Result of FASTA (omim) for
pFN21AE2378
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2378, 488 aa
1>>>pF1KE2378 488 - 488 aa - 488 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1933+/-0.000436; mu= 8.7279+/- 0.027
mean_var=129.4962+/-26.440, 0's: 0 Z-trim(114.3): 118 B-trim: 1250 in 1/53
Lambda= 0.112706
statistics sampled from 23896 (24017) to 23896 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.282), width: 16
Scan time: 9.320
The best scores are: opt bits E(85289)
NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 3343 555.4 1.3e-157
XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 518.5 1.6e-146
XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 518.5 1.6e-146
NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 2880 480.1 5.8e-135
NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 1833 309.9 9.3e-84
XP_011539611 (OMIM: 601241) PREDICTED: histone dea ( 289) 1614 274.2 3.6e-73
NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 1089 188.9 2.2e-47
XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 1083 187.9 4.9e-47
XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379) 992 173.1 1.2e-42
XP_011535999 (OMIM: 605166) PREDICTED: histone dea ( 241) 933 163.4 6.6e-40
XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274) 882 155.1 2.3e-37
NP_001159890 (OMIM: 300269) histone deacetylase 8 ( 286) 821 145.2 2.3e-34
XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350) 816 144.5 4.8e-34
NP_001159891 (OMIM: 300269) histone deacetylase 8 ( 256) 721 128.9 1.7e-29
XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389) 536 99.0 2.6e-20
XP_016885133 (OMIM: 300269) PREDICTED: histone dea ( 324) 530 97.9 4.5e-20
XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415) 530 98.0 5.5e-20
XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268) 469 88.0 3.7e-17
NP_001308156 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12
NP_001308157 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12
NP_001308155 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12
NP_001308158 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12
NP_006035 (OMIM: 300272,300863) histone deacetylas (1215) 384 74.6 1.8e-12
NP_001308154 (OMIM: 300272,300863) histone deacety (1229) 384 74.6 1.8e-12
XP_016885134 (OMIM: 300269) PREDICTED: histone dea ( 315) 374 72.6 1.9e-12
XP_016885132 (OMIM: 300269) PREDICTED: histone dea ( 341) 368 71.6 4e-12
NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 368 71.9 9.7e-12
NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 368 71.9 9.7e-12
XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 368 71.9 9.7e-12
XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 368 71.9 9.7e-12
XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 368 71.9 9.8e-12
XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 368 71.9 9.8e-12
XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 368 71.9 9.8e-12
XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 368 71.9 9.8e-12
XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 368 71.9 9.8e-12
NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 368 71.9 9.8e-12
XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 368 71.9 9.8e-12
XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 368 71.9 1e-11
NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 368 71.9 1e-11
XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 368 71.9 1e-11
NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 368 71.9 1e-11
XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 368 71.9 1e-11
XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 368 71.9 1e-11
XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 368 71.9 1e-11
XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 368 71.9 1e-11
XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 368 71.9 1e-11
XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 368 71.9 1e-11
XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 368 71.9 1e-11
XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 368 71.9 1e-11
NP_478056 (OMIM: 606543) histone deacetylase 9 iso (1011) 342 67.7 1.8e-10
>>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s (488 aa)
initn: 3343 init1: 3343 opt: 3343 Z-score: 2950.8 bits: 555.4 E(85289): 1.3e-157
Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488)
10 20 30 40 50 60
pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
430 440 450 460 470 480
pF1KE2 KSEQLSNP
::::::::
NP_001 KSEQLSNP
>>XP_016866288 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 3116 init1: 3116 opt: 3116 Z-score: 2751.7 bits: 518.5 E(85289): 1.6e-146
Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (31-488:1-458)
10 20 30 40 50 60
pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
::::::::::::::::::::::::::::::
XP_016 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30
70 80 90 100 110 120
pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
400 410 420 430 440 450
pF1KE2 KSEQLSNP
::::::::
XP_016 KSEQLSNP
>>XP_011534090 (OMIM: 605164) PREDICTED: histone deacety (458 aa)
initn: 3116 init1: 3116 opt: 3116 Z-score: 2751.7 bits: 518.5 E(85289): 1.6e-146
Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (31-488:1-458)
10 20 30 40 50 60
pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
::::::::::::::::::::::::::::::
XP_011 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30
70 80 90 100 110 120
pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
400 410 420 430 440 450
pF1KE2 KSEQLSNP
::::::::
XP_011 KSEQLSNP
>>NP_004955 (OMIM: 601241) histone deacetylase 1 [Homo s (482 aa)
initn: 2951 init1: 2811 opt: 2880 Z-score: 2544.0 bits: 480.1 E(85289): 5.8e-135
Smith-Waterman score: 2880; 85.9% identity (95.0% similar) in 483 aa overlap (1-483:1-478)
10 20 30 40 50 60
pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
:: .:: ..:::::::::.::::::::::::::::::::::::::::::::::::::::
NP_004 MAQTQGT-RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
.::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
.:::::.::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::::
NP_004 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
::::..::::::.::::::::::.::::::::::::::.:::::::: ::.::::.::::
NP_004 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
:::::::::::::::::::::: ::::::::::::::::::::::::::::::::: ::.
