Result of FASTA (omim) for
pFN21AE2483
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2483, 335 aa
1>>>pF1KE2483 335 - 335 aa - 335 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5576+/-0.000476; mu= 15.0646+/- 0.029
mean_var=111.4255+/-20.649, 0's: 0 Z-trim(111.7): 143 B-trim: 33 in 1/52
Lambda= 0.121502
statistics sampled from 20178 (20355) to 20178 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.239), width: 16
Scan time: 7.240
The best scores are: opt bits E(85289)
NP_001108086 (OMIM: 602281) lactadherin isoform b ( 335) 2357 424.5 1.5e-118
NP_005919 (OMIM: 602281) lactadherin isoform a pre ( 387) 2040 369.0 9e-102
NP_001297249 (OMIM: 602281) lactadherin isoform c ( 379) 1880 341.0 2.5e-93
XP_016877695 (OMIM: 602281) PREDICTED: lactadherin ( 243) 1588 289.6 4.7e-78
NP_001297248 (OMIM: 602281) lactadherin isoform d ( 343) 1541 281.5 1.8e-75
NP_001297250 (OMIM: 602281) lactadherin isoform e ( 275) 1258 231.8 1.3e-60
NP_001265571 (OMIM: 606018) EGF-like repeat and di ( 470) 929 174.4 4.3e-43
NP_005702 (OMIM: 606018) EGF-like repeat and disco ( 480) 929 174.4 4.4e-43
XP_016856149 (OMIM: 188055,227400,600880,601367,61 (2087) 574 112.8 6.4e-24
NP_000121 (OMIM: 188055,227400,600880,601367,61230 (2224) 574 112.9 6.7e-24
NP_000123 (OMIM: 134500,300841,306700) coagulation (2351) 539 106.8 4.9e-22
NP_001019800 (OMIM: 602069) neuropilin-1 isoform c ( 609) 385 79.1 2.6e-14
XP_011518058 (OMIM: 602069) PREDICTED: neuropilin- ( 628) 385 79.2 2.7e-14
NP_001019799 (OMIM: 602069) neuropilin-1 isoform b ( 644) 385 79.2 2.7e-14
XP_011518057 (OMIM: 602069) PREDICTED: neuropilin- ( 656) 385 79.2 2.8e-14
XP_006717589 (OMIM: 602069) PREDICTED: neuropilin- ( 663) 385 79.2 2.8e-14
XP_016872355 (OMIM: 602069) PREDICTED: neuropilin- ( 742) 385 79.2 3e-14
XP_006717588 (OMIM: 602069) PREDICTED: neuropilin- ( 888) 385 79.3 3.4e-14
XP_006717587 (OMIM: 602069) PREDICTED: neuropilin- ( 889) 385 79.3 3.4e-14
XP_016872354 (OMIM: 602069) PREDICTED: neuropilin- ( 899) 385 79.3 3.4e-14
NP_001316997 (OMIM: 602069) neuropilin-1 isoform f ( 906) 385 79.3 3.4e-14
XP_006717585 (OMIM: 602069) PREDICTED: neuropilin- ( 907) 385 79.3 3.4e-14
NP_001231902 (OMIM: 602069) neuropilin-1 isoform e ( 916) 385 79.3 3.4e-14
NP_001231901 (OMIM: 602069) neuropilin-1 isoform d ( 917) 385 79.3 3.4e-14
NP_003864 (OMIM: 602069) neuropilin-1 isoform a pr ( 923) 385 79.3 3.5e-14
XP_006717584 (OMIM: 602069) PREDICTED: neuropilin- ( 924) 385 79.3 3.5e-14
NP_063916 (OMIM: 134500,300841,306700) coagulation ( 216) 324 68.0 2.2e-11
XP_016867439 (OMIM: 604569,610042,612100) PREDICTE ( 714) 237 53.3 1.9e-06
NP_054860 (OMIM: 604569,610042,612100) contactin-a (1331) 237 53.6 2.9e-06
NP_000321 (OMIM: 300839,312700) retinoschisin prec ( 224) 199 46.1 8.7e-05
NP_001171628 (OMIM: 609555) probable carboxypeptid ( 660) 204 47.4 9.8e-05
NP_062555 (OMIM: 609555) probable carboxypeptidase ( 734) 204 47.5 0.00011
NP_387504 (OMIM: 610517) contactin-associated prot (1288) 199 46.9 0.00028
NP_003623 (OMIM: 602346,616286) contactin-associat (1384) 189 45.2 0.001
XP_016880727 (OMIM: 602346,616286) PREDICTED: cont (1384) 189 45.2 0.001
XP_011510721 (OMIM: 608698) PREDICTED: discoidin, ( 699) 176 42.6 0.0031
NP_563615 (OMIM: 608698) discoidin, CUB and LCCL d ( 775) 176 42.6 0.0033
