hs109|chrX ( 587) 3968 907.7 0
CCDS35303.1 ALAS2 gene_id:212|Hs109|chrX ( 550) 3042 698.0 8.1e-201
CCDS43960.1 ALAS2 gene_id:212|Hs109|chrX ( 574) 3042 698.0 8.4e-201
CCDS2847.1 ALAS1 gene_id:211|Hs109|chr3 ( 640) 2334 537.7 1.7e-152
CCDS13957.1 GCAT gene_id:23464|Hs109|chr22 ( 419) 767 182.8 7.8e-46
CCDS54527.1 GCAT gene_id:23464|Hs109|chr22 ( 445) 767 182.8 8.2e-46
CCDS13115.2 SPTLC3 gene_id:55304|Hs109|chr20 ( 552) 437 108.1 3.1e-23
CCDS9865.1 SPTLC2 gene_id:9517|Hs109|chr14 ( 562) 360 90.7 5.6e-18
CCDS6692.1 SPTLC1 gene_id:10558|Hs109|chr9 ( 473) 255 66.9 7e-11
>>CCDS14366.1 ALAS2 gene_id:212|Hs109|chrX (587 aa)
initn: 3968 init1: 3968 opt: 3968 Z-score: 4851.8 bits: 907.7 E(33420): 0
Smith-Waterman score: 3968; 100.0% identity (100.0% similar) in 587 aa overlap (1-587:1-587)
10 20 30 40 50 60
pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW
490 500 510 520 530 540
550 560 570 580
pF1KE2 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS14 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
550 560 570 580
>>CCDS35303.1 ALAS2 gene_id:212|Hs109|chrX (550 aa)
initn: 3712 init1: 3034 opt: 3042 Z-score: 3719.0 bits: 698.0 E(33420): 8.1e-201
Smith-Waterman score: 3642; 93.7% identity (93.7% similar) in 587 aa overlap (1-587:1-550)
10 20 30 40 50 60
pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIGRCPILATQGPNCSQIHLKATKAGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKTDLPSSLVSVSLRKPFSGPQ
:::::::::::::::::::::::::::::::::::::::::
CCDS35 DSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDVKAFKT-------------------
70 80 90 100
130 140 150 160 170 180
pF1KE2 EQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH
::::::::::::::::::::::::::::::::::::::::::
CCDS35 ------------------GNYVFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQH
110 120 130 140
190 200 210 220 230 240
pF1KE2 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 FSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELE
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE2 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 QELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKF
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE2 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 VFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVH
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE2 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE2 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRV
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE2 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 GNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAW
450 460 470 480 490 500
550 560 570 580
pF1KE2 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS35 TAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
510 520 530 540 550
>>CCDS43960.1 ALAS2 gene_id:212|Hs109|chrX (574 aa)
initn: 3712 init1: 3034 opt: 3042 Z-score: 3718.7 bits: 698.0 E(33420): 8.4e-201
Smith-Waterman score: 3642; 93.7% identity (93.7% similar) in 587 aa overlap (1-587:25-574)
10 20 30
pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIG
::::::::::::::::::::::::::::::::::::
CCDS43 MRGGEVALGWNKKKRLFCEDFRFKMVTAAMLLQCCPVLARGPTSLLGKVVKTHQFLFGIG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 RCPILATQGPNCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RCPILATQGPNCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQKAAPEVQEDV
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 KAFKTDLPSSLVSVSLRKPFSGPQEQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEK
::::: ::::::::::::::::::
CCDS43 KAFKT-------------------------------------GNYVFSYDQFFRDKIMEK
130 140
160 170 180 190 200 210
pF1KE2 KQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETL
150 160 170 180 190 200
220 230 240 250 260 270
pF1KE2 QRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGC
210 220 230 240 250 260
280 290 300 310 320 330
pF1KE2 EIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGA
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE2 ICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV
330 340 350 360 370 380
400 410 420 430 440 450
pF1KE2 GGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKH
390 400 410 420 430 440
460 470 480 490 500 510
pF1KE2 MRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KE2 RLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFG
510 520 530 540 550 560
580
pF1KE2 NMGPQYVTTYA
:::::::::::
CCDS43 NMGPQYVTTYA
570
>>CCDS2847.1 ALAS1 gene_id:211|Hs109|chr3 (640 aa)
initn: 2338 init1: 2271 opt: 2334 Z-score: 2851.4 bits: 537.7 E(33420): 1.7e-152
Smith-Waterman score: 2394; 60.9% identity (82.3% similar) in 598 aa overlap (1-578:48-632)
10 20 30
pF1KE2 MVTAAMLLQCCPVLARGPTSLLGKVVKTHQ
. :::. : . :.: :..:..