NP_004 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
:::::::::::::::::::::::::::::. :.::::: .:::::::: .:::::::.::
NP_004 EKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEE
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
:::::.::::::.: .. :: ::... :..:.. ..: .: ::.:.:. :: ..::.
NP_004 FSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEEEKTKE---EKPEAKGV
420 430 440 450 460 470
pF1KE2 KSEQLSNP
: :
NP_004 KEEVKLA
480
>>NP_003874 (OMIM: 605166) histone deacetylase 3 [Homo s (428 aa)
initn: 1131 init1: 978 opt: 1833 Z-score: 1624.7 bits: 309.9 E(85289): 9.3e-84
Smith-Waterman score: 1833; 58.8% identity (84.4% similar) in 422 aa overlap (10-429:3-421)
10 20 30 40 50 60
pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
: : :.:: :.::..:: ::::::::. .::.:.:.::::.:: ...:..:
NP_003 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQA
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
. ..: ..::..:: ::. . : ::. ..:... ::::.::::: ::::::. ::.:.
NP_003 SQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
::..:: . :.:.::::::::::: ::::::::::::..:::::::: :::::::::::
NP_003 GATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHH
120 130 140 150 160 170
190 200 210 220 230
pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYG
::::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.::
NP_003 GDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE2 QIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLML
..:.:.:..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.:
NP_003 HLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE2 GGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPE
::::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. .
NP_003 GGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQ
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE2 YMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACD
:...:.: .::::.:: :::.::.. .: : . : :: : ..: . . . .:
NP_003 YLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE--ADAEER-GPEENYSRPEAP
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE2 EEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTK
.:: :.. ...
NP_003 NEFYDGDHDNDKESDVEI
420
>>XP_011539611 (OMIM: 601241) PREDICTED: histone deacety (289 aa)
initn: 1677 init1: 1565 opt: 1614 Z-score: 1434.7 bits: 274.2 E(85289): 3.6e-73
Smith-Waterman score: 1614; 80.6% identity (92.7% similar) in 289 aa overlap (195-483:1-285)
170 180 190 200 210 220
pF1KE2 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYA
::::::::::::::::::::::::::::::
XP_011 MTVSFHKYGEYFPGTGDLRDIGAGKGKYYA
10 20 30
230 240 250 260 270 280
pF1KE2 VNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAK
::.:.::::::::: ::::..::::::.::::::::::.::::::::::::::.:::::
XP_011 VNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAK
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE2 CVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKL
::: ::.::::.:::::::::::::::::::::::::: :::::::::::::::::::::
XP_011 CVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKL
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE2 HISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDK
:::::::::::: ::.:::::::::::::::::::::::::::::. :.::::: .::::
XP_011 HISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDK
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE2 RISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEE
:::: .:::::::.:::::::.::::::.: .. :: ::... :..:.. ..: .: ::
XP_011 RISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEE
220 230 240 250 260
470 480
pF1KE2 DKSKDNSGEKTDTKGTKSEQLSNP
.:.:. :: ..::.: :
XP_011 EKTKE---EKPEAKGVKEEVKLA
270 280
>>NP_060956 (OMIM: 300269) histone deacetylase 8 isoform (377 aa)
initn: 975 init1: 551 opt: 1089 Z-score: 971.7 bits: 188.9 E(85289): 2.2e-47
Smith-Waterman score: 1089; 43.4% identity (77.1% similar) in 341 aa overlap (33-372:35-374)
10 20 30 40 50 60
pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA
:.: :.:.:. :.:...:.: .:. :.
