Result of FASTA (omim) for
pFN21AE2309
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2309, 1257 aa
1>>>pF1KE2309 1257 - 1257 aa - 1257 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4802+/-0.000446; mu= -9.4624+/- 0.028
mean_var=482.8480+/-97.846, 0's: 0 Z-trim(123.1): 164 B-trim: 0 in 0/59
Lambda= 0.058367
statistics sampled from 42133 (42326) to 42133 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.496), width: 16
Scan time: 14.730
The best scores are: opt bits E(85289)
NP_003595 (OMIM: 300904) insulin receptor substrat (1257) 8609 740.7 1.5e-212
XP_006724776 (OMIM: 300904) PREDICTED: insulin rec (1256) 8602 740.1 2.2e-212
XP_005262277 (OMIM: 300904) PREDICTED: insulin rec (1256) 8594 739.4 3.5e-212
XP_011529363 (OMIM: 300904) PREDICTED: insulin rec (1300) 8594 739.4 3.6e-212
NP_005535 (OMIM: 125853,147545) insulin receptor s (1242) 758 79.6 1.5e-13
NP_003740 (OMIM: 125853,600797) insulin receptor s (1338) 716 76.0 1.8e-12
NP_000217 (OMIM: 144200,607606) keratin, type I cy ( 623) 360 45.8 0.0011
>>NP_003595 (OMIM: 300904) insulin receptor substrate 4 (1257 aa)
initn: 8609 init1: 8609 opt: 8609 Z-score: 3937.1 bits: 740.7 E(85289): 1.5e-212
Smith-Waterman score: 8609; 100.0% identity (100.0% similar) in 1257 aa overlap (1-1257:1-1257)
10 20 30 40 50 60
pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
1210 1220 1230 1240 1250
>>XP_006724776 (OMIM: 300904) PREDICTED: insulin recepto (1256 aa)
initn: 8602 init1: 8602 opt: 8602 Z-score: 3933.9 bits: 740.1 E(85289): 2.2e-212
Smith-Waterman score: 8602; 100.0% identity (100.0% similar) in 1256 aa overlap (1-1256:1-1256)
10 20 30 40 50 60
pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRG
1210 1220 1230 1240 1250
>>XP_005262277 (OMIM: 300904) PREDICTED: insulin recepto (1256 aa)
initn: 8594 init1: 8594 opt: 8594 Z-score: 3930.3 bits: 739.4 E(85289): 3.5e-212
Smith-Waterman score: 8594; 100.0% identity (100.0% similar) in 1255 aa overlap (1-1255:1-1255)
10 20 30 40 50 60
pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRE
1210 1220 1230 1240 1250
>>XP_011529363 (OMIM: 300904) PREDICTED: insulin recepto (1300 aa)
initn: 8594 init1: 8594 opt: 8594 Z-score: 3930.1 bits: 739.4 E(85289): 3.6e-212
Smith-Waterman score: 8594; 100.0% identity (100.0% similar) in 1255 aa overlap (1-1255:1-1255)
10 20 30 40 50 60
pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRDGNFK
1210 1220 1230 1240 1250 1260
XP_011 SPLQSDYIATKTHFRRKVMLMEFYLRLLQICLKERKLRGF
1270 1280 1290 1300
>>NP_005535 (OMIM: 125853,147545) insulin receptor subst (1242 aa)
initn: 911 init1: 510 opt: 758 Z-score: 364.3 bits: 79.6 E(85289): 1.5e-13
Smith-Waterman score: 1196; 29.3% identity (53.3% similar) in 1231 aa overlap (78-1218:12-1140)
50 60 70 80 90 100
pF1KE2 SSCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLET-ADAP
.: : ::::: : :.:.:::. . : .:
NP_005 MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGP
10 20 30 40
110 120 130 140 150 160
pF1KE2 ARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRH
:::::::: .:.::. : :.: : : .::....:::.. .:
NP_005 ARLEYYENEKKWRHKSSA-------------------PKRSIPLESCFNINKRADSKNKH
50 60 70 80
170 180 190 200 210 220
pF1KE2 LIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGT--LGAQPDGEPAALAAA-
:.::.:.::.::..:..:.::.::: : .: ..: .. :. ::: : . ...
NP_005 LVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGL
90 100 110 120 130 140
230 240 250 260 270
pF1KE2 -AAAE-------PP--FYKDVWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVA
:.: :: .:.:::::.::.:::. :.: :..:::::.. . ::.::.:.:
NP_005 GEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAA
150 160 170 180 190 200
280 290 300 310 320 330
pF1KE2 SVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMRALCA
.::.::..::::::::..::.:::::.: ::::.:::::: :::::::: .:: :::. .
