Result of FASTA (omim) for
pFN21AE2541
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2541, 323 aa
1>>>pF1KE2541 323 - 323 aa - 323 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8791+/-0.000425; mu= 17.8513+/- 0.026
mean_var=62.3130+/-12.885, 0's: 0 Z-trim(110.5): 59 B-trim: 68 in 1/49
Lambda= 0.162474
statistics sampled from 18757 (18816) to 18757 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.221), width: 16
Scan time: 5.870
The best scores are: opt bits E(85289)
NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [H ( 323) 2156 514.3 1.4e-145
NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1 ( 352) 2156 514.3 1.5e-145
XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 ( 316) 2072 494.6 1.2e-139
NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [ ( 301) 1987 474.6 1.1e-133
NP_001304316 (OMIM: 600308) aquaporin-4 isoform de ( 296) 1362 328.1 1.4e-89
NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens ( 265) 796 195.4 1.1e-49
NP_036196 (OMIM: 154050,615274) lens fiber major i ( 263) 792 194.5 2.1e-49
NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo ( 271) 776 190.7 2.9e-48
NP_932766 (OMIM: 107776,110450) aquaporin-1 isofor ( 269) 722 178.1 1.8e-44
NP_001316801 (OMIM: 107776,110450) aquaporin-1 iso ( 323) 717 177.0 4.8e-44
XP_005268895 (OMIM: 600442) PREDICTED: aquaporin-5 ( 222) 677 167.5 2.4e-41
NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens ( 282) 664 164.5 2.4e-40
XP_016874795 (OMIM: 154050,615274) PREDICTED: lens ( 144) 424 108.0 1.2e-23
XP_011536656 (OMIM: 154050,615274) PREDICTED: lens ( 168) 417 106.4 4.2e-23
NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens ( 261) 395 101.4 2.1e-21
XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 ( 262) 395 101.4 2.1e-21
XP_011544125 (OMIM: 603750) PREDICTED: aquaporin-8 ( 148) 211 58.1 1.3e-08
NP_001307564 (OMIM: 602914) aquaporin-9 isoform 2 ( 193) 194 54.2 2.5e-07
NP_066190 (OMIM: 602914) aquaporin-9 isoform 1 [Ho ( 295) 196 54.8 2.6e-07
NP_001305073 (OMIM: 600170,607457) aquaporin-3 iso ( 237) 179 50.8 3.4e-06
NP_004916 (OMIM: 600170,607457) aquaporin-3 isofor ( 292) 179 50.8 4e-06
NP_001307565 (OMIM: 602914) aquaporin-9 isoform 3 ( 230) 161 46.5 6.2e-05
NP_001305086 (OMIM: 602974,614411) aquaporin-7 iso ( 256) 156 45.4 0.00015
NP_001305087 (OMIM: 602974,614411) aquaporin-7 iso ( 257) 156 45.4 0.00015
XP_016870189 (OMIM: 602974,614411) PREDICTED: aqua ( 341) 156 45.5 0.00019
NP_001161 (OMIM: 602974,614411) aquaporin-7 isofor ( 342) 156 45.5 0.00019
XP_005251510 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 156 45.5 0.00019
XP_011516168 (OMIM: 602974,614411) PREDICTED: aqua ( 342) 156 45.5 0.00019
NP_536354 (OMIM: 606578) aquaporin-10 [Homo sapien ( 301) 151 44.3 0.00039
XP_016870192 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047
XP_016870190 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047
XP_016870193 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047
XP_016870191 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047
XP_016870194 (OMIM: 602974,614411) PREDICTED: aqua ( 250) 149 43.7 0.00047
XP_011508406 (OMIM: 606578) PREDICTED: aquaporin-1 ( 302) 141 41.9 0.002
XP_016870195 (OMIM: 602974,614411) PREDICTED: aqua ( 200) 133 39.9 0.0053
NP_001305085 (OMIM: 602974,614411) aquaporin-7 iso ( 216) 133 39.9 0.0056
XP_006716828 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 133 40.0 0.007
XP_011516169 (OMIM: 602974,614411) PREDICTED: aqua ( 285) 133 40.0 0.007
>>NP_001641 (OMIM: 600308) aquaporin-4 isoform M1 [Homo (323 aa)
initn: 2156 init1: 2156 opt: 2156 Z-score: 2734.7 bits: 514.3 E(85289): 1.4e-145
Smith-Waterman score: 2156; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
250 260 270 280 290 300
310 320
pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV
:::::::::::::::::::::::
NP_001 VIDVDRGEEKKGKDQSGEVLSSV
310 320