NP_001309108 (OMIM: 610518) contactin-associated p (1228) 178 43.2 0.0035
NP_620481 (OMIM: 610518) contactin-associated prot (1235) 178 43.2 0.0035
NP_001309107 (OMIM: 610518) contactin-associated p (1258) 178 43.2 0.0036
NP_001309119 (OMIM: 610518) contactin-associated p (1260) 178 43.2 0.0036
NP_001309117 (OMIM: 610518) contactin-associated p (1273) 178 43.2 0.0036
XP_011521705 (OMIM: 610518) PREDICTED: contactin-a (1283) 178 43.2 0.0036
NP_207837 (OMIM: 610518) contactin-associated prot (1308) 178 43.2 0.0037
NP_957716 (OMIM: 602070) neuropilin-2 isoform 6 pr ( 555) 165 40.5 0.01
>>NP_001108086 (OMIM: 602281) lactadherin isoform b prec (335 aa)
initn: 2357 init1: 2357 opt: 2357 Z-score: 2249.2 bits: 424.5 E(85289): 1.5e-118
Smith-Waterman score: 2357; 99.7% identity (100.0% similar) in 335 aa overlap (1-335:1-335)
10 20 30 40 50 60
pF1KE2 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQIFPGNWDNHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQIFPGNWDNHS
250 260 270 280 290 300
310 320 330
pF1KE2 HKKNLFETPILARYVRILPVAWHNRIALRLELLGC
:::::::::::::::::::::::::::::::::::
NP_001 HKKNLFETPILARYVRILPVAWHNRIALRLELLGC
310 320 330
>>NP_005919 (OMIM: 602281) lactadherin isoform a preprop (387 aa)
initn: 2214 init1: 2040 opt: 2040 Z-score: 1948.1 bits: 369.0 E(85289): 9e-102
Smith-Waterman score: 2103; 85.6% identity (85.8% similar) in 367 aa overlap (1-315:1-367)
10 20 30 40 50 60
pF1KE2 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
NP_005 YAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
190 200 210 220 230 240
250 260 270 280 290
pF1KE2 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQ----------
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVT
250 260 270 280 290 300
300
pF1KE2 ------------------------------------------IFPGNWDNHSHKKNLFET
::::::::::::::::::
NP_005 GIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFET
310 320 330 340 350 360
310 320 330
pF1KE2 PILARYVRILPVAWHNRIALRLELLGC
:::::::
NP_005 PILARYVRILPVAWHNRIALRLELLGC
370 380
>>NP_001297249 (OMIM: 602281) lactadherin isoform c [Hom (379 aa)
initn: 2054 init1: 1880 opt: 1880 Z-score: 1796.6 bits: 341.0 E(85289): 2.5e-93
Smith-Waterman score: 1943; 84.5% identity (84.8% similar) in 343 aa overlap (25-315:17-359)
10 20 30 40 50 60
pF1KE2 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
::::::::::::::::::::::::::::::::::::
NP_001 MWPFPEGGNTIPILHTDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 YAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
180 190 200 210 220 230
250 260 270 280 290
pF1KE2 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQ----------
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVT
240 250 260 270 280 290
300
pF1KE2 ------------------------------------------IFPGNWDNHSHKKNLFET
::::::::::::::::::
NP_001 GIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFET
300 310 320 330 340 350
310 320 330
pF1KE2 PILARYVRILPVAWHNRIALRLELLGC
:::::::
NP_001 PILARYVRILPVAWHNRIALRLELLGC
360 370
>>XP_016877695 (OMIM: 602281) PREDICTED: lactadherin iso (243 aa)
initn: 1588 init1: 1588 opt: 1588 Z-score: 1522.4 bits: 289.6 E(85289): 4.7e-78
Smith-Waterman score: 1588; 99.6% identity (100.0% similar) in 228 aa overlap (1-228:1-228)
10 20 30 40 50 60