NP_005 AVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAM-S
210 220 230 240 250 260
340 350 360 370 380
pF1KE2 DEYRARCRSYSISIGAHLLTLLSARRHLGLVPLEPGGWLRRSRFEQFC------------
::.: : .: : : .. ... :.::. : : :::: :..
NP_005 DEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKP
270 280 290 300 310 320
390 400 410 420 430
pF1KE2 ---HLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPASFFRRLAP
..:: .::: : .: . . ::. : .: : : : : : . : . : . :
NP_005 GSFRVRASSDGEGTM--SRPASVDGSPVSPST-NRTHAHRHRGSAR-LHPPLNHSRSI-P
330 340 350 360 370
440 450 460 470 480 490
pF1KE2 SPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYM-PMNNWGSGN
:: :. .: :: :.:.. :. :: .: . : . .: .
NP_005 MPASRCSPSA--------TSPVSLSSSSTSGH-----------GSTSDCLFPRRSSASVS
380 390 400 410
500 510 520 530 540 550
pF1KE2 GRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHG
: : :: :. . .:: . .. . : : . . : .. : . ::.:
NP_005 GSPSDGGFISSDEYGSSPCDFRSSFRSVTPDS---LGHTPPARGEEELS--NYICMGGKG
420 430 440 450 460 470
560 570 580 590 600 610
pF1KE2 SGGGQRPGGGHG-SGGGQGPGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYF
. :.: . : ::.: :.: : .: . :. .....: :.. ..::..
NP_005 PSTLTAPNGHYILSRGGNGHRCTPGTGLG-TSPALAGDEAASAADLDNR----FRKRTHS
480 490 500 510 520
620 630 640 650 660
pF1KE2 GKLTQSKQQQMPPPPPPP----------PPPPPAGGTGGKGKSGGRFRLYFCVDRGATKE
. . . .: : : ::.::.:: . :. . : :. .:
NP_005 AGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGG--RLPGHRHSAFVPTRSYPEE
530 540 550 560 570 580
670 680 690 700 710 720
pF1KE2 CKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVS----SSDYMPMAP
: . : : :: . :: :.:: :::: :. : :.:::::.:
NP_005 GLEMH-------PLERRGGHHRPDSSTLHTDDGYMPMSPGVA-PVPSGRKGSGDYMPMSP
590 600 610 620 630
730 740 750 760 770
pF1KE2 QNVSASK------KRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSE
..::: . .:: . : ::::: : : .:. .:.... ... ..
NP_005 KSVSAPQQIINPIRRHPQR--VDPNGYMMMSP--SGGCSPDIGGGPSSSSSSSNAVPSGT
640 650 660 670 680 690
780 790 800 810 820
pF1KE2 SDYMFMAPGAGAI-------PKNPRNPQGGSSSKSWSSYFSL-P--NPFRSSP----LGQ
: . . :.:. :: : . .::. ..:... : . ::: :
NP_005 SYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGP
700 710 720 730 740 750
830 840 850 860 870
pF1KE2 NDNSEYVPMLPGKFLGRGLDKEVSYNWDPKDAA-------SKPSGEGSFSKPGDGGSPSK
.: .. :.: : :.. :... .:...: : ::. .. .: .: :
NP_005 ED-PQHKPVLSYYSLPRSF-KHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSST
760 770 780 790 800 810
880 890 900 910 920
pF1KE2 PSDHEPPKNKAKRPNRLSFITKGYKIKPKPQKPTHE------QREADSSSDYVNMDFTKR
:: :. : ...:. .: :. :..:.... .
NP_005 SSDS------------LGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPT
820 830 840 850
930 940 950 960 970 980
pF1KE2 ESNTPAPSTQGLP-------DSWGIIAEPRQSAFSNYVNVEFGVPFPNPANDLSDLLRAI
. . :... :: .. .. :. .. ..:::.::: .: : :
NP_005 RLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFG-------SDQSGYL---
860 870 880 890 900
990 1000 1010 1020 1030 1040
pF1KE2 PRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMALADSAIRYDAET
..:... :. : . . . : .:: : .. . :. : . .:
NP_005 --SGPVAFHSS----PSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQE-STGVEM
910 920 930 940 950 960
1050 1060 1070 1080 1090 1100
pF1KE2 GRIYVVDPFSEC-CMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSFFAAARAAVS
::. . : . : :: :. .. .. .: . . .: :....
