Result of FASTA (omim) for
pFN21AE2314
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2314, 2048 aa
1>>>pF1KE2314 2048 - 2048 aa - 2048 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2541+/-0.000529; mu= 15.7042+/- 0.033
mean_var=126.3708+/-25.064, 0's: 0 Z-trim(110.4): 128 B-trim: 0 in 0/57
Lambda= 0.114091
statistics sampled from 18576 (18694) to 18576 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.553), E-opt: 0.2 (0.219), width: 16
Scan time: 18.840
The best scores are: opt bits E(85289)
NP_065988 (OMIM: 189960,609644,614087) Fanconi ane (2048) 13460 2228.8 0
XP_011535336 (OMIM: 189960,609644,614087) PREDICTE (2053) 13440 2225.5 0
NP_001295062 (OMIM: 189960,609644,614087) Fanconi (2022) 11746 1946.7 0
XP_016877012 (OMIM: 189960,609644,614087) PREDICTE (1801) 11726 1943.4 0
XP_011535337 (OMIM: 189960,609644,614087) PREDICTE (2027) 11726 1943.4 0
XP_016877013 (OMIM: 189960,609644,614087) PREDICTE (1732) 11314 1875.6 0
XP_016877016 (OMIM: 189960,609644,614087) PREDICTE (1653) 10829 1795.7 0
XP_016877014 (OMIM: 189960,609644,614087) PREDICTE (1658) 10809 1792.4 0
XP_016877015 (OMIM: 189960,609644,614087) PREDICTE (1658) 10809 1792.4 0
XP_011535339 (OMIM: 189960,609644,614087) PREDICTE (1391) 9024 1498.6 0
NP_001295063 (OMIM: 189960,609644,614087) Fanconi ( 669) 4425 741.4 7.6e-213
NP_055129 (OMIM: 609631,616298) probable ATP-depen ( 925) 363 72.9 1.9e-11
XP_016880548 (OMIM: 608588) PREDICTED: probable AT ( 678) 247 53.7 8e-06
XP_016880549 (OMIM: 608588) PREDICTED: probable AT ( 678) 247 53.7 8e-06
NP_077024 (OMIM: 608588) probable ATP-dependent RN ( 678) 247 53.7 8e-06
NP_071451 (OMIM: 182250,606951,615846) interferon- (1025) 227 50.5 0.00011
NP_060365 (OMIM: 616621) probable ATP-dependent RN ( 796) 191 44.5 0.0054
XP_011527190 (OMIM: 616621) PREDICTED: probable AT ( 827) 191 44.5 0.0056
>>NP_065988 (OMIM: 189960,609644,614087) Fanconi anemia (2048 aa)
initn: 13460 init1: 13460 opt: 13460 Z-score: 11972.2 bits: 2228.8 E(85289): 0
Smith-Waterman score: 13460; 99.9% identity (100.0% similar) in 2048 aa overlap (1-2048:1-2048)
10 20 30 40 50 60
pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_065 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 QKNSEVDSPLHAVKKRRFPVNRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_065 QKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
1990 2000 2010 2020 2030 2040
pF1KE2 QDRLKSDI
::::::::
NP_065 QDRLKSDI
>>XP_011535336 (OMIM: 189960,609644,614087) PREDICTED: F (2053 aa)
initn: 9647 init1: 9647 opt: 13440 Z-score: 11954.4 bits: 2225.5 E(85289): 0
Smith-Waterman score: 13440; 99.6% identity (99.7% similar) in 2053 aa overlap (1-2048:1-2053)
10 20 30 40 50 60
pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
XP_011 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490
pF1KE2 QKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGI
:::::::::::::::::::.:: :::::::::::::::::::::::::::::::::
XP_011 QKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGI
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 SKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY
:::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_011 SKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY
1810 1820 1830 1840 1850 1860
1860 1870 1880 1890 1900 1910
pF1KE2 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT
1870 1880 1890 1900 1910 1920
1920 1930 1940 1950 1960 1970
pF1KE2 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF
1930 1940 1950 1960 1970 1980
1980 1990 2000 2010 2020 2030
pF1KE2 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML
1990 2000 2010 2020 2030 2040
2040
pF1KE2 PNDLNQDRLKSDI
:::::::::::::
XP_011 PNDLNQDRLKSDI
2050
>>NP_001295062 (OMIM: 189960,609644,614087) Fanconi anem (2022 aa)
initn: 11746 init1: 11746 opt: 11746 Z-score: 10447.5 bits: 1946.7 E(85289): 0
Smith-Waterman score: 13237; 98.6% identity (98.7% similar) in 2048 aa overlap (1-2048:1-2022)
10 20 30 40 50 60
pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQ-------------
190 200 210 220
250 260 270 280 290 300
pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------------AVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
230 240 250 260 270
310 320 330 340 350 360
pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_001 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
