Result of FASTA (ccds) for
pFN21AE2701
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2701, 4547 aa
1>>>pF1KE2701 4547 - 4547 aa - 4547 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.1393+/-0.00209; mu= -21.7448+/- 0.122
mean_var=741.2287+/-159.338, 0's: 0 Z-trim(107.1): 318 B-trim: 74 in 1/50
Lambda= 0.047108
statistics sampled from 9132 (9387) to 9132 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.575), E-opt: 0.2 (0.288), width: 16
Scan time: 13.980
The best scores are: opt bits E(32554)
CCDS43775.1 PLEC gene_id:5339|Hs108|chr8 (4547) 28825 1978.2 0
CCDS43770.1 PLEC gene_id:5339|Hs108|chr8 (4533) 28600 1962.9 0
CCDS43773.1 PLEC gene_id:5339|Hs108|chr8 (4547) 28595 1962.6 0
CCDS43771.1 PLEC gene_id:5339|Hs108|chr8 (4525) 28592 1962.4 0
CCDS43769.1 PLEC gene_id:5339|Hs108|chr8 (4574) 28587 1962.0 0
CCDS47936.1 PLEC gene_id:5339|Hs108|chr8 (4515) 28586 1962.0 0
CCDS43774.1 PLEC gene_id:5339|Hs108|chr8 (4551) 28586 1962.0 0
CCDS43772.1 PLEC gene_id:5339|Hs108|chr8 (4684) 28586 1962.0 0
CCDS4959.1 DST gene_id:667|Hs108|chr6 (2649) 3281 242.0 5.7e-62
CCDS435.1 MACF1 gene_id:23499|Hs108|chr1 (5430) 2794 209.1 9e-52
CCDS47443.1 DST gene_id:667|Hs108|chr6 (5171) 2684 201.6 1.5e-49
CCDS75474.1 DST gene_id:667|Hs108|chr6 (5537) 2684 201.6 1.6e-49
CCDS47368.1 DSP gene_id:1832|Hs108|chr6 (2272) 2334 177.6 1.2e-42
CCDS4501.1 DSP gene_id:1832|Hs108|chr6 (2871) 2334 177.6 1.4e-42
CCDS75800.1 EPPK1 gene_id:83481|Hs108|chr8 (5088) 2233 171.0 2.6e-40
CCDS8150.1 SPTBN2 gene_id:6712|Hs108|chr11 (2390) 1212 101.3 1.1e-19
CCDS33198.1 SPTBN1 gene_id:6711|Hs108|chr2 (2364) 1135 96.1 4.2e-18
CCDS33199.1 SPTBN1 gene_id:6711|Hs108|chr2 (2155) 1133 95.9 4.3e-18
CCDS32100.1 SPTB gene_id:6710|Hs108|chr14 (2137) 1127 95.5 5.6e-18
CCDS32099.1 SPTB gene_id:6710|Hs108|chr14 (2328) 1127 95.5 6e-18
CCDS12559.1 SPTBN4 gene_id:57731|Hs108|chr19 (2564) 1011 87.7 1.5e-15
CCDS61599.1 SPTBN5 gene_id:51332|Hs108|chr15 (3674) 1016 88.1 1.6e-15
CCDS10526.1 PPL gene_id:5493|Hs108|chr16 (1756) 926 81.8 6.3e-14
CCDS55395.1 DMD gene_id:1756|Hs108|chrX (3681) 915 81.3 1.9e-13
CCDS14233.1 DMD gene_id:1756|Hs108|chrX (3685) 900 80.3 3.8e-13
CCDS11737.1 EVPL gene_id:2125|Hs108|chr17 (2033) 881 78.8 5.9e-13
CCDS82207.1 EVPL gene_id:2125|Hs108|chr17 (2055) 881 78.8 5.9e-13
>>CCDS43775.1 PLEC gene_id:5339|Hs108|chr8 (4547 aa)
initn: 28825 init1: 28825 opt: 28825 Z-score: 10605.3 bits: 1978.2 E(32554): 0
Smith-Waterman score: 28825; 100.0% identity (100.0% similar) in 4547 aa overlap (1-4547:1-4547)
10 20 30 40 50 60
pF1KE2 MSQHQLRVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MSQHQLRVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 YHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIER
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
CCDS43 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KE2 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KE2 EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KE2 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVG
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KE2 PELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVH
2770 2780 2790 2800 2810 2820
2830 2840 2850 2860 2870 2880
pF1KE2 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLC
2830 2840 2850 2860 2870 2880
2890 2900 2910 2920 2930 2940
pF1KE2 LLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRD
2890 2900 2910 2920 2930 2940
2950 2960 2970 2980 2990 3000
pF1KE2 LLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQL
2950 2960 2970 2980 2990 3000
3010 3020 3030 3040 3050 3060
pF1KE2 QRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEA
3010 3020 3030 3040 3050 3060
3070 3080 3090 3100 3110 3120
pF1KE2 QAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQAL
3070 3080 3090 3100 3110 3120
3130 3140 3150 3160 3170 3180
pF1KE2 KKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKA
3130 3140 3150 3160 3170 3180
3190 3200 3210 3220 3230 3240
pF1KE2 YSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE
3190 3200 3210 3220 3230 3240
3250 3260 3270 3280 3290 3300
pF1KE2 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ
3250 3260 3270 3280 3290 3300
3310 3320 3330 3340 3350 3360
pF1KE2 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI
3310 3320 3330 3340 3350 3360
3370 3380 3390 3400 3410 3420
pF1KE2 YLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGP
3370 3380 3390 3400 3410 3420
3430 3440 3450 3460 3470 3480
pF1KE2 ELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHS
3430 3440 3450 3460 3470 3480
3490 3500 3510 3520 3530 3540
pF1KE2 HRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRL
3490 3500 3510 3520 3530 3540
3550 3560 3570 3580 3590 3600
pF1KE2 LPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQ
3550 3560 3570 3580 3590 3600
3610 3620 3630 3640 3650 3660
pF1KE2 RAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISL
3610 3620 3630 3640 3650 3660
3670 3680 3690 3700 3710 3720
pF1KE2 ETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVA
3670 3680 3690 3700 3710 3720
3730 3740 3750 3760 3770 3780
pF1KE2 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTI
3730 3740 3750 3760 3770 3780
3790 3800 3810 3820 3830 3840
pF1KE2 SLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEP
3790 3800 3810 3820 3830 3840
3850 3860 3870 3880 3890 3900
pF1KE2 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRS
3850 3860 3870 3880 3890 3900
3910 3920 3930 3940 3950 3960
pF1KE2 QVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRP
3910 3920 3930 3940 3950 3960
3970 3980 3990 4000 4010 4020
pF1KE2 GTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSG
3970 3980 3990 4000 4010 4020
4030 4040 4050 4060 4070 4080
pF1KE2 KLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL
4030 4040 4050 4060 4070 4080
4090 4100 4110 4120 4130 4140
pF1KE2 TDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRR
4090 4100 4110 4120 4130 4140
4150 4160 4170 4180 4190 4200
pF1KE2 VVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSG
4150 4160 4170 4180 4190 4200
4210 4220 4230 4240 4250 4260
pF1KE2 RQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISP
4210 4220 4230 4240 4250 4260
4270 4280 4290 4300 4310 4320
pF1KE2 AVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGG
4270 4280 4290 4300 4310 4320
4330 4340 4350 4360 4370 4380
pF1KE2 IIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLY
4330 4340 4350 4360 4370 4380
4390 4400 4410 4420 4430 4440
pF1KE2 YEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKT
4390 4400 4410 4420 4430 4440
4450 4460 4470 4480 4490 4500
pF1KE2 KLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAG
4450 4460 4470 4480 4490 4500
4510 4520 4530 4540
pF1KE2 SRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4510 4520 4530 4540
>>CCDS43770.1 PLEC gene_id:5339|Hs108|chr8 (4533 aa)
initn: 28594 init1: 28594 opt: 28600 Z-score: 10522.6 bits: 1962.9 E(32554): 0
Smith-Waterman score: 28600; 99.7% identity (99.8% similar) in 4526 aa overlap (22-4547:8-4533)
10 20 30 40 50 60
pF1KE2 MSQHQLRVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQ
:... : .. : ::::::::::::::::::::::::
CCDS43 MAGPLPDEQDFIQAYEEVREKYKDERDRVQKKTFTKWVNKHLIKAQ
10 20 30 40
70 80 90 100 110 120
pF1KE2 RHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 RNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRC
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 YHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE2 LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVD
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE2 GAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQ
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE2 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE2 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE2 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE2 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE2 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR
830 840 850 860 870 880
910 920 930 940 950 960
pF1KE2 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KE2 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KE2 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KE2 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KE2 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KE2 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIER
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
CCDS43 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KE2 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KE2 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KE2 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA
1370 1380 1390 1400 1410 1420
1450 1460 1470 1480 1490 1500
pF1KE2 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR
1430 1440 1450 1460 1470 1480
1510 1520 1530 1540 1550 1560
pF1KE2 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA
1490 1500 1510 1520 1530 1540
1570 1580 1590 1600 1610 1620
pF1KE2 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA
1550 1560 1570 1580 1590 1600
1630 1640 1650 1660 1670 1680
pF1KE2 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE
1610 1620 1630 1640 1650 1660
1690 1700 1710 1720 1730 1740
pF1KE2 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ
1670 1680 1690 1700 1710 1720
1750 1760 1770 1780 1790 1800
pF1KE2 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA
1730 1740 1750 1760 1770 1780
1810 1820 1830 1840 1850 1860
pF1KE2 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE
1790 1800 1810 1820 1830 1840
1870 1880 1890 1900 1910 1920
pF1KE2 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR
1850 1860 1870 1880 1890 1900
1930 1940 1950 1960 1970 1980
pF1KE2 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE
1910 1920 1930 1940 1950 1960
1990 2000 2010 2020 2030 2040
pF1KE2 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ
1970 1980 1990 2000 2010 2020
2050 2060 2070 2080 2090 2100
pF1KE2 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA
2030 2040 2050 2060 2070 2080
2110 2120 2130 2140 2150 2160
pF1KE2 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK
2090 2100 2110 2120 2130 2140
2170 2180 2190 2200 2210 2220
pF1KE2 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA
2150 2160 2170 2180 2190 2200
2230 2240 2250 2260 2270 2280
pF1KE2 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA
2210 2220 2230 2240 2250 2260
2290 2300 2310 2320 2330 2340
pF1KE2 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ
2270 2280 2290 2300 2310 2320
2350 2360 2370 2380 2390 2400
pF1KE2 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE
2330 2340 2350 2360 2370 2380
2410 2420 2430 2440 2450 2460
pF1KE2 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE
2390 2400 2410 2420 2430 2440
2470 2480 2490 2500 2510 2520
pF1KE2 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF
2450 2460 2470 2480 2490 2500
2530 2540 2550 2560 2570 2580
pF1KE2 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR
2510 2520 2530 2540 2550 2560
2590 2600 2610 2620 2630 2640
pF1KE2 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA
2570 2580 2590 2600 2610 2620
2650 2660 2670 2680 2690 2700
pF1KE2 EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG
2630 2640 2650 2660 2670 2680
2710 2720 2730 2740 2750 2760
pF1KE2 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVG
2690 2700 2710 2720 2730 2740
2770 2780 2790 2800 2810 2820
pF1KE2 PELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVH
2750 2760 2770 2780 2790 2800
2830 2840 2850 2860 2870 2880
pF1KE2 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLC
2810 2820 2830 2840 2850 2860
2890 2900 2910 2920 2930 2940
pF1KE2 LLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRD
2870 2880 2890 2900 2910 2920
2950 2960 2970 2980 2990 3000
pF1KE2 LLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQL
2930 2940 2950 2960 2970 2980
3010 3020 3030 3040 3050 3060
pF1KE2 QRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEA
2990 3000 3010 3020 3030 3040
3070 3080 3090 3100 3110 3120
pF1KE2 QAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQAL
3050 3060 3070 3080 3090 3100
3130 3140 3150 3160 3170 3180
pF1KE2 KKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKA
3110 3120 3130 3140 3150 3160
3190 3200 3210 3220 3230 3240
pF1KE2 YSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE
3170 3180 3190 3200 3210 3220
3250 3260 3270 3280 3290 3300
pF1KE2 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ
3230 3240 3250 3260 3270 3280
3310 3320 3330 3340 3350 3360
pF1KE2 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI
3290 3300 3310 3320 3330 3340
3370 3380 3390 3400 3410 3420
pF1KE2 YLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGP
3350 3360 3370 3380 3390 3400
3430 3440 3450 3460 3470 3480
pF1KE2 ELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHS
3410 3420 3430 3440 3450 3460
3490 3500 3510 3520 3530 3540
pF1KE2 HRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRL
3470 3480 3490 3500 3510 3520
3550 3560 3570 3580 3590 3600
pF1KE2 LPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQ
3530 3540 3550 3560 3570 3580
3610 3620 3630 3640 3650 3660
pF1KE2 RAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISL
3590 3600 3610 3620 3630 3640
3670 3680 3690 3700 3710 3720
pF1KE2 ETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVA
3650 3660 3670 3680 3690 3700
3730 3740 3750 3760 3770 3780
pF1KE2 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTI
3710 3720 3730 3740 3750 3760
3790 3800 3810 3820 3830 3840
pF1KE2 SLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEP
3770 3780 3790 3800 3810 3820
3850 3860 3870 3880 3890 3900
pF1KE2 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRS
3830 3840 3850 3860 3870 3880
3910 3920 3930 3940 3950 3960
pF1KE2 QVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRP
3890 3900 3910 3920 3930 3940
3970 3980 3990 4000 4010 4020
pF1KE2 GTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSG
3950 3960 3970 3980 3990 4000
4030 4040 4050 4060 4070 4080
pF1KE2 KLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL
4010 4020 4030 4040 4050 4060
4090 4100 4110 4120 4130 4140
pF1KE2 TDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRR
4070 4080 4090 4100 4110 4120
4150 4160 4170 4180 4190 4200
pF1KE2 VVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSG
4130 4140 4150 4160 4170 4180
4210 4220 4230 4240 4250 4260
pF1KE2 RQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISP
4190 4200 4210 4220 4230 4240
4270 4280 4290 4300 4310 4320
pF1KE2 AVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGG
4250 4260 4270 4280 4290 4300
4330 4340 4350 4360 4370 4380
pF1KE2 IIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLY
4310 4320 4330 4340 4350 4360
4390 4400 4410 4420 4430 4440
pF1KE2 YEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKT
4370 4380 4390 4400 4410 4420
4450 4460 4470 4480 4490 4500
pF1KE2 KLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAG
4430 4440 4450 4460 4470 4480
4510 4520 4530 4540
pF1KE2 SRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4490 4500 4510 4520 4530
>>CCDS43773.1 PLEC gene_id:5339|Hs108|chr8 (4547 aa)
initn: 28595 init1: 28595 opt: 28595 Z-score: 10520.8 bits: 1962.6 E(32554): 0
Smith-Waterman score: 28595; 99.8% identity (100.0% similar) in 4517 aa overlap (31-4547:31-4547)
10 20 30 40 50 60
pF1KE2 MSQHQLRVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQ
: .. ..:::::::::::::::::::::::
CCDS43 MEPSGSLFPSLVVVGHVVTLAAVWHWRRGRRWAQDEQDERDRVQKKTFTKWVNKHLIKAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 RHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 YHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIER
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
CCDS43 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLR
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE2 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE2 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEA
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE2 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE2 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE2 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE2 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE2 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KE2 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KE2 EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KE2 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVG
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KE2 PELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVH
2770 2780 2790 2800 2810 2820
2830 2840 2850 2860 2870 2880
pF1KE2 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLC
2830 2840 2850 2860 2870 2880
2890 2900 2910 2920 2930 2940
pF1KE2 LLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRD
2890 2900 2910 2920 2930 2940
2950 2960 2970 2980 2990 3000
pF1KE2 LLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQL
2950 2960 2970 2980 2990 3000
3010 3020 3030 3040 3050 3060
pF1KE2 QRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEA
3010 3020 3030 3040 3050 3060
3070 3080 3090 3100 3110 3120
pF1KE2 QAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQAL
3070 3080 3090 3100 3110 3120
3130 3140 3150 3160 3170 3180
pF1KE2 KKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKA
3130 3140 3150 3160 3170 3180
3190 3200 3210 3220 3230 3240
pF1KE2 YSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE
3190 3200 3210 3220 3230 3240
3250 3260 3270 3280 3290 3300
pF1KE2 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ
3250 3260 3270 3280 3290 3300
3310 3320 3330 3340 3350 3360
pF1KE2 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI
3310 3320 3330 3340 3350 3360
3370 3380 3390 3400 3410 3420
pF1KE2 YLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGP
3370 3380 3390 3400 3410 3420
3430 3440 3450 3460 3470 3480
pF1KE2 ELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHS
3430 3440 3450 3460 3470 3480
3490 3500 3510 3520 3530 3540
pF1KE2 HRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRL
3490 3500 3510 3520 3530 3540
3550 3560 3570 3580 3590 3600
pF1KE2 LPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQ
3550 3560 3570 3580 3590 3600
3610 3620 3630 3640 3650 3660
pF1KE2 RAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISL
3610 3620 3630 3640 3650 3660
3670 3680 3690 3700 3710 3720
pF1KE2 ETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVA
3670 3680 3690 3700 3710 3720
3730 3740 3750 3760 3770 3780
pF1KE2 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTI
3730 3740 3750 3760 3770 3780
3790 3800 3810 3820 3830 3840
pF1KE2 SLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEP
3790 3800 3810 3820 3830 3840
3850 3860 3870 3880 3890 3900
pF1KE2 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRS
3850 3860 3870 3880 3890 3900
3910 3920 3930 3940 3950 3960
pF1KE2 QVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRP
3910 3920 3930 3940 3950 3960
3970 3980 3990 4000 4010 4020
pF1KE2 GTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSG
3970 3980 3990 4000 4010 4020
4030 4040 4050 4060 4070 4080
pF1KE2 KLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL
4030 4040 4050 4060 4070 4080
4090 4100 4110 4120 4130 4140
pF1KE2 TDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRR
4090 4100 4110 4120 4130 4140
4150 4160 4170 4180 4190 4200
pF1KE2 VVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSG
4150 4160 4170 4180 4190 4200
4210 4220 4230 4240 4250 4260
pF1KE2 RQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISP
4210 4220 4230 4240 4250 4260
4270 4280 4290 4300 4310 4320
pF1KE2 AVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGG
4270 4280 4290 4300 4310 4320
4330 4340 4350 4360 4370 4380
pF1KE2 IIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLY
4330 4340 4350 4360 4370 4380
4390 4400 4410 4420 4430 4440
pF1KE2 YEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKT
4390 4400 4410 4420 4430 4440
4450 4460 4470 4480 4490 4500
pF1KE2 KLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAG
4450 4460 4470 4480 4490 4500
4510 4520 4530 4540
pF1KE2 SRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4510 4520 4530 4540
>>CCDS43771.1 PLEC gene_id:5339|Hs108|chr8 (4525 aa)
initn: 28592 init1: 28592 opt: 28592 Z-score: 10519.7 bits: 1962.4 E(32554): 0
Smith-Waterman score: 28592; 100.0% identity (100.0% similar) in 4511 aa overlap (37-4547:15-4525)
10 20 30 40 50 60
pF1KE2 RVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHISDL
::::::::::::::::::::::::::::::
CCDS43 MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDL
10 20 30 40
70 80 90 100 110 120
pF1KE2 YEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIA
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 DGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 WRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 WRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQP
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 DEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDV
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 EKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLL
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 AAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE2 EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGV
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE2 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE2 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE2 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE2 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE2 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE2 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLI
830 840 850 860 870 880
910 920 930 940 950 960
pF1KE2 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQ
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KE2 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KE2 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLE
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KE2 KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KE2 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KE2 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVE
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
CCDS43 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KE2 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KE2 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KE2 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS
1370 1380 1390 1400 1410 1420
1450 1460 1470 1480 1490 1500
pF1KE2 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE
1430 1440 1450 1460 1470 1480
1510 1520 1530 1540 1550 1560
pF1KE2 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA
1490 1500 1510 1520 1530 1540
1570 1580 1590 1600 1610 1620
pF1KE2 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE
1550 1560 1570 1580 1590 1600
1630 1640 1650 1660 1670 1680
pF1KE2 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ
1610 1620 1630 1640 1650 1660
1690 1700 1710 1720 1730 1740
pF1KE2 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA
1670 1680 1690 1700 1710 1720
1750 1760 1770 1780 1790 1800
pF1KE2 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARL
1730 1740 1750 1760 1770 1780
1810 1820 1830 1840 1850 1860
pF1KE2 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL
1790 1800 1810 1820 1830 1840
1870 1880 1890 1900 1910 1920
pF1KE2 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE
1850 1860 1870 1880 1890 1900
1930 1940 1950 1960 1970 1980
pF1KE2 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA
1910 1920 1930 1940 1950 1960
1990 2000 2010 2020 2030 2040
pF1KE2 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR
1970 1980 1990 2000 2010 2020
2050 2060 2070 2080 2090 2100
pF1KE2 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ
2030 2040 2050 2060 2070 2080
2110 2120 2130 2140 2150 2160
pF1KE2 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE
2090 2100 2110 2120 2130 2140
2170 2180 2190 2200 2210 2220
pF1KE2 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV
2150 2160 2170 2180 2190 2200
2230 2240 2250 2260 2270 2280
pF1KE2 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA
2210 2220 2230 2240 2250 2260
2290 2300 2310 2320 2330 2340
pF1KE2 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL
2270 2280 2290 2300 2310 2320
2350 2360 2370 2380 2390 2400
pF1KE2 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF
2330 2340 2350 2360 2370 2380
2410 2420 2430 2440 2450 2460
pF1KE2 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA
2390 2400 2410 2420 2430 2440
2470 2480 2490 2500 2510 2520
pF1KE2 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK
2450 2460 2470 2480 2490 2500
2530 2540 2550 2560 2570 2580
pF1KE2 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL
2510 2520 2530 2540 2550 2560
2590 2600 2610 2620 2630 2640
pF1KE2 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF
2570 2580 2590 2600 2610 2620
2650 2660 2670 2680 2690 2700
pF1KE2 DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKAT
2630 2640 2650 2660 2670 2680
2710 2720 2730 2740 2750 2760
pF1KE2 NEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 NEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK
2690 2700 2710 2720 2730 2740
2770 2780 2790 2800 2810 2820
pF1KE2 LLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPV
2750 2760 2770 2780 2790 2800
2830 2840 2850 2860 2870 2880
pF1KE2 DVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTD
2810 2820 2830 2840 2850 2860
2890 2900 2910 2920 2930 2940
pF1KE2 KAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFR
2870 2880 2890 2900 2910 2920
2950 2960 2970 2980 2990 3000
pF1KE2 TGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERS
2930 2940 2950 2960 2970 2980
3010 3020 3030 3040 3050 3060
pF1KE2 VRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGH
2990 3000 3010 3020 3030 3040
3070 3080 3090 3100 3110 3120
pF1KE2 IIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIP
3050 3060 3070 3080 3090 3100
3130 3140 3150 3160 3170 3180
pF1KE2 REQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPST
3110 3120 3130 3140 3150 3160
3190 3200 3210 3220 3230 3240
pF1KE2 GEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGF
3170 3180 3190 3200 3210 3220
3250 3260 3270 3280 3290 3300
pF1KE2 KGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFS
3230 3240 3250 3260 3270 3280
3310 3320 3330 3340 3350 3360
pF1KE2 GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTK
3290 3300 3310 3320 3330 3340
3370 3380 3390 3400 3410 3420
pF1KE2 EKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL
3350 3360 3370 3380 3390 3400
3430 3440 3450 3460 3470 3480
pF1KE2 LSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVD
3410 3420 3430 3440 3450 3460
3490 3500 3510 3520 3530 3540
pF1KE2 VAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGA
3470 3480 3490 3500 3510 3520
3550 3560 3570 3580 3590 3600
pF1KE2 EKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMA
3530 3540 3550 3560 3570 3580
3610 3620 3630 3640 3650 3660
pF1KE2 DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLL
3590 3600 3610 3620 3630 3640
3670 3680 3690 3700 3710 3720
pF1KE2 REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEA
3650 3660 3670 3680 3690 3700
3730 3740 3750 3760 3770 3780
pF1KE2 QAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAM
3710 3720 3730 3740 3750 3760
3790 3800 3810 3820 3830 3840
pF1KE2 KKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSY
3770 3780 3790 3800 3810 3820
3850 3860 3870 3880 3890 3900
pF1KE2 VDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEA
3830 3840 3850 3860 3870 3880
3910 3920 3930 3940 3950 3960
pF1KE2 TALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFEL
3890 3900 3910 3920 3930 3940
3970 3980 3990 4000 4010 4020
pF1KE2 LEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLF
3950 3960 3970 3980 3990 4000
4030 4040 4050 4060 4070 4080
pF1KE2 QAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDD
4010 4020 4030 4040 4050 4060
4090 4100 4110 4120 4130 4140
pF1KE2 TKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDP
4070 4080 4090 4100 4110 4120
4150 4160 4170 4180 4190 4200
pF1KE2 ETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDID
4130 4140 4150 4160 4170 4180
4210 4220 4230 4240 4250 4260
pF1KE2 DAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQ
4190 4200 4210 4220 4230 4240
4270 4280 4290 4300 4310 4320
pF1KE2 LASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPST
4250 4260 4270 4280 4290 4300
4330 4340 4350 4360 4370 4380
pF1KE2 GERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQR
4310 4320 4330 4340 4350 4360
4390 4400 4410 4420 4430 4440
pF1KE2 FLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISY
4370 4380 4390 4400 4410 4420
4450 4460 4470 4480 4490 4500
pF1KE2 KDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSF
4430 4440 4450 4460 4470 4480
4510 4520 4530 4540
pF1KE2 DATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
:::::::::::::::::::::::::::::::::::::::::
CCDS43 DATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4490 4500 4510 4520
>>CCDS43769.1 PLEC gene_id:5339|Hs108|chr8 (4574 aa)
initn: 28586 init1: 28586 opt: 28587 Z-score: 10517.8 bits: 1962.0 E(32554): 0
Smith-Waterman score: 28587; 99.8% identity (99.9% similar) in 4520 aa overlap (28-4547:59-4574)
10 20 30 40 50
pF1KE2 MSQHQLRVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLI
::.: . ::::::::::::::::::::
CCDS43 LPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIA----DERDRVQKKTFTKWVNKHLI
30 40 50 60 70 80
60 70 80 90 100 110
pF1KE2 KAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE2 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQG
150 160 170 180 190 200
180 190 200 210 220 230
pF1KE2 LRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE2 PEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH
270 280 290 300 310 320
300 310 320 330 340 350
pF1KE2 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV
330 340 350 360 370 380
360 370 380 390 400 410
pF1KE2 PPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADA
390 400 410 420 430 440
420 430 440 450 460 470
pF1KE2 LLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRL
450 460 470 480 490 500
480 490 500 510 520 530
pF1KE2 HERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH
510 520 530 540 550 560
540 550 560 570 580 590
pF1KE2 RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRL
570 580 590 600 610 620
600 610 620 630 640 650
pF1KE2 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES
630 640 650 660 670 680
660 670 680 690 700 710
pF1KE2 YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAH
690 700 710 720 730 740
720 730 740 750 760 770
pF1KE2 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY
750 760 770 780 790 800
780 790 800 810 820 830
pF1KE2 KGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPS
810 820 830 840 850 860
840 850 860 870 880 890
pF1KE2 HWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 HWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ
870 880 890 900 910 920
900 910 920 930 940 950
pF1KE2 SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAERE
930 940 950 960 970 980
960 970 980 990 1000 1010
pF1KE2 YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR
990 1000 1010 1020 1030 1040
1020 1030 1040 1050 1060 1070
pF1KE2 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQV
1050 1060 1070 1080 1090 1100
1080 1090 1100 1110 1120 1130
pF1KE2 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA
1110 1120 1130 1140 1150 1160
1140 1150 1160 1170 1180 1190
pF1KE2 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV
1170 1180 1190 1200 1210 1220
1200 1210 1220 1230 1240 1250
pF1KE2 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEE
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
CCDS43 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE
1230 1240 1250 1260 1270 1280
1260 1270 1280 1290 1300 1310
pF1KE2 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV
1290 1300 1310 1320 1330 1340
1320 1330 1340 1350 1360 1370
pF1KE2 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE
1350 1360 1370 1380 1390 1400
1380 1390 1400 1410 1420 1430
pF1KE2 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA
1410 1420 1430 1440 1450 1460
1440 1450 1460 1470 1480 1490
pF1KE2 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE
1470 1480 1490 1500 1510 1520
1500 1510 1520 1530 1540 1550
pF1KE2 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV
1530 1540 1550 1560 1570 1580
1560 1570 1580 1590 1600 1610
pF1KE2 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ
1590 1600 1610 1620 1630 1640
1620 1630 1640 1650 1660 1670
pF1KE2 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG
1650 1660 1670 1680 1690 1700
1680 1690 1700 1710 1720 1730
pF1KE2 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA
1710 1720 1730 1740 1750 1760
1740 1750 1760 1770 1780 1790
pF1KE2 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR
1770 1780 1790 1800 1810 1820
1800 1810 1820 1830 1840 1850
pF1KE2 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK
1830 1840 1850 1860 1870 1880
1860 1870 1880 1890 1900 1910
pF1KE2 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL
1890 1900 1910 1920 1930 1940
1920 1930 1940 1950 1960 1970
pF1KE2 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA
1950 1960 1970 1980 1990 2000
1980 1990 2000 2010 2020 2030
pF1KE2 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ
2010 2020 2030 2040 2050 2060
2040 2050 2060 2070 2080 2090
pF1KE2 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR
2070 2080 2090 2100 2110 2120
2100 2110 2120 2130 2140 2150
pF1KE2 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL
2130 2140 2150 2160 2170 2180
2160 2170 2180 2190 2200 2210
pF1KE2 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT
2190 2200 2210 2220 2230 2240
2220 2230 2240 2250 2260 2270
pF1KE2 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA
2250 2260 2270 2280 2290 2300
2280 2290 2300 2310 2320 2330
pF1KE2 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE
2310 2320 2330 2340 2350 2360
2340 2350 2360 2370 2380 2390
pF1KE2 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA
2370 2380 2390 2400 2410 2420
2400 2410 2420 2430 2440 2450
pF1KE2 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER
2430 2440 2450 2460 2470 2480
2460 2470 2480 2490 2500 2510
pF1KE2 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE
2490 2500 2510 2520 2530 2540
2520 2530 2540 2550 2560 2570
pF1KE2 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE
2550 2560 2570 2580 2590 2600
2580 2590 2600 2610 2620 2630
pF1KE2 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA
2610 2620 2630 2640 2650 2660
2640 2650 2660 2670 2680 2690
pF1KE2 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSS
2670 2680 2690 2700 2710 2720
2700 2710 2720 2730 2740 2750
pF1KE2 IAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEG
2730 2740 2750 2760 2770 2780
2760 2770 2780 2790 2800 2810
pF1KE2 VVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVID
2790 2800 2810 2820 2830 2840
2820 2830 2840 2850 2860 2870
pF1KE2 PVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPET
2850 2860 2870 2880 2890 2900
2880 2890 2900 2910 2920 2930
pF1KE2 GLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQ
2910 2920 2930 2940 2950 2960
2940 2950 2960 2970 2980 2990
pF1KE2 RRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELY
2970 2980 2990 3000 3010 3020
3000 3010 3020 3030 3040 3050
pF1KE2 QQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVAL
3030 3040 3050 3060 3070 3080
3060 3070 3080 3090 3100 3110
pF1KE2 LEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLF
3090 3100 3110 3120 3130 3140
3120 3130 3140 3150 3160 3170
pF1KE2 QALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRAD
3150 3160 3170 3180 3190 3200
3180 3190 3200 3210 3220 3230
pF1KE2 AKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKT
3210 3220 3230 3240 3250 3260
3240 3250 3260 3270 3280 3290
pF1KE2 PVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVET
3270 3280 3290 3300 3310 3320
3300 3310 3320 3330 3340 3350
pF1KE2 LRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCL
3330 3340 3350 3360 3370 3380
3360 3370 3380 3390 3400 3410
pF1KE2 AGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGV
3390 3400 3410 3420 3430 3440
3420 3430 3440 3450 3460 3470
pF1KE2 VGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDP
3450 3460 3470 3480 3490 3500
3480 3490 3500 3510 3520 3530
pF1KE2 VHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETG
3510 3520 3530 3540 3550 3560
3540 3550 3560 3570 3580 3590
pF1KE2 LRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIP
3570 3580 3590 3600 3610 3620
3600 3610 3620 3630 3640 3650
pF1KE2 EEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARI
3630 3640 3650 3660 3670 3680
3660 3670 3680 3690 3700 3710
pF1KE2 ISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSA
3690 3700 3710 3720 3730 3740
3720 3730 3740 3750 3760 3770
pF1KE2 EVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTE
3750 3760 3770 3780 3790 3800
3780 3790 3800 3810 3820 3830
pF1KE2 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL
3810 3820 3830 3840 3850 3860
3840 3850 3860 3870 3880 3890
pF1KE2 SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEEL
3870 3880 3890 3900 3910 3920
3900 3910 3920 3930 3940 3950
pF1KE2 VRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGI
3930 3940 3950 3960 3970 3980
3960 3970 3980 3990 4000 4010
pF1KE2 IRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDP
3990 4000 4010 4020 4030 4040
4020 4030 4040 4050 4060 4070
pF1KE2 YSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMN
4050 4060 4070 4080 4090 4100
4080 4090 4100 4110 4120 4130
pF1KE2 EILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVR
4110 4120 4130 4140 4150 4160
4140 4150 4160 4170 4180 4190
pF1KE2 KRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDR
4170 4180 4190 4200 4210 4220
4200 4210 4220 4230 4240 4250
pF1KE2 RSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYP
4230 4240 4250 4260 4270 4280
4260 4270 4280 4290 4300 4310
pF1KE2 ISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQAC
4290 4300 4310 4320 4330 4340
4320 4330 4340 4350 4360 4370
pF1KE2 TGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKG
4350 4360 4370 4380 4390 4400
4380 4390 4400 4410 4420 4430
pF1KE2 WLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 WLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTC
4410 4420 4430 4440 4450 4460
4440 4450 4460 4470 4480 4490
pF1KE2 PKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGS
4470 4480 4490 4500 4510 4520
4500 4510 4520 4530 4540
pF1KE2 RAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4530 4540 4550 4560 4570
>>CCDS47936.1 PLEC gene_id:5339|Hs108|chr8 (4515 aa)
initn: 28586 init1: 28586 opt: 28586 Z-score: 10517.5 bits: 1962.0 E(32554): 0
Smith-Waterman score: 28586; 100.0% identity (100.0% similar) in 4510 aa overlap (38-4547:6-4515)
10 20 30 40 50 60
pF1KE2 VPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHISDLY
::::::::::::::::::::::::::::::
CCDS47 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLY
10 20 30
70 80 90 100 110 120
pF1KE2 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE2 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE2 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE2 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE2 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE2 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KE2 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KE2 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KE2 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
CCDS47 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE
1180 1190 1200 1210 1220 1230
1270 1280 1290 1300 1310 1320
pF1KE2 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
