Result of FASTA (omim) for
pFN21AE2337
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2337, 867 aa
1>>>pF1KE2337 867 - 867 aa - 867 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.0318+/-0.000465; mu= -6.4256+/- 0.029
mean_var=279.3721+/-56.749, 0's: 0 Z-trim(117.9): 38 B-trim: 0 in 0/58
Lambda= 0.076733
statistics sampled from 30335 (30367) to 30335 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.691), E-opt: 0.2 (0.356), width: 16
Scan time: 9.880
The best scores are: opt bits E(85289)
NP_001243300 (OMIM: 612047) transcription factor E ( 867) 5678 642.9 1.9e-183
NP_078956 (OMIM: 612047) transcription factor E2F8 ( 867) 5678 642.9 1.9e-183
NP_001243301 (OMIM: 612047) transcription factor E ( 867) 5678 642.9 1.9e-183
XP_011518669 (OMIM: 612047) PREDICTED: transcripti ( 762) 3958 452.4 3.6e-126
NP_976328 (OMIM: 612046) transcription factor E2F7 ( 911) 911 115.2 1.5e-24
XP_011536268 (OMIM: 612046) PREDICTED: transcripti ( 866) 903 114.3 2.6e-24
XP_011536271 (OMIM: 612046) PREDICTED: transcripti ( 810) 710 92.9 6.6e-18
>>NP_001243300 (OMIM: 612047) transcription factor E2F8 (867 aa)
initn: 5678 init1: 5678 opt: 5678 Z-score: 3414.3 bits: 642.9 E(85289): 1.9e-183
Smith-Waterman score: 5678; 100.0% identity (100.0% similar) in 867 aa overlap (1-867:1-867)
10 20 30 40 50 60
pF1KE2 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
790 800 810 820 830 840
850 860
pF1KE2 FEGANKTSLGTLFVPQRKLEVSTEDVH
:::::::::::::::::::::::::::
NP_001 FEGANKTSLGTLFVPQRKLEVSTEDVH
850 860
>>NP_078956 (OMIM: 612047) transcription factor E2F8 [Ho (867 aa)
initn: 5678 init1: 5678 opt: 5678 Z-score: 3414.3 bits: 642.9 E(85289): 1.9e-183
Smith-Waterman score: 5678; 100.0% identity (100.0% similar) in 867 aa overlap (1-867:1-867)
10 20 30 40 50 60
pF1KE2 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
790 800 810 820 830 840
850 860
pF1KE2 FEGANKTSLGTLFVPQRKLEVSTEDVH
:::::::::::::::::::::::::::
NP_078 FEGANKTSLGTLFVPQRKLEVSTEDVH
850 860
>>NP_001243301 (OMIM: 612047) transcription factor E2F8 (867 aa)
initn: 5678 init1: 5678 opt: 5678 Z-score: 3414.3 bits: 642.9 E(85289): 1.9e-183
Smith-Waterman score: 5678; 100.0% identity (100.0% similar) in 867 aa overlap (1-867:1-867)
10 20 30 40 50 60
pF1KE2 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
790 800 810 820 830 840
850 860
pF1KE2 FEGANKTSLGTLFVPQRKLEVSTEDVH
:::::::::::::::::::::::::::
NP_001 FEGANKTSLGTLFVPQRKLEVSTEDVH
850 860
>>XP_011518669 (OMIM: 612047) PREDICTED: transcription f (762 aa)
initn: 4957 init1: 3945 opt: 3958 Z-score: 2386.1 bits: 452.4 E(85289): 3.6e-126
Smith-Waterman score: 4751; 87.8% identity (87.9% similar) in 867 aa overlap (1-867:1-762)
10 20 30 40 50 60
pF1KE2 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW
::::::::::::::::::::::::::::::.