CCDS28 FLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQ--QIKETPPASEKDKTAKAK-
20 30 40 50 60 70
40 50 60 70 80
pF1KE2 FLFGIGRCPILATQGPNCSQIHLKATKAGGDSPSWAKG---HCPFMLSELQDGKSKIVQK
. . : . :.:. .:. .: :. ..: .:::. ..... :.. :
CCDS28 ----VQQTPDGSQQSPDGTQL-----PSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCK
80 90 100 110 120
90 100 110 120 130
pF1KE2 AAPEVQEDVKAF--------KTDLPSSLVSVS--------LRKPFSGPQEQEQISGKVTH
:. :.::::. . .:. :.:::. : : :. . :.: .:.:
CCDS28 ASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIM-QKQRPERVSH
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE2 LIQNNMPGNY-VFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKD
:.:.:.: . .:.::.::. :: :::.:::::::::::: : .:.:. .:.. ...:.
CCDS28 LLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE2 VSVWCSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKD
::::::::::::::::.: :...::..:::::::::::::::::::.::.:::.:: ::
CCDS28 VSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKD
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE2 SALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHL
.::::::::::::::::::::..::::::::.::::::::::::: . :..::::: .::
CCDS28 AALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHL
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE2 KKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGA
..::..:.:..:::::::::::::::.:::::::::.:..::.:::::::::::::.::.
CCDS28 RELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGG
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE2 GIGERDGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSG
:::.:::.: :.::::::::::::::::::::: .:.: :::::::::::::::::.:.:
CCDS28 GIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAG
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE2 ALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLC
::::::.::. ::..::: :::::: :::.::: ::::. :::::::.::..:: :...:
CCDS28 ALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVC
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE2 DLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDV
: :.:.:.:::::::::::::::::::.::.:::.::::. :.:.::..: ::: :.
CCDS28 DELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPH
550 560 570 580 590 600
560 570 580
pF1KE2 SVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
: : :::::::.:::.::: :.:::...
CCDS28 SSAECNFCRRPLHFEVMSEREKSYFSGLSKLVSAQA
610 620 630 640
>>CCDS13957.1 GCAT gene_id:23464|Hs109|chr22 (419 aa)
initn: 719 init1: 329 opt: 767 Z-score: 936.5 bits: 182.8 E(33420): 7.8e-46
Smith-Waterman score: 767; 37.4% identity (69.6% similar) in 345 aa overlap (194-537:70-409)
170 180 190 200 210 220
pF1KE2 VFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGA
.:.:.:::.: ::.:.:: ..:.. :::
CCDS13 GAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGL
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 GGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAG
...: : ::...: .:: ..:..::...:.:. ::. :: . :: : . : . ::
CCDS13 SSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDAN-AGLFE-ALLTPEDAVLSDEL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE2 NHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEEL
::::.:.::: : :. .:: : :. :.... . ..:: . . :::: : ::.:.
CCDS13 NHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEI
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE2 CDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV-GGYIAS
: .. .::::.:.:: ::.:. : : : : :.: .. ::..:::::.: . ::: ..
CCDS13 CCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTG
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE2 TRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLM
::...:. : ..:..:::: :.. : ... :: : .... .. .....:. .
CCDS13 PGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMG--SNTIVQSMAAKTQRFRSKME
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE2 DRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSP
:. . : :. .:.: : :.. : .: :.::.: ...::.::.:. .:. :
CCDS13 AAGFTISGASHPICPVMLGDARLASRMADDML-KRGIFVIGFSYPVVPKGKARIRVQISA
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE2 HHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQY
:: . .. :: ..