NP_060 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
NP_060 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
NP_060 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: ::
NP_060 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
. ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.:::
NP_060 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
:::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. ..
NP_060 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF
.: . . ::.
NP_060 QILNYIKGNLKHVV
370
>>XP_011529288 (OMIM: 300269) PREDICTED: histone deacety (441 aa)
initn: 525 init1: 525 opt: 1083 Z-score: 965.4 bits: 187.9 E(85289): 4.9e-47
Smith-Waterman score: 1083; 44.0% identity (77.7% similar) in 332 aa overlap (33-363:73-403)
10 20 30 40 50 60
pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA
:.: :.:.:. :.:...:.: .:. :.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
70 80 90 100 110 120
pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
130 140 150 160 170 180
pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: ::
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
250 260 270 280 290 300
pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
. ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
310 320 330 340 350 360
pF1KE2 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
:::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. ..
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ
350 360 370 380 390 400
370 380 390 400 410 420
pF1KE2 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF
.:
XP_011 QILNYIKEKWPVGFGAQCFYLGKCGKAKTTEGQRNLKHVV
410 420 430 440
>>XP_011529289 (OMIM: 300269) PREDICTED: histone deacety (379 aa)
initn: 863 init1: 439 opt: 992 Z-score: 886.4 bits: 173.1 E(85289): 1.2e-42
Smith-Waterman score: 992; 45.2% identity (78.3% similar) in 299 aa overlap (33-330:73-370)
10 20 30 40 50 60
pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA
:.: :.:.:. :.:...:.: .:. :.
XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
50 60 70 80 90 100
70 80 90 100 110 120
pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA
:::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....:
XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA
110 120 130 140 150 160
130 140 150 160 170 180
pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD
: . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.::::
XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI
:::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: ::
XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI
230 240 250 260 270 280
250 260 270 280 290 300
pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG
. ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.:::
XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG
290 300 310 320 330 340
310 320 330 340 350 360
pF1KE2 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME
:::.. :.:::::: :.: : . .:.:
XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHENMPVNT
350 360 370
>>XP_011535999 (OMIM: 605166) PREDICTED: histone deacety (241 aa)
initn: 869 init1: 716 opt: 933 Z-score: 837.4 bits: 163.4 E(85289): 6.6e-40
Smith-Waterman score: 933; 54.4% identity (82.3% similar) in 237 aa overlap (195-429:1-234)
170 180 190 200 210 220
pF1KE2 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYY
:::::::::.:: :::::. ..:: .:.::
XP_011 MTVSFHKYGNYFFPGTGDMYEVGAESGRYY
10 20 30
230 240 250 260 270 280
pF1KE2 AVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHA
.: :.::::::.:: ..:.:.:..:...:::. .:::::::::. ::::::::...::.
XP_011 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE2 KCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFK
.::: ::.::.:::.:::::::.:::::::::::.. .. : .::::..:::::.:::
XP_011 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE2 LHISPSN-MTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDP
:: . :. . :::. .:...:.: .::::.:: :::.::.. .: : . : :: :
XP_011 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE--ADA
160 170 180 190 200
410 420 430 440 450 460
pF1KE2 DKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVK
..: . . . .: .:: :.. ...
XP_011 EER-GPEENYSRPEAPNEFYDGDHDNDKESDVEI
210 220 230 240
488 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:31:01 2016 done: Sun Nov 6 09:31:02 2016
Total Scan time: 9.320 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]