Result of FASTA (omim) for
pFN21AE2667
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2667, 1105 aa
1>>>pF1KE2667 1105 - 1105 aa - 1105 aa
Library: /omim/omim.rfq.tfa
61127809 residues in 85815 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.8838+/-0.000415; mu= -9.3833+/- 0.026
mean_var=304.0232+/-63.215, 0's: 0 Z-trim(121.4): 62 B-trim: 365 in 1/56
Lambda= 0.073556
statistics sampled from 37931 (37997) to 37931 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.443), width: 16
Scan time: 12.950
The best scores are: opt bits E(85815)
NP_001295104 (OMIM: 249420,613293) SH3 and PX doma ( 430) 746 93.4 3.2e-18
NP_001017995 (OMIM: 249420,613293) SH3 and PX doma ( 911) 746 93.5 6.1e-18
XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 ( 939) 746 93.5 6.3e-18
NP_000256 (OMIM: 233700,608512) neutrophil cytosol ( 390) 517 69.1 6e-11
NP_751907 (OMIM: 611256) NADPH oxidase organizer 1 ( 371) 355 51.9 8.6e-06
XP_016878417 (OMIM: 611256) PREDICTED: NADPH oxida ( 376) 355 51.9 8.7e-06
XP_005255156 (OMIM: 611256) PREDICTED: NADPH oxida ( 376) 355 51.9 8.7e-06
NP_751908 (OMIM: 611256) NADPH oxidase organizer 1 ( 376) 355 51.9 8.7e-06
XP_016878416 (OMIM: 611256) PREDICTED: NADPH oxida ( 376) 355 51.9 8.7e-06
NP_653204 (OMIM: 611256) NADPH oxidase organizer 1 ( 370) 345 50.8 1.8e-05
NP_001254650 (OMIM: 611256) NADPH oxidase organize ( 375) 345 50.8 1.8e-05
>>NP_001295104 (OMIM: 249420,613293) SH3 and PX domain-c (430 aa)
initn: 1188 init1: 746 opt: 746 Z-score: 448.2 bits: 93.4 E(85815): 3.2e-18
Smith-Waterman score: 1544; 55.4% identity (74.4% similar) in 446 aa overlap (6-448:7-396)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFP
. .. :.::.::: :.::::::: ::::......::::::::::::::.:::::
NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFR
.:::::::::::::::::::::::::::::::::: ::::::.::..:::.:::::::..
NP_001 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 FFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATA-EPMILEQYVVVSNYK
:::.::::.:::::.. .:.:: :.: :. .::.:::::::.::.
NP_001 FFETRPEDLNPPKEEH-IGKKKS---------------GGDQTSVDPMVLEQYVVVANYQ
130 140 150 160
180 190 200 210 220 230
pF1KE2 KQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTG
:::.::.::..:.:::.:::::::::::::.::::::::: ::.:.:..:. ...
NP_001 KQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE---
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE2 EEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDD
:::::... :::....::...:.:..::::.::::::: ::: :::::::::::::
NP_001 EEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----
230 240 250 260 270
300 310 320 330 340 350
pF1KE2 LPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNA
: . :. :: : : .: ..: .
NP_001 ------NSGEPL-----------------------PPKPGPG--SPSHPGALDLDGVSRQ
280 290 300
360 370 380 390 400 410
pF1KE2 SNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPP
.: ::: . .: .: . :. ::..: ::::::. .. :..:::::
NP_001 QN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPP
310 320 330 340 350 360
420 430 440 450 460 470
pF1KE2 EPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDK
::.:: :::::::::. : :::::..: :.:
NP_001 IPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEDHKNVHLESPVEVPLRRIKMRTALGKHV
370 380 390 400 410 420
480 490 500 510 520 530
pF1KE2 RKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFG
NP_001 AASMEM
430
>>NP_001017995 (OMIM: 249420,613293) SH3 and PX domain-c (911 aa)
initn: 1634 init1: 746 opt: 746 Z-score: 443.1 bits: 93.5 E(85815): 6.1e-18
Smith-Waterman score: 1971; 37.1% identity (58.7% similar) in 1112 aa overlap (6-1104:7-910)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFP
. .. :.::.::: :.::::::: ::::......::::::::::::::.:::::
NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFR
.:::::::::::::::::::::::::::::::::: ::::::.::..:::.:::::::..
NP_001 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 FFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATA-EPMILEQYVVVSNYK
:::.::::.:::::.. .:.:: :.: :. .::.:::::::.::.
NP_001 FFETRPEDLNPPKEEH-IGKKKS---------------GGDQTSVDPMVLEQYVVVANYQ
130 140 150 160
180 190 200 210 220 230
pF1KE2 KQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTG
:::.::.::..:.:::.:::::::::::::.::::::::: ::.:.:..:. ...