pF1KE2 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_016 YAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNARKADLRRGADD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQIFPGNWDNHS
XP_016 REQ
>>NP_001297248 (OMIM: 602281) lactadherin isoform d prec (343 aa)
initn: 1791 init1: 1540 opt: 1541 Z-score: 1476.0 bits: 281.5 E(85289): 1.8e-75
Smith-Waterman score: 1667; 73.3% identity (73.8% similar) in 367 aa overlap (1-315:1-323)
10 20 30 40 50 60
pF1KE2 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKG
::::::::::::::::::::::::.
NP_001 MPRPRLLAALCGALLCAPSLLVALE-----------------------------------
10 20
70 80 90 100 110 120
pF1KE2 YAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
::::::.::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---------CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPS
30 40 50 60 70
130 140 150 160 170 180
pF1KE2 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHK
80 90 100 110 120 130
190 200 210 220 230 240
pF1KE2 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNS
140 150 160 170 180 190
250 260 270 280 290
pF1KE2 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQ----------
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVT
200 210 220 230 240 250
300
pF1KE2 ------------------------------------------IFPGNWDNHSHKKNLFET
::::::::::::::::::
NP_001 GIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFET
260 270 280 290 300 310
310 320 330
pF1KE2 PILARYVRILPVAWHNRIALRLELLGC
:::::::
NP_001 PILARYVRILPVAWHNRIALRLELLGC
320 330 340
>>NP_001297250 (OMIM: 602281) lactadherin isoform e [Hom (275 aa)
initn: 1258 init1: 1258 opt: 1258 Z-score: 1209.1 bits: 231.8 E(85289): 1.3e-60
Smith-Waterman score: 1321; 79.6% identity (79.6% similar) in 255 aa overlap (113-315:1-255)
90 100 110 120 130 140
pF1KE2 NSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVV
::::::::::::::::::::::::::::::
NP_001 MVNAWTPSSNDDNPWIQVNLLRRMWVTGVV
10 20 30
150 160 170 180 190 200
pF1KE2 TQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEA
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE2 QYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSW
100 110 120 130 140 150
270 280 290
pF1KE2 NPSYARLDKQGNFNAWVAGSYGNDQWLQ--------------------------------
::::::::::::::::::::::::::::
NP_001 NPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVA
160 170 180 190 200 210
300 310 320 330
pF1KE2 --------------------IFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRL
:::::::::::::::::::::::::
NP_001 YSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRL
220 230 240 250 260 270
pF1KE2 ELLGC
NP_001 ELLGC
>>NP_001265571 (OMIM: 606018) EGF-like repeat and discoi (470 aa)
initn: 937 init1: 441 opt: 929 Z-score: 894.6 bits: 174.4 E(85289): 4.3e-43
Smith-Waterman score: 938; 45.4% identity (68.7% similar) in 313 aa overlap (19-291:60-370)
10 20 30 40
pF1KE2 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGD
: .: . :. ::::::: :: ::. :::
NP_001 PCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVGPCTPNPCHNGGTCE-ISEAYRGD
30 40 50 60 70 80
50 60 70
pF1KE2 VFPSYTCTCLKGYAGNHCET--------------------------------------KC
.: .:.: : .:. : ::. ::
NP_001 TFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKC
90 100 110 120 130 140
80 90 100 110 120 130
pF1KE2 VEPLGMENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQV
:::.:.: :.:.::.:::.. ...:::.: : ::::. :..:::: . :: ::::.
