Result of FASTA (omim) for
pFN21AE2592
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2592, 224 aa
1>>>pF1KE2592 224 - 224 aa - 224 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.2663+/-0.000337; mu= 19.5088+/- 0.021
mean_var=58.3976+/-11.597, 0's: 0 Z-trim(116.0): 25 B-trim: 394 in 1/50
Lambda= 0.167833
statistics sampled from 26771 (26794) to 26771 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.314), width: 16
Scan time: 3.780
The best scores are: opt bits E(85289)
NP_001161302 (OMIM: 616876) transmembrane emp24 do ( 193) 261 70.9 1.6e-12
NP_006818 (OMIM: 605406) transmembrane emp24 domai ( 219) 258 70.3 3e-12
NP_006849 (OMIM: 605395) transmembrane emp24 domai ( 227) 256 69.8 4.2e-12
NP_001289990 (OMIM: 612038) transmembrane emp24 do ( 168) 242 66.3 3.6e-11
NP_001289991 (OMIM: 612038) transmembrane emp24 do ( 168) 242 66.3 3.6e-11
NP_872353 (OMIM: 612038) transmembrane emp24 domai ( 227) 242 66.4 4.4e-11
XP_006722694 (OMIM: 605395) PREDICTED: transmembra ( 189) 176 50.3 2.5e-06
NP_057124 (OMIM: 616876) transmembrane emp24 domai ( 229) 145 42.9 0.00053
NP_001289989 (OMIM: 612038) transmembrane emp24 do ( 127) 126 38.1 0.0084
>>NP_001161302 (OMIM: 616876) transmembrane emp24 domain (193 aa)
initn: 221 init1: 139 opt: 261 Z-score: 345.7 bits: 70.9 E(85289): 1.6e-12
Smith-Waterman score: 261; 28.9% identity (62.2% similar) in 180 aa overlap (21-190:13-188)
10 20 30 40 50
pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALL--LLVPGPGG-----ASEITFELPDNAKQCFYEDI
::: : .:.:: .: :..:: :: . :.:::. .
NP_001 MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPM
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 AQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNE
.. .:.::. :. :.: .: .:.::.: :..:. :. . .. : : :::.:
NP_001 PLKASLEIEYQVLDGAGLDIDFHLASPEGKTLVFEQRKS-DGVHTVETEVGDYMFCFDNT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 FSTFTHKTVYFDF---QVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRL
:::...:...:.. ..::. .:. . .: . ..... : .: . ..
NP_001 FSTISEKVIFFELILDNMGEQAQ--EQEDWKKYITGTDILDMKLEDILDPIIKIASDVQI
120 130 140 150 160
180 190 200 210 220
pF1KE2 REAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS
: : . ....:. :.
NP_001 RLHLGIHQQHQVQTK-QKWAHTNSA
170 180 190
>>NP_006818 (OMIM: 605406) transmembrane emp24 domain-co (219 aa)
initn: 224 init1: 104 opt: 258 Z-score: 341.0 bits: 70.3 E(85289): 3e-12
Smith-Waterman score: 258; 27.5% identity (56.5% similar) in 207 aa overlap (16-216:10-216)
10 20 30 40 50
pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALLLL-VPGPGGASEITFELPDNAKQCFYEDIAQGTKC
: : :::::: . :: . :.:.:: :...:. :.: .
NP_006 MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLV
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 TLEFQVI--TGGHYDVDCRLE--DPDGKVLYKEMKKQYDSFTFTASKNGTYKFCF-SNEF
: ... .:: . .:. : :..::.. .:.::. .. :: :.
NP_006 TGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 STFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQ
. . . : .:.. : . . .: : .: ... .:... .... :: .
NP_006 GRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEE
120 130 140 150 160 170
180 190 200 210 220
pF1KE2 GRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS
:. :. :::: :.:. . :. .. ::: :. ::. :.
