Result of FASTA (omim) for
pFN21AE2620
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2620, 548 aa
1>>>pF1KE2620 548 - 548 aa - 548 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.8538+/-0.000394; mu= -1.6782+/- 0.024
mean_var=312.5326+/-61.476, 0's: 0 Z-trim(122.8): 99 B-trim: 33 in 1/59
Lambda= 0.072548
statistics sampled from 41375 (41512) to 41375 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.487), width: 16
Scan time: 12.220
The best scores are: opt bits E(85289)
NP_444514 (OMIM: 608021) WAP, Kazal, immunoglobuli ( 548) 3953 427.5 5.3e-119
NP_783165 (OMIM: 610895) WAP, Kazal, immunoglobuli ( 576) 1582 179.3 2.8e-44
NP_001317270 (OMIM: 610895) WAP, Kazal, immunoglob ( 483) 1279 147.6 8.6e-35
NP_001624 (OMIM: 176870) protein AMBP preproprotei ( 352) 290 43.9 0.001
NP_001257933 (OMIM: 600033) tissue factor pathway ( 186) 254 39.9 0.0086
>>NP_444514 (OMIM: 608021) WAP, Kazal, immunoglobulin, K (548 aa)
initn: 3953 init1: 3953 opt: 3953 Z-score: 2257.5 bits: 427.5 E(85289): 5.3e-119
Smith-Waterman score: 3953; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:1-548)
10 20 30 40 50 60
pF1KE2 MPALRPLLPLLLLLRLTSGAGLLPGLGSHPGVCPNQLSPNLWVDAQSTCERECSRDQDCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 MPALRPLLPLLLLLRLTSGAGLLPGLGSHPGVCPNQLSPNLWVDAQSTCERECSRDQDCA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPVCRCRDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 AAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPVCRCRDRC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTARPTPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 EKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPETTARPTPG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AAPVPPALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 AAPVPPALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRENLIMRPDQMYGNV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 VVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPARDAAPSIPAPAECL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 VVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPARDAAPSIPAPAECL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 PDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARGFETYEACQQACARGPGDACV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 PDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARGFETYEACQQACARGPGDACV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRESCEDACPVPRTPPCRAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 LPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFHSRESCEDACPVPRTPPCRAC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 RLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 TLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSYVRAASEKRVKKILELLEKQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 TLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSYVRAASEKRVKKILELLEKQAC
490 500 510 520 530 540
pF1KE2 ELLNRFQD
::::::::
NP_444 ELLNRFQD
>>NP_783165 (OMIM: 610895) WAP, Kazal, immunoglobulin, K (576 aa)
initn: 1756 init1: 535 opt: 1582 Z-score: 916.0 bits: 179.3 E(85289): 2.8e-44
Smith-Waterman score: 2193; 56.1% identity (77.0% similar) in 560 aa overlap (7-546:19-572)
10 20 30 40
pF1KE2 MPALRPLLPLLLLLRLTSGAGLLPGLG-SHPGVCPNQLSPNLWVDAQS
:: ::::: . . :: . :: :.:::...:::::::::
NP_783 MWAPRCRRFWSRWEQVAALLLLLLLLGVPPRSLALPPIRYSHAGICPNDMNPNLWVDAQS
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE2 TCERECSRDQDCAAAEKCCINVCGLHSCVAARF---PGS--PAAPTTAASCEGFVCPQQG
::.::: ::.: . :::: :::: .::::::. :. :.. :.:. :.: :::
NP_783 TCRRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPKEATCDHFMCLQQG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 SDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLS
:.::::::::::.:.::::::::::::::::::::::::::::: .:. : .: :.. ..