1180 1190 1200 1210 1220 1230
1270 1280 1290 1300 1310 1320
pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
1240 1250 1260 1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420 1430 1440
pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
1360 1370 1380 1390 1400 1410
1450 1460 1470 1480 1490 1500
pF1KE2 QKNSEVDSPLHAVKKRRFPVNRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 QKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
1420 1430 1440 1450 1460 1470
1510 1520 1530 1540 1550 1560
pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
1480 1490 1500 1510 1520 1530
1570 1580 1590 1600 1610 1620
pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
1540 1550 1560 1570 1580 1590
1630 1640 1650 1660 1670 1680
pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
1600 1610 1620 1630 1640 1650
1690 1700 1710 1720 1730 1740
pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
1660 1670 1680 1690 1700 1710
1750 1760 1770 1780 1790 1800
pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
1720 1730 1740 1750 1760 1770
1810 1820 1830 1840 1850 1860
pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
1780 1790 1800 1810 1820 1830
1870 1880 1890 1900 1910 1920
pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
1840 1850 1860 1870 1880 1890
1930 1940 1950 1960 1970 1980
pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
1900 1910 1920 1930 1940 1950
1990 2000 2010 2020 2030 2040
pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
1960 1970 1980 1990 2000 2010
pF1KE2 QDRLKSDI
::::::::
NP_001 QDRLKSDI
2020
>>XP_016877012 (OMIM: 189960,609644,614087) PREDICTED: F (1801 aa)
initn: 9647 init1: 9647 opt: 11726 Z-score: 10430.5 bits: 1943.4 E(85289): 0
Smith-Waterman score: 11726; 99.1% identity (99.3% similar) in 1799 aa overlap (1-1794:1-1799)
10 20 30 40 50 60
pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
XP_016 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490
pF1KE2 QKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGI
:::::::::::::::::::.:: :::::::::::::::::::::::::::::::::
XP_016 QKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGI
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC
::::::::::::::::::::::::::::::::::::::::::::: : ::..:
XP_016 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKLTSRNLHVCTSNSSE
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 SKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY
XP_016 G
>>XP_011535337 (OMIM: 189960,609644,614087) PREDICTED: F (2027 aa)
initn: 7933 init1: 7933 opt: 11726 Z-score: 10429.7 bits: 1943.4 E(85289): 0
Smith-Waterman score: 13217; 98.3% identity (98.4% similar) in 2053 aa overlap (1-2048:1-2027)
10 20 30 40 50 60
pF1KE2 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFR
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQ-------------
190 200 210 220
250 260 270 280 290 300
pF1KE2 ILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 -------------AVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAI
230 240 250 260 270
310 320 330 340 350 360
pF1KE2 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGE
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE2 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMF
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE2 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVM
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE2 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTL
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE2 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQ
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE2 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKS
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE2 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKP
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE2 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELE
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE2 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIV
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE2 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRT
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
XP_011 KQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE2 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLF
