Result of FASTA (omim) for
pFN21AE2682
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2682, 659 aa
1>>>pF1KE2682 659 - 659 aa - 659 aa
Library: /omim/omim.rfq.tfa
61573307 residues in 86401 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1528+/-0.000349; mu= 15.8651+/- 0.022
mean_var=95.1580+/-18.997, 0's: 0 Z-trim(115.6): 186 B-trim: 0 in 0/53
Lambda= 0.131478
statistics sampled from 26103 (26298) to 26103 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.304), width: 16
Scan time: 12.450
The best scores are: opt bits E(86401)
NP_001230076 (OMIM: 602426) nuclear valosin-contai ( 765) 4326 831.3 0
XP_016856875 (OMIM: 602426) PREDICTED: nuclear val ( 738) 4269 820.5 0
NP_996671 (OMIM: 602426) nuclear valosin-containin ( 750) 4269 820.5 0
XP_016856872 (OMIM: 602426) PREDICTED: nuclear val ( 812) 4269 820.5 0
NP_002524 (OMIM: 602426) nuclear valosin-containin ( 856) 4269 820.5 0
XP_016856868 (OMIM: 602426) PREDICTED: nuclear val ( 890) 4269 820.5 0
NP_001230075 (OMIM: 602426) nuclear valosin-contai ( 667) 3495 673.6 6.2e-193
XP_011542501 (OMIM: 602426) PREDICTED: nuclear val ( 765) 3495 673.7 7e-193
XP_011542502 (OMIM: 602426) PREDICTED: nuclear val ( 765) 3495 673.7 7e-193
XP_011542500 (OMIM: 602426) PREDICTED: nuclear val ( 777) 3495 673.7 7.1e-193
XP_016856870 (OMIM: 602426) PREDICTED: nuclear val ( 839) 3495 673.7 7.5e-193
XP_016856871 (OMIM: 602426) PREDICTED: nuclear val ( 839) 3495 673.7 7.5e-193
XP_011542498 (OMIM: 602426) PREDICTED: nuclear val ( 883) 3495 673.7 7.8e-193
XP_016856867 (OMIM: 602426) PREDICTED: nuclear val ( 917) 3495 673.7 8.1e-193
XP_016856869 (OMIM: 602426) PREDICTED: nuclear val ( 889) 3266 630.3 9.4e-180
XP_016856873 (OMIM: 602426) PREDICTED: nuclear val ( 789) 2656 514.5 5.8e-145
XP_016856874 (OMIM: 602426) PREDICTED: nuclear val ( 756) 2452 475.8 2.5e-133
NP_001303242 (OMIM: 601498,614862,614863,616617) p ( 892) 798 162.1 7.9e-39
XP_011512963 (OMIM: 601498,614862,614863,616617) P ( 952) 798 162.2 8.3e-39
NP_000278 (OMIM: 601498,614862,614863,616617) pero ( 980) 798 162.2 8.5e-39
XP_016867808 (OMIM: 214100,234580,601539,602136) P ( 700) 744 151.8 7.8e-36
NP_001269607 (OMIM: 214100,234580,601539,602136) p (1075) 744 152.0 1.1e-35
NP_001269606 (OMIM: 214100,234580,601539,602136) p (1226) 744 152.0 1.2e-35
NP_000457 (OMIM: 214100,234580,601539,602136) pero (1283) 744 152.0 1.3e-35
NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 719 147.1 2.1e-34
XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790) 719 147.1 2.3e-34
XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 719 147.1 2.4e-34
NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 719 147.2 2.6e-34
NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 719 147.2 2.6e-34
XP_016863318 (OMIM: 613940,616577) PREDICTED: sper ( 765) 674 138.6 8.4e-32
XP_016863316 (OMIM: 613940,616577) PREDICTED: sper ( 823) 674 138.6 8.9e-32
XP_016863315 (OMIM: 613940,616577) PREDICTED: sper ( 859) 674 138.6 9.2e-32
XP_011529980 (OMIM: 613940,616577) PREDICTED: sper ( 916) 674 138.6 9.7e-32
XP_016863314 (OMIM: 613940,616577) PREDICTED: sper ( 917) 674 138.6 9.7e-32
XP_016863319 (OMIM: 613940,616577) PREDICTED: sper ( 593) 668 137.4 1.5e-31
NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 665 136.9 2.8e-31
XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 599 124.1 7.3e-28
NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 599 124.2 9.5e-28
XP_016876280 (OMIM: 614764) PREDICTED: katanin p60 ( 322) 593 123.0 1.8e-27
XP_016876281 (OMIM: 614764) PREDICTED: katanin p60 ( 322) 593 123.0 1.8e-27
XP_016876282 (OMIM: 614764) PREDICTED: katanin p60 ( 322) 593 123.0 1.8e-27
NP_001014402 (OMIM: 614764) katanin p60 ATPase-con ( 490) 593 123.1 2.5e-27
XP_005266631 (OMIM: 614764) PREDICTED: katanin p60 ( 490) 593 123.1 2.5e-27
NP_115492 (OMIM: 614764) katanin p60 ATPase-contai ( 490) 593 123.1 2.5e-27
XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 587 122.1 7.5e-27
NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 587 122.1 8e-27
XP_011515297 (OMIM: 611941) PREDICTED: ATPase fami ( 953) 586 121.9 1.1e-26
XP_011515296 (OMIM: 611941) PREDICTED: ATPase fami (1260) 586 122.0 1.3e-26
NP_054828 (OMIM: 611941) ATPase family AAA domain- (1390) 586 122.1 1.4e-26
NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 577 120.0 1.8e-26
>>NP_001230076 (OMIM: 602426) nuclear valosin-containing (765 aa)
initn: 4326 init1: 4326 opt: 4326 Z-score: 4435.8 bits: 831.3 E(86401): 0
Smith-Waterman score: 4326; 100.0% identity (100.0% similar) in 659 aa overlap (1-659:107-765)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKG
::::::::::::::::::::::::::::::
NP_001 ELEDEHLAKRARQGEEDNEYTESYSDDDSSMEDYPDPQDSKDSSLLESDMKRKGKLKNKG
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE2 SKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKRKKEDLQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHP
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE2 EVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLR
200 210 220 230 240 250
160 170 180 190 200 210
pF1KE2 ELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVI
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE2 GATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTP
320 330 340 350 360 370
280 290 300 310 320 330
pF1KE2 GFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDE
380 390 400 410 420 430
340 350 360 370 380 390
pF1KE2 LQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALE
440 450 460 470 480 490
400 410 420 430 440 450
pF1KE2 DIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVK
500 510 520 530 540 550
460 470 480 490 500 510
pF1KE2 GPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLT
560 570 580 590 600 610
520 530 540 550 560 570
pF1KE2 EMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTK
620 630 640 650 660 670
580 590 600 610 620 630
pF1KE2 PPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKH
680 690 700 710 720 730
640 650
pF1KE2 FEEAFKKVRSSISKKDQIMYERLQESLSR
:::::::::::::::::::::::::::::
NP_001 FEEAFKKVRSSISKKDQIMYERLQESLSR
740 750 760
>>XP_016856875 (OMIM: 602426) PREDICTED: nuclear valosin (738 aa)
initn: 4269 init1: 4269 opt: 4269 Z-score: 4377.6 bits: 820.5 E(86401): 0
Smith-Waterman score: 4269; 100.0% identity (100.0% similar) in 652 aa overlap (8-659:87-738)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
XP_016 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE2 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE2 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE2 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE2 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE2 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
480 490 500 510 520 530
460 470 480 490 500 510
pF1KE2 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
540 550 560 570 580 590
520 530 540 550 560 570
pF1KE2 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
600 610 620 630 640 650
580 590 600 610 620 630
pF1KE2 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
660 670 680 690 700 710
640 650
pF1KE2 VRSSISKKDQIMYERLQESLSR
::::::::::::::::::::::
XP_016 VRSSISKKDQIMYERLQESLSR
720 730
>>NP_996671 (OMIM: 602426) nuclear valosin-containing pr (750 aa)
initn: 4269 init1: 4269 opt: 4269 Z-score: 4377.5 bits: 820.5 E(86401): 0
Smith-Waterman score: 4269; 100.0% identity (100.0% similar) in 652 aa overlap (8-659:99-750)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
NP_996 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE2 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE2 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE2 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE2 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE2 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE2 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE2 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
670 680 690 700 710 720
640 650
