Result of FASTA (omim) for
pFN21AE2743
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2743, 1139 aa
1>>>pF1KE2743 1139 - 1139 aa - 1139 aa
Library: /omim/omim.rfq.tfa
65951994 residues in 93482 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4858+/-0.000409; mu= 21.6878+/- 0.026
mean_var=72.0124+/-14.380, 0's: 0 Z-trim(110.8): 29 B-trim: 1112 in 2/53
Lambda= 0.151137
statistics sampled from 20083 (20098) to 20083 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.564), E-opt: 0.2 (0.215), width: 16
Scan time: 7.220
The best scores are: opt bits E(93482)
NP_653273 (OMIM: 607038,607039) otoancorin isoform (1139) 7439 1632.2 0
NP_001155155 (OMIM: 607038,607039) otoancorin isof (1060) 6868 1507.7 0
NP_733764 (OMIM: 607038,607039) otoancorin isoform ( 815) 5327 1171.7 0
XP_011544050 (OMIM: 607038,607039) otoancorin isof ( 798) 4999 1100.1 0
XP_016878440 (OMIM: 607038,607039) otoancorin isof ( 597) 3745 826.6 0
NP_714544 (OMIM: 603720,606440,611102,612997) ster (1775) 397 96.9 1.3e-18
NP_037536 (OMIM: 601051) mesothelin isoform 2 prep ( 630) 221 58.3 2e-07
NP_001170826 (OMIM: 601051) mesothelin isoform 1 p ( 622) 198 53.2 6.3e-06
NP_005814 (OMIM: 601051) mesothelin isoform 1 prep ( 622) 198 53.2 6.3e-06
>>NP_653273 (OMIM: 607038,607039) otoancorin isoform 1 p (1139 aa)
initn: 7439 init1: 7439 opt: 7439 Z-score: 8757.1 bits: 1632.2 E(93482): 0
Smith-Waterman score: 7439; 99.9% identity (99.9% similar) in 1139 aa overlap (1-1139:1-1139)
10 20 30 40 50 60
pF1KE2 MSQEPTTYSLFLFLFLSHGVSSYTVPNSRQDLHPLLQNMAEEIIDGSYLNALLDLIQFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 MSQEPTTYSLFLFLFLSHGVSSYTVPNSRQDLHPLLQNMAEEIIDGSYLNALLDLIQFQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 SHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQFRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 SHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQFRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 AMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVEIL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 GKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGILQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 GKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGILQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 TSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVYDI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 TPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSHLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 TPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSHLR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 GFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLNQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 GFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLNQV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAVSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 SGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAVSQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 YVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 YVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKELG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 RSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 YQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 YQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 KTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 KTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 PEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 PEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 RTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 MEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 LEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 LEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAIN
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 ITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 ITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 LTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPL
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 LTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130
pF1KE2 QLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 QLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW
1090 1100 1110 1120 1130
>>NP_001155155 (OMIM: 607038,607039) otoancorin isoform (1060 aa)
initn: 6868 init1: 6868 opt: 6868 Z-score: 8084.7 bits: 1507.7 E(93482): 0
Smith-Waterman score: 6868; 99.9% identity (99.9% similar) in 1051 aa overlap (89-1139:10-1060)
60 70 80 90 100 110
pF1KE2 QSSHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQF
::::::::::::::::::::::::::::::
NP_001 MGNSITYRDQAAVENHLEQRLHQPQKLLEDLRKTDAQQF
10 20 30
120 130 140 150 160 170