>>NP_001304313 (OMIM: 600308) aquaporin-4 isoform M1x [H (352 aa)
initn: 2156 init1: 2156 opt: 2156 Z-score: 2734.2 bits: 514.3 E(85289): 1.5e-145
Smith-Waterman score: 2156; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323)
10 20 30 40 50 60
pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
250 260 270 280 290 300
310 320
pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV
:::::::::::::::::::::::
NP_001 VIDVDRGEEKKGKDQSGEVLSSVXLEDRTESRQDSLELSSDFLPPIKETDLL
310 320 330 340 350
>>XP_011524244 (OMIM: 600308) PREDICTED: aquaporin-4 iso (316 aa)
initn: 2072 init1: 2072 opt: 2072 Z-score: 2628.4 bits: 494.6 E(85289): 1.2e-139
Smith-Waterman score: 2072; 100.0% identity (100.0% similar) in 312 aa overlap (12-323:5-316)
10 20 30 40 50 60
pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFEIKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
240 250 260 270 280 290
310 320
pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV
:::::::::::::::::::::::
XP_011 VIDVDRGEEKKGKDQSGEVLSSV
300 310
>>NP_004019 (OMIM: 600308) aquaporin-4 isoform M23 [Homo (301 aa)
initn: 1987 init1: 1987 opt: 1987 Z-score: 2521.0 bits: 474.6 E(85289): 1.1e-133
Smith-Waterman score: 1987; 100.0% identity (100.0% similar) in 301 aa overlap (23-323:1-301)
10 20 30 40 50 60
pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
::::::::::::::::::::::::::::::::::::::
NP_004 MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
10 20 30
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
220 230 240 250 260 270
310 320
pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV
:::::::::::::::::::::::
NP_004 VIDVDRGEEKKGKDQSGEVLSSV
280 290 300
>>NP_001304316 (OMIM: 600308) aquaporin-4 isoform delta4 (296 aa)
initn: 1362 init1: 1362 opt: 1362 Z-score: 1729.4 bits: 328.1 E(85289): 1.4e-89
Smith-Waterman score: 1892; 91.6% identity (91.6% similar) in 323 aa overlap (1-323:1-296)
10 20 30 40 50 60
pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
::::::::::::::::::::::::: ::::::::
NP_001 KRTDVTGSIALAIGFSVAIGHLFAI---------------------------YWVGPIIG
190 200 210
250 260 270 280 290 300
pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
220 230 240 250 260 270
310 320
pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV
:::::::::::::::::::::::
NP_001 VIDVDRGEEKKGKDQSGEVLSSV
280 290
>>NP_001642 (OMIM: 600442) aquaporin-5 [Homo sapiens] (265 aa)
initn: 806 init1: 555 opt: 796 Z-score: 1013.1 bits: 195.4 E(85289): 1.1e-49
Smith-Waterman score: 796; 50.2% identity (77.2% similar) in 263 aa overlap (27-288:3-254)
10 20 30 40 50 60
pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
: : . :: ::: ::::: ::::...:::...:
NP_001 MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWP
10 20 30
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
.. ::. .. :.: :::.:.:..: .: .::::::::.:.:.. .::. .. ::.:
NP_001 SA---LPT-ILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
:: .::: :::::: :.: .. :.:.:. ...: : :....::::.::::.. :::: ::
NP_001 AQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDS
100 110 120 130 140 150
190 200 210 220 230
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWE-NHWIYWVGPII
.::. .:: ::.::.::..::: .: .:: ::::::::::::.:. . ::..:::::.
NP_001 RRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIV
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE2 GAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVV
:::::. :: :.. :. . ..:. . ::.: :: . : :
NP_001 GAVLAAILYFYLLFPN-------SLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR
220 230 240 250 260
300 310 320
pF1KE2 HVIDVDRGEEKKGKDQSGEVLSSV
>>NP_036196 (OMIM: 154050,615274) lens fiber major intri (263 aa)
initn: 792 init1: 695 opt: 792 Z-score: 1008.0 bits: 194.5 E(85289): 2.1e-49
Smith-Waterman score: 792; 44.7% identity (77.8% similar) in 257 aa overlap (31-287:6-251)
10 20 30 40 50 60
pF1KE2 MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG
. .::.:. :::.: :..:...:::.. :.