pF1KE2 VRSSISKKDQIMYERLQESLSR
::::::::::::::::::::::
NP_996 VRSSISKKDQIMYERLQESLSR
730 740 750
>>XP_016856872 (OMIM: 602426) PREDICTED: nuclear valosin (812 aa)
initn: 4269 init1: 4269 opt: 4269 Z-score: 4377.0 bits: 820.5 E(86401): 0
Smith-Waterman score: 4269; 100.0% identity (100.0% similar) in 652 aa overlap (8-659:161-812)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
XP_016 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
140 150 160 170 180 190
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
200 210 220 230 240 250
100 110 120 130 140 150
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
260 270 280 290 300 310
160 170 180 190 200 210
pF1KE2 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
320 330 340 350 360 370
220 230 240 250 260 270
pF1KE2 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
380 390 400 410 420 430
280 290 300 310 320 330
pF1KE2 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
440 450 460 470 480 490
340 350 360 370 380 390
pF1KE2 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
500 510 520 530 540 550
400 410 420 430 440 450
pF1KE2 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
560 570 580 590 600 610
460 470 480 490 500 510
pF1KE2 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
620 630 640 650 660 670
520 530 540 550 560 570
pF1KE2 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
680 690 700 710 720 730
580 590 600 610 620 630
pF1KE2 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
740 750 760 770 780 790
640 650
pF1KE2 VRSSISKKDQIMYERLQESLSR
::::::::::::::::::::::
XP_016 VRSSISKKDQIMYERLQESLSR
800 810
>>NP_002524 (OMIM: 602426) nuclear valosin-containing pr (856 aa)
initn: 4269 init1: 4269 opt: 4269 Z-score: 4376.7 bits: 820.5 E(86401): 0
Smith-Waterman score: 4269; 100.0% identity (100.0% similar) in 652 aa overlap (8-659:205-856)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
NP_002 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
180 190 200 210 220 230
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
240 250 260 270 280 290
100 110 120 130 140 150
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
300 310 320 330 340 350
160 170 180 190 200 210
pF1KE2 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
360 370 380 390 400 410
220 230 240 250 260 270
pF1KE2 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
420 430 440 450 460 470
280 290 300 310 320 330
pF1KE2 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
480 490 500 510 520 530
340 350 360 370 380 390
pF1KE2 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
540 550 560 570 580 590
400 410 420 430 440 450
pF1KE2 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
600 610 620 630 640 650
460 470 480 490 500 510
pF1KE2 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
660 670 680 690 700 710
520 530 540 550 560 570
pF1KE2 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
720 730 740 750 760 770
580 590 600 610 620 630
pF1KE2 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
780 790 800 810 820 830
640 650
pF1KE2 VRSSISKKDQIMYERLQESLSR
::::::::::::::::::::::
NP_002 VRSSISKKDQIMYERLQESLSR
840 850
>>XP_016856868 (OMIM: 602426) PREDICTED: nuclear valosin (890 aa)
initn: 4269 init1: 4269 opt: 4269 Z-score: 4376.4 bits: 820.5 E(86401): 0
Smith-Waterman score: 4269; 100.0% identity (100.0% similar) in 652 aa overlap (8-659:239-890)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
XP_016 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
210 220 230 240 250 260
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
270 280 290 300 310 320
100 110 120 130 140 150
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQAV
330 340 350 360 370 380
160 170 180 190 200 210
pF1KE2 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPD
390 400 410 420 430 440
220 230 240 250 260 270
pF1KE2 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADL
450 460 470 480 490 500
280 290 300 310 320 330