pF1KE2 RTAMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTAMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVE
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 ILGKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILGKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGI
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 LQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVY
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE2 DITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMIKCSH
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE2 LRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLN
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE2 QVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAV
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE2 SQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKE
400 410 420 430 440 450
540 550 560 570 580 590
pF1KE2 LGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALL
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE2 SPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDS
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE2 HKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPD
580 590 600 610 620 630
720 730 740 750 760 770
pF1KE2 LNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASK
640 650 660 670 680 690
780 790 800 810 820 830
pF1KE2 MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDL
700 710 720 730 740 750
840 850 860 870 880 890
pF1KE2 RCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNE
760 770 780 790 800 810
900 910 920 930 940 950
pF1KE2 SELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCA
820 830 840 850 860 870
960 970 980 990 1000 1010
pF1KE2 INITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIA
880 890 900 910 920 930
1020 1030 1040 1050 1060 1070
pF1KE2 AGLTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLS
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLS
940 950 960 970 980 990
1080 1090 1100 1110 1120 1130
pF1KE2 PLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLL
1000 1010 1020 1030 1040 1050
pF1KE2 W
:
NP_001 W
1060
>>NP_733764 (OMIM: 607038,607039) otoancorin isoform 2 [ (815 aa)
initn: 5327 init1: 5327 opt: 5327 Z-score: 6270.5 bits: 1171.7 E(93482): 0
Smith-Waterman score: 5327; 99.6% identity (99.8% similar) in 815 aa overlap (325-1139:1-815)
300 310 320 330 340 350
pF1KE2 DMVYDITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLELLDATVAQVLLYQMI
. ::::::::::::::::::::::::::::
NP_733 MFRLGLLVCFYNDLELLDATVAQVLLYQMI
10 20 30
360 370 380 390 400 410
pF1KE2 KCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 KCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAI
40 50 60 70 80 90
420 430 440 450 460 470
pF1KE2 STLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 STLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVL
100 110 120 130 140 150
480 490 500 510 520 530
pF1KE2 RSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 RSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVL
160 170 180 190 200 210
540 550 560 570 580 590
pF1KE2 KDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 KDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNN
220 230 240 250 260 270
600 610 620 630 640 650
pF1KE2 FALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 FALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSL
280 290 300 310 320 330
660 670 680 690 700 710
pF1KE2 VLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 VLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLR
340 350 360 370 380 390
720 730 740 750 760 770
pF1KE2 DCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 DCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQ
400 410 420 430 440 450
780 790 800 810 820 830
pF1KE2 AASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 AASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWA
460 470 480 490 500 510
840 850 860 870 880 890
pF1KE2 LEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIAL
520 530 540 550 560 570
900 910 920 930 940 950
pF1KE2 ALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGA
580 590 600 610 620 630
960 970 980 990 1000 1010
pF1KE2 TLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 TLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQEL
640 650 660 670 680 690
1020 1030 1040 1050 1060 1070
pF1KE2 GTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQR
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GTIAAGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQR
700 710 720 730 740 750
1080 1090 1100 1110 1120 1130
pF1KE2 RRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 RRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLM
760 770 780 790 800 810
pF1KE2 AKLLW
:::::
NP_733 AKLLW