NP_036 MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWA
10 20 30
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
: :. .. ... :::..::.:: :::::.:.::::: :.. ..:. .. :.:
NP_036 ----PGPLHVLQVAMAFGLALATLVQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
:: :::. ::..:: ::::.: :.:... .: ...:.. ::...:.:.:. :::. :
NP_036 AQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDE
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
.:. ::.:::.:::.:.::::.. ::::.:::::::.::.. ::. :::.::::::::
NP_036 RRNGQLGSVALAVGFSLALGHLFGMYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPIIG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
. :.. ::.... : :.: ..:. . ::. .: ... .:
NP_036 GGLGSLLYDFLLFP------RLK-SISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL
220 230 240 250 260
310 320
pF1KE2 VIDVDRGEEKKGKDQSGEVLSSV
>>NP_000477 (OMIM: 107777,125800) aquaporin-2 [Homo sapi (271 aa)
initn: 775 init1: 677 opt: 776 Z-score: 987.6 bits: 190.7 E(85289): 2.9e-48
Smith-Waterman score: 776; 51.4% identity (82.9% similar) in 222 aa overlap (33-254:8-225)
10 20 30 40 50 60
pF1KE2 DRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGT
:: .:: ::::: :.::...:::..::
NP_000 MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNW---
10 20 30
70 80 90 100 110 120
pF1KE2 EKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQ
. :: ... :.. :::.:.:.:: .:::::.::::::::: . ..:. ...::.:::
NP_000 PQALP-SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQ
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 CLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKR
:::. ::..:. .:: .. : :.:. . .. :::... :::..:.:::. :::: : .:
NP_000 LLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 TDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAV
. :. ::.::::::.:::..:.::: :::::::..:::. :....::..:.::..::.
NP_000 GENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAI
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 LAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVI
:.. ::.::. :
NP_000 LGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
220 230 240 250 260 270
>>NP_932766 (OMIM: 107776,110450) aquaporin-1 isoform 1 (269 aa)
initn: 698 init1: 608 opt: 722 Z-score: 919.2 bits: 178.1 E(85289): 1.8e-44
Smith-Waterman score: 722; 45.2% identity (75.7% similar) in 259 aa overlap (34-288:10-265)
10 20 30 40 50 60
pF1KE2 RPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG---
::.::.::::: .::..:.::....
NP_932 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPV
10 20 30
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
:... : : .:: :::::::..: :::::.:.:::::.... . .::: ....::
NP_932 GNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYII
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
:::.:::....:: .: . ..:: . . ....:.:: .:.: :.:::. ..:. :
NP_932 AQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
.: :. :: ::::.:::.:::.::.::: ..::::::: ::: :. ::::.::::.::
NP_932 RRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIG
160 170 180 190 200 210
250 260 270 280 290
pF1KE2 AVLAGGLYEYVFCP-DVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVV
..:: .:.... : . .. : : : :.. ....: :.::
NP_932 GALAVLIYDFILAPRSSDLTDRVKVWTSG---QVEEYDLDADDINSRVEMKPK
220 230 240 250 260
300 310 320
pF1KE2 HVIDVDRGEEKKGKDQSGEVLSSV
>>NP_001316801 (OMIM: 107776,110450) aquaporin-1 isoform (323 aa)
initn: 720 init1: 630 opt: 717 Z-score: 911.8 bits: 177.0 E(85289): 4.8e-44
Smith-Waterman score: 717; 48.7% identity (79.5% similar) in 224 aa overlap (34-254:10-233)
10 20 30 40 50 60
pF1KE2 RPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWG---
::.::.::::: .::..:.::....
NP_001 MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPV
10 20 30
70 80 90 100 110 120
pF1KE2 GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA
:... : : .:: :::::::..: :::::.:.:::::.... . .::: ....::
NP_001 GNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYII
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 AQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS
:::.:::....:: .: . ..:: . . ....:.:: .:.: :.:::. ..:. :
NP_001 AQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
.: :. :: ::::.:::.:::.::.::: ..::::::: ::: :. ::::.::::.::
NP_001 RRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 AVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
..:: .:.... :
NP_001 GALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRSFLGTKIYQFTHSLEV
220 230 240 250 260 270
323 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:42:06 2016 done: Tue Nov 8 03:42:07 2016
Total Scan time: 5.870 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]