NP_005 GRLGPAPPGAASICRPTRAVPS--SRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA
970 980 990 1000 1010 1020
1110 1120 1130 1140 1150
pF1KE2 AFPTDSLERDLSPSSAPAVASAAEPTLALSQV-VAAASALAAAP-GIGAAAAAAGFDSAS
: . :: : ... . :..: :: . . .:: :.: ..: : :. .: . . .
NP_005 AEEV-SLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSP
1030 1040 1050 1060 1070
1160 1170 1180 1190 1200 1210
pF1KE2 ARWFQPVANAADAEAVRGAQDVAG-GSNPGAHNPSANLARGDNQA-GGAAAAAAAPEPPP
: . . :: .. : .. .:.:.: . .. : . : ::....... :
NP_005 NRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVK
1080 1090 1100 1110 1120 1130
1220 1230 1240 1250
pF1KE2 RSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
:
NP_005 RHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEP
1140 1150 1160 1170 1180 1190
>>NP_003740 (OMIM: 125853,600797) insulin receptor subst (1338 aa)
initn: 1124 init1: 469 opt: 716 Z-score: 344.7 bits: 76.0 E(85289): 1.8e-12
Smith-Waterman score: 1136; 29.9% identity (52.1% similar) in 1308 aa overlap (79-1226:31-1212)
50 60 70 80 90 100
pF1KE2 SCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLE-------
: : ::::::::::.:.:::.
NP_003 MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA
10 20 30 40 50 60
110 120 130 140 150
pF1KE2 -----TADAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSV
.: : ::::::. .:.: . .:: :.:::.: :...
NP_003 TAGGGSAPQPPRLEYYESEKKWR------------SKAGA-------PKRVIALDCCLNI
70 80 90 100
160 170 180 190 200 210
pF1KE2 SQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGE
..::::....::::.:.:::::..::::.:::.:: :. :. :. : .. : : .
NP_003 NKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEG---RAAAGDAPPAAA
110 120 130 140 150
220 230 240 250
pF1KE2 PAAL------------AAAAAAEPPF---------YKDVWQVIVKPRGLGHRKELSGVFR
::: :.::.:: . :..:::: .::.:::. :.:.::.:
NP_003 PAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYR
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE2 LCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCV
:::. . . ::.:: : ::..::..:::::::...::.:::::.: ::::::::.:: :
NP_003 LCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSV
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE2 VAQNMHELFLEKMRALCAD-EYRARCRSYSISIGA-HLLTLLSARRHLGLVPLEPG--GW
::::.:: .:: :.:: :.: : .: : . .: : ... .:::: :: : :. :
NP_003 VAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGL
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE2 LRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPAS
.:::: ... .:: :.:. :.. . :... :.
NP_003 VRRSRTDSLA------------------ATP--PAAKCSSCRVRTASEGDGGAAAGAAAA
340 350 360 370
440 450 460 470 480
pF1KE2 FFR--RLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGN--PQGKEDQEGSGGDY
: .: :: : :..:: : .:: : :. : . : : :. : .
NP_003 GARPVSVAGSPLSP-GPVRAP---LSRSHTLSG-GCGGRGSKVALLPAGGALQH-SRSMS
380 390 400 410 420 430
490 500 510 520 530
pF1KE2 MPM-NNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQ------CSGEGQ-GSRGGQGSNGQG
::. .. .... :: ......:.:: : . : :: : :. ...:.
NP_003 MPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSP
440 450 460 470 480 490
540 550 560 570 580
pF1KE2 SGGNQCSRDGQGTAGG-------HGSGG----GQRPGGGHGSGGGQGPGDGHGSGGGKNS
: . : : :.. : : :. .. : . :.:::. : . ..
NP_003 SDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHC
500 510 520 530 540 550
590 600 610 620 630 640
pF1KE2 GGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGK
: . :: ... : .:: :.::.: . : ..:. .: : . .:
NP_003 GRSYRRVSGDAAQ-DLDRG--LRKRTY-SLTTPARQRPVPQPSSASLDEYTLMRATFSG-
560 570 580 590 600
650 660 670 680 690 700
pF1KE2 SGGRFRLYFCVDRGATKECKEAKEVKDAEIPEGAAR---GPHRARAFDEDEDDPYVPMRP
:.:: .: . :. . .: :: . : ::. . . :: :.:: :
NP_003 SAGR----LCPSCPAS-----SPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTP
610 620 630 640 650
710 720 730 740 750
pF1KE2 GVA-----TPLVSSSDYMPMAPQNVSASKKRHSRSPFEDSRGYMMMFPRVSPP-PAPSP-
:.: . :.:::::.: .::: :. .: . . . : ..: :::.