pF1KE2 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQRLLGL
510 520 530 540 550 560
340 350 360 370 380 390
pF1KE2 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELT
570 580 590 600 610 620
400 410 420 430 440 450
pF1KE2 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM
630 640 650 660 670 680
460 470 480 490 500 510
pF1KE2 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEA
690 700 710 720 730 740
520 530 540 550 560 570
pF1KE2 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADV
750 760 770 780 790 800
580 590 600 610 620 630
pF1KE2 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEEAFKK
810 820 830 840 850 860
640 650
pF1KE2 VRSSISKKDQIMYERLQESLSR
::::::::::::::::::::::
XP_016 VRSSISKKDQIMYERLQESLSR
870 880 890
>>NP_001230075 (OMIM: 602426) nuclear valosin-containing (667 aa)
initn: 4182 init1: 3495 opt: 3495 Z-score: 3584.8 bits: 673.6 E(86401): 6.2e-193
Smith-Waterman score: 4132; 96.0% identity (96.0% similar) in 667 aa overlap (20-659:1-667)
10 20 30 40 50 60
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEF
:::::::::::::::::::::::::::::::::::::::::
NP_001 MKRKGKLKNKGSKRKKEDLQEVDGEIEAVLQKKAKARGLEF
10 20 30 40
70 80 90 100 110 120
pF1KE2 QISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHA
50 60 70 80 90 100
130 140 150
pF1KE2 IAG---------------------------ELDLPILKVAAPEIVSGVSGESEQKLRELF
::: ::::::::::::::::::::::::::::::
NP_001 IAGAECSGMITAHCSFDFSGSNDPPASASQELDLPILKVAAPEIVSGVSGESEQKLRELF
110 120 130 140 150 160
160 170 180 190 200 210
pF1KE2 EQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGAT
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE2 NRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCRKLRLPQAFDFCHLAHLTPGFV
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE2 GADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLPSKGVQEERLGTEPTSETQDELQR
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE2 LLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIR
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE2 EELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPE
410 420 430 440 450 460
460 470 480 490 500 510
pF1KE2 LLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMD
470 480 490 500 510 520
520 530 540 550 560 570
pF1KE2 GLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAILKTITKNGTKPPL
530 540 550 560 570 580
580 590 600 610 620 630
pF1KE2 DADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELKVSHKHFEE
590 600 610 620 630 640
640 650
pF1KE2 AFKKVRSSISKKDQIMYERLQESLSR
::::::::::::::::::::::::::
NP_001 AFKKVRSSISKKDQIMYERLQESLSR
650 660
>>XP_011542501 (OMIM: 602426) PREDICTED: nuclear valosin (765 aa)
initn: 4255 init1: 3495 opt: 3495 Z-score: 3583.9 bits: 673.7 E(86401): 7e-193
Smith-Waterman score: 4205; 96.0% identity (96.0% similar) in 679 aa overlap (8-659:87-765)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
XP_011 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
120 130 140 150 160 170
100 110 120 130
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAG---------------------------ELDLPIL
:::::::::::::::::::::::::: :::::::
XP_011 VVPPRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPIL
180 190 200 210 220 230
140 150 160 170 180 190
pF1KE2 KVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQ
240 250 260 270 280 290
200 210 220 230 240 250
pF1KE2 LLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTL
300 310 320 330 340 350
260 270 280 290 300 310
pF1KE2 CRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLP
360 370 380 390 400 410
320 330 340 350 360 370
pF1KE2 SKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSA
420 430 440 450 460 470
380 390 400 410 420 430
pF1KE2 KREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG
480 490 500 510 520 530
440 450 460 470 480 490
pF1KE2 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC
540 550 560 570 580 590
500 510 520 530 540 550
pF1KE2 PRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVG
600 610 620 630 640 650