XP_011 LCHKFLARYPNYPNPAVNNDICLDEVAEELT-----------------------------
130 140 150
190 200 210 220 230 240
pF1KE2 HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGH
XP_011 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE2 PDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
::::::::::::::::::::::::::::::::::::::::::::
XP_011 ----------------SVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
160 170 180 190
310 320 330 340 350 360
pF1KE2 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPV
200 210 220 230 240 250
370 380 390 400 410 420
pF1KE2 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IHFTPSDLEVRRSSKENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIK
260 270 280 290 300 310
430 440 450 460 470 480
pF1KE2 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVN
320 330 340 350 360 370
490 500 510 520 530 540
pF1KE2 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGL
380 390 400 410 420 430
550 560 570 580 590 600
pF1KE2 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
440 450 460 470 480 490
610 620 630 640 650 660
pF1KE2 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENS
500 510 520 530 540 550
670 680 690 700 710 720
pF1KE2 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALAS
560 570 580 590 600 610
730 740 750 760 770 780
pF1KE2 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQG
620 630 640 650 660 670
790 800 810 820 830 840
pF1KE2 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMD
680 690 700 710 720 730
850 860
pF1KE2 FEGANKTSLGTLFVPQRKLEVSTEDVH
:::::::::::::::::::::::::::
XP_011 FEGANKTSLGTLFVPQRKLEVSTEDVH
740 750 760
>>NP_976328 (OMIM: 612046) transcription factor E2F7 [Ho (911 aa)
initn: 1206 init1: 499 opt: 911 Z-score: 562.0 bits: 115.2 E(85289): 1.5e-24
Smith-Waterman score: 1401; 37.3% identity (61.1% similar) in 934 aa overlap (2-863:27-907)
10 20 30
pF1KE2 MEN-EKENLFCEPHKRGLMKTPLKESTTANIVLAE
:: .:::.: . ..: :::.:. .
NP_976 MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVD-RSRMAPKTPIKNEPIDLSKQKK
10 20 30 40 50
40 50 60 70 80 90
pF1KE2 IQPDFGPLTTPTKPKEGSQGEPWTPTANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEA-
. :. .:.: :.: . .:.:::::::::::::::.::.::.:..:.::: . .:
NP_976 FTPERNPIT-PVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAF
60 70 80 90 100 110
100 110 120 130 140
pF1KE2 KDCIHEHLSGD----EFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEE
: .. . :: ::::..::::.:::::::.:::::::.:: . .. : :::::
NP_976 TDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVS
120 130 140 150 160 170
150 160 170 180 190 200
pF1KE2 LNVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMI
:.:::::::::::::::::.:::.:::.: :::::.: ::: .:. .:::.:: ::. ..
NP_976 LGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYL
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE2 KKKEYEQEFDFIKSYSIEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVM
..: :.:.: .:.. .. :.. :... .. .... . ..:.:::::::::.:
NP_976 QQK----ELDLI-DYKFGER--KKDGDPDSQEQQ-LLDFSEPDCPSSSANSRKDKSLRIM
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE2 SQKFVMLFLVSTPQIVSLEVAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIK
::::::::::: .::.:.::::::: :. . :.::::::.::::::::::.:: :::
NP_976 SQKFVMLFLVSKTKIVTLDVAAKILI-EESQDAPDHSKFKTKVRRLYDIANVLTSLALIK
300 310 320 330 340
330 340 350 360 370 380
pF1KE2 KVHVTEERGRKPAFKWTGPEISPNTSGSSPVIHFTPSDL-EVRRSSK---ENCAKNLFST
:::::::::::::::: :: .:.. .. . : : :..: . . :::.
NP_976 KVHVTEERGRKPAFKWIGP--VDFSSSDEELVDVSASVLPELKRETYGQIQVCAKQ----
350 360 370 380 390 400
390 400 410 420 430 440
pF1KE2 RGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICK
...:: :. . :.. : .::.:: :::: . . :.:. . ....:::. .
NP_976 ----KLARHGSF-NTVQASERIQRKVNSEPSSPYREE-----QGSGGYSLEIGSLAAVYR
410 420 430 440 450
450 460 470 480 490
pF1KE2 MQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPLGMVPL------
...:..:. . : . :. ::::. : .... : . : .:. :
NP_976 QKIEDNSQGKAFASKRVVPPSSSLDPVAPF-PVLSVDPEYCVNPLAHPVFSVAQTDLQAF
460 470 480 490 500 510
500 510 520 530 540 550
pF1KE2 -IPSPLSSAVPLILPQAPSGPSYAIYLQPTQ-AHQSVT--PPQGLSPTVCTTHSSKATGS
. . :.. : . : .: :. :.:. : : .. : .: . . . :.::
NP_976 SMQNGLNGQVDVSLASAASAVES---LKPALLAGQPLVYVPSASLFMLYGSLQEGPASGS
520 530 540 550 560
560 570 580 590 600
pF1KE2 KDSTDATTEKAANDTSKASASTRPGSLL----PAPERQGAKSR-TRE----PAGERGSKR
. : . .: . .:: . : : : . : .: .:: : . :.