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE2 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENL
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE2 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSL
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KE2 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDV
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KE2 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANS
1120 1130 1140 1150 1160 1170
1210 1220 1230 1240 1250 1260
pF1KE2 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLY
1180 1190 1200 1210 1220 1230
1270 1280 1290 1300 1310 1320
pF1KE2 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEEL
1240 1250 1260 1270 1280 1290
1330 1340 1350 1360 1370 1380
pF1KE2 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNST
1300 1310 1320 1330 1340 1350
1390 1400 1410 1420 1430 1440
pF1KE2 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPED
1360 1370 1380 1390 1400 1410
1450 1460 1470 1480 1490
pF1KE2 QKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGI
:::::::::::::::::::.:: :::::::::::::::::::::::::::::::::
XP_011 QKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGI
1420 1430 1440 1450 1460 1470
1500 1510 1520 1530 1540 1550
pF1KE2 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQA
1480 1490 1500 1510 1520 1530
1560 1570 1580 1590 1600 1610
pF1KE2 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCK
1540 1550 1560 1570 1580 1590
1620 1630 1640 1650 1660 1670
pF1KE2 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSE
1600 1610 1620 1630 1640 1650
1680 1690 1700 1710 1720 1730
pF1KE2 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTS
1660 1670 1680 1690 1700 1710
1740 1750 1760 1770 1780 1790
pF1KE2 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASC
1720 1730 1740 1750 1760 1770
1800 1810 1820 1830 1840 1850
pF1KE2 SKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY
:::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_011 SKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDY
1780 1790 1800 1810 1820 1830
1860 1870 1880 1890 1900 1910
pF1KE2 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRT
1840 1850 1860 1870 1880 1890
1920 1930 1940 1950 1960 1970
pF1KE2 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQF
1900 1910 1920 1930 1940 1950
1980 1990 2000 2010 2020 2030
pF1KE2 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQML
1960 1970 1980 1990 2000 2010
2040
pF1KE2 PNDLNQDRLKSDI
:::::::::::::
XP_011 PNDLNQDRLKSDI
2020
>>XP_016877013 (OMIM: 189960,609644,614087) PREDICTED: F (1732 aa)
initn: 7521 init1: 7521 opt: 11314 Z-score: 10064.3 bits: 1875.6 E(85289): 0
Smith-Waterman score: 11314; 99.5% identity (99.7% similar) in 1732 aa overlap (322-2048:1-1732)
300 310 320 330 340 350
pF1KE2 PLGEELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVG
::::::::::::::::::::::::::::::
XP_016 MRRDIPNLTKYQIILARDQFRKNPSPNIVG
10 20 30
360 370 380 390 400 410
pF1KE2 IQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMK
40 50 60 70 80 90
420 430 440 450 460 470
pF1KE2 LYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTE
100 110 120 130 140 150
480 490 500 510 520 530
pF1KE2 KKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQ
160 170 180 190 200 210
540 550 560 570 580 590
pF1KE2 FRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSE
220 230 240 250 260 270
600 610 620 630 640 650
pF1KE2 GREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEK
280 290 300 310 320 330
660 670 680 690 700 710
pF1KE2 PSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFS
340 350 360 370 380 390
720 730 740 750 760 770
pF1KE2 SLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHE
400 410 420 430 440 450
780 790 800 810 820 830
pF1KE2 EGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIE
460 470 480 490 500 510
840 850 860 870 880 890
pF1KE2 SDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQ
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_016 SDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQ
520 530 540 550 560 570
900 910 920 930 940 950
pF1KE2 EDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFND
580 590 600 610 620 630
960 970 980 990 1000 1010
pF1KE2 EKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEI
640 650 660 670 680 690
1020 1030 1040 1050 1060 1070
pF1KE2 AKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPN
700 710 720 730 740 750
1080 1090 1100 1110 1120 1130
pF1KE2 DNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQD
760 770 780 790 800 810
1140 1150 1160 1170 1180 1190
pF1KE2 ESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQ
820 830 840 850 860 870
1200 1210 1220 1230 1240 1250
pF1KE2 DQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSD
880 890 900 910 920 930
1260 1270 1280 1290 1300 1310
pF1KE2 SNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLP
940 950 960 970 980 990
1320 1330 1340 1350 1360 1370
pF1KE2 LSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQ
1000 1010 1020 1030 1040 1050
1380 1390 1400 1410 1420 1430
pF1KE2 RFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAK
1060 1070 1080 1090 1100 1110
1440 1450 1460 1470 1480
pF1KE2 GNVLNSPEDQKNSEVDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKV
::::::::::::::::::::::::::::.:: ::::::::::::::::::::::::
XP_016 GNVLNSPEDQKNSEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKV
1120 1130 1140 1150 1160 1170
1490 1500 1510 1520 1530 1540
pF1KE2 CNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFL
1180 1190 1200 1210 1220 1230
1550 1560 1570 1580 1590 1600
pF1KE2 NDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSF
1240 1250 1260 1270 1280 1290
1610 1620 1630 1640 1650 1660
pF1KE2 CVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSR
1300 1310 1320 1330 1340 1350
1670 1680 1690 1700 1710 1720
pF1KE2 IILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNP
1360 1370 1380 1390 1400 1410
1730 1740 1750 1760 1770 1780
pF1KE2 LAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALE
1420 1430 1440 1450 1460 1470
1790 1800 1810 1820 1830 1840
pF1KE2 DSSTSGASCSKSRPHLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVE
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
XP_016 DSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVE
1480 1490 1500 1510 1520 1530
1850 1860 1870 1880 1890 1900
pF1KE2 VCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTG
1540 1550 1560 1570 1580 1590
1910 1920 1930 1940 1950 1960
pF1KE2 DTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVN
1600 1610 1620 1630 1640 1650
1970 1980 1990 2000 2010 2020
pF1KE2 SNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYI
1660 1670 1680 1690 1700 1710
2030 2040
pF1KE2 HYVFDIQMLPNDLNQDRLKSDI
::::::::::::::::::::::
XP_016 HYVFDIQMLPNDLNQDRLKSDI
1720 1730
>>XP_016877016 (OMIM: 189960,609644,614087) PREDICTED: F (1653 aa)
initn: 10829 init1: 10829 opt: 10829 Z-score: 9633.1 bits: 1795.7 E(85289): 0
Smith-Waterman score: 10829; 99.8% identity (99.9% similar) in 1653 aa overlap (396-2048:1-1653)
370 380 390 400 410 420
pF1KE2 SLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRS
::::::::::::::::::::::::::::::
XP_016 MTRSKNELGRNEDFMKLYNHLECMFARTRS
10 20 30
430 440 450 460 470 480
pF1KE2 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF
40 50 60 70 80 90
490 500 510 520 530 540
pF1KE2 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV
100 110 120 130 140 150
550 560 570 580 590 600
pF1KE2 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK
160 170 180 190 200 210
610 620 630 640 650 660
pF1KE2 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY
220 230 240 250 260 270
670 680 690 700 710 720
pF1KE2 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST
280 290 300 310 320 330
730 740 750 760 770 780
pF1KE2 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL
340 350 360 370 380 390
790 800 810 820 830 840
pF1KE2 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI
400 410 420 430 440 450
850 860 870 880 890 900
pF1KE2 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRTSDTDE
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDE
460 470 480 490 500 510
910 920 930 940 950 960
pF1KE2 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KE2 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KE2 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV
640 650 660 670 680 690
1090 1100 1110 1120 1130 1140
pF1KE2 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD
700 710 720 730 740 750
1150 1160 1170 1180 1190 1200
pF1KE2 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD
760 770 780 790 800 810
1210 1220 1230 1240 1250 1260
pF1KE2 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE
820 830 840 850 860 870
1270 1280 1290 1300 1310 1320