CCDS13 VHSEEDIDRCVEAFVEVGRLHGALP
400 410
>>CCDS54527.1 GCAT gene_id:23464|Hs109|chr22 (445 aa)
initn: 719 init1: 329 opt: 767 Z-score: 936.1 bits: 182.8 E(33420): 8.2e-46
Smith-Waterman score: 767; 37.4% identity (69.6% similar) in 345 aa overlap (194-537:96-435)
170 180 190 200 210 220
pF1KE2 VFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQETLQRHGAGA
.:.:.:::.: ::.:.:: ..:.. :::
CCDS54 GPGTVIFPGLPLPHLSCCIHLLSFTSGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGL
70 80 90 100 110 120
230 240 250 260 270 280
pF1KE2 GGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAG
...: : ::...: .:: ..:..::...:.:. ::. :: . :: : . : . ::
CCDS54 SSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDAN-AGLFE-ALLTPEDAVLSDEL
130 140 150 160 170 180
290 300 310 320 330 340
pF1KE2 NHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEEL
::::.:.::: : :. .:: : :. :.... . ..:: . . :::: : ::.:.
CCDS54 NHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEI
190 200 210 220 230 240
350 360 370 380 390 400
pF1KE2 CDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCV-GGYIAS
: .. .::::.:.:: ::.:. : : : : :.: .. ::..:::::.: . ::: ..
CCDS54 CCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTG
250 260 270 280 290 300
410 420 430 440 450 460
pF1KE2 TRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLM
::...:. : ..:..:::: :.. : ... :: : .... .. .....:. .
CCDS54 PGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMG--SNTIVQSMAAKTQRFRSKME
310 320 330 340 350 360
470 480 490 500 510 520
pF1KE2 DRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSP
:. . : :. .:.: : :.. : .: :.::.: ...::.::.:. .:. :
CCDS54 AAGFTISGASHPICPVMLGDARLASRMADDML-KRGIFVIGFSYPVVPKGKARIRVQISA
370 380 390 400 410 420
530 540 550 560 570 580
pF1KE2 HHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQY
:: . .. :: ..
CCDS54 VHSEEDIDRCVEAFVEVGRLHGALP
430 440
>>CCDS13115.2 SPTLC3 gene_id:55304|Hs109|chr20 (552 aa)
initn: 360 init1: 178 opt: 437 Z-score: 530.7 bits: 108.1 E(33420): 3.1e-23
Smith-Waterman score: 613; 28.2% identity (64.0% similar) in 419 aa overlap (145-536:110-520)
120 130 140 150 160
pF1KE2 PFSGPQEQEQISGKVTHLIQNNMPGNYVFSYDQFFRDKIMEKKQDHTYR--------VFK
...:. ... . .:. : .:
CCDS13 RDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPICSAPGPLFD
80 90 100 110 120 130
170 180 190 200 210 220
pF1KE2 TVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMS-RHPQVLQATQETLQRHGAGAGG
..: .: : .. .:. . ::: : ..::.. .. . ... ...:. .:.:...
CCDS13 LMERVSDDYNWTFRFTGRVI--KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVAS
140 150 160 170 180 190
230 240 250 260 270 280
pF1KE2 TRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDAGNH
::. :: : :::. .:.. . ..:..:. :..:. .. .: . :: : :: ::
CCDS13 TRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPAL--VGKGCLILSDELNH
200 210 220 230 240 250
290 300 310 320 330
pF1KE2 ASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKS----NPKIPK-----IVAFETVHSMDGA
.:.. : : :::. .:.::. . :.:::. . .:. . .. : :.::.:.
