Result of FASTA (omim) for
pFN21AE2458
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2458, 276 aa
1>>>pF1KE2458 276 - 276 aa - 276 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9887+/-0.000446; mu= 11.6773+/- 0.028
mean_var=88.0260+/-17.354, 0's: 0 Z-trim(110.8): 114 B-trim: 298 in 2/51
Lambda= 0.136700
statistics sampled from 19095 (19202) to 19095 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.225), width: 16
Scan time: 6.390
The best scores are: opt bits E(85289)
NP_008929 (OMIM: 609202) secretagogin [Homo sapien ( 276) 1827 370.6 1.8e-102
XP_016865670 (OMIM: 609202) PREDICTED: secretagogi ( 222) 1455 297.2 1.8e-80
NP_001731 (OMIM: 114051) calretinin isoform 1 [Hom ( 271) 611 130.8 2.8e-30
NP_004920 (OMIM: 114050) calbindin [Homo sapiens] ( 261) 561 120.9 2.5e-27
NP_009019 (OMIM: 114051) calretinin isoform 22k [H ( 192) 466 102.1 8.5e-22
>>NP_008929 (OMIM: 609202) secretagogin [Homo sapiens] (276 aa)
initn: 1827 init1: 1827 opt: 1827 Z-score: 1960.6 bits: 370.6 E(85289): 1.8e-102
Smith-Waterman score: 1827; 100.0% identity (100.0% similar) in 276 aa overlap (1-276:1-276)
10 20 30 40 50 60
pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 QENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGV
190 200 210 220 230 240
250 260 270
pF1KE2 DLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP
::::::::::::::::::::::::::::::::::::
NP_008 DLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP
250 260 270
>>XP_016865670 (OMIM: 609202) PREDICTED: secretagogin is (222 aa)
initn: 1455 init1: 1455 opt: 1455 Z-score: 1565.5 bits: 297.2 E(85289): 1.8e-80
Smith-Waterman score: 1455; 100.0% identity (100.0% similar) in 222 aa overlap (55-276:1-222)
30 40 50 60 70 80
pF1KE2 DADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLHKVKQQFMTTQDASKDGRIRMKELA
::::::::::::::::::::::::::::::
XP_016 MKANLHKVKQQFMTTQDASKDGRIRMKELA
10 20 30
90 100 110 120 130 140
pF1KE2 GMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKA
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE2 ISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEK
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE2 IFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKS
160 170 180 190 200 210
270
pF1KE2 ELALCLGLKINP
::::::::::::
XP_016 ELALCLGLKINP
220
>>NP_001731 (OMIM: 114051) calretinin isoform 1 [Homo sa (271 aa)
initn: 343 init1: 317 opt: 611 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30
Smith-Waterman score: 611; 38.4% identity (71.1% similar) in 263 aa overlap (9-270:13-265)
10 20 30 40 50
pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHML-MKLGTDDTVM
:..: :. : ..:..:::: .:::: :::. :: .. . :.
NP_001 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 KANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWR
. :. . ..:: : ..::.:.: ::: ..: .::::: ::.. . ::.:::. ::
NP_001 SDNFGEKMKEFMQKYDKNSDGKIEMAELA-QILPTEENFLLCFRQH--VGSSAEFMEAWR
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 KYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLA
:::.: ::.: : ::..:: ::. . .. .: ::.::: :....:: : ::.: :....
NP_001 KYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 RILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQP
:.: .::::::.:. ..:: :. ::..:: ...: .. :.:...::..: .
NP_001 RLLPVQENFLLKFQGMKLTSEE----FNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKK
180 190 200 210 220 230
240 250 260 270
pF1KE2 SISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP
.. .: ..:. .. .. . ::. ...: . :
NP_001 EMNIQQLTNYRKSVM---SLAEAGKLYRKDLEIVLCSEPPM
240 250 260 270
>>NP_004920 (OMIM: 114050) calbindin [Homo sapiens] (261 aa)
initn: 352 init1: 352 opt: 561 Z-score: 611.6 bits: 120.9 E(85289): 2.5e-27
Smith-Waterman score: 561; 37.6% identity (66.2% similar) in 263 aa overlap (12-271:11-259)
10 20 30 40 50 60
pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH
. :. :...: .:::: .::.: :::. .....: .:
NP_004 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQ----NLIQELQQARKKAGLELS
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD
. :. ::.: . ::: . : .:::::::: .. : : :::. :::::.:
NP_004 PEMKTFVDQYGQRDDGKIGIVELAHV-LPTEENFLLLFRCQQ-LKSCEEFMKTWRKYDTD
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL
:::: . ::.:::.::. . .:.....:: ::: :.:.:: :.::.:.:...::.: .
NP_004 HSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPV
120 130 140 150 160 170
190 200 210 220 230
pF1KE2 QENFLLQFK-MDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISG
::::::.:. . :. : :.: : :: . .: .. :.:...::. : . ...
NP_004 QENFLLKFQGIKMCGKE-----FNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDI
180 190 200 210 220
240 250 260 270
pF1KE2 VDLDKFREILLRHCDVNKDGKIQKSELAL--CLGLKINP
.. ... .. : ::. ...::: : :
NP_004 NNITTYKKNIMALSD---GGKLYRTDLALILCAGDN
230 240 250 260
>>NP_009019 (OMIM: 114051) calretinin isoform 22k [Homo (192 aa)
initn: 398 init1: 261 opt: 466 Z-score: 512.3 bits: 102.1 E(85289): 8.5e-22
Smith-Waterman score: 466; 44.2% identity (72.7% similar) in 172 aa overlap (9-179:13-181)
10 20 30 40 50
pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHML-MKLGTDDTVM
:..: :. : ..:..:::: .:::: :::. :: .. . :.
NP_009 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE2 KANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWR
. :. . ..:: : ..::.:.: ::: ..: .::::: ::.. . ::.:::. ::
NP_009 SDNFGEKMKEFMQKYDKNSDGKIEMAELA-QILPTEENFLLCFRQH--VGSSAEFMEAWR
70 80 90 100 110
120 130 140 150 160 170
pF1KE2 KYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLA
:::.: ::.: : ::..:: ::. . .. .: ::.::: :....:: : ::.: :....
NP_009 KYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 RILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQP
:: :
NP_009 RIEAATLTSMSWMPF
180 190
276 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:12:40 2016 done: Mon Nov 7 20:12:41 2016
Total Scan time: 6.390 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]