Result of FASTA (omim) for
pFN21AE2643
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2643, 105 aa
1>>>pF1KE2643 105 - 105 aa - 105 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.4615+/-0.000324; mu= 14.1381+/- 0.020
mean_var=56.0249+/-11.245, 0's: 0 Z-trim(115.5): 47 B-trim: 65 in 1/51
Lambda= 0.171350
statistics sampled from 25942 (25990) to 25942 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.305), width: 16
Scan time: 3.140
The best scores are: opt bits E(85289)
NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 705 181.6 2e-46
NP_001231867 (OMIM: 187700) thioredoxin isoform 2 ( 85) 300 81.4 2.3e-16
XP_011524565 (OMIM: 603049) PREDICTED: thioredoxin ( 282) 284 77.9 9e-15
NP_004777 (OMIM: 603049) thioredoxin-like protein ( 289) 284 77.9 9.2e-15
XP_016881582 (OMIM: 603049) PREDICTED: thioredoxin ( 289) 284 77.9 9.2e-15
XP_006722643 (OMIM: 603049) PREDICTED: thioredoxin ( 292) 284 77.9 9.3e-15
NP_036605 (OMIM: 609063,616811) thioredoxin, mitoc ( 166) 229 64.1 7.4e-11
XP_006724289 (OMIM: 609063,616811) PREDICTED: thio ( 166) 229 64.1 7.4e-11
XP_005261565 (OMIM: 609063,616811) PREDICTED: thio ( 197) 229 64.2 8.5e-11
NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 ( 335) 180 52.2 5.6e-07
NP_001186797 (OMIM: 612754) glutaredoxin-3 isoform ( 335) 180 52.2 5.6e-07
NP_057700 (OMIM: 607421,610852) thioredoxin domain ( 588) 172 50.5 3.4e-06
NP_001139021 (OMIM: 616412) thioredoxin domain-con ( 324) 169 49.5 3.6e-06
NP_110437 (OMIM: 616412) thioredoxin domain-contai ( 432) 169 49.6 4.5e-06
NP_005304 (OMIM: 602046) protein disulfide-isomera ( 505) 155 46.2 5.6e-05
NP_055866 (OMIM: 609170) endoplasmic reticulum res ( 406) 142 42.9 0.00044
NP_001258510 (OMIM: 607987) dnaJ homolog subfamily ( 747) 144 43.6 0.0005
NP_061854 (OMIM: 607987) dnaJ homolog subfamily C ( 793) 144 43.6 0.00052
NP_006840 (OMIM: 608012) protein disulfide-isomera ( 525) 136 41.5 0.0015
NP_000909 (OMIM: 112240,176790) protein disulfide- ( 508) 134 41.0 0.0021
XP_011524337 (OMIM: 616102) PREDICTED: protein dis ( 229) 130 39.7 0.0022
XP_011524336 (OMIM: 616102) PREDICTED: protein dis ( 231) 130 39.8 0.0022
NP_006801 (OMIM: 616942) protein disulfide-isomera ( 519) 132 40.5 0.0029
NP_061895 (OMIM: 616102) protein disulfide-isomera ( 454) 130 40.0 0.0037
NP_001269634 (OMIM: 611099) protein disulfide-isom ( 488) 126 39.0 0.0079
NP_001269633 (OMIM: 611099) protein disulfide-isom ( 492) 126 39.0 0.0079
NP_001137484 (OMIM: 616715) thioredoxin-related tr ( 258) 123 38.1 0.0081
NP_057043 (OMIM: 616715) thioredoxin-related trans ( 296) 123 38.1 0.009
>>NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Homo s (105 aa)
initn: 705 init1: 705 opt: 705 Z-score: 954.5 bits: 181.6 E(85289): 2e-46
Smith-Waterman score: 705; 100.0% identity (100.0% similar) in 105 aa overlap (1-105:1-105)
10 20 30 40 50 60
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
10 20 30 40 50 60
70 80 90 100
pF1KE2 DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
:::::::::::::::::::::::::::::::::::::::::::::
NP_003 DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
70 80 90 100
>>NP_001231867 (OMIM: 187700) thioredoxin isoform 2 [Hom (85 aa)
initn: 300 init1: 300 opt: 300 Z-score: 414.7 bits: 81.4 E(85289): 2.3e-16
Smith-Waterman score: 525; 81.0% identity (81.0% similar) in 105 aa overlap (1-105:1-85)
10 20 30 40 50 60
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
:::::::::::::::::::::::::::::::::::::::::::
NP_001 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFH-----------------
10 20 30 40
70 80 90 100
pF1KE2 DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
::::::::::::::::::::::::::::::::::::::::::
NP_001 ---DVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
50 60 70 80
>>XP_011524565 (OMIM: 603049) PREDICTED: thioredoxin-lik (282 aa)
initn: 284 init1: 284 opt: 284 Z-score: 386.2 bits: 77.9 E(85289): 9e-15
Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105)
10 20 30 40 50
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD
:: . : :: :..::..:.:: :. :::: : : : :.:.:: ...:::::
XP_011 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
: .:: .:. ... ::: ::.. .. ...::. :: :..