NP_006 MRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE
180 190 200 210
>>NP_006849 (OMIM: 605395) transmembrane emp24 domain-co (227 aa)
initn: 372 init1: 246 opt: 256 Z-score: 338.2 bits: 69.8 E(85289): 4.2e-12
Smith-Waterman score: 362; 35.6% identity (58.4% similar) in 219 aa overlap (22-220:10-227)
10 20 30 40 50
pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALLLLVPGP---GGAS-------EITFELPDNAKQCFY
::: ::.: : :::. :.:: :: . :::::
NP_006 MMAAGAALALALWLLMP-PVEVGGAGPPPIQDGEFTFLLPAGRKQCFY
10 20 30 40
60 70 80 90 100 110
pF1KE2 EDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCF
.. ... :.::: :. ::: ::.:.: .: .: .: : .. : ::.::
NP_006 QSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCF
50 60 70 80 90 100
120 130 140 150 160
pF1KE2 SNEFSTFTHKTVYF---------DFQV-GEDPPLFPSENRVSALTQMESACVSIHEALKS
.: :::...: :.: : .: : . : : . ... . ... :.
NP_006 DNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLER
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 VIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTT
:.. : .: ::. :. : :: .::. .. .::.:.. :: :: ::.::: . :
NP_006 SIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT
170 180 190 200 210 220
pF1KE2 RVGS
>>NP_001289990 (OMIM: 612038) transmembrane emp24 domain (168 aa)
initn: 242 init1: 156 opt: 242 Z-score: 321.6 bits: 66.3 E(85289): 3.6e-11
Smith-Waterman score: 242; 31.8% identity (62.4% similar) in 157 aa overlap (68-216:17-166)
40 50 60 70 80 90
pF1KE2 TFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS--
: : .: .::::::. ...:: :
NP_001 MWDKQKEVFLPSTPGLGMHVEV----KDPDGKVV---LSRQYGSEG
10 20 30
100 110 120 130 140
pF1KE2 -FTFTASKNGTYKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFPSENRVSALTQMES
::::. : ...:. :.... :. . :..:.:::: .: . ::...
NP_001 RFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 ACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLK
.. . .... : . : :: . : .:. : :: .::.....::....: :. ::
NP_001 RARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLK
100 110 120 130 140 150
210 220
pF1KE2 SFFSDKRTTTTRVGS
::: :.
NP_001 SFFEAKKLV
160
>>NP_001289991 (OMIM: 612038) transmembrane emp24 domain (168 aa)
initn: 242 init1: 156 opt: 242 Z-score: 321.6 bits: 66.3 E(85289): 3.6e-11
Smith-Waterman score: 242; 31.8% identity (62.4% similar) in 157 aa overlap (68-216:17-166)
40 50 60 70 80 90
pF1KE2 TFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS--
: : .: .::::::. ...:: :
NP_001 MWDKQKEVFLPSTPGLGMHVEV----KDPDGKVV---LSRQYGSEG
10 20 30
100 110 120 130 140
pF1KE2 -FTFTASKNGTYKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFPSENRVSALTQMES
::::. : ...:. :.... :. . :..:.:::: .: . ::...
NP_001 RFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 ACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLK
.. . .... : . : :: . : .:. : :: .::.....::....: :. ::
NP_001 RARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLK
100 110 120 130 140 150
210 220
pF1KE2 SFFSDKRTTTTRVGS
::: :.
NP_001 SFFEAKKLV
160
>>NP_872353 (OMIM: 612038) transmembrane emp24 domain-co (227 aa)
initn: 288 init1: 156 opt: 242 Z-score: 319.9 bits: 66.4 E(85289): 4.4e-11
Smith-Waterman score: 273; 30.4% identity (58.4% similar) in 214 aa overlap (23-216:16-225)
10 20 30 40 50
pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGT---
:::::. ::. . :.. .. :.:: :.: . :
NP_872 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVI
10 20 30 40 50
60 70 80 90 100
pF1KE2 ---------KCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS---FTFTASKNGT
: : : : . ...::::::. ...:: : ::::. :
NP_872 GNYRTQMWDKQKEVFLPSTPG-LGMHVEVKDPDGKVV---LSRQYGSEGRFTFTSHTPGD
60 70 80 90 100
110 120 130 140 150 160
pF1KE2 YKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKS
...:. :.... :. . :..:.:::: .: . ::... .. . ...