1240 1250 1260 1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KE2 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420 1430 1440
pF1KE2 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
1360 1370 1380 1390 1400 1410
1450 1460 1470 1480 1490 1500
pF1KE2 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
1420 1430 1440 1450 1460 1470
1510 1520 1530 1540 1550 1560
pF1KE2 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
1480 1490 1500 1510 1520 1530
1570 1580 1590 1600 1610 1620
pF1KE2 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
1540 1550 1560 1570 1580 1590
1630 1640 1650 1660 1670 1680
pF1KE2 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
1600 1610 1620 1630 1640 1650
1690 1700 1710 1720 1730 1740
pF1KE2 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
1660 1670 1680 1690 1700 1710
1750 1760 1770 1780 1790 1800
pF1KE2 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
1720 1730 1740 1750 1760 1770
1810 1820 1830 1840 1850 1860
pF1KE2 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
1780 1790 1800 1810 1820 1830
1870 1880 1890 1900 1910 1920
pF1KE2 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
1840 1850 1860 1870 1880 1890
1930 1940 1950 1960 1970 1980
pF1KE2 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
1900 1910 1920 1930 1940 1950
1990 2000 2010 2020 2030 2040
pF1KE2 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
1960 1970 1980 1990 2000 2010
2050 2060 2070 2080 2090 2100
pF1KE2 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
2020 2030 2040 2050 2060 2070
2110 2120 2130 2140 2150 2160
pF1KE2 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
2080 2090 2100 2110 2120 2130
2170 2180 2190 2200 2210 2220
pF1KE2 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
2140 2150 2160 2170 2180 2190
2230 2240 2250 2260 2270 2280
pF1KE2 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
2200 2210 2220 2230 2240 2250
2290 2300 2310 2320 2330 2340
pF1KE2 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
2260 2270 2280 2290 2300 2310
2350 2360 2370 2380 2390 2400
pF1KE2 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
2320 2330 2340 2350 2360 2370
2410 2420 2430 2440 2450 2460
pF1KE2 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
2380 2390 2400 2410 2420 2430
2470 2480 2490 2500 2510 2520
pF1KE2 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
2440 2450 2460 2470 2480 2490
2530 2540 2550 2560 2570 2580
pF1KE2 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
2500 2510 2520 2530 2540 2550
2590 2600 2610 2620 2630 2640
pF1KE2 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
2560 2570 2580 2590 2600 2610
2650 2660 2670 2680 2690 2700
pF1KE2 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
2620 2630 2640 2650 2660 2670
2710 2720 2730 2740 2750 2760
pF1KE2 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
2680 2690 2700 2710 2720 2730
2770 2780 2790 2800 2810 2820
pF1KE2 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
2740 2750 2760 2770 2780 2790
2830 2840 2850 2860 2870 2880
pF1KE2 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
2800 2810 2820 2830 2840 2850
2890 2900 2910 2920 2930 2940
pF1KE2 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
2860 2870 2880 2890 2900 2910
2950 2960 2970 2980 2990 3000
pF1KE2 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
2920 2930 2940 2950 2960 2970
3010 3020 3030 3040 3050 3060
pF1KE2 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
2980 2990 3000 3010 3020 3030
3070 3080 3090 3100 3110 3120
pF1KE2 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
3040 3050 3060 3070 3080 3090
3130 3140 3150 3160 3170 3180
pF1KE2 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
3100 3110 3120 3130 3140 3150
3190 3200 3210 3220 3230 3240
pF1KE2 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
3160 3170 3180 3190 3200 3210
3250 3260 3270 3280 3290 3300
pF1KE2 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
3220 3230 3240 3250 3260 3270
3310 3320 3330 3340 3350 3360
pF1KE2 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
3280 3290 3300 3310 3320 3330
3370 3380 3390 3400 3410 3420
pF1KE2 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
3340 3350 3360 3370 3380 3390
3430 3440 3450 3460 3470 3480
pF1KE2 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
3400 3410 3420 3430 3440 3450
3490 3500 3510 3520 3530 3540
pF1KE2 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
3460 3470 3480 3490 3500 3510
3550 3560 3570 3580 3590 3600
pF1KE2 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
3520 3530 3540 3550 3560 3570
3610 3620 3630 3640 3650 3660
pF1KE2 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
3580 3590 3600 3610 3620 3630
3670 3680 3690 3700 3710 3720
pF1KE2 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
3640 3650 3660 3670 3680 3690
3730 3740 3750 3760 3770 3780
pF1KE2 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
3700 3710 3720 3730 3740 3750
3790 3800 3810 3820 3830 3840
pF1KE2 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
3760 3770 3780 3790 3800 3810
3850 3860 3870 3880 3890 3900
pF1KE2 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
3820 3830 3840 3850 3860 3870
3910 3920 3930 3940 3950 3960
pF1KE2 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
3880 3890 3900 3910 3920 3930
3970 3980 3990 4000 4010 4020
pF1KE2 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
3940 3950 3960 3970 3980 3990
4030 4040 4050 4060 4070 4080
pF1KE2 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
4000 4010 4020 4030 4040 4050
4090 4100 4110 4120 4130 4140
pF1KE2 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
4060 4070 4080 4090 4100 4110
4150 4160 4170 4180 4190 4200
pF1KE2 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
4120 4130 4140 4150 4160 4170
4210 4220 4230 4240 4250 4260
pF1KE2 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
4180 4190 4200 4210 4220 4230
4270 4280 4290 4300 4310 4320
pF1KE2 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
4240 4250 4260 4270 4280 4290
4330 4340 4350 4360 4370 4380
pF1KE2 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
4300 4310 4320 4330 4340 4350
4390 4400 4410 4420 4430 4440
pF1KE2 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
4360 4370 4380 4390 4400 4410
4450 4460 4470 4480 4490 4500
pF1KE2 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS47 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
4420 4430 4440 4450 4460 4470
4510 4520 4530 4540
pF1KE2 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::::::::
CCDS47 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4480 4490 4500 4510
>>CCDS43774.1 PLEC gene_id:5339|Hs108|chr8 (4551 aa)
initn: 28586 init1: 28586 opt: 28586 Z-score: 10517.5 bits: 1962.0 E(32554): 0
Smith-Waterman score: 28586; 100.0% identity (100.0% similar) in 4510 aa overlap (38-4547:42-4551)
10 20 30 40 50 60
pF1KE2 VPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHISDLY
::::::::::::::::::::::::::::::
CCDS43 REVLLERPCWLDGGCEPARRGYLYQQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLY
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE2 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE2 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE2 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE2 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE2 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE2 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE2 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
440 450 460 470 480 490
490 500 510 520 530 540
pF1KE2 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
500 510 520 530 540 550
550 560 570 580 590 600
pF1KE2 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
560 570 580 590 600 610
610 620 630 640 650 660
pF1KE2 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
620 630 640 650 660 670
670 680 690 700 710 720
pF1KE2 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
680 690 700 710 720 730
730 740 750 760 770 780
pF1KE2 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
740 750 760 770 780 790
790 800 810 820 830 840
pF1KE2 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
800 810 820 830 840 850
850 860 870 880 890 900
pF1KE2 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
860 870 880 890 900 910
910 920 930 940 950 960
pF1KE2 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
920 930 940 950 960 970
970 980 990 1000 1010 1020
pF1KE2 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
980 990 1000 1010 1020 1030
1030 1040 1050 1060 1070 1080
pF1KE2 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
1040 1050 1060 1070 1080 1090
1090 1100 1110 1120 1130 1140
pF1KE2 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
1100 1110 1120 1130 1140 1150
1150 1160 1170 1180 1190 1200
pF1KE2 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
1160 1170 1180 1190 1200 1210
1210 1220 1230 1240 1250 1260
pF1KE2 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
CCDS43 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE
1220 1230 1240 1250 1260 1270
1270 1280 1290 1300 1310 1320
pF1KE2 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
1280 1290 1300 1310 1320 1330
1330 1340 1350 1360 1370 1380
pF1KE2 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
1340 1350 1360 1370 1380 1390
1390 1400 1410 1420 1430 1440
pF1KE2 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
1400 1410 1420 1430 1440 1450
1450 1460 1470 1480 1490 1500
pF1KE2 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
1460 1470 1480 1490 1500 1510
1510 1520 1530 1540 1550 1560
pF1KE2 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
1520 1530 1540 1550 1560 1570
1570 1580 1590 1600 1610 1620
pF1KE2 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
1580 1590 1600 1610 1620 1630
1630 1640 1650 1660 1670 1680
pF1KE2 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
1640 1650 1660 1670 1680 1690
1690 1700 1710 1720 1730 1740
pF1KE2 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
1700 1710 1720 1730 1740 1750
1750 1760 1770 1780 1790 1800
pF1KE2 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
1760 1770 1780 1790 1800 1810
1810 1820 1830 1840 1850 1860
pF1KE2 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
1820 1830 1840 1850 1860 1870
1870 1880 1890 1900 1910 1920
pF1KE2 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
1880 1890 1900 1910 1920 1930
1930 1940 1950 1960 1970 1980
pF1KE2 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
1940 1950 1960 1970 1980 1990
1990 2000 2010 2020 2030 2040
pF1KE2 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
2000 2010 2020 2030 2040 2050
2050 2060 2070 2080 2090 2100
pF1KE2 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
2060 2070 2080 2090 2100 2110
2110 2120 2130 2140 2150 2160
pF1KE2 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
2120 2130 2140 2150 2160 2170
2170 2180 2190 2200 2210 2220
pF1KE2 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
2180 2190 2200 2210 2220 2230
2230 2240 2250 2260 2270 2280
pF1KE2 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
2240 2250 2260 2270 2280 2290
2290 2300 2310 2320 2330 2340
pF1KE2 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
2300 2310 2320 2330 2340 2350
2350 2360 2370 2380 2390 2400
pF1KE2 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
2360 2370 2380 2390 2400 2410
2410 2420 2430 2440 2450 2460
pF1KE2 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
2420 2430 2440 2450 2460 2470
2470 2480 2490 2500 2510 2520
pF1KE2 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
2480 2490 2500 2510 2520 2530
2530 2540 2550 2560 2570 2580
pF1KE2 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
2540 2550 2560 2570 2580 2590
2590 2600 2610 2620 2630 2640
pF1KE2 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
2600 2610 2620 2630 2640 2650
2650 2660 2670 2680 2690 2700
pF1KE2 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
2660 2670 2680 2690 2700 2710
2710 2720 2730 2740 2750 2760
pF1KE2 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
2720 2730 2740 2750 2760 2770
2770 2780 2790 2800 2810 2820
pF1KE2 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
2780 2790 2800 2810 2820 2830
2830 2840 2850 2860 2870 2880
pF1KE2 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
2840 2850 2860 2870 2880 2890
2890 2900 2910 2920 2930 2940
pF1KE2 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
2900 2910 2920 2930 2940 2950
2950 2960 2970 2980 2990 3000
pF1KE2 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
2960 2970 2980 2990 3000 3010
3010 3020 3030 3040 3050 3060
pF1KE2 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
3020 3030 3040 3050 3060 3070
3070 3080 3090 3100 3110 3120
pF1KE2 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
3080 3090 3100 3110 3120 3130
3130 3140 3150 3160 3170 3180
pF1KE2 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
3140 3150 3160 3170 3180 3190
3190 3200 3210 3220 3230 3240
pF1KE2 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
3200 3210 3220 3230 3240 3250
3250 3260 3270 3280 3290 3300
pF1KE2 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
3260 3270 3280 3290 3300 3310
3310 3320 3330 3340 3350 3360
pF1KE2 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