pF1KE2 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY
880 890 900 910 920 930
1330 1340 1350 1360 1370 1380
pF1KE2 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE
940 950 960 970 980 990
1390 1400 1410 1420 1430 1440
pF1KE2 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE
1000 1010 1020 1030 1040 1050
1450 1460 1470 1480 1490 1500
pF1KE2 VDSPLHAVKKRRFPVNRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLK
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLK
1060 1070 1080 1090 1100 1110
1510 1520 1530 1540 1550 1560
pF1KE2 HVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIY
1120 1130 1140 1150 1160 1170
1570 1580 1590 1600 1610 1620
pF1KE2 MKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCV
1180 1190 1200 1210 1220 1230
1630 1640 1650 1660 1670 1680
pF1KE2 DFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRE
1240 1250 1260 1270 1280 1290
1690 1700 1710 1720 1730 1740
pF1KE2 SNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEV
1300 1310 1320 1330 1340 1350
1750 1760 1770 1780 1790 1800
pF1KE2 SDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGT
1360 1370 1380 1390 1400 1410
1810 1820 1830 1840 1850 1860
pF1KE2 HTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVER
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVER
1420 1430 1440 1450 1460 1470
1870 1880 1890 1900 1910 1920
pF1KE2 RSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTL
1480 1490 1500 1510 1520 1530
1930 1940 1950 1960 1970 1980
pF1KE2 IGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYI
1540 1550 1560 1570 1580 1590
1990 2000 2010 2020 2030 2040
pF1KE2 TALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLK
1600 1610 1620 1630 1640 1650
pF1KE2 SDI
:::
XP_016 SDI
>>XP_016877014 (OMIM: 189960,609644,614087) PREDICTED: F (1658 aa)
initn: 7016 init1: 7016 opt: 10809 Z-score: 9615.3 bits: 1792.4 E(85289): 0
Smith-Waterman score: 10809; 99.5% identity (99.6% similar) in 1658 aa overlap (396-2048:1-1658)
370 380 390 400 410 420
pF1KE2 SLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRS
::::::::::::::::::::::::::::::
XP_016 MTRSKNELGRNEDFMKLYNHLECMFARTRS
10 20 30
430 440 450 460 470 480
pF1KE2 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF
40 50 60 70 80 90
490 500 510 520 530 540
pF1KE2 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV
100 110 120 130 140 150
550 560 570 580 590 600
pF1KE2 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK
160 170 180 190 200 210
610 620 630 640 650 660
pF1KE2 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY
220 230 240 250 260 270
670 680 690 700 710 720
pF1KE2 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST
280 290 300 310 320 330
730 740 750 760 770 780
pF1KE2 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL
340 350 360 370 380 390
790 800 810 820 830 840
pF1KE2 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI
400 410 420 430 440 450
850 860 870 880 890 900
pF1KE2 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRTSDTDE
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDE
460 470 480 490 500 510
910 920 930 940 950 960
pF1KE2 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KE2 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KE2 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV
640 650 660 670 680 690
1090 1100 1110 1120 1130 1140
pF1KE2 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD
700 710 720 730 740 750
1150 1160 1170 1180 1190 1200
pF1KE2 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD
760 770 780 790 800 810
1210 1220 1230 1240 1250 1260
pF1KE2 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE
820 830 840 850 860 870
1270 1280 1290 1300 1310 1320
pF1KE2 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY
880 890 900 910 920 930
1330 1340 1350 1360 1370 1380
pF1KE2 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE
940 950 960 970 980 990
1390 1400 1410 1420 1430 1440
pF1KE2 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE
1000 1010 1020 1030 1040 1050
1450 1460 1470 1480 1490 1500
pF1KE2 VDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
::::::::::::::.:: ::::::::::::::::::::::::::::::::::::::
XP_016 VDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
1060 1070 1080 1090 1100 1110
1510 1520 1530 1540 1550 1560
pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
