Result of FASTA (omim) for
pFN21AE2733
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2733, 348 aa
1>>>pF1KE2733 348 - 348 aa - 348 aa
Library: /omim/omim.rfq.tfa
64942286 residues in 91783 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4391+/-0.000294; mu= 4.5865+/- 0.018
mean_var=254.5663+/-50.133, 0's: 0 Z-trim(125.5): 262 B-trim: 116 in 2/57
Lambda= 0.080385
statistics sampled from 50650 (51062) to 50650 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.839), E-opt: 0.2 (0.556), width: 16
Scan time: 4.480
The best scores are: opt bits E(91783)
NP_000374 (OMIM: 240300,607358) autoimmune regulat ( 545) 1881 230.7 6.4e-60
NP_056372 (OMIM: 610771) chromodomain-helicase-DNA (1954) 314 49.5 7.7e-05
XP_005256488 (OMIM: 602120) chromodomain-helicase- (1185) 279 45.2 0.00092
XP_016879558 (OMIM: 602120) chromodomain-helicase- (1888) 279 45.4 0.0013
NP_005843 (OMIM: 602120) chromodomain-helicase-DNA (1966) 279 45.5 0.0013
NP_001005273 (OMIM: 602120) chromodomain-helicase- (2000) 279 45.5 0.0013
XP_006721491 (OMIM: 602120) chromodomain-helicase- (2025) 279 45.5 0.0013
XP_016879557 (OMIM: 602120) chromodomain-helicase- (2036) 279 45.5 0.0013
XP_016879555 (OMIM: 602120) chromodomain-helicase- (2036) 279 45.5 0.0013
XP_016879556 (OMIM: 602120) chromodomain-helicase- (2045) 279 45.5 0.0013
XP_016879559 (OMIM: 602120) chromodomain-helicase- (2050) 279 45.5 0.0013
XP_016879553 (OMIM: 602120) chromodomain-helicase- (2055) 279 45.5 0.0013
XP_016879552 (OMIM: 602120) chromodomain-helicase- (2056) 279 45.5 0.0013
NP_001005271 (OMIM: 602120) chromodomain-helicase- (2059) 279 45.5 0.0013
XP_005256486 (OMIM: 602120) chromodomain-helicase- (2060) 279 45.5 0.0013
XP_005256485 (OMIM: 602120) chromodomain-helicase- (2080) 279 45.5 0.0013
XP_016879551 (OMIM: 602120) chromodomain-helicase- (2105) 279 45.5 0.0014
XP_016879550 (OMIM: 602120) chromodomain-helicase- (2109) 279 45.5 0.0014
XP_006721487 (OMIM: 602120) chromodomain-helicase- (2111) 279 45.5 0.0014
XP_006721486 (OMIM: 602120) chromodomain-helicase- (2114) 279 45.5 0.0014
XP_005256484 (OMIM: 602120) chromodomain-helicase- (2115) 279 45.5 0.0014
XP_016874223 (OMIM: 603277,617159) chromodomain-he (1892) 278 45.3 0.0014
XP_016874222 (OMIM: 603277,617159) chromodomain-he (1893) 278 45.3 0.0014
XP_016874221 (OMIM: 603277,617159) chromodomain-he (1895) 278 45.3 0.0014
XP_016874220 (OMIM: 603277,617159) chromodomain-he (1899) 278 45.3 0.0014
XP_016874219 (OMIM: 603277,617159) chromodomain-he (1900) 278 45.3 0.0014
NP_001350535 (OMIM: 603277,617159) chromodomain-he (1902) 278 45.3 0.0014
XP_005253725 (OMIM: 603277,617159) chromodomain-he (1905) 278 45.3 0.0014
NP_001284482 (OMIM: 603277,617159) chromodomain-he (1905) 278 45.3 0.0014
XP_016874218 (OMIM: 603277,617159) chromodomain-he (1906) 278 45.3 0.0014
XP_006719024 (OMIM: 603277,617159) chromodomain-he (1908) 278 45.3 0.0014
XP_016874217 (OMIM: 603277,617159) chromodomain-he (1911) 278 45.3 0.0014
XP_016874216 (OMIM: 603277,617159) chromodomain-he (1912) 278 45.3 0.0014
NP_001264 (OMIM: 603277,617159) chromodomain-helic (1912) 278 45.3 0.0014