>>XP_011544050 (OMIM: 607038,607039) otoancorin isoform (798 aa)
initn: 4999 init1: 4999 opt: 4999 Z-score: 5884.1 bits: 1100.1 E(93482): 0
Smith-Waterman score: 4999; 99.9% identity (99.9% similar) in 762 aa overlap (378-1139:1-762)
350 360 370 380 390 400
pF1KE2 VLLYQMIKCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSP
::::::::::::::::::::::::::::::
XP_011 MENQTLNETLGSLSDAVVGLTYSQLESLSP
10 20 30
410 420 430 440 450 460
pF1KE2 EAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKR
40 50 60 70 80 90
470 480 490 500 510 520
pF1KE2 KDISQVLRSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDISQVLRSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQP
100 110 120 130 140 150
530 540 550 560 570 580
pF1KE2 GFNSTVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFNSTVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAH
160 170 180 190 200 210
590 600 610 620 630 640
pF1KE2 FQDFQNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQDFQNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLG
220 230 240 250 260 270
650 660 670 680 690 700
pF1KE2 KSWLDSLVLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSWLDSLVLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWA
280 290 300 310 320 330
710 720 730 740 750 760
pF1KE2 TALHGLRDCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TALHGLRDCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATK
340 350 360 370 380 390
770 780 790 800 810 820
pF1KE2 FPEILLQAASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPEILLQAASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLA
400 410 420 430 440 450
830 840 850 860 870 880
pF1KE2 EANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIV
460 470 480 490 500 510
890 900 910 920 930 940
pF1KE2 SLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSF
520 530 540 550 560 570
950 960 970 980 990 1000
pF1KE2 HLVGLGATLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLVGLGATLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWT
580 590 600 610 620 630
1010 1020 1030 1040 1050 1060
pF1KE2 SSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAA
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_011 SSVLQELGTIAAGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAA
640 650 660 670 680 690
1070 1080 1090 1100 1110 1120
pF1KE2 AVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLG
700 710 720 730 740 750
1130
pF1KE2 CPLLVLMAKLLW
::::::::::::
XP_011 CPLLVLMAKLLWCLPFPWDSAEWMAVKLSLNSQNIPCFWWRWWWLFWF
760 770 780 790
>>XP_016878440 (OMIM: 607038,607039) otoancorin isoform (597 aa)
initn: 3745 init1: 3745 opt: 3745 Z-score: 4408.3 bits: 826.6 E(93482): 0
Smith-Waterman score: 3745; 99.8% identity (99.8% similar) in 561 aa overlap (579-1139:1-561)
550 560 570 580 590 600
pF1KE2 ELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSPYQVNCLAW
::::::::::::::::::::::::::::::
XP_016 MSTDFFLAHFQDFQNNFALLSPYQVNCLAW
10 20 30
610 620 630 640 650 660
pF1KE2 KYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHKKTSVLRKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHKKTSVLRKV
40 50 60 70 80 90
670 680 690 700 710 720
pF1KE2 QQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLNPEQKAAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLNPEQKAAVR
100 110 120 130 140 150
730 740 750 760 770 780
pF1KE2 LKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMARTLPTKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMARTLPTKEF
160 170 180 190 200 210
790 800 810 820 830 840
pF1KE2 LWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRCMEEDTFIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRCMEEDTFIR
220 230 240 250 260 270
850 860 870 880 890 900
pF1KE2 TVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSS
280 290 300 310 320 330
910 920 930 940 950 960
pF1KE2 IDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIK
340 350 360 370 380 390
970 980 990 1000 1010 1020
pF1KE2 ISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAGLTKAALRM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
XP_016 ISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAGLTKAELRM
400 410 420 430 440 450
1030 1040 1050 1060 1070 1080
pF1KE2 LDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQA
460 470 480 490 500 510
1090 1100 1110 1120 1130
pF1KE2 LDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLWCLPFPWDSA
520 530 540 550 560 570
XP_016 EWMAVKLSLNSQNIPCFWWRWWWLFWF
580 590
>>NP_714544 (OMIM: 603720,606440,611102,612997) stereoci (1775 aa)
initn: 384 init1: 206 opt: 397 Z-score: 455.9 bits: 96.9 E(93482): 1.3e-18
Smith-Waterman score: 462; 23.7% identity (51.1% similar) in 947 aa overlap (251-1122:861-1757)
230 240 250 260 270 280
pF1KE2 DKTSAHSQRALYSWMTGILQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIE
.: : ::.. . :: .:.. ..:: .