3320 3330 3340 3350 3360 3370
3370 3380 3390 3400 3410 3420
pF1KE2 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
3380 3390 3400 3410 3420 3430
3430 3440 3450 3460 3470 3480
pF1KE2 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
3440 3450 3460 3470 3480 3490
3490 3500 3510 3520 3530 3540
pF1KE2 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
3500 3510 3520 3530 3540 3550
3550 3560 3570 3580 3590 3600
pF1KE2 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
3560 3570 3580 3590 3600 3610
3610 3620 3630 3640 3650 3660
pF1KE2 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
3620 3630 3640 3650 3660 3670
3670 3680 3690 3700 3710 3720
pF1KE2 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
3680 3690 3700 3710 3720 3730
3730 3740 3750 3760 3770 3780
pF1KE2 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
3740 3750 3760 3770 3780 3790
3790 3800 3810 3820 3830 3840
pF1KE2 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
3800 3810 3820 3830 3840 3850
3850 3860 3870 3880 3890 3900
pF1KE2 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
3860 3870 3880 3890 3900 3910
3910 3920 3930 3940 3950 3960
pF1KE2 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
3920 3930 3940 3950 3960 3970
3970 3980 3990 4000 4010 4020
pF1KE2 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
3980 3990 4000 4010 4020 4030
4030 4040 4050 4060 4070 4080
pF1KE2 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
4040 4050 4060 4070 4080 4090
4090 4100 4110 4120 4130 4140
pF1KE2 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
4100 4110 4120 4130 4140 4150
4150 4160 4170 4180 4190 4200
pF1KE2 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
4160 4170 4180 4190 4200 4210
4210 4220 4230 4240 4250 4260
pF1KE2 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
4220 4230 4240 4250 4260 4270
4270 4280 4290 4300 4310 4320
pF1KE2 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
4280 4290 4300 4310 4320 4330
4330 4340 4350 4360 4370 4380
pF1KE2 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
4340 4350 4360 4370 4380 4390
4390 4400 4410 4420 4430 4440
pF1KE2 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
4400 4410 4420 4430 4440 4450
4450 4460 4470 4480 4490 4500
pF1KE2 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
4460 4470 4480 4490 4500 4510
4510 4520 4530 4540
pF1KE2 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::::::::
CCDS43 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4520 4530 4540 4550
>>CCDS43772.1 PLEC gene_id:5339|Hs108|chr8 (4684 aa)
initn: 28586 init1: 28586 opt: 28586 Z-score: 10517.3 bits: 1962.0 E(32554): 0
Smith-Waterman score: 28586; 100.0% identity (100.0% similar) in 4510 aa overlap (38-4547:175-4684)
10 20 30 40 50 60
pF1KE2 VPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHISDLY
::::::::::::::::::::::::::::::
CCDS43 LEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTFTKWVNKHLIKAQRHISDLY
150 160 170 180 190 200
70 80 90 100 110 120
pF1KE2 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIAD
210 220 230 240 250 260
130 140 150 160 170 180
pF1KE2 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSW
270 280 290 300 310 320
190 200 210 220 230 240
pF1KE2 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD
330 340 350 360 370 380
250 260 270 280 290 300
pF1KE2 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRF
390 400 410 420 430 440
310 320 330 340 350 360
pF1KE2 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 PSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVE
450 460 470 480 490 500
370 380 390 400 410 420
pF1KE2 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLA
510 520 530 540 550 560
430 440 450 460 470 480
pF1KE2 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE
570 580 590 600 610 620
490 500 510 520 530 540
pF1KE2 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 YNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD
630 640 650 660 670 680
550 560 570 580 590 600
pF1KE2 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS
690 700 710 720 730 740
610 620 630 640 650 660
pF1KE2 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL
750 760 770 780 790 800
670 680 690 700 710 720
pF1KE2 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF
810 820 830 840 850 860
730 740 750 760 770 780
pF1KE2 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR
870 880 890 900 910 920
790 800 810 820 830 840
pF1KE2 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS
930 940 950 960 970 980
850 860 870 880 890 900
pF1KE2 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIR
990 1000 1010 1020 1030 1040
910 920 930 940 950 960
pF1KE2 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQ
1050 1060 1070 1080 1090 1100
970 980 990 1000 1010 1020
pF1KE2 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQ
1110 1120 1130 1140 1150 1160
1030 1040 1050 1060 1070 1080
pF1KE2 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK
1170 1180 1190 1200 1210 1220
1090 1100 1110 1120 1130 1140
pF1KE2 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD
1230 1240 1250 1260 1270 1280
1150 1160 1170 1180 1190 1200
pF1KE2 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR
1290 1300 1310 1320 1330 1340
1210 1220 1230 1240 1250 1260
pF1KE2 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
CCDS43 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE
1350 1360 1370 1380 1390 1400
1270 1280 1290 1300 1310 1320
pF1KE2 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT
1410 1420 1430 1440 1450 1460
1330 1340 1350 1360 1370 1380
pF1KE2 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE
1470 1480 1490 1500 1510 1520
1390 1400 1410 1420 1430 1440
pF1KE2 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR
1530 1540 1550 1560 1570 1580
1450 1460 1470 1480 1490 1500
pF1KE2 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES
1590 1600 1610 1620 1630 1640
1510 1520 1530 1540 1550 1560
pF1KE2 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL
1650 1660 1670 1680 1690 1700
1570 1580 1590 1600 1610 1620
pF1KE2 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA
1710 1720 1730 1740 1750 1760
1630 1640 1650 1660 1670 1680
pF1KE2 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR
1770 1780 1790 1800 1810 1820
1690 1700 1710 1720 1730 1740
pF1KE2 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT
1830 1840 1850 1860 1870 1880
1750 1760 1770 1780 1790 1800
pF1KE2 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR
1890 1900 1910 1920 1930 1940
1810 1820 1830 1840 1850 1860
pF1KE2 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR
1950 1960 1970 1980 1990 2000
1870 1880 1890 1900 1910 1920
pF1KE2 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI
2010 2020 2030 2040 2050 2060
1930 1940 1950 1960 1970 1980
pF1KE2 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE
2070 2080 2090 2100 2110 2120
1990 2000 2010 2020 2030 2040
pF1KE2 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL
2130 2140 2150 2160 2170 2180
2050 2060 2070 2080 2090 2100
pF1KE2 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS
2190 2200 2210 2220 2230 2240
2110 2120 2130 2140 2150 2160
pF1KE2 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM
2250 2260 2270 2280 2290 2300
2170 2180 2190 2200 2210 2220
pF1KE2 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE
2310 2320 2330 2340 2350 2360
2230 2240 2250 2260 2270 2280
pF1KE2 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA
2370 2380 2390 2400 2410 2420
2290 2300 2310 2320 2330 2340
pF1KE2 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ
2430 2440 2450 2460 2470 2480
2350 2360 2370 2380 2390 2400
pF1KE2 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR
2490 2500 2510 2520 2530 2540
2410 2420 2430 2440 2450 2460
pF1KE2 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK
2550 2560 2570 2580 2590 2600
2470 2480 2490 2500 2510 2520
pF1KE2 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA
2610 2620 2630 2640 2650 2660
2530 2540 2550 2560 2570 2580
pF1KE2 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL
2670 2680 2690 2700 2710 2720
2590 2600 2610 2620 2630 2640
pF1KE2 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD
2730 2740 2750 2760 2770 2780
2650 2660 2670 2680 2690 2700
pF1KE2 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN
2790 2800 2810 2820 2830 2840
2710 2720 2730 2740 2750 2760
pF1KE2 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL
2850 2860 2870 2880 2890 2900
2770 2780 2790 2800 2810 2820
pF1KE2 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD
2910 2920 2930 2940 2950 2960
2830 2840 2850 2860 2870 2880
pF1KE2 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDK
2970 2980 2990 3000 3010 3020
2890 2900 2910 2920 2930 2940
pF1KE2 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRT
3030 3040 3050 3060 3070 3080
2950 2960 2970 2980 2990 3000
pF1KE2 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSV
3090 3100 3110 3120 3130 3140
3010 3020 3030 3040 3050 3060
pF1KE2 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 RDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHI
3150 3160 3170 3180 3190 3200
3070 3080 3090 3100 3110 3120
pF1KE2 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 IDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPR
3210 3220 3230 3240 3250 3260
3130 3140 3150 3160 3170 3180
pF1KE2 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTG
3270 3280 3290 3300 3310 3320
3190 3200 3210 3220 3230 3240
pF1KE2 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFK
3330 3340 3350 3360 3370 3380
3250 3260 3270 3280 3290 3300
pF1KE2 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG
3390 3400 3410 3420 3430 3440
3310 3320 3330 3340 3350 3360
pF1KE2 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE
3450 3460 3470 3480 3490 3500
3370 3380 3390 3400 3410 3420
pF1KE2 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL
3510 3520 3530 3540 3550 3560
3430 3440 3450 3460 3470 3480
pF1KE2 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV
3570 3580 3590 3600 3610 3620
3490 3500 3510 3520 3530 3540
pF1KE2 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE
3630 3640 3650 3660 3670 3680
3550 3560 3570 3580 3590 3600
pF1KE2 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD
3690 3700 3710 3720 3730 3740
3610 3620 3630 3640 3650 3660
pF1KE2 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR
3750 3760 3770 3780 3790 3800
3670 3680 3690 3700 3710 3720
pF1KE2 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ
3810 3820 3830 3840 3850 3860
3730 3740 3750 3760 3770 3780
pF1KE2 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK
3870 3880 3890 3900 3910 3920
3790 3800 3810 3820 3830 3840
pF1KE2 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV
3930 3940 3950 3960 3970 3980
3850 3860 3870 3880 3890 3900
pF1KE2 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEAT
3990 4000 4010 4020 4030 4040
3910 3920 3930 3940 3950 3960
pF1KE2 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELL
4050 4060 4070 4080 4090 4100
3970 3980 3990 4000 4010 4020
pF1KE2 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 EAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQ
4110 4120 4130 4140 4150 4160
4030 4040 4050 4060 4070 4080
pF1KE2 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT
4170 4180 4190 4200 4210 4220
4090 4100 4110 4120 4130 4140
pF1KE2 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 KGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPE
4230 4240 4250 4260 4270 4280
4150 4160 4170 4180 4190 4200
pF1KE2 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 TGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDD
4290 4300 4310 4320 4330 4340
4210 4220 4230 4240 4250 4260
pF1KE2 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 AIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQL
4350 4360 4370 4380 4390 4400
4270 4280 4290 4300 4310 4320
pF1KE2 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTG
4410 4420 4430 4440 4450 4460
4330 4340 4350 4360 4370 4380
pF1KE2 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 ERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRF
4470 4480 4490 4500 4510 4520
4390 4400 4410 4420 4430 4440
pF1KE2 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 LEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYK
4530 4540 4550 4560 4570 4580
4450 4460 4470 4480 4490 4500
pF1KE2 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS43 DALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD
4590 4600 4610 4620 4630 4640
4510 4520 4530 4540
pF1KE2 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
::::::::::::::::::::::::::::::::::::::::
CCDS43 ATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPESAVA
4650 4660 4670 4680
>>CCDS4959.1 DST gene_id:667|Hs108|chr6 (2649 aa)
initn: 3728 init1: 2412 opt: 3281 Z-score: 1226.1 bits: 242.0 E(32554): 5.7e-62
Smith-Waterman score: 3788; 29.7% identity (59.0% similar) in 2932 aa overlap (390-3214:56-2636)
360 370 380 390 400 410
pF1KE2 GYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL
::: ::.:....: .. .::..: : :
CCDS49 DSNENLLLVHCGPTLINSCISFGSESFDGHRLEMLQQIANRVQRDSVICEDKLILAGNAL
30 40 50 60 70 80
420 430 440 450 460 470
pF1KE2 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE
::: . : .: : .:. . . ....: ::: : ::.. :..:. .:: .:..
