Result of FASTA (omim) for
pFN21AE2723
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2723, 302 aa
1>>>pF1KE2723 302 - 302 aa - 302 aa
Library: /omim/omim.rfq.tfa
64704883 residues in 91410 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1286+/-0.000344; mu= 15.7951+/- 0.021
mean_var=62.2399+/-12.210, 0's: 0 Z-trim(113.5): 134 B-trim: 55 in 1/54
Lambda= 0.162570
statistics sampled from 23570 (23717) to 23570 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.259), width: 16
Scan time: 3.340
The best scores are: opt bits E(91410)
NP_004744 (OMIM: 612830) short-chain dehydrogenase ( 302) 1979 472.8 3.8e-133
NP_001306154 (OMIM: 612830) short-chain dehydrogen ( 217) 1430 344.0 1.7e-94
NP_001311299 (OMIM: 612830) short-chain dehydrogen ( 217) 1430 344.0 1.7e-94
XP_016858298 (OMIM: 612830) short-chain dehydrogen ( 217) 1430 344.0 1.7e-94
XP_006711099 (OMIM: 612830) short-chain dehydrogen ( 186) 749 184.2 1.8e-46
NP_620419 (OMIM: 608989) epidermal retinol dehydro ( 309) 644 159.7 7e-39
NP_001304978 (OMIM: 608989) epidermal retinol dehy ( 318) 617 153.4 5.8e-37
NP_835236 (OMIM: 612127) 17-beta-hydroxysteroid de ( 300) 597 148.7 1.4e-35
NP_057329 (OMIM: 612831) estradiol 17-beta-dehydro ( 300) 597 148.7 1.4e-35
NP_742034 (OMIM: 607599) retinol dehydrogenase 10 ( 341) 556 139.1 1.2e-32
XP_011530323 (OMIM: 612831) estradiol 17-beta-dehy ( 151) 369 95.1 1e-19
NP_001129702 (OMIM: 612127) 17-beta-hydroxysteroid ( 264) 365 94.3 3.1e-19
NP_001304979 (OMIM: 608989) epidermal retinol dehy ( 265) 315 82.5 1e-15
XP_011515781 (OMIM: 608989) epidermal retinol dehy ( 274) 288 76.2 8.7e-14
NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 278 73.9 5.3e-13
XP_016876857 (OMIM: 612833) dehydrogenase/reductas ( 404) 278 74.0 6.1e-13
NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 276 73.4 6.4e-13
NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 263 70.4 5.6e-12
XP_016879915 (OMIM: 616160) dehydrogenase/reductas ( 325) 263 70.4 5.8e-12
NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325) 263 70.4 5.8e-12
XP_005256652 (OMIM: 616160) dehydrogenase/reductas ( 372) 263 70.4 6.5e-12
XP_024306453 (OMIM: 616160) dehydrogenase/reductas ( 287) 256 68.7 1.6e-11
XP_011522088 (OMIM: 616160) dehydrogenase/reductas ( 334) 256 68.7 1.9e-11
NP_066284 (OMIM: 611596) dehydrogenase/reductase S ( 278) 237 64.2 3.5e-10
NP_057226 (OMIM: 609574) very-long-chain 3-oxoacyl ( 312) 236 64.0 4.5e-10
NP_002026 (OMIM: 136440,617526) 3-ketodihydrosphin ( 332) 232 63.1 9.2e-10
XP_016873370 (OMIM: 609574) very-long-chain 3-oxoa ( 280) 229 62.4 1.3e-09
NP_001186700 (OMIM: 136880,601617) 11-cis retinol ( 318) 227 61.9 2e-09
NP_002896 (OMIM: 136880,601617) 11-cis retinol deh ( 318) 227 61.9 2e-09
NP_932349 (OMIM: 615196) dehydrogenase/reductase S ( 232) 225 61.4 2.1e-09
XP_005266734 (OMIM: 136440,617526) 3-ketodihydrosp ( 298) 226 61.7 2.2e-09
NP_000405 (OMIM: 233400,261515,601860) peroxisomal ( 736) 225 61.7 5.5e-09
XP_006720068 (OMIM: 611596) dehydrogenase/reductas ( 233) 217 59.5 7.8e-09
NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 210 57.9 2.8e-08
NP_683695 (OMIM: 609769,617574) short-chain dehydr ( 313) 210 57.9 3.1e-08
NP_001099041 (OMIM: 616161) dehydrogenase/reductas ( 311) 204 56.5 8.2e-08
NP_056540 (OMIM: 608575) retinol dehydrogenase 8 [ ( 331) 203 56.3 1e-07
NP_005516 (OMIM: 600713,614662) corticosteroid 11- ( 292) 202 56.1 1.1e-07