NP_714 IRDYSPGMRPEQKEALAKRLLAPELFGEVPAW-PQELLWAVLPLLPHLPLENFLQLSPHQ
840 850 860 870 880
290 300 310 320 330
pF1KE2 I-GLFISYDNATKQLDMVYDITPELAQAFLERISSSNFNMRNTSTIHRLGLLVCFYNDLE
: .: :. : . : :. :. . ... . . ..::: :.:: . :
NP_714 IQALEDSWPAA--------GLGPGHARHVLRSLVNQSVQ-DGEEQVRRLGPLACFLSPEE
890 900 910 920 930 940
340 350 360 370 380 390
pF1KE2 L-----LDATVAQVLLYQMIKCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAV
: :. .. : ...:. : . .. ::: . .. . .:. :
NP_714 LQSLVPLSDPTGPVE-RGLLECAA-NGTLSPEGRVAYELLGVL--RSSGGAVLSPRELRV
950 960 970 980 990
400 410 420 430 440
pF1KE2 VGLTYSQL-----ESLSPEAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQ
. .::: . :: ... . .: : .. . .:...: .. : .. ::. .. .
NP_714 WAPLFSQLGLRFLQELSEPQLRAMLPVL-QGTSVTPAQAVLLLGRLLPRHD-LSLEELCS
1000 1010 1020 1030 1040 1050
450 460 470 480 490 500
pF1KE2 MGALLAGVSTQAFCSMKRKDISQVLRSAVSQYVSDLS--PAQQQGILSKMVQAED-----
. :: :.: :.. .. :. :: .: : . .:: : : . : . ...:
NP_714 LHLLLPGLSPQTLQAIPRR----VLVGACSCLAPELSRLSACQTAALLQTFRVKDGVKNM
1060 1070 1080 1090 1100 1110
510 520 530 540
pF1KE2 --TAPG-IVEIQGAFFKE------VSLFDLRRQPGFNSTVLKDK----ELGRS--QALFL
:. : : : : . . :. :. . ..: .. :: : :: ::
NP_714 GTTGAGPAVCIPGQPIPTTWPDCLLPLLPLKLLQLDSLALLANRRRYWELPWSEQQAQFL
1120 1130 1140 1150 1160 1170
550 560 570 580 590 600
pF1KE2 YE-LLLKTTRRPEELLSAGQLVKGVTCSHIDAMST--DFFLAHFQDFQNNFALLSPYQVN
.. . . :. ..: . : :. :..: .. ... ::. . . .: . . ..
NP_714 WKKMQVPTNLTLRNLQALGTLAGGMSCEFLQQINSMVDFLEVVHMIYQLPTRVRGSLRA-
1180 1190 1200 1210 1220
610 620 630 640 650
pF1KE2 CLAWKYWEVSRLSMP-PFL------LAALPARYLASVP-------ASQCVPFLISLGKSW
:. : . :..:: : : .: .. : ..: ... . ... : .
NP_714 CI-WAELQ-RRMAMPEPEWTTVGPELNGLDSKLLLDLPIQLMDRLSNESIMLVVELVQRA
1230 1240 1250 1260 1270 1280
660 670 680 690 700
pF1KE2 LDSLV-LDSHKKTSVLRKVQQCL---DDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAW
..:. : ..... ... : : . .. : ... .: :. : . : : .
NP_714 PEQLLALTPLHQAALAERALQNLAPKETPVSGE-VLETLGPLVGFLGTEST-RQIPLQIL
1290 1300 1310 1320 1330 1340
710 720 730 740 750 760
pF1KE2 ATALHGLRD-CPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIA
. : :. : . . . : . : :. :. . ... : .. .: . .: :
NP_714 LSHLSQLQGFCLGETFATELGWLLLQESVLGKPELWSQDEVEQAGRLVFTLSTEAISLIP
1350 1360 1370 1380 1390 1400
770 780 790 800 810
pF1KE2 TKF--PEILL-----QAASKMART--LPTKEFLWA-----VFQSVRNSSDKIPSYDPMPG
. :: : : . ...:. : . : : : :: ... .: .:.:.
NP_714 REALGPETLERLLEKQQSWEQSRVGQLCREPQLAAKKAALVAGVVRPAAEDLP--EPVPN
1410 1420 1430 1440 1450 1460
820 830 840 850 860 870
pF1KE2 CHGVVAPSSDDIFKLAEANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKA
: : . : : :. .. :: . : . :... :.. .: . ::
NP_714 CADVRG-----TFP-----AAWSATQIAEMELSDFEDCLTLFAGDPGLGPEELRAAMGKA
1470 1480 1490 1500 1510
880 890 900 910 920 930
pF1KE2 IQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQ
:.: : .: ..:..:::. ..:.. ::..: : . ....:. :. : . ...