XP_011 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP
70 80 90 100 110 120
XP_011 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM
130 140 150 160 170 180
>>NP_004777 (OMIM: 603049) thioredoxin-like protein 1 [H (289 aa)
initn: 284 init1: 284 opt: 284 Z-score: 386.0 bits: 77.9 E(85289): 9.2e-15
Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105)
10 20 30 40 50
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD
:: . : :: :..::..:.:: :. :::: : : : :.:.:: ...:::::
NP_004 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
: .:: .:. ... ::: ::.. .. ...::. :: :..
NP_004 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP
70 80 90 100 110 120
NP_004 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM
130 140 150 160 170 180
>>XP_016881582 (OMIM: 603049) PREDICTED: thioredoxin-lik (289 aa)
initn: 284 init1: 284 opt: 284 Z-score: 386.0 bits: 77.9 E(85289): 9.2e-15
Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105)
10 20 30 40 50
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD
:: . : :: :..::..:.:: :. :::: : : : :.:.:: ...:::::
XP_016 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
: .:: .:. ... ::: ::.. .. ...::. :: :..
XP_016 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP
70 80 90 100 110 120
XP_016 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM
130 140 150 160 170 180
>>XP_006722643 (OMIM: 603049) PREDICTED: thioredoxin-lik (292 aa)
initn: 284 init1: 284 opt: 284 Z-score: 386.0 bits: 77.9 E(85289): 9.3e-15
Smith-Waterman score: 284; 41.2% identity (68.6% similar) in 102 aa overlap (2-103:4-105)
10 20 30 40 50
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVD
:: . : :: :..::..:.:: :. :::: : : : :.:.:: ...:::::
XP_006 MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVD
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 VDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
: .:: .:. ... ::: ::.. .. ...::. :: :..
XP_006 VHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIP
70 80 90 100 110 120
XP_006 KGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSM
130 140 150 160 170 180
>>NP_036605 (OMIM: 609063,616811) thioredoxin, mitochond (166 aa)
initn: 127 init1: 115 opt: 229 Z-score: 315.9 bits: 64.1 E(85289): 7.4e-11
Smith-Waterman score: 229; 36.9% identity (71.8% similar) in 103 aa overlap (5-105:64-165)
10 20 30
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGP
:.. ::. . . .. ::::: : ::::
NP_036 TPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRV-VNSETPVVVDFHAQWCGP
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE2 CKMIKPFFHSL-SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGAN
::.. : .... ......:.. .::.:: :.: : ::. .:: .:.:. : .: : .
NP_036 CKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK
100 110 120 130 140 150
100
pF1KE2 KE-KLEATINELV
: .::: ...:.
NP_036 DEDQLEAFLKKLIG
160
>>XP_006724289 (OMIM: 609063,616811) PREDICTED: thioredo (166 aa)
initn: 127 init1: 115 opt: 229 Z-score: 315.9 bits: 64.1 E(85289): 7.4e-11
Smith-Waterman score: 229; 36.9% identity (71.8% similar) in 103 aa overlap (5-105:64-165)
10 20 30
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGP
:.. ::. . . .. ::::: : ::::
XP_006 TPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRV-VNSETPVVVDFHAQWCGP
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE2 CKMIKPFFHSL-SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGAN
::.. : .... ......:.. .::.:: :.: : ::. .:: .:.:. : .: : .
XP_006 CKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK
100 110 120 130 140 150
100
pF1KE2 KE-KLEATINELV
: .::: ...:.
XP_006 DEDQLEAFLKKLIG
160
>>XP_005261565 (OMIM: 609063,616811) PREDICTED: thioredo (197 aa)
initn: 127 init1: 115 opt: 229 Z-score: 314.8 bits: 64.2 E(85289): 8.5e-11
Smith-Waterman score: 229; 36.9% identity (71.8% similar) in 103 aa overlap (5-105:95-196)
10 20 30
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGP
:.. ::. . . .. ::::: : ::::
XP_005 TPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRV-VNSETPVVVDFHAQWCGP
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE2 CKMIKPFFHSL-SEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGAN
::.. : .... ......:.. .::.:: :.: : ::. .:: .:.:. : .: : .
XP_005 CKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK
130 140 150 160 170 180
100
pF1KE2 KE-KLEATINELV
: .::: ...:.
XP_005 DEDQLEAFLKKLIG
190
>>NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 [Hom (335 aa)
initn: 79 init1: 79 opt: 180 Z-score: 246.2 bits: 52.2 E(85289): 5.6e-07
Smith-Waterman score: 180; 28.0% identity (64.0% similar) in 100 aa overlap (2-101:13-112)
10 20 30 40
pF1KE2 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKY
:... : :.: : . .:.:: : : : : ... . :...
NP_006 MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 SNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
.: :...... .:. . :.. .::: :::..::. ...::. .: .
NP_006 PQVSFVKLEAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSGS
70 80 90 100 110 120
NP_006 FLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFD
130 140 150 160 170 180
105 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:41:58 2016 done: Tue Nov 8 17:41:58 2016
Total Scan time: 3.140 Total Display time: -0.040
Function used was FASTA [36.3.4 Apr, 2011]