1120 1130 1140 1150 1160 1170
1570 1580 1590 1600 1610 1620
pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
1180 1190 1200 1210 1220 1230
1630 1640 1650 1660 1670 1680
pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
1240 1250 1260 1270 1280 1290
1690 1700 1710 1720 1730 1740
pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
1300 1310 1320 1330 1340 1350
1750 1760 1770 1780 1790 1800
pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
1360 1370 1380 1390 1400 1410
1810 1820 1830 1840 1850 1860
pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
1420 1430 1440 1450 1460 1470
1870 1880 1890 1900 1910 1920
pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
1480 1490 1500 1510 1520 1530
1930 1940 1950 1960 1970 1980
pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
1540 1550 1560 1570 1580 1590
1990 2000 2010 2020 2030 2040
pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
1600 1610 1620 1630 1640 1650
pF1KE2 QDRLKSDI
::::::::
XP_016 QDRLKSDI
>>XP_016877015 (OMIM: 189960,609644,614087) PREDICTED: F (1658 aa)
initn: 7016 init1: 7016 opt: 10809 Z-score: 9615.3 bits: 1792.4 E(85289): 0
Smith-Waterman score: 10809; 99.5% identity (99.6% similar) in 1658 aa overlap (396-2048:1-1658)
370 380 390 400 410 420
pF1KE2 SLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRS
::::::::::::::::::::::::::::::
XP_016 MTRSKNELGRNEDFMKLYNHLECMFARTRS
10 20 30
430 440 450 460 470 480
pF1KE2 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSF
40 50 60 70 80 90
490 500 510 520 530 540
pF1KE2 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCV
100 110 120 130 140 150
550 560 570 580 590 600
pF1KE2 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNK
160 170 180 190 200 210
610 620 630 640 650 660
pF1KE2 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSY
220 230 240 250 260 270
670 680 690 700 710 720
pF1KE2 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQEST
280 290 300 310 320 330
730 740 750 760 770 780
pF1KE2 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYL
340 350 360 370 380 390
790 800 810 820 830 840
pF1KE2 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHI
400 410 420 430 440 450
850 860 870 880 890 900
pF1KE2 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSLDNDRNSTVENIFQEDLPNDKRTSDTDE
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 KPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDE
460 470 480 490 500 510
910 920 930 940 950 960
pF1KE2 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KE2 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPC
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KE2 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDV
640 650 660 670 680 690
1090 1100 1110 1120 1130 1140
pF1KE2 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFD
700 710 720 730 740 750
1150 1160 1170 1180 1190 1200
pF1KE2 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRD
760 770 780 790 800 810
1210 1220 1230 1240 1250 1260
pF1KE2 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLE
820 830 840 850 860 870
1270 1280 1290 1300 1310 1320
pF1KE2 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGY
880 890 900 910 920 930
1330 1340 1350 1360 1370 1380
pF1KE2 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSE
940 950 960 970 980 990
1390 1400 1410 1420 1430 1440
pF1KE2 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSE
1000 1010 1020 1030 1040 1050
1450 1460 1470 1480 1490 1500
pF1KE2 VDSPLHAVKKRRFPVNR-----SELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
::::::::::::::.:: ::::::::::::::::::::::::::::::::::::::
XP_016 VDSPLHAVKKRRFPINRVSKYQSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKR
1060 1070 1080 1090 1100 1110
1510 1520 1530 1540 1550 1560
pF1KE2 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSE
1120 1130 1140 1150 1160 1170
1570 1580 1590 1600 1610 1620
pF1KE2 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSE
1180 1190 1200 1210 1220 1230
1630 1640 1650 1660 1670 1680
pF1KE2 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNV
1240 1250 1260 1270 1280 1290
1690 1700 1710 1720 1730 1740
pF1KE2 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKD
1300 1310 1320 1330 1340 1350
1750 1760 1770 1780 1790 1800
pF1KE2 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRP
1360 1370 1380 1390 1400 1410