NP_001 SGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQI
150 160 170 180 190 200
140 150 160 170 180
pF1KE2 NLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFV--GNWNK
:: :.: ::::.::::.:..: ::.:..:.::: .:. . .. :. ....: :: ..
NP_001 NLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWA-MYKVKGTNEDMVFRGNIDN
210 220 230 240 250 260
190 200 210 220 230 240
pF1KE2 NAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITA
:. ..: : :..:::::::: :. ::::.:::::::.::..:::.:.. : : ::::
NP_001 NTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITA
270 280 290 300 310 320
250 260 270 280 290 300
pF1KE2 SSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQIFPGNWDNHSHKKNLFET
:: ..: .. .:.:.: :::::::. :::..: ..::::.
NP_001 SSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAK
330 340 350 360 370 380
310 320 330
pF1KE2 PILARYVRILPVAWHNRIALRLELLGC
NP_001 DFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIR
390 400 410 420 430 440
>--
initn: 299 init1: 205 opt: 206 Z-score: 209.7 bits: 47.6 E(85289): 6.1e-05
Smith-Waterman score: 206; 42.3% identity (77.5% similar) in 71 aa overlap (265-335:397-466)
240 250 260 270 280 290
pF1KE2 GLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQIFPG
:: .: ... . :.. . ... ..: :
NP_001 WLQVDLLVPTKVTGIITQGAKDFGHVQFVGSY-KLAYSNDGEHWTVYQDEKQRKDKVFQG
370 380 390 400 410 420
300 310 320 330
pF1KE2 NWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC
:.:: .:.::... :: ::..:::: .:..::.:: :::::
NP_001 NFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
430 440 450 460 470
>>NP_005702 (OMIM: 606018) EGF-like repeat and discoidin (480 aa)
initn: 933 init1: 441 opt: 929 Z-score: 894.5 bits: 174.4 E(85289): 4.4e-43
Smith-Waterman score: 934; 45.9% identity (69.2% similar) in 305 aa overlap (27-291:78-380)
10 20 30 40 50
pF1KE2 MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCT
:. ::::::: :: ::. :::.: .:.:
NP_005 CECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCE-ISEAYRGDTFIGYVCK
50 60 70 80 90 100
60 70
pF1KE2 CLKGYAGNHCET--------------------------------------KCVEPLGMEN
: .:. : ::. :: :::.:.
NP_005 CPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEG
110 120 130 140 150 160
80 90 100 110 120 130
pF1KE2 GNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWV
: :.:.::.:::.. ...:::.: : ::::. :..:::: . :: ::::.:: :.: :
NP_005 GIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRV
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE2 TGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFV--GNWNKNAVHVNLF
:::.::::.:..: ::.:..:.::: .:. . .. :. ....: :: ..:. ..: :
NP_005 TGVITQGAKRIGSPEYIKSYKIAYSNDGKTWA-MYKVKGTNEDMVFRGNIDNNTPYANSF
230 240 250 260 270 280
200 210 220 230 240 250
pF1KE2 ETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWG
:..:::::::: :. ::::.:::::::.::..:::.:.. : : :::::: ..: .
NP_005 TPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLN
290 300 310 320 330 340
260 270 280 290 300 310
pF1KE2 LHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQIFPGNWDNHSHKKNLFETPILARYVR
. .:.:.: :::::::. :::..: ..::::.