NP_872 HQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQ
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE2 VIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTT
. : . : :: . : .:. : :: .::.....::....: :. ::::: :.
NP_872 IQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
170 180 190 200 210 220
pF1KE2 RVGS
>>XP_006722694 (OMIM: 605395) PREDICTED: transmembrane e (189 aa)
initn: 296 init1: 172 opt: 176 Z-score: 234.5 bits: 50.3 E(85289): 2.5e-06
Smith-Waterman score: 279; 33.7% identity (57.1% similar) in 175 aa overlap (56-220:16-189)
30 40 50 60 70 80
pF1KE2 LLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVL
: :. ::: :. ::: ::.:.: .:
XP_006 MRVEARGAATGTGWGGCGCA-AVQVIGGAGLDVDFTLESPQGVLL
10 20 30 40
90 100 110 120 130
pF1KE2 YKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYF---------DFQV-GEDPPLF
.: .: : .. : ::.::.: :::...: :.: : .: : .
XP_006 VSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVE
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE2 PSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEAL
: : . ... . ... :. :.. : .: ::. :. : :: .::. ..
XP_006 PEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVA
110 120 130 140 150 160
200 210 220
pF1KE2 ILLVVSIGQVFLLKSFFSDKRTTTTRVGS
.::.:.. :: :: ::.::: . :
XP_006 VLLLVAVLQVCTLKRFFQDKRPVPT
170 180
>>NP_057124 (OMIM: 616876) transmembrane emp24 domain-co (229 aa)
initn: 352 init1: 145 opt: 145 Z-score: 192.9 bits: 42.9 E(85289): 0.00053
Smith-Waterman score: 361; 32.6% identity (63.8% similar) in 218 aa overlap (21-220:13-229)
10 20 30 40 50
pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALL--LLVPGPGG-----ASEITFELPDNAKQCFYEDI
::: : .:.:: .: :..:: :: . :.:::. .
NP_057 MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPM
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 AQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNE
.. .:.::. :. :.: .: .:.::.: :..:. :. . .. : : :::.:
NP_057 PLKASLEIEYQVLDGAGLDIDFHLASPEGKTLVFEQRKS-DGVHTVETEVGDYMFCFDNT
60 70 80 90 100 110
120 130 140 150 160
pF1KE2 FSTFTHKTVYFDF---QVGEDPPLFPSENR-VSALTQMESACVSIHEALKSVIDY-----
:::...:...:.. ..::. . .. ... .. .: :...:. .
NP_057 FSTISEKVIFFELILDNMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKSG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE2 --QTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRV
:: .: ::. :. :. :: .::. . ....::: ::..:::.: ::: . :
NP_057 HIQTLLRAFEARDRNIQESNFDRVNFWSMVNLVVMVVVSAIQVYMLKSLFEDKRKSRT
180 190 200 210 220
pF1KE2 GS
>>NP_001289989 (OMIM: 612038) transmembrane emp24 domain (127 aa)
initn: 134 init1: 85 opt: 126 Z-score: 171.3 bits: 38.1 E(85289): 0.0084
Smith-Waterman score: 126; 29.4% identity (58.7% similar) in 109 aa overlap (68-165:17-118)
40 50 60 70 80 90
pF1KE2 TFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS--
: : .: .::::::. ...:: :
NP_001 MWDKQKEVFLPSTPGLGMHVEV----KDPDGKVV---LSRQYGSEG
10 20 30
100 110 120 130 140
pF1KE2 -FTFTASKNGTYKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFP---SENRVSALTQ
::::. : ...:. :.... :. . :..:.:::: .: ...... :
NP_001 RFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 MESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVF
.. : ... :::
NP_001 RARQLLDQVEQIQKEQDYQRASAYLLVI
100 110 120
224 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:43:21 2016 done: Tue Nov 8 16:43:21 2016
Total Scan time: 3.780 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]