NP_001 KQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE---
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE2 EEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDD
:::::... :::....::...:.:..::::.::::::: ::: :::::::::::::
NP_001 EEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----
230 240 250 260 270
300 310 320 330 340 350
pF1KE2 LPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNA
: . :. :: : : .: ..: .
NP_001 ------NSGEPL-----------------------PPKPGPG--SPSHPGALDLDGVSRQ
280 290 300
360 370 380 390 400 410
pF1KE2 SNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPP
.: ::: . .: .: . :. ::..: ::::::. .. :..:::::
NP_001 QN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPP
310 320 330 340 350 360
420 430 440 450 460 470
pF1KE2 EPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDK
::.:: :::::::::. : :::::..: :.:::.:: .::::.:: .:::::::..:::
NP_001 IPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDK
370 380 390 400 410 420
480 490 500 510 520 530
pF1KE2 RKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFG
:: ::. .::. : : . . . : ..: :.. . . .: : :
NP_001 YKK------TSNASRPNFLAPLP-HEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGV
430 440 450 460 470
540 550 560 570 580 590
pF1KE2 FDSEPELSEE-----PVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETI
.:: :.. : .::.. . .. .... . .. .:.. : .
NP_001 MDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEE-KPSLPPRKESIIKSEGEL
480 490 500 510 520 530
600 610 620 630 640 650
pF1KE2 YENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQA
: : : .:. :: . :: . :. : . ..: . : .:.
NP_001 LERERERQRTEQL---RGPT--PKPPGVILPMMPAKHIPPA---RDSRRPEPKPDKSRLF
540 550 560 570 580
660 670 680 690 700 710
pF1KE2 EMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKD
.. :: . . .. . . .. . .::.. :: :. :: ::.
NP_001 QL-KNDMGLECGHKVLAKEV----KKPNLRPISKSKTDL-PEEKPDA----TPQ------
590 600 610 620 630
720 730 740 750 760 770
pF1KE2 ADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSED
: : : :...:. :.: . :.....:: .:: .::: .::.:
NP_001 ---NPFLKSRPQVRPKPAPSP--KTEPPQGEDQVDICNLRSKLRP----------AKSQD
640 650 660 670
780 790 800 810 820 830
pF1KE2 SELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEI
. : .:: . ... ... . : :::. ..::
NP_001 KSL-------LDGEGPQAVGGQDVAFSRSFLPG------EGPG----------RAQD---
680 690 700 710
840 850 860 870 880 890
pF1KE2 SFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQN
: :. .: .:.. .. : :. : : :
NP_001 ---------------------RTGKQDGLSPKE---ISCRAPPRPA-KTTDPV-------
720 730
900 910 920 930 940
pF1KE2 EGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTS-GTPAVK---MRNGVRQV
.:: . :. . :.. ..:: :: ...: : :. .. ..
NP_001 -SKSVPV--------PLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRA
740 750 760 770 780 790
950 960 970 980 990 1000
pF1KE2 AVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAER
: : ... :: :: .:: . : :: . ..:.. :. :.
NP_001 APTPGRALLVPPKAKPFLS------NSLGGQDDTRGKGSLGPWGTGKI------GENREK
800 810 820 830
1010 1020 1030 1040 1050 1060
pF1KE2 AASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKD-VYVSIADYEGDEETAGFQE
::. :.: . ..::: .::..::.:::..:..:::
NP_001 AAAA------------SVPNA--------------DGLKDSLYVAVADFEGDKDTSSFQE
840 850 860 870
1070 1080 1090 1100
pF1KE2 GVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN
:. .:: :.: .:::.::.:.:. ..::.:::::.::
NP_001 GTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
880 890 900 910
>>XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 and (939 aa)
initn: 1630 init1: 746 opt: 746 Z-score: 442.9 bits: 93.5 E(85815): 6.3e-18
Smith-Waterman score: 1925; 36.3% identity (57.6% similar) in 1137 aa overlap (6-1104:7-938)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFP
. .. :.::.::: :.::::::: ::::......::::::::::::::.:::::
XP_016 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFR
.:::::::::::::::::::::::::::::::::: ::::::.::..:::.:::::::..
XP_016 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE2 FFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATA-EPMILEQYVVVSNYK
:::.::::.:::::.. .:.:: :.: :. .::.:::::::.::.
XP_016 FFETRPEDLNPPKEEH-IGKKKS---------------GGDQTSVDPMVLEQYVVVANYQ
130 140 150 160
180 190 200 210 220
pF1KE2 KQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD---------
:::.::.::..:.:::.:::::::::::::.::::::::: ::.:.:..:.
XP_016 KQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVS
170 180 190 200 210 220
230 240 250 260 270
pF1KE2 ----------------SDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLE
.:. . . .::::... :::....::...:.:..::::.::::
XP_016 WRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLE
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE2 GWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKET
::: ::: ::::::::::::: : . :.