NP_005 MDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFV
350 360 370 380 390 400
320 330
pF1KE2 ILPVAWHNRIALRLELLGC
NP_005 GSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYG
410 420 430 440 450 460
>--
initn: 299 init1: 205 opt: 206 Z-score: 209.5 bits: 47.6 E(85289): 6.2e-05
Smith-Waterman score: 206; 42.3% identity (77.5% similar) in 71 aa overlap (265-335:407-476)
240 250 260 270 280 290
pF1KE2 GLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQIFPG
:: .: ... . :.. . ... ..: :
NP_005 WLQVDLLVPTKVTGIITQGAKDFGHVQFVGSY-KLAYSNDGEHWTVYQDEKQRKDKVFQG
380 390 400 410 420 430
300 310 320 330
pF1KE2 NWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC
:.:: .:.::... :: ::..:::: .:..::.:: :::::
NP_005 NFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
440 450 460 470 480
>>XP_016856149 (OMIM: 188055,227400,600880,601367,612309 (2087 aa)
initn: 599 init1: 240 opt: 574 Z-score: 550.4 bits: 112.8 E(85289): 6.4e-24
Smith-Waterman score: 574; 42.1% identity (67.1% similar) in 228 aa overlap (70-291:1770-1988)
40 50 60 70 80 90
pF1KE2 EISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQ
: :.:. .: :..::: :: :::
XP_016 SKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASE----FLG--
1740 1750 1760 1770 1780 1790
100 110 120 130 140 150
pF1KE2 HWVPELARLNRAGMVNAWT----PSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYL
.: :.::::: .: :::. . ..:::::.. ... .::. ::::.. . :
XP_016 YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYT
1800 1810 1820 1830 1840 1850
160 170 180 190 200 210
pF1KE2 KAFKVAYSLNGHEFD-FIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHT
: :::: : ... : . ... : :: . .... : :. :. :.:.:. :: ..
XP_016 TEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYN
1860 1870 1880 1890 1900 1910
220 230 240 250 260 270
pF1KE2 ACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTW-GLHLFSWNPSYARLDKQG
:::.:: :::.:::..:::..:..: .::::::: :.: : . :.: :::. ::
XP_016 RPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDY---WEPFRARLNAQG
1920 1930 1940 1950 1960 1970
280 290 300 310 320 330
pF1KE2 NFNAWVAGSYGNDQWLQIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELL
::: : . .: :::.:
XP_016 RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPY
1980 1990 2000 2010 2020 2030
>>NP_000121 (OMIM: 188055,227400,600880,601367,612309,61 (2224 aa)
initn: 599 init1: 240 opt: 574 Z-score: 550.1 bits: 112.9 E(85289): 6.7e-24
Smith-Waterman score: 574; 42.1% identity (67.1% similar) in 228 aa overlap (70-291:1907-2125)
40 50 60 70 80 90
pF1KE2 EISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQ
: :.:. .: :..::: :: :::
NP_000 SKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASE----FLG--
1880 1890 1900 1910 1920 1930
100 110 120 130 140 150
pF1KE2 HWVPELARLNRAGMVNAWT----PSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYL
.: :.::::: .: :::. . ..:::::.. ... .::. ::::.. . :
NP_000 YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYT
1940 1950 1960 1970 1980 1990
160 170 180 190 200 210
pF1KE2 KAFKVAYSLNGHEFD-FIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHT
: :::: : ... : . ... : :: . .... : :. :. :.:.:. :: ..
NP_000 TEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYN
2000 2010 2020 2030 2040 2050
220 230 240 250 260 270
pF1KE2 ACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTW-GLHLFSWNPSYARLDKQG
:::.:: :::.:::..:::..:..: .::::::: :.: : . :.: :::. ::
NP_000 RPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDY---WEPFRARLNAQG
2060 2070 2080 2090 2100
280 290 300 310 320 330
pF1KE2 NFNAWVAGSYGNDQWLQIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELL
::: : . .: :::.:
NP_000 RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPY
2110 2120 2130 2140 2150 2160
335 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:45:59 2016 done: Mon Nov 7 20:46:00 2016
Total Scan time: 7.240 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]