CCDS49 QSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRD
90 100 110 120 130 140
480 490
pF1KE2 RLVAIRTE----YN------------------LRLKAGVA--------------------
...:.:.: :. :..: :
CCDS49 EIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLT
150 160 170 180 190 200
500 510
pF1KE2 --------------------APA--------------TQVAQVTLQSVQ----RRPELED
.:: . : .::... :.: :..
CCDS49 SSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKS
210 220 230 240 250 260
520 530 540 550 560
pF1KE2 STL-----------RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF
: : ...:::: ::.: : ..: .::: ::::::..: .:...:..::::
CCDS49 SLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEF
270 280 290 300 310 320
570 580 590 600 610 620
pF1KE2 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKE
......:. .: :.. . .: . : ::. :::::::.:. . : :..::.::. ::.:
CCDS49 ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNE
330 340 350 360 370 380
630 640 650 660 670 680
pF1KE2 LMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP
:.::::::::::..:::.::::.. ::. .. :::::. ::..:: .:. ...:: :.::
CCDS49 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP
390 400 410 420 430 440
690 700 710 720 730 740
pF1KE2 ARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK
:: :.:...::.::::::.:::: :.: :.:::.:::.::.:..:: :..:..:..::
CCDS49 ARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRK
450 460 470 480 490 500
750 760 770 780 790 800
pF1KE2 YSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLP
::::::... .::::.:....:::.: .::. ...: .::...:::::. :.. .:
CCDS49 YSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIP
510 520 530 540 550 560
810 820 830 840 850 860
pF1KE2 LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEA
. :.:::.:.:.:..: ::: :.. .. ..:::.: .:.:: :::::: :::::.:: .
CCDS49 IKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDL
570 580 590 600 610 620
870 880 890 900 910 920
pF1KE2 VTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHS
..:.: :.: ..::::. :..:::...:. : ... ::. ..:...:. : :..:.: .
CCDS49 ANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN
630 640 650 660 670 680
930 940 950 960 970 980
pF1KE2 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE
:. ... ::.:::.. :. : . :.: . :...::.::.: :. :::: . :::
CCDS49 LQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISE
690 700 710 720 730 740
990 1000 1010 1020 1030 1040
pF1KE2 LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAE
...:::.:: :: : ....: ::... .: . ::.::.: . :.: : .. .. . :
CCDS49 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE
750 760 770 780 790 800
1050 1060 1070 1080 1090 1100
pF1KE2 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH
. .. : ..:::::::...: ...:: :.:. :..::::..::...::.:: ... .
CCDS49 EFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLY
810 820 830 840 850 860
1110 1120 1130 1140 1150 1160
pF1KE2 EEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG
: .: : .:: : ..: ..::. :.... .. .: ::.:::. :. ..... . .
CCDS49 ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYK
870 880 890 900 910 920
1170 1180 1190 1200 1210 1220
pF1KE2 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR
:::.. . .:.. ::.:::: : .: : : :.:: .:..:.:::.. :: :.:...
CCDS49 ERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVET
930 940 950 960 970 980
1230 1240 1250 1260 1270 1280
pF1KE2 RQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT
:..:: .:... ::.:.. :. ::: . :..:::..:.:: ..:::::: .:
CCDS49 TQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT
990 1000 1010 1020 1030 1040
1290 1300 1310 1320 1330 1340
pF1KE2 YKAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE
:.:... ::.:. ..::... .:::..::::.:. :.:: .::::: ...:.:.:::
CCDS49 YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE
1050 1060 1070 1080 1090 1100
1350 1360 1370 1380 1390 1400
pF1KE2 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA
: .: .: . . :..:. : . ... . .::. :: :.
CCDS49 E----IKRCKETSEHGAYSDLLQRQK----ATVLENSKLTGKISELE-RMVAEL------
1110 1120 1130 1140 1150
1410 1420 1430 1440 1450 1460
pF1KE2 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ
..:: ..::: ..:...: :.. . :..: ...: : : . : .::. :.
CCDS49 ----KKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVRE
1160 1170 1180 1190 1200
1470 1480 1490 1500 1510 1520
pF1KE2 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA
. .:: ::. .: . ::::.. ..:. .: :..... .: : .: . . .
CCDS49 KEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDL
1210 1220 1230 1240 1250 1260
1530 1540 1550 1560 1570 1580
pF1KE2 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE
..:.. .. :.. : . :: . ..: : . : : ::: . ... . ::...:
CCDS49 EQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----
1270 1280 1290 1300 1310 1320
1590 1600 1610 1620 1630 1640
pF1KE2 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ
: .... . .:. . : . :: . ::
CCDS49 KITEIQYTCRENALPVCPIT---------QATSCRAV-----------------------
1330 1340
1650 1660 1670 1680 1690 1700
pF1KE2 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ
. : : .::: : : ..:. : :: .
CCDS49 --------TGLQQEHDKQKAE--------------------------ELKQQVDELTAAN
1350 1360 1370
1710 1720 1730 1740 1750 1760
pF1KE2 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL
: :::.. .: : . . : .. :: ::: .. : .: . : .. :.:
CCDS49 R-KAEQDMRELTYELN-ALQLEKTSSEEKARLLKD------KLDETNNTLRCLKLELE--
1380 1390 1400 1410 1420
1770 1780 1790 1800 1810 1820
pF1KE2 LASKARAEE-ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR
: .::. :.. : ..: :. .:. .: .::. :. . ::. :: :. .
CCDS49 --RKDQAEKGYSQQLRELGRQ-LNQTTGKAEEAMQEASDLKKI----KRNYQLELESLNH
1430 1440 1450 1460 1470
1830 1840 1850 1860 1870 1880
pF1KE2 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ
.... .: :. :. .: :. . : ... . ... ..: : :
CCDS49 EKGKLQR----------EVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERL----QICQ
1480 1490 1500 1510 1520
1890 1900 1910 1920 1930 1940
pF1KE2 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL
.:.: :: .:::
CCDS49 RKSD--------------------------------------HLKEQFEK----------
1530
1950 1960 1970 1980 1990 2000
pF1KE2 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA
:.:: ... :: .: ....:. .:: .. .
CCDS49 --------------SHEQL------LQNIKAE-----KENNDKIQR---LNEELEKSNEC
1540 1550 1560
2010 2020 2030 2040 2050 2060
pF1KE2 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ
: : :: :::: : :.. .:.. .:.::: . .. : .:. .
CCDS49 A----EMLKQKVEELTR------QNNETKLMM------QRIQAESENIVLEKQTIQQRCE
1570 1580 1590 1600 1610
2070 2080 2090 2100 2110 2120
pF1KE2 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQA-EREAAQSRRQVEEAERLKQSAEE
: .. ::::. : .. . :. . ... :.. :.:. : : .::. ..
CCDS49 ALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSE---FKQKCDQ
1620 1630 1640 1650 1660
2130 2140 2150 2160 2170 2180
pF1KE2 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR-QKA
: . .. .::. : .:: : ... :. .:: .. :.:
CCDS49 Q-------NIIIQNTKKEV-----RNLNAELNASKEE----------KRRGEQKVQLQQA
1670 1680 1690 1700
2190 2200 2210 2220 2230 2240
pF1KE2 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK
:: :::.. .... : :.. .. .: . : . . .: ::. : .::.:
CCDS49 QV-QELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEF---RKKMEKL--
1710 1720 1730 1740 1750 1760
2250 2260 2270 2280 2290 2300
pF1KE2 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA
..... .:: .: : .. ::.: . :.: :.: . ...: :..:
CCDS49 MESKVITENDISGIR-LDFVS--LQQENSR----AQENAKLC-----ETNIKEL-ERQLQ
1770 1780 1790 1800
2310 2320 2330 2340 2350 2360
pF1KE2 QQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET
: : :.: . ..:.: . : : ::. :..:. .. :..: ::. :.
CCDS49 QYR---EQMQQGQHMEANHYQKCQKLEDELIAQKREV--------ENLKQKMDQQIKEH-
1810 1820 1830 1840 1850
2370 2380 2390 2400 2410 2420
pF1KE2 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRT
..:: . :. .. . : :. : :. . : . : :
CCDS49 -----------EHQLVL------LQCEIQKKSTAK-----DCT-FKPDFEMTVKECQHSG
1860 1870 1880 1890
2430 2440 2450 2460 2470
pF1KE2 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKEKLQQEAKLLQLKSEEMQT
::.... : : . . .. . :.: . .:. ...: . :..:. :
CCDS49 ELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQ
1900 1910 1920 1930 1940 1950
2480 2490 2500 2510 2520 2530
pF1KE2 VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ
.: . : . :: .: .: . . :. : :: . . : .. : . :.
