Result of FASTA (omim) for
pFN21AE2562
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2562, 265 aa
1>>>pF1KE2562 265 - 265 aa - 265 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.1681+/-0.00037; mu= -3.2502+/- 0.023
mean_var=227.4562+/-45.827, 0's: 0 Z-trim(120.7): 48 B-trim: 380 in 1/59
Lambda= 0.085040
statistics sampled from 36167 (36224) to 36167 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.425), width: 16
Scan time: 5.730
The best scores are: opt bits E(85289)
NP_954654 (OMIM: 164040) nucleophosmin isoform 2 [ ( 265) 1765 228.8 7.8e-60
XP_005265977 (OMIM: 164040) PREDICTED: nucleophosm ( 230) 1504 196.8 3e-50
NP_001032827 (OMIM: 164040) nucleophosmin isoform ( 259) 1312 173.2 4.1e-43
NP_002511 (OMIM: 164040) nucleophosmin isoform 1 [ ( 294) 1312 173.3 4.5e-43
XP_011532866 (OMIM: 164040) PREDICTED: nucleophosm ( 230) 881 120.3 3.1e-27
NP_008924 (OMIM: 606456) nucleoplasmin-3 [Homo sap ( 178) 347 54.7 1.3e-07
XP_011542665 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033
NP_877724 (OMIM: 608073) nucleoplasmin-2 isoform 1 ( 214) 257 43.8 0.00033
XP_011542664 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033
XP_016868438 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033
XP_016868437 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033
NP_001273609 (OMIM: 608073) nucleoplasmin-2 isofor ( 214) 257 43.8 0.00033
XP_011542662 (OMIM: 608073) PREDICTED: nucleoplasm ( 289) 251 43.1 0.00069
NP_001273610 (OMIM: 608073) nucleoplasmin-2 isofor ( 136) 227 39.9 0.0029
NP_005372 (OMIM: 164035) nucleolin [Homo sapiens] ( 710) 232 41.1 0.007
>>NP_954654 (OMIM: 164040) nucleophosmin isoform 2 [Homo (265 aa)
initn: 1765 init1: 1765 opt: 1765 Z-score: 1195.2 bits: 228.8 E(85289): 7.8e-60
Smith-Waterman score: 1765; 100.0% identity (100.0% similar) in 265 aa overlap (1-265:1-265)
10 20 30 40 50 60
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFI
190 200 210 220 230 240
250 260
pF1KE2 NYVKNCFRMTDQEAIQDLWQWRKSL
:::::::::::::::::::::::::
NP_954 NYVKNCFRMTDQEAIQDLWQWRKSL
250 260
>>XP_005265977 (OMIM: 164040) PREDICTED: nucleophosmin i (230 aa)
initn: 1504 init1: 1504 opt: 1504 Z-score: 1023.0 bits: 196.8 E(85289): 3e-50
Smith-Waterman score: 1504; 100.0% identity (100.0% similar) in 228 aa overlap (1-228:1-228)
10 20 30 40 50 60
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFI
::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKAH
190 200 210 220 230
250 260
pF1KE2 NYVKNCFRMTDQEAIQDLWQWRKSL
>>NP_001032827 (OMIM: 164040) nucleophosmin isoform 3 [H (259 aa)
initn: 1287 init1: 1287 opt: 1312 Z-score: 895.0 bits: 173.2 E(85289): 4.1e-43
Smith-Waterman score: 1436; 88.7% identity (88.7% similar) in 257 aa overlap (1-228:1-257)
10 20 30 40 50 60
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
130 140 150 160 170 180
190 200 210
pF1KE2 FDDEEAEEKAPVKK-----------------------------GQESFKKQEKTPKTPKG
:::::::::::::: :::::::::::::::::
NP_001 FDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKG
190 200 210 220 230 240
220 230 240 250 260
pF1KE2 PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
:::::::::::::::::
NP_001 PSSVEDIKAKMQASIEKAH
250
>>NP_002511 (OMIM: 164040) nucleophosmin isoform 1 [Homo (294 aa)
initn: 1287 init1: 1287 opt: 1312 Z-score: 894.2 bits: 173.3 E(85289): 4.5e-43
Smith-Waterman score: 1697; 90.1% identity (90.1% similar) in 294 aa overlap (1-265:1-294)
10 20 30 40 50 60
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
130 140 150 160 170 180
190 200 210
pF1KE2 FDDEEAEEKAPVKK-----------------------------GQESFKKQEKTPKTPKG
:::::::::::::: :::::::::::::::::
NP_002 FDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKG
190 200 210 220 230 240
220 230 240 250 260
pF1KE2 PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
250 260 270 280 290
>>XP_011532866 (OMIM: 164040) PREDICTED: nucleophosmin i (230 aa)
initn: 856 init1: 856 opt: 881 Z-score: 609.9 bits: 120.3 E(85289): 3.1e-27
Smith-Waterman score: 1266; 87.4% identity (87.4% similar) in 230 aa overlap (65-265:1-230)
40 50 60 70 80 90
pF1KE2 NDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEI
::::::::::::::::::::::::::::::
XP_011 MNYEGSPIKVTLATLKMSVQPTVSLGGFEI
10 20 30
100 110 120 130 140 150
pF1KE2 TPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQK
40 50 60 70 80 90
160 170 180 190
pF1KE2 KVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKK--------------------
::::::::::::::::::::::::::::::::::::::::
XP_011 KVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDS
100 110 120 130 140 150
200 210 220 230 240
pF1KE2 ---------GQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKN
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKN
160 170 180 190 200 210
250 260
pF1KE2 CFRMTDQEAIQDLWQWRKSL
::::::::::::::::::::
XP_011 CFRMTDQEAIQDLWQWRKSL
220 230
>>NP_008924 (OMIM: 606456) nucleoplasmin-3 [Homo sapiens (178 aa)
initn: 344 init1: 280 opt: 347 Z-score: 257.4 bits: 54.7 E(85289): 1.3e-07
Smith-Waterman score: 347; 40.8% identity (70.7% similar) in 147 aa overlap (10-146:30-176)
10 20 30
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKAD-KDYHFKVDN-DEN
.:. ....:::::.. ... :::.. :.
NP_008 MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE2 EHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPV
:: :.: . : ::::: ..::. : :.. . : : .:.::.: :: .:: :.. :::
NP_008 EHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPV
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE2 VLRLKCGSGPVHISGQHLVAV------EEDAESEDEE--EEDVKLLSISGKRSAPGGGSK
..::: :::::.:.:.: ... ::..: :.:. ::.:.: : .. :
NP_008 TFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP
130 140 150 160 170
160 170 180 190 200 210
pF1KE2 VPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPK
>>XP_011542665 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa)
initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033
Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214)
10 20 30 40 50
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH
:.::::. .. . :. . . .. .: :.:. :: ::.:.:
XP_011 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL
:: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::.
XP_011 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER
70 80 90 100 110 120
120 130 140 150 160
pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED
. ::..: :.::::: . .:: ....: : ::::....: .
XP_011 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ
. ..:: : . .: .: : : :::
XP_011 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK
190 200 210
230 240 250 260
pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
>>NP_877724 (OMIM: 608073) nucleoplasmin-2 isoform 1 [Ho (214 aa)
initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033
Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214)
10 20 30 40 50
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH
:.::::. .. . :. . . .. .: :.:. :: ::.:.:
NP_877 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL
:: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::.
NP_877 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER
70 80 90 100 110 120
120 130 140 150 160
pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED
. ::..: :.::::: . .:: ....: : ::::....: .
NP_877 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ
. ..:: : . .: .: : : :::
NP_877 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK
190 200 210
230 240 250 260
pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
>>XP_011542664 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa)
initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033
Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214)
10 20 30 40 50
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH
:.::::. .. . :. . . .. .: :.:. :: ::.:.:
XP_011 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL
:: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::.
XP_011 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER
70 80 90 100 110 120
120 130 140 150 160
pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED
. ::..: :.::::: . .:: ....: : ::::....: .
XP_011 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ
. ..:: : . .: .: : : :::
XP_011 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK
190 200 210
230 240 250 260
pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
>>XP_016868438 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa)
initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033
Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214)
10 20 30 40 50
pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH
:.::::. .. . :. . . .. .: :.:. :: ::.:.:
XP_016 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL
:: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::.
XP_016 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER
70 80 90 100 110 120
120 130 140 150 160
pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED
. ::..: :.::::: . .:: ....: : ::::....: .
XP_016 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ
. ..:: : . .: .: : : :::
XP_016 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK
190 200 210
230 240 250 260
pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
265 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 10:58:27 2016 done: Tue Nov 8 10:58:28 2016
Total Scan time: 5.730 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]