XP_016874215 (OMIM: 603277,617159) chromodomain-he (1913) 278 45.3 0.0014
XP_006719023 (OMIM: 603277,617159) chromodomain-he (1914) 278 45.3 0.0014
XP_016874214 (OMIM: 603277,617159) chromodomain-he (1914) 278 45.3 0.0014
XP_006719022 (OMIM: 603277,617159) chromodomain-he (1915) 278 45.3 0.0014
XP_024304573 (OMIM: 603277,617159) chromodomain-he (1920) 278 45.3 0.0014
XP_024304572 (OMIM: 603277,617159) chromodomain-he (1928) 278 45.3 0.0014
XP_024304571 (OMIM: 603277,617159) chromodomain-he (1934) 278 45.3 0.0014
XP_006719021 (OMIM: 603277,617159) chromodomain-he (1940) 278 45.3 0.0014
XP_024304570 (OMIM: 603277,617159) chromodomain-he (1941) 278 45.3 0.0014
XP_011518811 (OMIM: 612000) tripartite motif-conta (1367) 261 43.2 0.0043
XP_011518829 (OMIM: 612000) tripartite motif-conta ( 743) 252 41.9 0.0059
XP_011518828 (OMIM: 612000) tripartite motif-conta (1001) 252 42.0 0.0072
NP_003843 (OMIM: 603406) transcription intermediar (1016) 252 42.0 0.0072
XP_024302749 (OMIM: 603406) transcription intermed (1031) 252 42.0 0.0073
NP_056989 (OMIM: 603406) transcription intermediar (1050) 252 42.0 0.0074
NP_055633 (OMIM: 612000) tripartite motif-containi (1216) 252 42.1 0.0082
>>NP_000374 (OMIM: 240300,607358) autoimmune regulator [ (545 aa)
initn: 1851 init1: 1851 opt: 1881 Z-score: 1197.3 bits: 230.7 E(91783): 6.4e-60
Smith-Waterman score: 1881; 83.5% identity (89.8% similar) in 322 aa overlap (29-348:227-545)
10 20 30 40 50
pF1KE2 MWLVYSSGAPGTQQPARNRVFFPIGMAPGGVCWRPDGWGTGGQGRISGPGSMGAGQRL
:: . :. . .:.:. .. .: : .
NP_000 GDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLV
200 210 220 230 240 250
60 70 80 90 100 110
pF1KE2 GSSGTQRCCWGSCFGKEVAL-RRVLHPSPVCMGVS-CLCQKNEDECAVCRDGGELICCDG
..:.: : : :. : .. :.:. . . : :::::::::::::::::::::
NP_000 RAKGAQGAAPG---GGEARLGQQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDG
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE2 CPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSA
320 330 340 350 360 370
180 190 200 210 220 230
pF1KE2 GEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGAR
380 390 400 410 420 430
240 250 260 270 280 290
pF1KE2 CGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPA
440 450 460 470 480 490
300 310 320 330 340
pF1KE2 RLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS
500 510 520 530 540
>>NP_056372 (OMIM: 610771) chromodomain-helicase-DNA-bin (1954 aa)
initn: 323 init1: 263 opt: 314 Z-score: 208.4 bits: 49.5 E(91783): 7.7e-05
Smith-Waterman score: 314; 43.6% identity (62.4% similar) in 101 aa overlap (95-191:408-506)
70 80 90 100 110 120
pF1KE2 RCCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRA
:...::. : ::.:::::.:::.:: .
NP_056 PEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSS
380 390 400 410 420 430
130 140 150 160 170 180
pF1KE2 FHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEV
.:: ::.::: :::.: : : : .. : . : ::: .:. :: . :
NP_056 YHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPP--APFMVGLPGPDVEP
440 450 460 470 480 490
190 200 210 220 230 240
pF1KE2 RGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVC
:: .:: :.