NP_976 GSERDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSLVMPKK
570 580 590 600 610 620
610 620 630 640 650
pF1KE2 ASMLEDSGSKKKFKE----DLKGLE---NVSATLFPSGYLIPLTQCSS-LGAESILS---
: : .: : . . :: .. .. :. :: . :: : : .
NP_976 PSDSTDLASPKTMGNRASIPLKDIHVNGQLPAAEEISGKATANSLVSSEWGNPSRNTDVE
630 640 650 660 670 680
660 670 680 690 700
pF1KE2 --GKENSSALSPNHRIY---SSPIAGV----IPVTSSEL------TAVNFPSFHVTPLKL
.::: :. :. : .:: ::. . ...:. .. ..::: : : .
NP_976 KPSKENESTKEPSLLQYLCVQSP-AGLNGFNVLLSGSQTPPTVGPSSGQLPSFSV-PCMV
690 700 710 720 730 740
710 720 730 740 750
pF1KE2 MVSPTSVAAVPVGNSPALASSHPVPIQN-----PSSAIVNFTLQHLGLISPNVQLSASPG
. :: .. :: :::. : :... :... :::.: :: :. :: ..:
NP_976 LPSPP-LGPFPVLYSPAM----PGPVSSTLGALPNTGPVNFSLPGLGSIA---QLLVGPT
750 760 770 780 790
760 770 780 790 800
pF1KE2 SGIVPVSPRIESVNVAPENAGTQQGRATNYDSPVPGQS-----QPN-----GQSVAVTGA
. . : : . :.. :. :.. . ::: ..: ::. :. :.:.
NP_976 AVVNPKSSTLPSAD--PQ----LQSQPSLNLSPVMSRSHSVVQQPESPVYVGHPVSVVKL
800 810 820 830 840 850
810 820 830 840 850 860
pF1KE2 QQ-PVPVTPKGSQLVA-ESFFRTPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVST
.: :::::::. : . :.::.:::. :. . .. : .: ::.::. .
NP_976 HQSPVPVTPKSIQRTHRETFFKTPGSLGDPVLKRRERNQSRNTSS------AQRRLEIPS
860 870 880 890 900
pF1KE2 EDVH
NP_976 GGAD
910
>>XP_011536268 (OMIM: 612046) PREDICTED: transcription f (866 aa)
initn: 1000 init1: 499 opt: 903 Z-score: 557.5 bits: 114.3 E(85289): 2.6e-24
Smith-Waterman score: 1115; 34.2% identity (57.8% similar) in 931 aa overlap (2-863:27-862)
10 20 30
pF1KE2 MEN-EKENLFCEPHKRGLMKTPLKESTTANIVLAE
:: .:::.: . ..: :::.:. .
XP_011 MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVD-RSRMAPKTPIKNEPIDLSKQKK
10 20 30 40 50
40 50 60 70 80 90
pF1KE2 IQPDFGPLTTPTKPKEGSQGEPWTPTANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEA-
. :. .:.: :.: . .:.:::::::::::::::.::.::.:..:.::: . .:
XP_011 FTPERNPIT-PVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAF
60 70 80 90 100 110
100 110 120 130 140
pF1KE2 KDCIHEHLSGD----EFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEE
: .. . :: ::::..::::.:::::::.:::::::.:: . .. : :::::
XP_011 TDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVS
120 130 140 150 160 170
150 160 170 180 190 200
pF1KE2 LNVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMI
:.:::::::::::::::::.:::.:::.: :::::.: ::: .:. .:::.:: ::. ..
XP_011 LGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYL
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE2 KKKEYEQEFDFIKSYSIEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVM
..: :.:.: .:.. .. :.. :... .. .... . ..:.:::::::::.:
XP_011 QQK----ELDLI-DYKFGER--KKDGDPDSQ-EQQLLDFSEPDCPSSSANSRKDKSLRIM
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE2 SQKFVMLFLVSTPQIVSLEVAAKILIGEDHVEDLDKSKFKTKIRRLYDI-ANVLSSLDLI
::::::::::: .::.:.::::::: :. . :.::::.. .: :. :.::
XP_011 SQKFVMLFLVSKTKIVTLDVAAKILI-EESQDAPDHSKFKNE--ELVDVSASVL------
300 310 320 330 340
330 340 350 360 370 380
pF1KE2 KKVHVTEERGRKPAFKWTGPEISPNTSGSSPVIHFTPSDLEVRRSSKENCAKNLFSTRGK
::.. .: :. : :::.
XP_011 -------------------PELKRETYGQIQV-----------------CAKQ-------
350
390 400 410 420 430 440
pF1KE2 PNFTRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQL
...:: :. . :.. : .::.:: :::: . . :.:. . ....:::. ....
