Result of FASTA (omim) for
pFN21AE2453
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2453, 885 aa
1>>>pF1KE2453 885 - 885 aa - 885 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0345+/-0.000416; mu= 13.0452+/- 0.026
mean_var=108.7258+/-22.599, 0's: 0 Z-trim(113.6): 209 B-trim: 0 in 0/58
Lambda= 0.123001
statistics sampled from 22753 (22963) to 22753 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.269), width: 16
Scan time: 11.530
The best scores are: opt bits E(85289)
NP_003710 (OMIM: 603390,609161,614190) high affini ( 885) 5951 1067.5 0
XP_005248678 (OMIM: 603390,609161,614190) PREDICTE ( 884) 5932 1064.2 0
XP_016865492 (OMIM: 603390,609161,614190) PREDICTE ( 812) 5377 965.7 0
XP_005248681 (OMIM: 603390,609161,614190) PREDICTE ( 783) 5210 936.0 0
XP_006714789 (OMIM: 603390,609161,614190) PREDICTE ( 905) 5209 935.9 0
XP_011542005 (OMIM: 603390,609161,614190) PREDICTE ( 780) 5204 935.0 0
XP_006714788 (OMIM: 603390,609161,614190) PREDICTE ( 906) 5205 935.2 0
XP_005248680 (OMIM: 603390,609161,614190) PREDICTE ( 784) 5203 934.8 0
XP_011542004 (OMIM: 603390,609161,614190) PREDICTE ( 774) 5201 934.4 0
XP_011542003 (OMIM: 603390,609161,614190) PREDICTE ( 805) 5201 934.4 0
XP_016865493 (OMIM: 603390,609161,614190) PREDICTE ( 773) 5194 933.2 0
XP_016865495 (OMIM: 603390,609161,614190) PREDICTE ( 761) 5131 922.0 0
NP_001025024 (OMIM: 603390,609161,614190) high aff ( 865) 5085 913.9 0
XP_011542001 (OMIM: 603390,609161,614190) PREDICTE ( 834) 4650 836.7 0
XP_016865496 (OMIM: 603390,609161,614190) PREDICTE ( 712) 4648 836.3 0
XP_011542006 (OMIM: 603390,609161,614190) PREDICTE ( 647) 4352 783.7 0
NP_001025025 (OMIM: 603390,609161,614190) high aff ( 838) 3679 664.4 6.5e-190
NP_002596 (OMIM: 602972) high affinity cAMP-specif ( 829) 3622 654.2 7.1e-187
NP_001230066 (OMIM: 602972) high affinity cAMP-spe ( 757) 3578 646.4 1.5e-184
XP_016865497 (OMIM: 603390,609161,614190) PREDICTE ( 687) 3340 604.2 7e-172
XP_016865494 (OMIM: 603390,609161,614190) PREDICTE ( 787) 3340 604.2 7.9e-172
NP_001025022 (OMIM: 603390,609161,614190) high aff ( 788) 3340 604.2 7.9e-172
XP_011542002 (OMIM: 603390,609161,614190) PREDICTE ( 809) 3340 604.2 8e-172
XP_016877798 (OMIM: 602972) PREDICTED: high affini ( 639) 3106 562.6 2.1e-159
NP_001025023 (OMIM: 603390,609161,614190) high aff ( 830) 3057 554.0 1.1e-156
XP_016877800 (OMIM: 602972) PREDICTED: high affini ( 582) 2831 513.8 9.4e-145
XP_011519970 (OMIM: 602972) PREDICTED: high affini ( 571) 2671 485.4 3.2e-136
NP_775656 (OMIM: 602972) high affinity cAMP-specif ( 783) 2672 485.6 3.8e-136
XP_016877797 (OMIM: 602972) PREDICTED: high affini ( 727) 2492 453.7 1.5e-126
XP_016877799 (OMIM: 602972) PREDICTED: high affini ( 596) 2316 422.4 3.1e-117
NP_001284371 (OMIM: 600127) cAMP-specific 3',5'-cy ( 503) 632 123.6 2.4e-27
XP_005270982 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 632 123.6 2.5e-27
XP_005270981 (OMIM: 600127) PREDICTED: cAMP-specif ( 517) 632 123.6 2.5e-27
XP_011539868 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 632 123.6 2.5e-27
XP_016856935 (OMIM: 600127) PREDICTED: cAMP-specif ( 530) 632 123.6 2.5e-27
XP_006710743 (OMIM: 600127) PREDICTED: cAMP-specif ( 531) 632 123.6 2.5e-27
NP_001032416 (OMIM: 600127) cAMP-specific 3',5'-cy ( 564) 632 123.6 2.7e-27
XP_016856934 (OMIM: 600127) PREDICTED: cAMP-specif ( 597) 632 123.6 2.8e-27
NP_001284369 (OMIM: 600127) cAMP-specific 3',5'-cy ( 644) 632 123.6 3e-27
NP_001284370 (OMIM: 600127) cAMP-specific 3',5'-cy ( 661) 632 123.6 3.1e-27
NP_001032417 (OMIM: 600127) cAMP-specific 3',5'-cy ( 721) 632 123.6 3.3e-27
NP_002591 (OMIM: 600127) cAMP-specific 3',5'-cycli ( 736) 632 123.6 3.4e-27
NP_001032418 (OMIM: 600127) cAMP-specific 3',5'-cy ( 736) 632 123.6 3.4e-27
XP_005259990 (OMIM: 600126) PREDICTED: cAMP-specif ( 582) 612 120.0 3.2e-26
NP_006193 (OMIM: 600126) cAMP-specific 3',5'-cycli ( 647) 612 120.1 3.5e-26
XP_011526357 (OMIM: 600126) PREDICTED: cAMP-specif ( 657) 612 120.1 3.6e-26
NP_001104779 (OMIM: 600126) cAMP-specific 3',5'-cy ( 825) 612 120.1 4.4e-26
NP_001104778 (OMIM: 600126) cAMP-specific 3',5'-cy ( 860) 612 120.1 4.5e-26
NP_001230050 (OMIM: 600126) cAMP-specific 3',5'-cy ( 864) 612 120.1 4.5e-26
XP_011526356 (OMIM: 600126) PREDICTED: cAMP-specif ( 864) 612 120.1 4.5e-26
>>NP_003710 (OMIM: 603390,609161,614190) high affinity c (885 aa)
initn: 5951 init1: 5951 opt: 5951 Z-score: 5709.1 bits: 1067.5 E(85289): 0
Smith-Waterman score: 5951; 100.0% identity (100.0% similar) in 885 aa overlap (1-885:1-885)
10 20 30 40 50 60
pF1KE2 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
790 800 810 820 830 840
850 860 870 880
pF1KE2 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
:::::::::::::::::::::::::::::::::::::::::::::
NP_003 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
850 860 870 880
>>XP_005248678 (OMIM: 603390,609161,614190) PREDICTED: h (884 aa)