CCDS49 CYSEYFSQTSTELQITF-DETNPIT---RLSEIEKIRDQAL--------NNSRPPVRYQD
1960 1970 1980 1990 2000
2540 2550 2560 2570 2580 2590
pF1KE2 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL
. :.: .... .: :. .:.. . :. :.:.. :::
CCDS49 NACEMELVKVLTPLEIAKNKQYDM-------HTEVTTLKQEKNPVPS--AEE--------
2010 2020 2030 2040
2600 2610 2620 2630 2640 2650
pF1KE2 QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA--EPEHSFDGLRRKVSAQ
. : :: : . .. :. . .:: : . . : .:.:::. :.:.
CCDS49 -WMLEGCRA----SGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTAR
2050 2060 2070 2080 2090
2660 2670 2680 2690 2700 2710
pF1KE2 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL
.: :: .:. . ...: : ::.:. . . ..: .::::: :..:.::.: .:
CCDS49 QLVEAKLLDMRTIEQLRLGLKTVEEVQKT--LNKFLTKATSIAGLYLESTKEKISFASAA
2100 2110 2120 2130 2140 2150
2720 2730 2740 2750 2760 2770
pF1KE2 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG
.: ... .:: .::::::.::..::. .. .:..:: .::: ::.. .:: ::.:..:
CCDS49 ERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVG
2160 2170 2180 2190 2200 2210
2780 2790 2800 2810 2820 2830
pF1KE2 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD
:. :... .:.::::.. .. :..: ..::::::.:::::::.. ::: ..: ..: ..
CCDS49 YS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLN
2220 2230 2240 2250 2260 2270
2840 2850 2860 2870 2880 2890
pF1KE2 EEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVY
. . . : .::..:. : .::... : : .::. :: : :. :.:. ::
CCDS49 NAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPF-------GERNI
2280 2290 2300 2310 2320
2900 2910 2920 2930 2940 2950
pF1KE2 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKII
.. ... . . ..:.. :. .:..: . .:.:... ... ..
CCDS49 SNLNVKKTHRISVVDTK----TGSELTVYEAF---------QRNLIEKSIYLELSGQQYQ
2330 2340 2350 2360 2370
2960 2970 2980 2990 3000 3010
pF1KE2 KIIITVVEEQEQKGRLCFEGLRSL-VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDT
: ..... . .: : .:. .::. : .. :.: .. ..:. .
CCDS49 WKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-SL
2380 2390 2400 2410 2420 2430
3020 3030 3040 3050 3060 3070
pF1KE2 VRRALRGANV---IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPAT
. : . .. .:: :: .:...:. .: ...:. :. ::::..:: :::: :
CCDS49 LSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLT
2440 2450 2460 2470 2480 2490
3080 3090 3100 3110 3120 3130
pF1KE2 SARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLR
. . : ::.. ::: : ..: . : ..:: : :.. .:. .:.. ..: .:.:.:
CCDS49 GKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIR
2500 2510 2520 2530 2540 2550
3140 3150 3160 3170 3180 3190
pF1KE2 LLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATY
:. : :::...:. :. .. : : .: . :. .. .. :.: . ::
CCDS49 CLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTY
2560 2570 2580 2590 2600 2610
3200 3210 3220 3230 3240 3250
pF1KE2 GELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVT
: .. : :::.:: .::
CCDS49 KEALEKADFDFHTGLKLLEVSEPLMTGISSLYYSS
2620 2630 2640
>>CCDS435.1 MACF1 gene_id:23499|Hs108|chr1 (5430 aa)
initn: 3775 init1: 1689 opt: 2794 Z-score: 1042.9 bits: 209.1 E(32554): 9e-52
Smith-Waterman score: 4748; 29.2% identity (59.4% similar) in 4145 aa overlap (16-3908:52-4012)
10 20 30 40
pF1KE2 MSQHQLRVPQPEGLGRKRTSSEDNLYLAVLRASEGKKDERDRVQK
.:. .:.:.. . :: ::::::::
CCDS43 SERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQK
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE2 KTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQI
:::::::::::.:...::.::::::::::::::::::::: .:::::::::::.::::::
CCDS43 KTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQI
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE2 ALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLL
:::.:..:::::::::::::.::::::::::::::::::::::: .::.: ::.::::::
CCDS43 ALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLL
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE2 LWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSV
::.:... :: :..: ::.: : ::..:::.:::..: :.::..: :.: :::.::: :
CCDS43 LWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEV
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE2 AERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYR
::: :::::::: ::::::.:::::.::::::.:::.:.::. .:. :.:.. :::::.
CCDS43 AER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQ
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE2 ELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQS
: :. :...:: . .. ::.. :.. :..:...::: :. ::: .:.: . .:.
CCDS43 SRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKL
330 340 350 360 370 380
350 360 370 380 390 400
pF1KE2 LEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEA
:: .. :..:.: :::: :::.::::: . .:::::.:: :::: : .:..:.: :
CCDS43 LEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGA
390 400 410 420 430 440
410 420 430 440 450 460
pF1KE2 GLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHP
:::.:. : ::.:. : .:. : ..: ... ...:: : :.: :.: .
CCDS43 LNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYY
450 460 470 480 490 500
470 480 490 500
pF1KE2 QGEQMYRRVYRLHERLVAIRTE-YNLRLKAGV-----------------AAPATQVAQVT
: :.. ::.::...::..: : :: :. : : :.... .
CCDS43 QLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSS
510 520 530 540 550 560
510 520 530 540 550
pF1KE2 LQSVQRRP----EL------ED-STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG
: :.: :: :: ..::.. .::.:::: : ... :::: :::::: ::
CCDS43 STSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLE
570 580 590 600 610 620
560 570 580 590 600 610
pF1KE2 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE
... .: :.::. .....:: ::..: . .: . ::.:. :: :: ..:. :.: :.
CCDS43 TQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQ
630 640 650 660 670 680
620 630 640 650 660 670
pF1KE2 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ
:::.::. :: ::.:::::::::...:::: :.:..::.. .: : ::: :. .. ::
CCDS43 SLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQ
690 700 710 720 730 740
680 690 700 710 720 730
pF1KE2 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG
.... : :.:::. :::...::.:.: .:: ::: :.: :.:::.::::::::.:: :.
CCDS43 DTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELES
750 760 770 780 790 800
740 750 760 770 780 790
pF1KE2 QLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP
:..::....::::::......::::::::..:::::: . :. ...:. :.:..:::::
CCDS43 FLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKP
810 820 830 840 850 860
800 810 820 830 840 850
pF1KE2 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF
: : : ... . . :::::.:.:.:. :.::: : .: ..:::.: .:.:: ::::::
CCDS43 RSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCF
870 880 890 900 910 920
860 870 880 890 900 910
pF1KE2 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRT
:.::::..: : ..:.: ..: ...:::::::. :::..:. ::.:..:...:.: .:.
CCDS43 LIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRS
930 940 950 960 970 980
920 930 940 950 960 970
pF1KE2 LKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA
: : .: ...:. ::. ::.::.:. :. ::: :.: .:. ..:.:..:.:.
CCDS43 SAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENED
990 1000 1010 1020 1030 1040
980 990 1000 1010 1020 1030
pF1KE2 QEESRCQRCISELKDIRLQLEACETRTVHRLR-LP---LDKEPARECAQRIAEQQKAQAE
.::. . :::::.:::.:: : :.:.:.. : :.. .. : :::::...: .
CCDS43 KEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQED
1050 1060 1070 1080 1090 1100
1040 1050 1060 1070 1080 1090
pF1KE2 VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTIS
.. : . . .: . .. : : ..:::::::.: . :...: .::..::.::::..
CCDS43 LQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVD
1110 1120 1130 1140 1150 1160
1100 1110 1120 1130 1140 1150
pF1KE2 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE
...:. : :: .....: .:.. ..: : : ::: ..:.. .... .. .:..: .:
CCDS43 VIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEE
1170 1180 1190 1200 1210 1220
1160 1170 1180 1190 1200 1210
pF1KE2 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY
. :. :.:.... ::....::..:. .:: :::. :.:: ..:: :::.. . : :
CCDS43 IAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDY
1230 1240 1250 1260 1270 1280
1220 1230 1240 1250 1260 1270
pF1KE2 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLQQEQALLEEIERHGEKVEECQRFA
: : :.... .::... ::... :::.:. ::. ::::. :...::.:.
CCDS43 RACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFS
1290 1300 1310 1320 1330 1340
1280 1290 1300 1310 1320 1330
pF1KE2 KQYINAIKDYELQLVTYKAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS
.:: . .:::::::.:::: .: ::.:. .. :.:... ::..::::.:. :.:::.
CCDS43 QQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTT
1350 1360 1370 1380 1390 1400
1340 1350 1360 1370 1380
pF1KE2 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVE---AALEKQRQLAEAHAQAKAQAER
:..:.::..:::.::::...:... :. :.. :. ..: .. : . ...: ...
CCDS43 QHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDI
1410 1420 1430 1440 1450 1460
1390 1400 1410 1420 1430
pF1KE2 EAKEL-QQRMQEEVVRREEAAVDA----------------QQQKRSIQEELQQLRQSSE-
: : :: ..::.. ..: . .: ...:..:.:.:. : .. .
CCDS43 EKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHD
1470 1480 1490 1500 1510 1520
1440 1450 1460 1470 1480
pF1KE2 ----AEIQAKARQAEAAERSRLR-IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA
. : . :.. :.... . .... . . ::: : :: : . ..:. .
CCDS43 LCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQ-
1530 1540 1550 1560 1570
1490 1500 1510 1520 1530 1540
pF1KE2 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRL
: .: .. . ...::. : . . . ... ... : . : : : ::.:
CCDS43 --QDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLH
1580 1590 1600 1610 1620 1630
1550 1560 1570 1580
pF1KE2 QAEEA------ERRLRQAEVERARQVQVALETAQRSAEAEL-QSKR---------ASFAE
::.: : :. : :.:.: . :: . .: :: ..:. .: .
CCDS43 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGS
1640 1650 1660 1670 1680 1690
1590 1600 1610 1620 1630 1640
pF1KE2 KTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL
. .:: .: :... :.: :. : . ... . ..: ..:. : : .. :
CCDS43 SGGQLLTNLPGMEQLSGASL----EKGALDTTDGYMGVNQAPEKLD----KQCEMMKARH
1700 1710 1720 1730 1740
1650 1660 1670 1680 1690 1700
pF1KE2 QAEEVAQQKSLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTA
: : ..::... : :. .: . . .. ::: . :..:.: . . . .::.. :
CCDS43 Q-ELLSQQQNFILA---TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA
1750 1760 1770 1780 1790 1800
1710 1720 1730 1740 1750
pF1KE2 Q--QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAATQKRQ-ELEAEL
. : . ..:: .. . .. :. . :.:: ... :. . ::: . ..
CCDS43 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV
1810 1820 1830 1840 1850 1860
1760 1770 1780 1790 1800
pF1KE2 AKVRAEMEVLLASKARAEE------ESRSTSEKS---KQRLEAEAGRFRELAEEAARLRA
. ..... . : .. . :.. :: . :..:. . :. : . .:: .