1810 1820 1830 1840 1850 1860
pF1KE2 HLAGTHTSLRLAQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNR
1420 1430 1440 1450 1460 1470
1870 1880 1890 1900 1910 1920
pF1KE2 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDS
1480 1490 1500 1510 1520 1530
1930 1940 1950 1960 1970 1980
pF1KE2 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIP
1540 1550 1560 1570 1580 1590
1990 2000 2010 2020 2030 2040
pF1KE2 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLN
1600 1610 1620 1630 1640 1650
pF1KE2 QDRLKSDI
::::::::
XP_016 QDRLKSDI
>>XP_011535339 (OMIM: 189960,609644,614087) PREDICTED: F (1391 aa)
initn: 5230 init1: 5230 opt: 9024 Z-score: 8028.6 bits: 1498.6 E(85289): 0
Smith-Waterman score: 9024; 99.2% identity (99.5% similar) in 1390 aa overlap (664-2048:3-1391)
640 650 660 670 680 690
pF1KE2 NPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYR
..: ::::::::::::::::::::::::::
XP_011 MGTFR-GMRQSSLKKDWFLSEEEFKLWNRLYR
10 20 30
700 710 720 730 740 750
pF1KE2 LRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSD
40 50 60 70 80 90
760 770 780 790 800 810
pF1KE2 RCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHK
100 110 120 130 140 150
820 830 840 850 860 870
pF1KE2 KSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHG
160 170 180 190 200 210
880 890 900 910 920 930
pF1KE2 IIDSLDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKS
::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKS
220 230 240 250 260 270
940 950 960 970 980 990
pF1KE2 TSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERF
280 290 300 310 320 330
1000 1010 1020 1030 1040 1050
pF1KE2 LSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNS
340 350 360 370 380 390
1060 1070 1080 1090 1100 1110
pF1KE2 LKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGE
400 410 420 430 440 450
1120 1130 1140 1150 1160 1170
pF1KE2 NNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLV
460 470 480 490 500 510
1180 1190 1200 1210 1220 1230
pF1KE2 SQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFD
520 530 540 550 560 570
1240 1250 1260 1270 1280 1290
pF1KE2 LGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGT
580 590 600 610 620 630
1300 1310 1320 1330 1340 1350
pF1KE2 VIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKI
640 650 660 670 680 690
1360 1370 1380 1390 1400 1410
pF1KE2 RKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLT
700 710 720 730 740 750
1420 1430 1440 1450 1460
pF1KE2 SNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPVNR-----SELSSS
::::::::::::::::::::::::::::::::::::::::::::::.:: ::::::
XP_011 SNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRVSKYQSELSSS
760 770 780 790 800 810
1470 1480 1490 1500 1510 1520
pF1KE2 DESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSS
820 830 840 850 860 870
1530 1540 1550 1560 1570 1580
pF1KE2 DENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNI
880 890 900 910 920 930
1590 1600 1610 1620 1630 1640
pF1KE2 NIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVM
940 950 960 970 980 990
1650 1660 1670 1680 1690 1700
pF1KE2 LKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSV
1000 1010 1020 1030 1040 1050
1710 1720 1730 1740 1750 1760
pF1KE2 PSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDS
1060 1070 1080 1090 1100 1110
1770 1780 1790 1800 1810 1820
pF1KE2 QKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLAQEGKGTCILVGGHEIT
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_011 QKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEIT
1120 1130 1140 1150 1160 1170
1830 1840 1850 1860 1870 1880
pF1KE2 SGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQ
1180 1190 1200 1210 1220 1230
1890 1900 1910 1920 1930 1940
pF1KE2 SMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKEL
1240 1250 1260 1270 1280 1290
1950 1960 1970 1980 1990 2000
pF1KE2 SLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEI
1300 1310 1320 1330 1340 1350
2010 2020 2030 2040
pF1KE2 SMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI
::::::::::::::::::::::::::::::::::::::::
XP_011 SMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI
1360 1370 1380 1390
2048 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 19:46:07 2016 done: Sun Nov 6 19:46:10 2016
Total Scan time: 18.840 Total Display time: 1.320
Function used was FASTA [36.3.4 Apr, 2011]