NP_714 KQLWGPPRGFRPEQILQLGRLLIGLGDRELQELILVDWGVLSTLGQIDGWSTTQLRIVVS
1520 1530 1540 1550 1560 1570
940 950 960 970 980
pF1KE2 GYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL--LCSTHVL
..: .:: .. : ::..:: :::.. :. :. :: .. .::: :: . :
NP_714 SFLRQSGRHVSHLDFVHLTALGYTLCGLRPEELQHISSWEFSQAALFLGTLHLQCSEEQL
1580 1590 1600 1610 1620 1630
990 1000 1010 1020 1030 1040
pF1KE2 AEFKRKAEVV---FGDPTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLP
: . :. :: ..: .. :.::::::. :: : . . : ::. .:
NP_714 -EVLAHLLVLPGGFGPISNWGPEIFTEIGTIAAGIPDLALSALLRGQIQGVTPLAISVIP
1640 1650 1660 1670 1680 1690
1050 1060 1070 1080 1090 1100
pF1KE2 DEIFKEL-SAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAG
: . : :..:: .:.::: : ::: : ... : : ...: . :
NP_714 PPKFAVVFSPIQLSSLTSAQAVAVTPEQMAFLSPEQRRAVAWA-----QHEGKESPEQQG
1700 1710 1720 1730 1740
1110 1120 1130
pF1KE2 PTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW
:: : .::.:
NP_714 -------RSTAWGLQDWSRPSWSLVLTISFLGHLL
1750 1760 1770
>>NP_037536 (OMIM: 601051) mesothelin isoform 2 prepropr (630 aa)
initn: 79 init1: 51 opt: 221 Z-score: 255.2 bits: 58.3 E(93482): 2e-07
Smith-Waterman score: 259; 22.9% identity (47.8% similar) in 558 aa overlap (562-1090:61-580)
540 550 560 570 580 590
pF1KE2 TVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDF
:: ::. : :......::. .
NP_037 VQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLL-GFPCAEVSGLSTERVRELAVAL
40 50 60 70 80
600 610 620 630 640
pF1KE2 QNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYL------ASVPASQCVPFLIS
.. . :: :. ::: ::: :: : ::: : : . :. :.
NP_037 AQKNVKLSTEQLRCLA------HRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSR
90 100 110 120 130 140
650 660 670 680 690 700
pF1KE2 LGKSWLDSLVLDSHKKTSVLRKVQQC--LDDSIADEYTVDIMGNLLCHLPAAIIDRGISP
. :. .: : . .. .: . : . :. .: : .:.: : ::. : ..
NP_037 ITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPG----RFVAE
150 160 170 180 190
710 720 730 740 750
pF1KE2 RAWATALHGLRDCPD-LNPEQKAAVRLKLLG---QYGLPQHWTAETTKDLGPFLVLFSGD
: . : : .:: :. .:. :.: : : :: :. :.. : : .: ...
NP_037 SA-EVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQP
200 210 220 230 240 250
760 770 780 790 800 810
pF1KE2 ELSSIATKFPEILLQAASK-MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAP
. :: . : .:. . : . .: : : .: .: :
NP_037 IIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRF---RREVEKT-------AC-----P
260 270 280 290 300
820 830 840 850 860 870
pF1KE2 SSDDIFKLAEA---NACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVW
:. .. :. : :: :.. . .. ..:. :. :: .::.: ...