CCDS43 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGS
1870 1880 1890 1900 1910 1920
1810 1820 1830 1840 1850 1860
pF1KE2 -----LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAAIGEATRLKTEAEIALKEKEA
:.. . : . .: : :: :..:.. .:. . . . . :.:. :
CCDS43 HLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA
1930 1940 1950 1960 1970 1980
1870 1880 1890 1900 1910
pF1KE2 EN----ERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKASDSELERQKGLV
:. :.:...:.: ..: . : . ..: :..... : : ::.. :.
CCDS43 EHQVPVEKLQKVARDIM----EIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS-LL
1990 2000 2010 2020 2030 2040
1920 1930 1940 1950 1960
pF1KE2 EDTLRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTLR-----SKEQA
. .. : ..:.: . .: :. :. :: : : :. ... .....
CCDS43 QKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKS
2050 2060 2070 2080 2090 2100
1970 1980 1990 2000 2010
pF1KE2 ELEAARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE---
:::.:. :: . . :. .: .. ..: . : : ..:
CCDS43 SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
2110 2120 2130 2140 2150 2160
2020 2030 2040 2050 2060
pF1KE2 ----RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF-AVQQKEQELQQ
.:. .:. :. ..: . .. :. . :. :.. . . .... ::..
CCDS43 HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSS
2170 2180 2190 2200 2210 2220
2070 2080 2090 2100 2110 2120
pF1KE2 T-----LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA
: :.:. ...:: . .....: :. . ... . :. :. .. ::..
CCDS43 CGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETE
2230 2240 2250 2260 2270 2280
2130 2140 2150 2160 2170
pF1KE2 -----EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME-----KHK
: ... . . :.:.. .. :.. . .:. . . . :: ..
CCDS43 GSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
2290 2300 2310 2320 2330 2340
2180 2190 2200 2210
pF1KE2 KFAE---------------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA
: . .: .. .... ... . :. :. . .: :: . .
CCDS43 KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM
2350 2360 2370 2380 2390 2400
2220 2230 2240 2250 2260 2270
pF1KE2 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE---EAEKM
:. .. ..: . : : . : :... : . . . .... :: : .. :.
CCDS43 EEVHKEANSVLQWLES---KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI
2410 2420 2430 2440 2450
2280 2290 2300 2310 2320
pF1KE2 KQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK----
..: : : : :. .::: ... :: .. . .: . .. : . :..:
CCDS43 QKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQA
2460 2470 2480 2490 2500 2510
2330 2340 2350 2360 2370 2380
pF1KE2 AEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER
::..: ..::: . :. : ... : ...: . . .::.::.. ... :.
CCDS43 AESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHEQLNEAAQG
2520 2530 2540 2550 2560 2570
2390 2400 2410 2420 2430 2440
pF1KE2 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD
. ...: . ...... : . .. :. .::. ..: ..:.. . :. .:
CCDS43 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSR--SSQIDQAIVKSTQYQELLQDL-
2580 2590 2600 2610 2620 2630
2450 2460 2470 2480 2490 2500
pF1KE2 AERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL
.:..: . .: .. . : :: ::. . ::: .:.. : : .. :.:
CCDS43 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT--LCDELSVL
2640 2650 2660 2670 2680 2690
2510 2520 2530 2540 2550 2560
pF1KE2 QRERFIEQE-KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-QRLVASMEEARRRQHE
:.....: : .:: :: : :. . .: .:: :.. ... :.
CCDS43 IGEQYLKDELKKRLET-----VALPLQGLED-------LAADRINRLQAALASTQQFQQM
2700 2710 2720 2730
2570 2580 2590 2600 2610
pF1KE2 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTAS
.: .: .. :. :: .. .. . .::. ::: :: ... :: : ..:
CCDS43 FDE-LRTWLDDKQS--QQAKNCP--ISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE
2740 2750 2760 2770 2780 2790
2620 2630 2640 2650 2660 2670
pF1KE2 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ--RLQEAGILSAEELQRLAQGH
. ..: :.. .: .. .. : .:.. . ::.. . .:.. : ..
CCDS43 GESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDC-MQKAQKYQWHVEDL
2800 2810 2820 2830 2840 2850
2680 2690 2700 2710 2720 2730
pF1KE2 TTV--DELARREDVRHYLQGRSSIAGLLL-KATNEKLSVYAALQRQLLSPGTALILLEAQ
. : :. ..: :. . ..:: :: ... .: . : : .: ::....
CCDS43 VPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNS--AADILINSS
2860 2870 2880 2890 2900 2910
2740 2750 2760 2770 2780 2790
pF1KE2 AASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQ
:. : .:... .:. . .: ::. : : :. . .. . :. ..
CCDS43 EAD---EDGIRDEKAGINQNM--DAVTEELQAKTGSLEEMTQRLREFQES-----FKNIE
2920 2930 2940 2950 2960
2800 2810 2820 2830 2840
pF1KE2 KGLIVREHGIRLLEA---QIATGGVIDPVHSHR-----VPVDVAYRRGYFDEEMNRVLAD
: . .: .....: : .. .. ..... . .: : :. : . . . :
CCDS43 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRN-FTQGLVEDAPD
2970 2980 2990 3000 3010 3020
2850 2860 2870 2880 2890 2900
pF1KE2 PSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVF
:: .. . . .. .. .:.. .: ..: :.. . .: :.. ..:..:
CCDS43 GSDASQLLHQAEVAQQ-EFLEVKQRV----NSG-CVM-MENKLEGIGQF---HCRVREMF
3030 3040 3050 3060 3070
2910 2920 2930 2940 2950 2960
pF1KE2 EKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEE
. : . .: . .: :. : .: .... .. .: ..::
CCDS43 SQL---ADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE
3080 3090 3100 3110 3120
2970 2980 2990 3000 3010
pF1KE2 QEQKGRLCFEGLRSLVPAAELLESRVIDR------ELYQQLQRGE---RSVRDVAEVDTV
. : : . ::. . : . ... .: .: : : : :... . .. :.
CCDS43 E---GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTA
3130 3140 3150 3160 3170 3180
3020 3030 3040 3050 3060 3070
pF1KE2 RRALRGANVIAGVWLEEAGQKLSIYNALKKDLL-PSDMAVALLEAQAGTGHIIDPATSAR
. .. . ..:. .: .:.:. .. ..:. . : .: :. : :. . ::
CCDS43 AEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMK---LQQVNGLGQGL--IQSAG
3190 3200 3210 3220 3230
3080 3090 3100 3110 3120 3130
pF1KE2 LTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLD
: . : : . ..:. . . . ..: .. .: ...:. :
CCDS43 KDCD------VQGLEHDMEEINARWNTLNKK---VAQRIAQLQEALLHCGKFQDALEPLL
3240 3250 3260 3270 3280 3290
3140 3150 3160 3170 3180 3190
pF1KE2 AQLS-TGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGE
. :. : .. .: . :. :. .. .: :. .: . . . :. : .:
CCDS43 SWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG-GRIAQSAE
3300 3310 3320 3330 3340
3200 3210 3220 3230 3240 3250
pF1KE2 LQQRCR-PDQLTGLS--LLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTV
: .: . :: .: : ::: :::..: . : . :..: :.. : .:
CCDS43 LADREKITGQLESLESRWTELLSKAA-ARQKQLEDILVLAKQFHETAE--PISDFL--SV
3350 3360 3370 3380 3390 3400
3260 3270 3280 3290 3300
pF1KE2 TVWELISSEYF---TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL
: .: .:: ::. .:...:. ..:. :. : :... . : :.:.:
CCDS43 TEKKLANSEPVGTQTAKIQQQIIRH-----KALEEDIENHATDVHQAVKIGQ---SLSSL
3410 3420 3430 3440 3450
3310 3320 3330 3340 3350 3360
pF1KE2 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK
.:. .::::. ....:. . ..: . .::. . : .. :: :
CCDS43 TSPAE------QGVLSE-KIDSLQARYSEIQD--RCCRKAALLDQALSNARLFGEDEVEV
3460 3470 3480 3490 3500
3370 3380 3390 3400 3410 3420
pF1KE2 VS----IYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG--VVGPEL
.. . . . ... .: . .: : . . :.. : .:.: : ..
CCDS43 LNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT
3510 3520 3530 3540 3550 3560
3430 3440 3450 3460
pF1KE2 HEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHG-------------IRLLEAQI
:..: .. . : . :. :.. .:.. :: . .: .: ..
CCDS43 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL
3570 3580 3590 3600 3610 3620
3470 3480 3490 3500 3510 3520
pF1KE2 ATGGIIDPVHSHRVPVDVAYQRGYFSEEM-NRVLADPSDDTKGFFDPNTHENLTYRQLLE
::.: .:. ....: :. .: : .:.. : .... : :::
CCDS43 ATSGGQSPT-GEQIPQFQQRQKELKKEVMEHRLVLDTVNEVS-------------RALLE
3630 3640 3650 3660 3670
3530 3540 3550 3560 3570 3580
pF1KE2 RCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLW
. :: : . :. ..: : .: :....: ..... :
CCDS43 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQ-----QYEQAADAELAW
3680 3690 3700 3710 3720
3590 3600 3610 3620 3630 3640
pF1KE2 EVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLT
. : .: .::: . : .: . : .. : : : .:.. .
CCDS43 -------VAETKR-KLMA-----------LGPIRLEQDQTTAQLQVQKAFSIDIIRHKDS
3730 3740 3750 3760
3650 3660 3670 3680 3690
pF1KE2 AEDLFEAR--IISL---ETYNLLREGTRSLREALEAESAW-CYLYGTGSVAGVYLPG---
..:: : :.. : ..:.: :.:: . :: : :. : : .
CCDS43 MDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE
3770 3780 3790 3800 3810 3820
3700 3710 3720 3730 3740 3750
pF1KE2 SRQTLSIY----QALKKGLLSAEVARLLLEAQAATGFLL-DPVKGERLTVDEAVRKGLVG
. . :: . .:: : : . . :. : : . . .. .:. .. .:
CCDS43 TYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLK---IG
3830 3840 3850 3860 3870 3880
3760 3770 3780 3790 3800 3810
pF1KE2 PELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRL
:.:.. :. :.. .. : ... ... .:.:. ..:: : .: . :..
CCDS43 PQLKE--LNPEEG-EMVEEKY-QKAENMYAQIKEEV--RQRALALDEAVSQSTQITE---
3890 3900 3910 3920 3930
3820 3830 3840 3850 3860 3870
pF1KE2 GFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLL
:: .: . .. ..: : . . :: .:.: :. .. .
CCDS43 -FHDKIEPMLETL---ENLSSRLRMPPLIPAEVDK-----------IRECISDNKSATVE
3940 3950 3960 3970 3980
3880 3890 3900 3910 3920 3930
pF1KE2 LPLSDARKLTFRGLRKQITMEELV-RSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTS
: . . .:..:... :::. ::: :. :
CCDS43 L---EKLQPSFEALKRR--GEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER
3990 4000 4010 4020 4030
3940 3950 3960 3970 3980 3990
pF1KE2 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM
CCDS43 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETD
4040 4050 4060 4070 4080 4090
4547 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Aug 18 10:17:45 2017 done: Fri Aug 18 10:17:49 2017
Total Scan time: 13.980 Total Display time: 8.090
Function used was FASTA [36.3.4 Apr, 2011]