initn: 5208 init1: 5208 opt: 5932 Z-score: 5690.9 bits: 1064.2 E(85289): 0
Smith-Waterman score: 5932; 99.9% identity (99.9% similar) in 885 aa overlap (1-885:1-884)
10 20 30 40 50 60
pF1KE2 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_005 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVK-VSSAEV
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
780 790 800 810 820 830
850 860 870 880
pF1KE2 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
840 850 860 870 880
>>XP_016865492 (OMIM: 603390,609161,614190) PREDICTED: h (812 aa)
initn: 4653 init1: 4653 opt: 5377 Z-score: 5159.2 bits: 965.7 E(85289): 0
Smith-Waterman score: 5377; 99.9% identity (99.9% similar) in 806 aa overlap (1-806:1-805)
10 20 30 40 50 60
pF1KE2 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVK-VSSAEV
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
::::::::::::::::::::::::::
XP_016 DVANPCRPLDLCIEWAGRISEEYFAQPLHICQP
780 790 800 810
>>XP_005248681 (OMIM: 603390,609161,614190) PREDICTED: h (783 aa)
initn: 5210 init1: 5210 opt: 5210 Z-score: 4999.3 bits: 936.0 E(85289): 0
Smith-Waterman score: 5210; 99.5% identity (99.6% similar) in 778 aa overlap (108-885:6-783)
80 90 100 110 120 130
pF1KE2 SSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLI
: :. ::::::::::::::::::::::::
XP_005 MDQLYCPPSACQVSSAEVRIGPMRLTQDPIQVLLI
10 20 30
140 150 160 170 180 190
pF1KE2 FAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCR
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE2 SIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHG
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE2 EVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADL
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE2 PKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSL
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE2 KKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRR
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE2 YPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDE
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE2 DPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESW
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE2 DFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNS
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE2 THAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVL
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE2 YNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVN
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE2 KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAG
640 650 660 670 680 690
800 810 820 830 840 850
pF1KE2 RISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPAL
700 710 720 730 740 750
860 870 880
pF1KE2 MQHLADNYKHWKTLDDLKCKSLRLPSDS
::::::::::::::::::::::::::::
XP_005 MQHLADNYKHWKTLDDLKCKSLRLPSDS
760 770 780
>>XP_006714789 (OMIM: 603390,609161,614190) PREDICTED: h (905 aa)
initn: 5200 init1: 5200 opt: 5209 Z-score: 4997.4 bits: 935.9 E(85289): 0
Smith-Waterman score: 5901; 97.8% identity (97.8% similar) in 905 aa overlap (1-885:1-905)
10 20 30 40 50 60
pF1KE2 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
10 20 30 40 50 60
70 80 90 100 110
pF1KE2 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVK-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKIGASQTS
70 80 90 100 110 120
120 130 140 150 160
pF1KE2 -------------QVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCN
:::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNLRVKKVDAYLHQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCN
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE2 IARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDD
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE2 HEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHE
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE2 AIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE2 WQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDN
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE2 SQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINII
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE2 NAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNE
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE2 YVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKV
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE2 FSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSL
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE2 DQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDT
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE2 KCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNP
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE2 AGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMP
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE2 VFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLR
850 860 870 880 890 900
pF1KE2 LPSDS