NP_001193670 (OMIM: 600713,614662) corticosteroid ( 292) 202 56.1 1.1e-07
NP_861420 (OMIM: 600713,614662) corticosteroid 11- ( 292) 202 56.1 1.1e-07
NP_001207422 (OMIM: 616161) dehydrogenase/reductas ( 312) 202 56.1 1.1e-07
NP_077284 (OMIM: 616159) dehydrogenase/reductase S ( 260) 200 55.6 1.4e-07
XP_005257715 (OMIM: 616159) dehydrogenase/reductas ( 229) 197 54.8 2e-07
NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl ( 303) 197 54.9 2.5e-07
NP_612461 (OMIM: 610410) dehydrogenase/reductase S ( 313) 197 54.9 2.6e-07
NP_001129522 (OMIM: 610410) dehydrogenase/reductas ( 313) 197 54.9 2.6e-07
XP_005259026 (OMIM: 612832) 17-beta-hydroxysteroid ( 212) 195 54.3 2.6e-07
XP_024305019 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 195 54.4 3e-07
XP_024305018 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 195 54.4 3e-07
XP_024305017 (OMIM: 606623) 17-beta-hydroxysteroid ( 259) 195 54.4 3e-07
>>NP_004744 (OMIM: 612830) short-chain dehydrogenase/red (302 aa)
initn: 1979 init1: 1979 opt: 1979 Z-score: 2511.9 bits: 472.8 E(91410): 3.8e-133
Smith-Waterman score: 1979; 100.0% identity (100.0% similar) in 302 aa overlap (1-302:1-302)
10 20 30 40 50 60
pF1KE2 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG
250 260 270 280 290 300
pF1KE2 RT
::
NP_004 RT
>>NP_001306154 (OMIM: 612830) short-chain dehydrogenase/ (217 aa)
initn: 1430 init1: 1430 opt: 1430 Z-score: 1818.1 bits: 344.0 E(91410): 1.7e-94
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 217 aa overlap (86-302:1-217)
60 70 80 90 100 110
pF1KE2 REFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVG
::::::::::::::::::::::::::::::
NP_001 MGTECHYFICDVGNREEVYQTAKAVREKVG
10 20 30
120 130 140 150 160 170
pF1KE2 DITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNS
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 VLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFP
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
160 170 180 190 200 210
300
pF1KE2 NTFKGRT
:::::::
NP_001 NTFKGRT
>>NP_001311299 (OMIM: 612830) short-chain dehydrogenase/ (217 aa)
initn: 1430 init1: 1430 opt: 1430 Z-score: 1818.1 bits: 344.0 E(91410): 1.7e-94
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 217 aa overlap (86-302:1-217)
60 70 80 90 100 110
pF1KE2 REFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVG
::::::::::::::::::::::::::::::
NP_001 MGTECHYFICDVGNREEVYQTAKAVREKVG
10 20 30
120 130 140 150 160 170
pF1KE2 DITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNS
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 VLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFP
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
160 170 180 190 200 210
300
pF1KE2 NTFKGRT
:::::::
NP_001 NTFKGRT
>>XP_016858298 (OMIM: 612830) short-chain dehydrogenase/ (217 aa)
initn: 1430 init1: 1430 opt: 1430 Z-score: 1818.1 bits: 344.0 E(91410): 1.7e-94
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 217 aa overlap (86-302:1-217)
60 70 80 90 100 110
pF1KE2 REFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVG
::::::::::::::::::::::::::::::
XP_016 MGTECHYFICDVGNREEVYQTAKAVREKVG
10 20 30
120 130 140 150 160 170
pF1KE2 DITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNS
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 VLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFP
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
