Result of FASTA (omim) for
pFN21AE2734
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2734, 313 aa
1>>>pF1KE2734 313 - 313 aa - 313 aa
Library: /omim/omim.rfq.tfa
64942286 residues in 91783 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1477+/-0.000367; mu= 16.4618+/- 0.023
mean_var=64.5755+/-13.138, 0's: 0 Z-trim(112.5): 123 B-trim: 969 in 1/53
Lambda= 0.159603
statistics sampled from 22105 (22235) to 22105 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.242), width: 16
Scan time: 3.270
The best scores are: opt bits E(91783)
NP_683695 (OMIM: 609769,617574) short-chain dehydr ( 313) 2071 485.7 5.5e-137
XP_006719735 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70
XP_005269266 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70
XP_011537227 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70
XP_005269265 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70
XP_011537228 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70
XP_005269264 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70
XP_011537229 (OMIM: 606623) 17-beta-hydroxysteroid ( 317) 1103 262.8 6.9e-70
NP_003716 (OMIM: 606623) 17-beta-hydroxysteroid de ( 317) 1103 262.8 6.9e-70
NP_002896 (OMIM: 136880,601617) 11-cis retinol deh ( 318) 1004 240.0 5e-63
NP_001186700 (OMIM: 136880,601617) 11-cis retinol ( 318) 1004 240.0 5e-63
NP_001135743 (OMIM: 612131) dehydrogenase/reductas ( 319) 940 225.3 1.4e-58
NP_954674 (OMIM: 612131) dehydrogenase/reductase S ( 319) 940 225.3 1.4e-58
NP_001135742 (OMIM: 612131) dehydrogenase/reductas ( 319) 940 225.3 1.4e-58
XP_011508777 (OMIM: 612131) dehydrogenase/reductas ( 319) 940 225.3 1.4e-58
NP_001276692 (OMIM: 612131) dehydrogenase/reductas ( 379) 940 225.3 1.6e-58
XP_024305019 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 917 220.0 4.6e-57
XP_024305018 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 917 220.0 4.6e-57
XP_024305017 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 917 220.0 4.6e-57
XP_016862498 (OMIM: 603063) D-beta-hydroxybutyrate ( 324) 661 161.1 3e-39
XP_016862499 (OMIM: 603063) D-beta-hydroxybutyrate ( 324) 661 161.1 3e-39
XP_016862501 (OMIM: 603063) D-beta-hydroxybutyrate ( 330) 661 161.1 3.1e-39
XP_016862497 (OMIM: 603063) D-beta-hydroxybutyrate ( 330) 661 161.1 3.1e-39
XP_016862500 (OMIM: 603063) D-beta-hydroxybutyrate ( 330) 661 161.1 3.1e-39
NP_976059 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 661 161.1 3.2e-39
NP_976060 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 661 161.1 3.2e-39
NP_004042 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 661 161.1 3.2e-39
XP_005269409 (OMIM: 603063) D-beta-hydroxybutyrate ( 343) 661 161.1 3.2e-39
XP_016862496 (OMIM: 603063) D-beta-hydroxybutyrate ( 343) 661 161.1 3.2e-39
XP_011511369 (OMIM: 603063) D-beta-hydroxybutyrate ( 347) 661 161.1 3.2e-39
NP_002144 (OMIM: 109685) estradiol 17-beta-dehydro ( 387) 560 137.9 3.5e-32
XP_005269412 (OMIM: 603063) D-beta-hydroxybutyrate ( 206) 490 121.6 1.5e-27
XP_016862504 (OMIM: 603063) D-beta-hydroxybutyrate ( 206) 490 121.6 1.5e-27
NP_000187 (OMIM: 218030,614232) corticosteroid 11- ( 405) 481 119.7 1.1e-26
NP_000404 (OMIM: 109684) estradiol 17-beta-dehydro ( 328) 304 78.9 1.7e-14
NP_001317148 (OMIM: 109684) estradiol 17-beta-dehy ( 329) 292 76.1 1.2e-13
NP_056540 (OMIM: 608575) retinol dehydrogenase 8 [ ( 331) 291 75.9 1.4e-13
NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 251 66.7 8.3e-11
XP_016876857 (OMIM: 612833) dehydrogenase/reductas ( 404) 251 66.7 9.6e-11
NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 239 63.9 4.9e-10
NP_620419 (OMIM: 608989) epidermal retinol dehydro ( 309) 238 63.7 6.1e-10
NP_001304978 (OMIM: 608989) epidermal retinol dehy ( 318) 238 63.7 6.3e-10
XP_024306453 (OMIM: 616160) dehydrogenase/reductas ( 287) 232 62.3 1.5e-09
NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 232 62.3 1.6e-09
XP_016879915 (OMIM: 616160) dehydrogenase/reductas ( 325) 232 62.3 1.7e-09
NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325) 232 62.3 1.7e-09
XP_011522088 (OMIM: 616160) dehydrogenase/reductas ( 334) 232 62.3 1.7e-09
XP_005256652 (OMIM: 616160) dehydrogenase/reductas ( 372) 232 62.3 1.9e-09
NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 228 61.3 2.7e-09
NP_000851 (OMIM: 119900,259100,601688) 15-hydroxyp ( 266) 212 57.6 3.4e-08
>>NP_683695 (OMIM: 609769,617574) short-chain dehydrogen (313 aa)
initn: 2071 init1: 2071 opt: 2071 Z-score: 2580.9 bits: 485.7 E(91783): 5.5e-137
Smith-Waterman score: 2071; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313)
10 20 30 40 50 60
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF
250 260 270 280 290 300
310
pF1KE2 ILSRYLPRPADSV
:::::::::::::
NP_683 ILSRYLPRPADSV
310
>>XP_006719735 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
XP_006 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
XP_006 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
XP_006 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
XP_006 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
XP_006 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
XP_006 LADYILTRSWPKPAQAV