NP_037 SGKKAREIDESLIFYKKWELEA--CVDAALLATQMDRVNAIP-FTYEQLDVLKHKLDELY
310 320 330 340 350 360
880 890 900 910 920
pF1KE2 DMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASL---------SWQTEWTP-GQ
:. . : : :: . : .. .... ...:..:. .: : :. : :
NP_037 --PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQ
370 380 390 400 410
930 940 950 960 970 980
pF1KE2 AESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL-LC
. .... .. : .: . . . ::... :. . : . .: : : :
NP_037 VATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAV--RPQDLDTC
420 430 440 450 460 470
990 1000 1010 1020 1030 1040
pF1KE2 STHVLAEFKRKAEVVFGD--PTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAI
. . : . ::...: . .:. .. . :: : :. :... . . . .
NP_037 DPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLG----GAPTEDLKALSQQNVSMDLATFM
480 490 500 510 520 530
1050 1060 1070 1080 1090 1100
pF1KE2 KCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPA
: : .. :: :::. . .. ..: . :.. :. ::
NP_037 KLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPN
540 550 560 570 580 590
1110 1120 1130
pF1KE2 SAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW
NP_037 GYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA
600 610 620 630
>>NP_001170826 (OMIM: 601051) mesothelin isoform 1 prepr (622 aa)
initn: 79 init1: 51 opt: 198 Z-score: 228.2 bits: 53.2 E(93482): 6.3e-06
Smith-Waterman score: 271; 23.0% identity (48.5% similar) in 551 aa overlap (562-1090:61-572)
540 550 560 570 580 590
pF1KE2 TVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDF
:: ::. : :......::. .
NP_001 VQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLL-GFPCAEVSGLSTERVRELAVAL
40 50 60 70 80
600 610 620 630 640
pF1KE2 QNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYL------ASVPASQCVPFLIS
.. . :: :. ::: ::: :: : ::: : : . :. :.
NP_001 AQKNVKLSTEQLRCLA------HRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSR
90 100 110 120 130 140
650 660 670 680 690 700
pF1KE2 LGKSWLDSLVLDSHKKTSVLRKVQQC--LDDSIADEYTVDIMGNLLCHLPAAIIDRGISP
. :. .: : . .. .: . : . :. .: : .:.: : ::. : ..
NP_001 ITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPG----RFVAE
150 160 170 180 190
710 720 730 740 750
pF1KE2 RAWATALHGLRDCPD-LNPEQKAAVRLKLLG---QYGLPQHWTAETTKDLGPFLVLFSGD
: . : : .:: :. .:. :.: : : :: :. :.. : : .: ...
NP_001 SA-EVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQP
200 210 220 230 240 250
760 770 780 790 800 810
pF1KE2 ELSSIATKFPEILLQAASK-MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAP
. :: . : .:. . : . .: : : .: .: :
NP_001 IIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRF---RREVEKT-------AC-----P
260 270 280 290 300
820 830 840 850 860 870
pF1KE2 SSDDIFKLAEA---NACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVW
:. .. :. : :: :.. . .. ..:. :. :: .::.: ...
NP_001 SGKKAREIDESLIFYKKWELEA--CVDAALLATQMDRVNAIP-FTYEQLDVLKHKLDELY
310 320 330 340 350 360
880 890 900 910 920 930
pF1KE2 DMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASL---SWQTEWTPGQAESILQG
:. . : : :: . : .. .... ...:..:. .: . : .: :. ....
NP_001 --PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSP-QVATLIDR
370 380 390 400 410
940 950 960 970 980 990
pF1KE2 YLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL-LCSTHVLAE
.. : .: . . . ::... :. . : . .: : : :. . :
NP_001 FVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAV--RPQDLDTCDPRQLDV
420 430 440 450 460 470
1000 1010 1020 1030 1040
pF1KE2 FKRKAEVVFGD--PTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEI
. ::...: . .:. .. . :: : :. :... . . . .: : .