160 170 180 190 200 210
300
pF1KE2 NTFKGRT
:::::::
XP_016 NTFKGRT
>>XP_006711099 (OMIM: 612830) short-chain dehydrogenase/ (186 aa)
initn: 749 init1: 749 opt: 749 Z-score: 955.9 bits: 184.2 E(91410): 1.8e-46
Smith-Waterman score: 749; 100.0% identity (100.0% similar) in 114 aa overlap (1-114:1-114)
10 20 30 40 50 60
pF1KE2 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVSQPLSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
XP_006 TEAGDGGPEDSGSCAAQPGPPPPPMDNACPRYLEKHTSTGCTRGDPQILRNLHLHEHFQR
130 140 150 160 170 180
>>NP_620419 (OMIM: 608989) epidermal retinol dehydrogena (309 aa)
initn: 635 init1: 440 opt: 644 Z-score: 819.5 bits: 159.7 E(91410): 7e-39
Smith-Waterman score: 644; 36.2% identity (67.2% similar) in 293 aa overlap (9-298:11-302)
10 20 30 40 50
pF1KE2 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREF
: .: . .. ...: . .:: .... : :::::.: :.:: :: .:
NP_620 MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 AERGARKIVLWGRTEKCLKETTEEIRQMG-TECHYFICDVGNREEVYQTAKAVREKVGDI
:. :. .::: ... .:: . :. : :. : . :: ...: ::..: :...:::.
NP_620 ARLGSV-LVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDV
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 TILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVL
.::.:::..: ::...: :. . :: .: ...:: ::::: :. ..::.::..:
NP_620 SILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 ALSAIPGAIDYCTSKASAFAFMESLTLGLL--DCPGVSATTVLPFHTSTEMFQGMRVRFP
.::.. : :::.:: .::.: ::. . . :...: : :: .: ::.: . :
NP_620 GLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
.:.: :.:. .... :::. .. : .: .. ...:::.:: . : . : :
NP_620 SLLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAM
240 250 260 270 280 290
300
pF1KE2 NTFKGRT
. :
NP_620 DGFVDQKKKL
300
>>NP_001304978 (OMIM: 608989) epidermal retinol dehydrog (318 aa)
initn: 616 init1: 440 opt: 617 Z-score: 785.1 bits: 153.4 E(91410): 5.8e-37
Smith-Waterman score: 617; 36.5% identity (69.0% similar) in 271 aa overlap (9-276:11-280)
10 20 30 40 50
pF1KE2 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREF
: .: . .. ...: . .:: .... : :::::.: :.:: :: .:
NP_001 MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 AERGARKIVLWGRTEKCLKETTEEIRQMG-TECHYFICDVGNREEVYQTAKAVREKVGDI
:. :. .::: ... .:: . :. : :. : . :: ...: ::..: :...:::.
NP_001 ARLGSV-LVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDV
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 TILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVL
.::.:::..: ::...: :. . :: .: ...:: ::::: :. ..::.::..:
NP_001 SILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 ALSAIPGAIDYCTSKASAFAFMESLTLGLL--DCPGVSATTVLPFHTSTEMFQGMRVRFP
.::.. : :::.:: .::.: ::. . . :...: : :: .: ::.: . :
NP_001 GLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 NLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCM
.:.: :.:. .... :::. .. : .: .. ...:: .
NP_001 SLLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKRLHLAQDGSECLTEAMWDRAK
240 250 260 270 280 290
300
pF1KE2 NTFKGRT
NP_001 DPGQAIRNSGLRSHYSLSL
300 310
>>NP_835236 (OMIM: 612127) 17-beta-hydroxysteroid dehydr (300 aa)
initn: 514 init1: 403 opt: 597 Z-score: 760.1 bits: 148.7 E(91410): 1.4e-35
Smith-Waterman score: 597; 34.5% identity (70.9% similar) in 275 aa overlap (9-281:7-277)
10 20 30 40 50 60
pF1KE2 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
.... . .:: ... : . .: . .... : :::::.:.::::: . :::.