310
>>XP_005269266 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
XP_005 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
XP_005 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
XP_005 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
XP_005 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
XP_005 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
XP_005 LADYILTRSWPKPAQAV
310
>>XP_011537227 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
XP_011 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
XP_011 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
XP_011 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
XP_011 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
XP_011 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
XP_011 LADYILTRSWPKPAQAV
310
>>XP_005269265 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
XP_005 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
XP_005 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
XP_005 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
XP_005 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
XP_005 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
XP_005 LADYILTRSWPKPAQAV
310
>>XP_011537228 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
XP_011 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
XP_011 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
XP_011 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
XP_011 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
XP_011 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
XP_011 LADYILTRSWPKPAQAV
310
>>XP_005269264 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
XP_005 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
XP_005 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
XP_005 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
XP_005 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
XP_005 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
XP_005 LADYILTRSWPKPAQAV
310
>>XP_011537229 (OMIM: 606623) 17-beta-hydroxysteroid deh (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
XP_011 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
XP_011 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
XP_011 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
XP_011 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
XP_011 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
XP_011 LADYILTRSWPKPAQAV
310
>>NP_003716 (OMIM: 606623) 17-beta-hydroxysteroid dehydr (317 aa)
initn: 1073 init1: 1049 opt: 1103 Z-score: 1376.3 bits: 262.8 E(91783): 6.9e-70
Smith-Waterman score: 1103; 50.8% identity (80.2% similar) in 313 aa overlap (1-313:5-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAAC
.::.. : .. .:... ..:..:..:::::::::::::::::.:: ::..:::::
NP_003 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 FTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSG
.::.:...:. .:: ::.:. ::::: ::: ::.:::...::..:::.::::::. :
NP_003 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 PNEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSK
:::. .: .....:::.:.:.::: :::.:.:::::.::.:: :::: . :::::::
NP_003 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 FGVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGE
.::::::: .:::. .::::. :.::: .::.. . . ::.. :.. :.. ...::.
NP_003 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 DYFRIYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.:: . .:. . . : . ::::..: :: ::. : :::...:::. :::
NP_003 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..:.::.: :.::..:
NP_003 LADYILTRSWPKPAQAV
310
>>NP_002896 (OMIM: 136880,601617) 11-cis retinol dehydro (318 aa)
initn: 980 init1: 810 opt: 1004 Z-score: 1253.1 bits: 240.0 E(91783): 5e-63
Smith-Waterman score: 1004; 51.2% identity (77.0% similar) in 291 aa overlap (24-313:27-317)
10 20 30 40 50
pF1KE2 MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACF
:. .::::::::::: ::: :: .::..:::.:.
NP_002 MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 TEEGSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGP
: :.. ::: .: ::.:::::.: .:.. ::.::. .: : ::..:::::::. ::
NP_002 TPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 NEWLTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKF
. :::.::: .:.::: .: : ::: .::....:::::.:..: ::.:. :::::::::
NP_002 TPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE2 GVEAFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGED
:.::::::.::.. .::..: :.::: .:: . . :.::. .. : ::: :. ::
NP_002 GLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE2 YFRIYTDKLKNIMQ-VAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTP
.. : . ::. . .: . : .:::...: :: ::.:: :::::..: . ::.
NP_002 FLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAS
250 260 270 280 290 300
300 310
pF1KE2 VTDFILSRYLPRPADSV
..: .:. ::.::..:
NP_002 LVDAVLTWVLPKPAQAVY
310
313 residues in 1 query sequences
64942286 residues in 91783 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Sep 25 16:01:40 2018 done: Tue Sep 25 16:01:40 2018
Total Scan time: 3.270 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]