XP_011 -KLARHGSF-NTVQASERIQRKVNSEPSSPYREE-----QGSGGYSLEIGSLAAVYRQKI
360 370 380 390 400 410
450 460 470 480 490 500
pF1KE2 EEQSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPLGMVPL-------IP
:..:. . : . :. ::::. : .... : . : .:. : .
XP_011 EDNSQGKAFASKRVVPPSSSLDPVAPF-PVLSVDPEYCVNPLAHPVFSVAQTDLQAFSMQ
420 430 440 450 460 470
510 520 530 540 550
pF1KE2 SPLSSAVPLILPQAPSGPSYAIYLQPTQ-AHQSVT--PPQGLSPTVCTTHSSKATGSKDS
. :.. : . : .: :. :.:. : : .. : .: . . . :.:: .
XP_011 NGLNGQVDVSLASAASAVES---LKPALLAGQPLVYVPSASLFMLYGSLQEGPASGSGSE
480 490 500 510 520
560 570 580 590 600
pF1KE2 TDATTEKAANDTSKASASTRPGSLL----PAPERQGAKSR-TRE----PAGERGSKRASM
: . .: . .:: . : : : . : .: .:: : . :. :
XP_011 RDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSLVMPKKPSD
530 540 550 560 570 580
610 620 630 640 650
pF1KE2 LEDSGSKKKFKE----DLKGLE---NVSATLFPSGYLIPLTQCSS-LGAESILS-----G
: .: : . . :: .. .. :. :: . :: : : . .
XP_011 STDLASPKTMGNRASIPLKDIHVNGQLPAAEEISGKATANSLVSSEWGNPSRNTDVEKPS
590 600 610 620 630 640
660 670 680 690 700
pF1KE2 KENSSALSPNHRIY---SSPIAGV----IPVTSSEL------TAVNFPSFHVTPLKLMVS
::: :. :. : .:: ::. . ...:. .. ..::: : : .. :
XP_011 KENESTKEPSLLQYLCVQSP-AGLNGFNVLLSGSQTPPTVGPSSGQLPSFSV-PCMVLPS
650 660 670 680 690 700
710 720 730 740 750
pF1KE2 PTSVAAVPVGNSPALASSHPVPIQN-----PSSAIVNFTLQHLGLISPNVQLSASPGSGI
: .. :: :::. : :... :... :::.: :: :. :: ..: . .
XP_011 PP-LGPFPVLYSPAM----PGPVSSTLGALPNTGPVNFSLPGLGSIA---QLLVGPTAVV
710 720 730 740 750
760 770 780 790 800
pF1KE2 VPVSPRIESVNVAPENAGTQQGRATNYDSPVPGQS-----QPN-----GQSVAVTGAQQ-
: : . :.. :. :.. . ::: ..: ::. :. :.:. .:
XP_011 NPKSSTLPSAD--PQ----LQSQPSLNLSPVMSRSHSVVQQPESPVYVGHPVSVVKLHQS
760 770 780 790 800 810
810 820 830 840 850 860
pF1KE2 PVPVTPKGSQLVA-ESFFRTPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVSTEDV
:::::::. : . :.::.:::. :. . .. : .: ::.::. .
XP_011 PVPVTPKSIQRTHRETFFKTPGSLGDPVLKRRERNQSRNTSS------AQRRLEIPSGGA
820 830 840 850 860
pF1KE2 H
XP_011 D
>>XP_011536271 (OMIM: 612046) PREDICTED: transcription f (810 aa)
initn: 1034 init1: 506 opt: 710 Z-score: 442.5 bits: 92.9 E(85289): 6.6e-18
Smith-Waterman score: 1200; 36.4% identity (60.5% similar) in 848 aa overlap (83-863:11-806)
60 70 80 90 100 110
pF1KE2 QGEPWTPTANLKMLISAVSPEIRNRDQKRGLFDNRSGLPEAK-DCIHEHLSGDEFEKSQP
.: .. .:: .: : . . . :::::..:
XP_011 MHLQILYRVMFFVSEEALPYSKLDVVGDS-AVDEFEKQRP
10 20 30
120 130 140 150 160 170
pF1KE2 SRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVS
:::.:::::::.:::::::.:: . .. : ::::: :.:::::::::::::::::.::
XP_011 SRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVS
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE2 RLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHII
:.:::.: :::::.: ::: .:. .:::.:: ::. ....:: .:.: .:.. ..