NP_835 MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAK
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
: . .::: ... ..::. : :..:. : .. : .::::.:.. . :...:::.::.
NP_835 RQS-ILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIV
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
::::..:. .:... :. . :. ..: ::.:: :::.:: :.: ..:::: . :: .
NP_835 VNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHE
120 130 140 150 160 170
190 200 210 220 230
pF1KE2 AIPGAIDYCTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLF
.:: : ::.:: .: .: ..:: : : :.... . : ..: . .. .: :.
NP_835 GIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR---LW
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 PPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTF
: :. . :.: .... :. ....: .. .. :...::. :
NP_835 PVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVG
240 250 260 270 280 290
300
pF1KE2 KGRT
NP_835 HKIKMK
300
>>NP_057329 (OMIM: 612831) estradiol 17-beta-dehydrogena (300 aa)
initn: 464 init1: 393 opt: 597 Z-score: 760.1 bits: 148.7 E(91410): 1.4e-35
Smith-Waterman score: 597; 35.9% identity (70.4% similar) in 284 aa overlap (6-287:5-283)
10 20 30 40 50 60
pF1KE2 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
: :...:: .: ... : : .: . .... : :::::.:.:::: : :::
NP_057 MKFLLDILLLLPL-LIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFA-
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
. :.::: ... :.::. . . .:.. : :. : .:::..:..:: :. ..::..::
NP_057 KLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSIL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
::::.::. ..:. ..: . :. ..:.:..::::::::: : . ..:::: . :. .
NP_057 VNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHV
120 130 140 150 160 170
190 200 210 220 230
pF1KE2 AIPGAIDYCTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLF
..: . ::.:: .: .: ..:: :. :. ::..: . : ..: .... . .:
NP_057 SVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPST---SLG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 PPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTF
: :.:: :. : .... .: ....: .. :. :. :::. : ...
NP_057 PTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKRKISVKFDAVIG
240 250 260 270 280 290
300
pF1KE2 KGRT
NP_057 YKMKAQ
300
>>NP_742034 (OMIM: 607599) retinol dehydrogenase 10 [Hom (341 aa)
initn: 575 init1: 366 opt: 556 Z-score: 707.3 bits: 139.1 E(91410): 1.2e-32
Smith-Waterman score: 628; 37.2% identity (65.4% similar) in 309 aa overlap (19-298:18-324)
10 20 30 40 50 60
pF1KE2 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
.:. :: :: : : .... . ::::.: :.:: .: :::.
NP_742 MNIVVEFFVVTFKVLWAFVLAAARWLVRP-KEKSVAGQVCLITGAGSGLGRLFALEFAR
10 20 30 40 50
70 80 90
pF1KE2 RGARKIVLWGRTEKCLKETTEEIRQM----------------GTE-----CHY----FIC
: : .::: . . .::. .:.. : : :. . :
NP_742 RRAL-LVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTC
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE2 DVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTT
:::.::.:: ::. ::..::....:::::.:: :. :.. :. . ... .: ..::::
NP_742 DVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTT
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE2 KAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLT--LGLLDCPGVS
::::: :::...:::: . : :.: . :. :::.:: .. .: :::. : . :..
NP_742 KAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIK
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE2 ATTVLPFHTSTEMFQGMRVR--FPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALV
.: : :. ..: ::.: :.: . ..:::::. ......:. .: .. : :. ..
NP_742 TTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVT
240 250 260 270 280 290
280 290 300
pF1KE2 ILKSILPQAALEEIHKFSGTYTCMNTFKGRT
..::::: :. ...: :. :: :
NP_742 FMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI
300 310 320 330 340
302 residues in 1 query sequences
64704883 residues in 91410 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Jul 7 15:57:34 2018 done: Sat Jul 7 15:57:34 2018
Total Scan time: 3.340 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]