NP_001 LYPKARLAFQNMNGSEYFVKIQSFLG----GAPTEDLKALSQQNVSMDLATFMKLRTDAV
480 490 500 510 520 530
1050 1060 1070 1080 1090 1100
pF1KE2 FKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRT
. :: :::. . .. ..: . :.. :. ::
NP_001 LPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDL
540 550 560 570 580 590
1110 1120 1130
pF1KE2 SSSRSPAGALQSWGLWLGCPLLVLMAKLLW
NP_001 SMQEALSGTPCLLGPGPVLTVLALLLASTLA
600 610 620
>>NP_005814 (OMIM: 601051) mesothelin isoform 1 prepropr (622 aa)
initn: 79 init1: 51 opt: 198 Z-score: 228.2 bits: 53.2 E(93482): 6.3e-06
Smith-Waterman score: 271; 23.0% identity (48.5% similar) in 551 aa overlap (562-1090:61-572)
540 550 560 570 580 590
pF1KE2 TVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDF
:: ::. : :......::. .
NP_005 VQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLL-GFPCAEVSGLSTERVRELAVAL
40 50 60 70 80
600 610 620 630 640
pF1KE2 QNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYL------ASVPASQCVPFLIS
.. . :: :. ::: ::: :: : ::: : : . :. :.
NP_005 AQKNVKLSTEQLRCLA------HRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSR
90 100 110 120 130 140
650 660 670 680 690 700
pF1KE2 LGKSWLDSLVLDSHKKTSVLRKVQQC--LDDSIADEYTVDIMGNLLCHLPAAIIDRGISP
. :. .: : . .. .: . : . :. .: : .:.: : ::. : ..
NP_005 ITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPG----RFVAE
150 160 170 180 190
710 720 730 740 750
pF1KE2 RAWATALHGLRDCPD-LNPEQKAAVRLKLLG---QYGLPQHWTAETTKDLGPFLVLFSGD
: . : : .:: :. .:. :.: : : :: :. :.. : : .: ...
NP_005 SA-EVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQP
200 210 220 230 240 250
760 770 780 790 800 810
pF1KE2 ELSSIATKFPEILLQAASK-MARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAP
. :: . : .:. . : . .: : : .: .: :
NP_005 IIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRF---RREVEKT-------AC-----P
260 270 280 290 300
820 830 840 850 860 870
pF1KE2 SSDDIFKLAEA---NACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVW
:. .. :. : :: :.. . .. ..:. :. :: .::.: ...
NP_005 SGKKAREIDESLIFYKKWELEA--CVDAALLATQMDRVNAIP-FTYEQLDVLKHKLDELY
310 320 330 340 350 360
880 890 900 910 920 930
pF1KE2 DMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASL---SWQTEWTPGQAESILQG
:. . : : :: . : .. .... ...:..:. .: . : .: :. ....
NP_005 --PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSP-QVATLIDR
370 380 390 400 410
940 950 960 970 980 990
pF1KE2 YLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTL-LCSTHVLAE
.. : .: . . . ::... :. . : . .: : : :. . :
NP_005 FVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAV--RPQDLDTCDPRQLDV
420 430 440 450 460 470
1000 1010 1020 1030 1040
pF1KE2 FKRKAEVVFGD--PTEWTSSVLQELGTIAAGLTKAALRMLDKDLMPYFQPSAIKCLPDEI
. ::...: . .:. .. . :: : :. :... . . . .: : .
NP_005 LYPKARLAFQNMNGSEYFVKIQSFLG----GAPTEDLKALSQQNVSMDLATFMKLRTDAV
480 490 500 510 520 530
1050 1060 1070 1080 1090 1100
pF1KE2 FKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRT
. :: :::. . .. ..: . :.. :. ::
NP_005 LPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDL
540 550 560 570 580 590
1110 1120 1130
pF1KE2 SSSRSPAGALQSWGLWLGCPLLVLMAKLLW
NP_005 SMQEALSGTPCLLGPGPVLTVLALLLASTLA
600 610 620
1139 residues in 1 query sequences
65951994 residues in 93482 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Jun 21 11:08:40 2019 done: Fri Jun 21 11:08:41 2019
Total Scan time: 7.220 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]