XP_016 GWWKIRYQGKEGWAPASYLKK----------NSGEPL-----------------------
290 300 310
340 350 360 370 380 390
pF1KE2 PPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISS
:: : : .: ..: . .: ::: . .: .: . :. :
XP_016 PPKPGPG--SPSHPGALDLDGVSRQQN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRS
320 330 340 350 360
400 410 420 430 440 450
pF1KE2 PNLRTRPPPRRESSL--GFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVID
:..: ::::::. .. :..::::: ::.:: :::::::::. : :::::..: :.:::.
XP_016 PKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIE
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE2 KNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPT
:: .::::.:: .:::::::..::: :: ::. .::. : : . . . : .
XP_016 KNLSGWWYIQIEDKEGWAPATFIDKYKK------TSNASRPNFLAPLP-HEVTQLRLGEA
430 440 450 460 470 480
520 530 540 550 560
pF1KE2 GASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEE-----PVEDRASGERRPAQPHRPSP
.: :.. . . .: : : .:: :.. : .::.. . ..
XP_016 AALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEIS
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE2 ASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTR
.... . .. .:.. : . : : : .:. :: . :: .
XP_016 DPDMEE-KPSLPPRKESIIKSEGELLERERERQRTEQL---RGPT--PKPPGVILPMMPA
550 560 570 580 590
630 640 650 660 670 680
pF1KE2 KNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKT
:. : . ..: . : .:. .. :: . . .. . . .. . .::.
XP_016 KHIPPA---RDSRRPEPKPDKSRLFQL-KNDMGLECGHKVLAKEV----KKPNLRPISKS
600 610 620 630 640
690 700 710 720 730 740
pF1KE2 SGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMD
. :: :. :: ::. : : : :...:. :.: . :.....:
XP_016 KTDL-PEEKPDA----TPQ---------NPFLKSRPQVRPKPAPSP--KTEPPQGEDQVD
650 660 670 680 690
750 760 770 780 790 800
pF1KE2 ISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPT
: .:: .::: .::.:. : .:: . ... ... . :
XP_016 ICNLRSKLRP----------AKSQDKSL-------LDGEGPQAVGGQDVAFSRSFLPG--
700 710 720 730
810 820 830 840 850 860
pF1KE2 KKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL
:::. ..:: : :. .: .:..
XP_016 ----EGPG----------RAQD------------------------RTGKQDGLSPKE--
740 750
870 880 890 900 910 920
pF1KE2 VLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPP
.. : :. : : : .:: . :. . :.. ..:: ::
XP_016 -ISCRAPPRPA-KTTDPV--------SKSVPV--------PLQEAPQQRPVVPPRRPPPP
760 770 780 790
930 940 950 960 970 980
pF1KE2 GGFGKTS-GTPAVK---MRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLR
...: : :. .. ..: : ... :: :: .:: . : :
XP_016 KKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLS------NSLGGQDDTR
800 810 820 830 840
990 1000 1010 1020 1030 1040
pF1KE2 GVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIH
: . ..:.. :. :.::. :.: .
XP_016 GKGSLGPWGTGKI------GENREKAAAA------------SVPNA--------------
850 860 870
1050 1060 1070 1080 1090 1100
pF1KE2 NNLKD-VYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYL
..::: .::..::.:::..:..::::. .:: :.: .:::.::.:.:. ..::.:::::
XP_016 DGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL
880 890 900 910 920 930
pF1KE2 EKKN
.::
XP_016 RKKP
>>NP_000256 (OMIM: 233700,608512) neutrophil cytosol fac (390 aa)
initn: 714 init1: 254 opt: 517 Z-score: 317.6 bits: 69.1 E(85815): 6e-11
Smith-Waterman score: 714; 35.5% identity (69.4% similar) in 301 aa overlap (6-306:6-294)
10 20 30 40 50 60
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPI
.. ... ::: ::.::::.. : :.: . ...:::........ : . :::
NP_000 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRF
:.: .:..:::: ::. : .. .: .: . ::: .:. :: .::.: ... :
NP_000 EAGAINPENRIIPHLPAPKWFDGQR---AAENRQGTLTEYCSTLMSLPTKISRCPHLLDF
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 FEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ
:..::.:.. : : ..: .. . . ..: :.:: :.::. : ...::.:
NP_000 FKVRPDDLKLPT-DNQTKKPETYLMPKDGKSTATDITG------PIILQTYRAIANYEKT
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEE
.::..:..:.::.:.::.:::::: . . ..::.::..:: .. . : . . .::
NP_000 SGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGE-
180 190 200 210 220
250 260 270 280 290 300
pF1KE2 EKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLP
::... ::. ::... .: .::::.: :.::: :: :. :. ::.:. .:.