CCDS13 TSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGS
260 270 280 290 300 310
340 350 360 370 380 390
pF1KE2 ICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGI-MHKIDIISGTLGKAFGC
: : .. ....: : ..::.:..: : : :. : :. :..:.. ::. :.::
CCDS13 IVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGA
320 330 340 350 360 370
400 410 420 430 440 450
pF1KE2 VGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAHQ--
:::::. .::::..: .. . ....:. : . ..:..:. : .: :.:.:..:
CCDS13 SGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLA
380 390 400 410 420 430
460 470 480 490 500
pF1KE2 RNVKHMRQLLMDRGLPVIPCPS-HIIPIRV---GNAALNSKLCDLLLSKHGIYVQAINYP
.:....:: :.. :. . . ..:. . :..: .. .: .: :. : ...:
CCDS13 KNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFAR--HMLEKKIGVVV--VGFP
440 450 460 470 480 490
510 520 530 540 550 560
pF1KE2 TVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPLQDVSVAACNFCRRPVHFELM
..: .: :. : :. .:.. .: :
CCDS13 ATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELE
500 510 520 530 540 550
>>CCDS9865.1 SPTLC2 gene_id:9517|Hs109|chr14 (562 aa)
initn: 316 init1: 154 opt: 360 Z-score: 436.4 bits: 90.7 E(33420): 5.6e-18
Smith-Waterman score: 534; 28.0% identity (62.8% similar) in 379 aa overlap (174-536:153-528)
150 160 170 180 190 200
pF1KE2 SYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMS
.. . :. .. : : : .:::..
CCDS98 TRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFA
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE2 RHPQVLQ-ATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVAN
:. : :. ..:...:::. .::. :. : :::. .:.. ..:. .. :..:
CCDS98 RNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATN
190 200 210 220 230 240
270 280 290 300 310
pF1KE2 DSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKS----N
. .. .: . :: : :: ::::.. : : :::. .:.::. . :.:::. . .
CCDS98 SMNIPAL--VGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE2 PKIPK-----IVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIG
:. . .. : ..::.:.: : :. ....: : ..::.:..: : : :.
CCDS98 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE2 ERDGI-MHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGAL
: :. . .:.. ::. :.:: ::::.. ..:.:..:... . ...::: : :. .
CCDS98 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
370 380 390 400 410 420
440 450 460 470 480
pF1KE2 ESVRLLKGEEGQALRR--AHQ--RNVKHMRQLLMDRGLPVIPCP-SHIIPIRVGNAALNS
:.. . :..: .: . ..: .:....:. : . :. . : ..:. . : .
CCDS98 TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 KLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLLLAWTAVGLPL
. .: :..: : ....:..: : :. : :. .... ....
CCDS98 AFGREML-KRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKY
490 500 510 520 530
550 560 570 580
pF1KE2 QDVSVAACNFCRRPVHFELMSEWERSYFGNMGPQYVTTYA
CCDS98 SRHRLVPLLDRPFDETTYEETED
540 550 560
>>CCDS6692.1 SPTLC1 gene_id:10558|Hs109|chr9 (473 aa)
initn: 312 init1: 131 opt: 255 Z-score: 309.1 bits: 66.9 E(33420): 7e-11
Smith-Waterman score: 422; 27.9% identity (63.9% similar) in 269 aa overlap (186-443:95-361)
160 170 180 190 200 210
pF1KE2 KKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHPQVLQATQET
: .:. . : ..::. .:.: :. .
CCDS66 QPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALAS
70 80 90 100 110 120
220 230 240 250 260 270
pF1KE2 LQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPG
:...:.:. : :.. :: :..::..::.. . . :...: :.. :.. . .: :
CCDS66 LKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK--RG
130 140 150 160 170 180
280 290 300 310 320
pF1KE2 CEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLL------EKSNPKIPKI----V
.. : . .. .:.. : . .:.::: :..:: ...::. .. .
CCDS66 DIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFI
190 200 210 220 230 240
330 340 350 360 370 380
pF1KE2 AFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGI-MHKIDI
. : .. :.:::: :: ....: : :..: . :. : .: :. :. :: . ::.
CCDS66 VVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDL
250 260 270 280 290 300
390 400 410 420 430 440
pF1KE2 ISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQ
::... .:.. .::. . ..: : . :. :..::::.. ..:.:.. ... . :
CCDS66 ISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGI
310 320 330 340 350 360
450 460 470 480 490 500
pF1KE2 ALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAI
CCDS66 FAVLKEKCGQIHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNR
370 380 390 400 410 420
587 residues in 1 query sequences
18921897 residues in 33420 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Apr 23 11:12:52 2019 done: Tue Apr 23 11:12:52 2019
Total Scan time: 1.490 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]