NP_783 SECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFT
130 140 150 160 170 180
170 180 190 200 210
pF1KE2 WPPSSPGPPETTARPTPGAAPVP------PALYSSPSPQAVQVGGTASLHCDVSGRPPPA
:: .:: ::::: .:: .. .: ::: ..: :.: .: :.:. ::: ::: :
NP_783 WPNTSPPPPETTMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPE
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 VTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADF
.::::: ..:::..:::... ::::::.:.:::.:::. .:::.:::::::.::.:::::
NP_783 ITWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADF
250 260 270 280 290 300
280 290 300 310 320
pF1KE2 PLSVVQREPARDAAPSIPA----PA-ECL--PDVQACTGPTSPHLVLWHYDPQRGGCMTF
:::::. . : .. : : :: ::: :: . : : . . ::.: : ..:.::
NP_783 PLSVVRGHQAAATSESSPNGTAFPAAECLKPPDSEDC-GEEQTR---WHFDAQANNCLTF
310 320 330 340 350
330 340 350 360 370 380
pF1KE2 PARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVY
: :::::::. :: :: :: :::.::::... :::::. ::. :::
NP_783 TFGHCHRNLNHFETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVY
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE2 GGCEGNGNNFHSRESCEDACPVPR-TPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEP
::::::::::.:::.::..:: :: . ::::. :.::. :.:::::.:.::..:. :::
NP_783 GGCEGNGNNFESREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEP
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE2 EAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVR
.. : : :....::::.:::::::: . ::::: .::::::::.:... ::.:::::
NP_783 DS--GRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVD
480 490 500 510 520 530
510 520 530 540
pF1KE2 DGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD
:.:.: :.: :.: .::.:. :...:..:..:..:
NP_783 GGMAMLRPDSFVGASSARRVRKLREVMHKKTCDVLKEFLGLH
540 550 560 570
>>NP_001317270 (OMIM: 610895) WAP, Kazal, immunoglobulin (483 aa)
initn: 1451 init1: 535 opt: 1279 Z-score: 745.6 bits: 147.6 E(85289): 8.6e-35
Smith-Waterman score: 1890; 56.0% identity (77.8% similar) in 477 aa overlap (84-546:9-479)
60 70 80 90 100 110
pF1KE2 SRDQDCAAAEKCCINVCGLHSCVAARFPGSPAAPTTAASCEGFVCPQQGSDCDIWDGQPV
:.. :.:. :.: ::::.:::::::::
NP_001 MDVKGKKGPVGMPKEATCDHFMCLQQGSECDIWDGQPV
10 20 30
120 130 140 150 160 170
pF1KE2 CRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHIVPCKHVLSWPPSSPGPPET
:.:.::::::::::::::::::::::::::::: .:. : .: :.. ..:: .:: ::::
NP_001 CKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACSKGITLAVVTCRYHFTWPNTSPPPPET
40 50 60 70 80 90
180 190 200 210 220
pF1KE2 TARPTPGAAPVP------PALYSSPSPQAVQVGGTASLHCDVSGRPPPAVTWEKQSHQRE
: .:: .. .: ::: ..: :.: .: :.:. ::: ::: : .::::: ..::
NP_001 TMHPTTASPETPELDMAAPALLNNPVHQSVTMGETVSFLCDVVGRPRPEITWEKQLEDRE
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE2 NLIMRPDQMYGNVVVTSIGQLVLYNARPEDAGLYTCTARNAAGLLRADFPLSVVQREPAR
:..:::... ::::::.:.:::.:::. .:::.:::::::.::.::::::::::. . :
NP_001 NVVMRPNHVRGNVVVTNIAQLVIYNAQLQDAGIYTCTARNVAGVLRADFPLSVVRGHQAA
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE2 DAAPSIPA----PA-ECL--PDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCDGAARG
.. : : :: ::: :: . : : . . ::.: : ..:.:: :
NP_001 ATSESSPNGTAFPAAECLKPPDSEDC-GEEQTR---WHFDAQANNCLTFTFGHCHRNLNH
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE2 FETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGNGNNFH
:::::::. :: :: :: :::.::::... :::::. ::. :::::::::::::.
NP_001 FETYEACMLACMSGPLAACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFE
280 290 300 310 320 330
410 420 430 440 450
pF1KE2 SRESCEDACPVPR-TPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIARVAL
:::.::..:: :: . ::::. :.::. :.:::::.:.::..:. :::.. : : :..
NP_001 SREACEESCPFPRGNQRCRACKPRQKLVTSFCRSDFVILGRVSELTEEPDS--GRALVTV
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE2 EDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGEVRDGVAVLDAGSY
..::::.:::::::: . ::::: .::::::::.:... ::.::::: :.:.: :.
NP_001 DEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVDGGMAMLRPDSF
400 410 420 430 440 450
520 530 540
pF1KE2 VRAASEKRVKKILELLEKQACELLNRFQD
: :.: .::.:. :...:..:..:..:
NP_001 VGASSARRVRKLREVMHKKTCDVLKEFLGLH
460 470 480
>>NP_001624 (OMIM: 176870) protein AMBP preproprotein [H (352 aa)
initn: 346 init1: 220 opt: 290 Z-score: 187.9 bits: 43.9 E(85289): 0.001
Smith-Waterman score: 290; 41.1% identity (62.6% similar) in 107 aa overlap (306-412:240-340)
280 290 300 310 320 330
pF1KE2 FPLSVVQREPARDAAPSIPAPAECLPDVQACTGPTSPHLVLWHYDPQRGGCMTFPARGCD
: : :: .. :. .: :: ::
NP_001 QEEEGSGGGQLVTEVTKKEDSCQLGYSAGPCMGMTSRYF----YNGTSMACETFQYGGCM
210 220 230 240 250 260
340 350 360 370 380 390
pF1KE2 GAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHPFVYGGCEGN
: . .: : . : :.: : . :: :: :.::::.. ::.. . .: : ::::.::
NP_001 GNGNNFVTEKECLQTC-RTVA-ACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGN
270 280 290 300 310 320
400 410 420 430 440 450
pF1KE2 GNNFHSRESCEDACPVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVLEEPEAAGGIA
::.:.:.. :.. : ::
NP_001 GNKFYSEKECREYCGVPGDGDEELLRFSN
330 340 350
>>NP_001257933 (OMIM: 600033) tissue factor pathway inhi (186 aa)
initn: 244 init1: 219 opt: 254 Z-score: 171.1 bits: 39.9 E(85289): 0.0086
Smith-Waterman score: 254; 33.9% identity (59.5% similar) in 121 aa overlap (357-476:34-152)
330 340 350 360 370 380
pF1KE2 MTFPARGCDGAARGFETYEACQQACARGPGDACVLPAVQGPCRGWEPRWAYSPLLQQCHP
. :.:: ::::. :. :. :.:.
NP_001 ARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQ
10 20 30 40 50 60
390 400 410 420 430 440
pF1KE2 FVYGGCEGNGNNFHSRESCEDAC-PVPRTPPCRACRLRSKLALSLCRSDFAIVGRLTEVL
:.:::::::.:::.. :.:.::: . ..: ..:::. .. . : :. .
NP_001 FLYGGCEGNANNFYTWEACDDACWRIEKVP--KVCRLQVSVDDQCEGSTEKYFFNLSSMT
70 80 90 100 110 120
450 460 470 480 490 500
pF1KE2 EEPEAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMG
: .:: : .:. . :. . : . :
NP_001 CEKFFSGGCHRNRIENRFPDEATCMGFCAPKKNTEPVMLSPILAVEGMTITLLAGRIANV
130 140 150 160 170 180
510 520 530 540
pF1KE2 EVRDGVAVLDAGSYVRAASEKRVKKILELLEKQACELLNRFQD
NP_001 HVQKL
548 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 17:15:33 2016 done: Tue Nov 8 17:15:34 2016
Total Scan time: 12.220 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]