560 570 580 590 600 610
pF1KE2 LPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ
660 670 680 690 700 710
620 630 640 650
pF1KE2 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
720 730 740 750 760
>>XP_011542502 (OMIM: 602426) PREDICTED: nuclear valosin (765 aa)
initn: 4255 init1: 3495 opt: 3495 Z-score: 3583.9 bits: 673.7 E(86401): 7e-193
Smith-Waterman score: 4205; 96.0% identity (96.0% similar) in 679 aa overlap (8-659:87-765)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
XP_011 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
120 130 140 150 160 170
100 110 120 130
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAG---------------------------ELDLPIL
:::::::::::::::::::::::::: :::::::
XP_011 VVPPRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPIL
180 190 200 210 220 230
140 150 160 170 180 190
pF1KE2 KVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQ
240 250 260 270 280 290
200 210 220 230 240 250
pF1KE2 LLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTL
300 310 320 330 340 350
260 270 280 290 300 310
pF1KE2 CRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLP
360 370 380 390 400 410
320 330 340 350 360 370
pF1KE2 SKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSA
420 430 440 450 460 470
380 390 400 410 420 430
pF1KE2 KREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG
480 490 500 510 520 530
440 450 460 470 480 490
pF1KE2 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC
540 550 560 570 580 590
500 510 520 530 540 550
pF1KE2 PRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVG
600 610 620 630 640 650
560 570 580 590 600 610
pF1KE2 LPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ
660 670 680 690 700 710
620 630 640 650
pF1KE2 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
720 730 740 750 760
>>XP_011542500 (OMIM: 602426) PREDICTED: nuclear valosin (777 aa)
initn: 4255 init1: 3495 opt: 3495 Z-score: 3583.8 bits: 673.7 E(86401): 7.1e-193
Smith-Waterman score: 4205; 96.0% identity (96.0% similar) in 679 aa overlap (8-659:99-777)
10 20 30
pF1KE2 MEDYPDPQDSKDSSLLESDMKRKGKLKNKGSKRKKED
::::::::::::::::::::::::::::::
XP_011 IDKTPSVKKDSFFLDLSCEKSNPKKPITEIQDSKDSSLLESDMKRKGKLKNKGSKRKKED
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE2 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEVDGEIEAVLQKKAKARGLEFQISNVKFEDVGGNDMTLKEVCKMLIHMRHPEVYHHLG
130 140 150 160 170 180
100 110 120 130
pF1KE2 VVPPRGVLLHGPPGCGKTLLAHAIAG---------------------------ELDLPIL
:::::::::::::::::::::::::: :::::::
XP_011 VVPPRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASASQELDLPIL
190 200 210 220 230 240
140 150 160 170 180 190
pF1KE2 KVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRIVAQ
250 260 270 280 290 300
200 210 220 230 240 250
pF1KE2 LLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTL
310 320 330 340 350 360
260 270 280 290 300 310
pF1KE2 CRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEMEDLP
370 380 390 400 410 420
320 330 340 350 360 370
pF1KE2 SKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKGVQEERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSSVQPSA
430 440 450 460 470 480
380 390 400 410 420 430
pF1KE2 KREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG
490 500 510 520 530 540
440 450 460 470 480 490
pF1KE2 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALC
550 560 570 580 590 600
500 510 520 530 540 550
pF1KE2 PRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVG
610 620 630 640 650 660
560 570 580 590 600 610
pF1KE2 LPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQ
670 680 690 700 710 720
620 630 640 650
pF1KE2 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQESLSR
730 740 750 760 770
659 residues in 1 query sequences
61573307 residues in 86401 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Mar 10 10:42:01 2017 done: Fri Mar 10 10:42:03 2017
Total Scan time: 12.450 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]