NP_003 GAALAGSGSGSCRSDDYMPMSPASVSAPKQ--ILQP-RAAAAAAAAVPSAGPAGPAPTSA
660 670 680 690 700 710
760 770 780
pF1KE2 -----P------KA--PDTNKEDDS-------------KDNDSE----SDYMFMAPGAGA
: :: : .. .:: . :.. .::. ..:. ..
NP_003 AGRTFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAV
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 IPKNPRN------PQGGSSSKSWSS--YFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG
.: . :: .. . : ::: ... .:...:: : .. .::
NP_003 TTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLM--SSPVGRI
780 790 800 810 820 830
850 860 870 880 890
pF1KE2 LDKEV---SYNWDPKDAASKPSGEGSFSKPGDG-GSPSKPSDHEPP-----KNKAKRPNR
:..: . . :..::: : : . : :: .:: .: ...: ::.:
NP_003 LEEERLEPQATPGPSQAASA-FGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTR
840 850 860 870 880 890
900 910 920 930
pF1KE2 LSFITKGYKIKPKPQKPT-HEQR---EADSSSDYVNMDFTKRES--NTPAP-------ST
::. .: :. :. :: : : ..:.:.:: . . . ::: :.
NP_003 LSL--EGL-----PSLPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASS
900 910 920 930 940
940 950 960 970
pF1KE2 QGL-----PDSW------GIIAEPRQ-SAFSNYVNVEF--------GVPFPNPANDLSDL
..: : : : .. :: : .:.:.:..: :.: .:...:. :
NP_003 SSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGL
950 960 970 980 990 1000
980 990 1000 1010 1020 1030
pF1KE2 LRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEE------GDYIEVIFNSAMTPAMALA
: :.:. : :::: : ::. :.... :. .. ::.. :..
NP_003 LS--PEAS-----SPYPPLPPRP-SASPSSSLQPPPPPPAPGELYRLPPASAVATAQG-P
1010 1020 1030 1040 1050
1040 1050 1060 1070 1080 1090
pF1KE2 DSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSF
.: ...:: ..: . .. .: : :.: .:.
NP_003 GAASSLSSDTGDN---GDYTEMAFGVAATP-----PQPIA--------APPKPE------
1060 1070 1080 1090
1100 1110 1120 1130 1140 1150
pF1KE2 FAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASALAAAPGIGAAAAA
:::.: ::....: : .:..: : :: : :: .
NP_003 --AARVAS---PTSGVKR----LSLMEQVSGVEAFLQASQ--------PPDPHRGAKVIR
1100 1110 1120 1130
1160 1170 1180 1190 1200 1210
pF1KE2 AGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSA--NLARGDNQAGGAAAAA
: : ..: . . ... .: .. . . :: :: .. :.. .. ::....
NP_003 A--DPQGGRRRHSSETFSSTTTVTPVSP-SFAHNPKRHNSASVENVSLRKSSEGGVGVGP
1140 1150 1160 1170 1180 1190
1220 1230 1240 1250
pF1KE2 AAPEPPPRSRRV--PRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR
.. . :: : : : ::
NP_003 GGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYI
1200 1210 1220 1230 1240 1250
>>NP_000217 (OMIM: 144200,607606) keratin, type I cytosk (623 aa)
initn: 1534 init1: 309 opt: 360 Z-score: 187.1 bits: 45.8 E(85289): 0.0011
Smith-Waterman score: 372; 44.3% identity (66.5% similar) in 158 aa overlap (453-607:460-601)
430 440 450 460 470
pF1KE2 RRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGS---GNFGEEGNPQGKED
:.. . : ::.:. :. : :. :. .
NP_000 IECQNQEYSLLLSIKMRLEKEIETYHNLLEGGQEDFESSGAGKIGLGGRGGSGGSYGRGS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE2 QEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQG
. ::::.: :.:.: : :::.:: : ::.. .:: :: : :: :: :. :
NP_000 RGGSGGSYG-----GGGSGGGYGGGSGSRG-GSGGSYGGG---SGSGGGSGGGYGG---G
490 500 510 520 530
540 550 560 570 580 590
pF1KE2 SGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKG
:::.. . :..:::..:.: ::: :::::.: : : :::. .:::..:.::: :
NP_000 SGGGHSG----GSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFG
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE2 SDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCV
... : :
NP_000 GESGGSYGGGEEASGSGGGYGGGSGKSSHS
600 610 620
1257 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 17:45:56 2016 done: Mon Nov 7 17:45:58 2016
Total Scan time: 14.730 Total Display time: 0.360
Function used was FASTA [36.3.4 Apr, 2011]