NP_056 SLPPPKPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFD
500 510 520 530 540 550
>>XP_005256488 (OMIM: 602120) chromodomain-helicase-DNA- (1185 aa)
initn: 454 init1: 250 opt: 279 Z-score: 189.1 bits: 45.2 E(91783): 0.00092
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:508-603)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
XP_005 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
480 490 500 510 520 530
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
XP_005 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
540 550 560 570 580 590
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
XP_005 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
600 610 620 630 640 650
>>XP_016879558 (OMIM: 602120) chromodomain-helicase-DNA- (1888 aa)
initn: 483 init1: 250 opt: 279 Z-score: 186.7 bits: 45.4 E(91783): 0.0013
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:281-376)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
XP_016 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
260 270 280 290 300 310
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
XP_016 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
320 330 340 350 360
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
XP_016 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
370 380 390 400 410 420
>>NP_005843 (OMIM: 602120) chromodomain-helicase-DNA-bin (1966 aa)
initn: 454 init1: 250 opt: 279 Z-score: 186.5 bits: 45.5 E(91783): 0.0013
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:449-544)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
NP_005 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
420 430 440 450 460 470
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
NP_005 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
480 490 500 510 520 530
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
NP_005 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
540 550 560 570 580 590
>>NP_001005273 (OMIM: 602120) chromodomain-helicase-DNA- (2000 aa)
initn: 454 init1: 250 opt: 279 Z-score: 186.4 bits: 45.5 E(91783): 0.0013
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:449-544)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
NP_001 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
420 430 440 450 460 470
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
NP_001 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
480 490 500 510 520 530
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
NP_001 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
540 550 560 570 580 590
>>XP_006721491 (OMIM: 602120) chromodomain-helicase-DNA- (2025 aa)
initn: 454 init1: 250 opt: 279 Z-score: 186.3 bits: 45.5 E(91783): 0.0013
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:508-603)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
XP_006 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
480 490 500 510 520 530
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
XP_006 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
540 550 560 570 580 590
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
XP_006 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
600 610 620 630 640 650
>>XP_016879557 (OMIM: 602120) chromodomain-helicase-DNA- (2036 aa)
initn: 483 init1: 250 opt: 279 Z-score: 186.3 bits: 45.5 E(91783): 0.0013
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:429-524)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
XP_016 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
400 410 420 430 440 450
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
XP_016 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
460 470 480 490 500 510
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
XP_016 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
520 530 540 550 560 570
>>XP_016879555 (OMIM: 602120) chromodomain-helicase-DNA- (2036 aa)
initn: 483 init1: 250 opt: 279 Z-score: 186.3 bits: 45.5 E(91783): 0.0013
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:429-524)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
XP_016 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
400 410 420 430 440 450
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
XP_016 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
460 470 480 490 500 510
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
XP_016 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
520 530 540 550 560 570
>>XP_016879556 (OMIM: 602120) chromodomain-helicase-DNA- (2045 aa)
initn: 517 init1: 250 opt: 279 Z-score: 186.2 bits: 45.5 E(91783): 0.0013
Smith-Waterman score: 279; 39.4% identity (62.6% similar) in 99 aa overlap (96-190:438-533)
70 80 90 100 110 120
pF1KE2 CCWGSCFGKEVALRRVLHPSPVCMGVSCLCQKNEDE----CAVCRDGGELICCDGCPRAF
...::. : ::.:::::.:::.: ..
XP_016 SCPHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSY
410 420 430 440 450 460
130 140 150 160 170 180
pF1KE2 HLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVR
:. ::.::: .::.: : : : ... . . : :::: .: : ..: .
XP_016 HIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAP---QQADGNPD
470 480 490 500 510 520
190 200 210 220 230 240
pF1KE2 GPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCG
:: .:: :
XP_016 VPPPRPLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDY
530 540 550 560 570 580
348 residues in 1 query sequences
64942286 residues in 91783 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Sep 11 18:46:19 2018 done: Tue Sep 11 18:46:20 2018
Total Scan time: 4.480 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]