XP_011 RVAKNQYGWHGRHSLPKTLRNLQRLGEEQKYEEQMAYLQQKE----LDLI-DYKFGER--
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE2 KSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAA
:.. :... .. .... . ..:.:::::::::.:::::::::::: .::.:.:::
XP_011 KKDGDPDSQEQQ-LLDFSEPDCPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAA
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE2 KILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEIS
:::: :. . :.::::::.::::::::::.:: ::::::::::::::::::: ::
XP_011 KILI-EESQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGP--V
220 230 240 250 260
360 370 380 390 400
pF1KE2 PNTSGSSPVIHFTPSDL-EVRRSSK---ENCAKNLFSTRGKPNFTRHPSLIKLVKSIESD
.:.. .. . : : :..: . . :::. ...:: :. . :.. :
XP_011 DFSSSDEELVDVSASVLPELKRETYGQIQVCAKQ--------KLARHGSF-NTVQASERI
270 280 290 300 310
410 420 430 440 450 460
pF1KE2 RRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESRQKVKVQLARSG
.::.:: :::: . . :.:. . ....:::. ....:..:. . : . :.
XP_011 QRKVNSEPSSPYREE-----QGSGGYSLEIGSLAAVYRQKIEDNSQGKAFASKRVVPPSS
320 330 340 350 360 370
470 480 490 500 510 520
pF1KE2 PCKPVAPLDPPVNAEMELTAPSLIQPLGMVPL-------IPSPLSSAVPLILPQAPSGPS
::::. : .... : . : .:. : . . :.. : . : .: :.
XP_011 SLDPVAPF-PVLSVDPEYCVNPLAHPVFSVAQTDLQAFSMQNGLNGQVDVSLASAASAVE
380 390 400 410 420 430
530 540 550 560 570
pF1KE2 YAIYLQPTQ-AHQSVT--PPQGLSPTVCTTHSSKATGSKDSTDATTEKAANDTSKASAST
:.:. : : .. : .: . . . :.:: . : . .: . .:: .
XP_011 ---SLKPALLAGQPLVYVPSASLFMLYGSLQEGPASGSGSERDDRSSEAPATVELSSAPS
440 450 460 470 480 490
580 590 600 610 620
pF1KE2 RPGSLL----PAPERQGAKSR-TRE----PAGERGSKRASMLEDSGSKKKFKE----DLK
: : : . : .: .:: : . :. : : .: : . . ::
XP_011 AQKRLCEERKPQEEDEPATKRQSREYEDGPLSLVMPKKPSDSTDLASPKTMGNRASIPLK
500 510 520 530 540 550
630 640 650 660 670
pF1KE2 GLE---NVSATLFPSGYLIPLTQCSS-LGAESILS-----GKENSSALSPNHRIY---SS
.. .. :. :: . :: : : . .::: :. :. : .:
XP_011 DIHVNGQLPAAEEISGKATANSLVSSEWGNPSRNTDVEKPSKENESTKEPSLLQYLCVQS
560 570 580 590 600 610
680 690 700 710 720
pF1KE2 PIAGV----IPVTSSEL------TAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALASSH
: ::. . ...:. .. ..::: : : .. :: .. :: :::.
XP_011 P-AGLNGFNVLLSGSQTPPTVGPSSGQLPSFSV-PCMVLPSPP-LGPFPVLYSPAM----
620 630 640 650 660
730 740 750 760 770
pF1KE2 PVPIQN-----PSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGT
: :... :... :::.: :: :. :: ..: . . : : . :.. :.
XP_011 PGPVSSTLGALPNTGPVNFSLPGLGSIA---QLLVGPTAVVNPKSSTLPSAD--PQ----
670 680 690 700 710
780 790 800 810 820
pF1KE2 QQGRATNYDSPVPGQS-----QPN-----GQSVAVTGAQQ-PVPVTPKGSQLVA-ESFFR
:.. . ::: ..: ::. :. :.:. .: :::::::. : . :.::.
XP_011 LQSQPSLNLSPVMSRSHSVVQQPESPVYVGHPVSVVKLHQSPVPVTPKSIQRTHRETFFK
720 730 740 750 760 770
830 840 850 860
pF1KE2 TPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVSTEDVH
:::. :. . .. : .: ::.::. .
XP_011 TPGSLGDPVLKRRERNQSRNTSS------AQRRLEIPSGGAD
780 790 800 810
867 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 15:13:45 2016 done: Sun Nov 6 15:13:46 2016
Total Scan time: 9.880 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]