NP_000 -PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVS
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 TRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASN
....
NP_000 QAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGS
290 300 310 320 330 340
>>NP_751907 (OMIM: 611256) NADPH oxidase organizer 1 iso (371 aa)
initn: 193 init1: 164 opt: 355 Z-score: 225.0 bits: 51.9 E(85815): 8.6e-06
Smith-Waterman score: 361; 25.7% identity (56.8% similar) in 292 aa overlap (6-293:10-287)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD
:: :..:.... .. . ..: :::... . : ...: .:. : .
NP_751 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 KFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDE
::.:.: ..:..: : :. : . .. ::. .. : : :. ....
NP_751 TFPVEAGLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 VFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSN
. :: .: :..: :: : : . :.: . ..: . . . .. ..
NP_751 ITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQP
120 130 140 150 160
180 190 200 210 220 230
pF1KE2 YKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTRDDSDI
. :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : ..
NP_751 FCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGP
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE2 NTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYL
. ...: .. . . : :. ::.. :. :.:.. . .::: :: . : :: :
NP_751 SLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE2 KKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISL
.
NP_751 RPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRA
290 300 310 320 330 340
>>XP_016878417 (OMIM: 611256) PREDICTED: NADPH oxidase o (376 aa)
initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06
Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD
:: :..:.... .. . ..: :::... . : ...: .:. : .
XP_016 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI
::.:.: ..:..: : :. :. : . .. ::. .. : : :. ..
XP_016 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY
.. . :: .: :..: :: : : . :.: . ..: . . . ..
XP_016 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL
120 130 140 150 160
180 190 200 210 220
pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR
.. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : :
XP_016 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA
.. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . :
XP_016 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK
:: :.
XP_016 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT
290 300 310 320 330 340
>>XP_005255156 (OMIM: 611256) PREDICTED: NADPH oxidase o (376 aa)
initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06
Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD
:: :..:.... .. . ..: :::... . : ...: .:. : .
XP_005 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI
::.:.: ..:..: : :. :. : . .. ::. .. : : :. ..
XP_005 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY
.. . :: .: :..: :: : : . :.: . ..: . . . ..
XP_005 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL
120 130 140 150 160
180 190 200 210 220
pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR
.. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : :
XP_005 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA
.. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . :
XP_005 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK
:: :.
XP_005 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT
290 300 310 320 330 340
>>NP_751908 (OMIM: 611256) NADPH oxidase organizer 1 iso (376 aa)
initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06
Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD
:: :..:.... .. . ..: :::... . : ...: .:. : .
NP_751 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI
::.:.: ..:..: : :. :. : . .. ::. .. : : :. ..
NP_751 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY
.. . :: .: :..: :: : : . :.: . ..: . . . ..
NP_751 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL
120 130 140 150 160
180 190 200 210 220
pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR
.. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : :
NP_751 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA
.. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . :
NP_751 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK
:: :.
NP_751 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT
290 300 310 320 330 340
>>XP_016878416 (OMIM: 611256) PREDICTED: NADPH oxidase o (376 aa)
initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06
Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD
:: :..:.... .. . ..: :::... . : ...: .:. : .
XP_016 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI
::.:.: ..:..: : :. :. : . .. ::. .. : : :. ..
XP_016 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY
.. . :: .: :..: :: : : . :.: . ..: . . . ..
XP_016 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL
120 130 140 150 160
180 190 200 210 220
pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR
.. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : :
XP_016 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA
.. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . :
XP_016 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK
:: :.
XP_016 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT
290 300 310 320 330 340
>>NP_653204 (OMIM: 611256) NADPH oxidase organizer 1 iso (370 aa)
initn: 193 init1: 164 opt: 345 Z-score: 219.3 bits: 50.8 E(85815): 1.8e-05
Smith-Waterman score: 351; 25.7% identity (56.8% similar) in 292 aa overlap (6-293:10-286)
10 20 30 40 50
pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD
:: :..:.... .. . ..: :::... . : ...: .:. : .
NP_653 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKT-LKE
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 KFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDE
::.:.: ..:..: : :. : . .. ::. .. : : :. ....
NP_653 TFPVEAGLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 VFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSN
. :: .: :..: :: : : . :.: . ..: . . . .. ..
NP_653 ITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQP
120 130 140 150 160
180 190 200 210 220 230
pF1KE2 YKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTRDDSDI
. :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : ..
NP_653 FCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGP
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE2 NTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYL
. ...: .. . . : :. ::.. :. :.:.. . .::: :: . : :: :
NP_653 SLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE2 KKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISL
.
NP_653 RPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRA
290 300 310 320 330 340
1105 residues in 1 query sequences
61127809 residues in 85815 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Jan 20 09:31:52 2017 done: Fri Jan 20 09:31:53 2017
Total Scan time: 12.950 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]