:::::
XP_006 LPSDS
>>XP_011542005 (OMIM: 603390,609161,614190) PREDICTED: h (780 aa)
initn: 5204 init1: 5204 opt: 5204 Z-score: 4993.6 bits: 935.0 E(85289): 0
Smith-Waterman score: 5204; 99.9% identity (100.0% similar) in 774 aa overlap (112-885:7-780)
90 100 110 120 130 140
pF1KE2 SAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKE
:.::::::::::::::::::::::::::::
XP_011 MNNLSMVNQVSSAEVRIGPMRLTQDPIQVLLIFAKE
10 20 30
150 160 170 180 190 200
pF1KE2 DSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRA
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE2 TNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRS
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE2 QFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSD
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE2 KNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLC
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE2 CTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSM
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE2 ARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHT
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE2 SDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNI
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE2 FELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAA
460 470 480 490 500 510
630 640 650 660 670 680
pF1KE2 DVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDT
520 530 540 550 560 570
690 700 710 720 730 740
pF1KE2 AVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVN
580 590 600 610 620 630
750 760 770 780 790 800
pF1KE2 SINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISE
640 650 660 670 680 690
810 820 830 840 850 860
pF1KE2 EYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHL
700 710 720 730 740 750
870 880
pF1KE2 ADNYKHWKTLDDLKCKSLRLPSDS
::::::::::::::::::::::::
XP_011 ADNYKHWKTLDDLKCKSLRLPSDS
760 770 780
>>XP_006714788 (OMIM: 603390,609161,614190) PREDICTED: h (906 aa)
initn: 5201 init1: 5201 opt: 5205 Z-score: 4993.6 bits: 935.2 E(85289): 0
Smith-Waterman score: 5899; 97.7% identity (97.7% similar) in 906 aa overlap (1-885:1-906)
10 20 30 40 50 60
pF1KE2 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
10 20 30 40 50 60
70 80 90 100 110
pF1KE2 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVK-------
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKIGASQTS
70 80 90 100 110 120
120 130 140 150
pF1KE2 --------------QVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRC
::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNLRVKKVDAYLHQQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRC
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE2 NIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSD
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE2 DHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCH
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE2 EAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE2 EWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGD
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE2 NSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE2 INAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGN
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE2 EYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLK
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE2 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGS
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE2 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKD
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE2 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECN
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE2 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVM
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE2 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSL
850 860 870 880 890 900
880
pF1KE2 RLPSDS
::::::
XP_006 RLPSDS
>>XP_005248680 (OMIM: 603390,609161,614190) PREDICTED: h (784 aa)
initn: 5203 init1: 5203 opt: 5203 Z-score: 4992.6 bits: 934.8 E(85289): 0
Smith-Waterman score: 5203; 99.5% identity (99.9% similar) in 776 aa overlap (110-885:9-784)
80 90 100 110 120 130
pF1KE2 AGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFA
.. .::::::::::::::::::::::::::
XP_005 MDQLYCPPSACQQVSSAEVRIGPMRLTQDPIQVLLIFA
10 20 30
140 150 160 170 180 190
pF1KE2 KEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSI
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE2 RATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEV
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE2 RSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPK
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE2 SDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKK
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE2 LCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYP
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE2 SMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDP
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE2 HTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDF
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE2 NIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTH
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE2 AADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN
520 530 540 550 560 570
680 690 700 710 720 730
pF1KE2 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF
580 590 600 610 620 630
740 750 760 770 780 790
pF1KE2 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI
640 650 660 670 680 690
800 810 820 830 840 850
pF1KE2 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQ
700 710 720 730 740 750
860 870 880
pF1KE2 HLADNYKHWKTLDDLKCKSLRLPSDS
::::::::::::::::::::::::::
XP_005 HLADNYKHWKTLDDLKCKSLRLPSDS
760 770 780
>>XP_011542004 (OMIM: 603390,609161,614190) PREDICTED: h (774 aa)
initn: 5201 init1: 5201 opt: 5201 Z-score: 4990.8 bits: 934.4 E(85289): 0
Smith-Waterman score: 5201; 99.7% identity (100.0% similar) in 774 aa overlap (112-885:1-774)
90 100 110 120 130 140
pF1KE2 SAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKE
..::::::::::::::::::::::::::::
XP_011 MEQVSSAEVRIGPMRLTQDPIQVLLIFAKE
10 20 30
150 160 170 180 190 200
pF1KE2 DSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRA
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE2 TNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRS
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE2 QFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSD
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE2 KNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLC
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE2 CTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSM
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE2 ARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHT
340 350 360 370 380 390
510 520 530 540 550 560
pF1KE2 SDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNI
400 410 420 430 440 450
570 580 590 600 610 620
pF1KE2 FELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAA
460 470 480 490 500 510
630 640 650 660 670 680
pF1KE2 DVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDT
520 530 540 550 560 570
690 700 710 720 730 740
pF1KE2 AVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVN
580 590 600 610 620 630
750 760 770 780 790 800
pF1KE2 SINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISE
640 650 660 670 680 690
810 820 830 840 850 860
pF1KE2 EYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHL
700 710 720 730 740 750
870 880
pF1KE2 ADNYKHWKTLDDLKCKSLRLPSDS
::::::::::::::::::::::::
XP_011 ADNYKHWKTLDDLKCKSLRLPSDS
760 770
>>XP_011542003 (OMIM: 603390,609161,614190) PREDICTED: h (805 aa)
initn: 5201 init1: 5201 opt: 5201 Z-score: 4990.5 bits: 934.4 E(85289): 0
Smith-Waterman score: 5201; 99.9% identity (100.0% similar) in 773 aa overlap (113-885:33-805)
90 100 110 120 130 140
pF1KE2 AAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKED
.:::::::::::::::::::::::::::::
XP_011 QLYCPPSACQIGASQTSSNLRVKKVDAYLHQQVSSAEVRIGPMRLTQDPIQVLLIFAKED
10 20 30 40 50 60
150 160 170 180 190 200
pF1KE2 SQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRAT
70 80 90 100 110 120
210 220 230 240 250 260
pF1KE2 NPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQ
130 140 150 160 170 180
270 280 290 300 310 320
pF1KE2 FKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDK
190 200 210 220 230 240
330 340 350 360 370 380
pF1KE2 NRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCC
250 260 270 280 290 300
390 400 410 420 430 440
pF1KE2 TTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMA
310 320 330 340 350 360
450 460 470 480 490 500
pF1KE2 RIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTS
370 380 390 400 410 420
510 520 530 540 550 560
pF1KE2 DLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIF
430 440 450 460 470 480
570 580 590 600 610 620
pF1KE2 ELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAAD
490 500 510 520 530 540
630 640 650 660 670 680
pF1KE2 VLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA
550 560 570 580 590 600
690 700 710 720 730 740
pF1KE2 VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNS
610 620 630 640 650 660
750 760 770 780 790 800
pF1KE2 INKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEE
670 680 690 700 710 720
810 820 830 840 850 860
pF1KE2 YFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLA
730 740 750 760 770 780
870 880
pF1KE2 DNYKHWKTLDDLKCKSLRLPSDS
:::::::::::::::::::::::
XP_011 DNYKHWKTLDDLKCKSLRLPSDS
790 800
885 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:11:54 2016 done: Mon Nov 7 20:11:56 2016
Total Scan time: 11.530 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]